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Researcher

Bast, A.

Full professor - Key domain chair

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  1. 2007
  2. Published
    Wijnen, P. A. H. M., Op den Buisch, R., Drent, M., Kuipers, P. M. J. C., Neefs, C., Bast, A., ... Koek, G. H. (2007). Review article: The prevalence and clinical relevance of cytochrome P450 polymorphisms. Alimentary Pharmacology & Therapeutics, 26(2), 211-219. https://doi.org/10.1111/j.1365-2036.2007.03490.x
  3. Published
    Bruynzeel, A. M., Niessen, H. W. M., Bronzwaer, J. G., van der Hoeven, J. J., Berkhof, J., Bast, A., ... van Groeningen, C. J. (2007). The effect of monohydroxyethylrutoside on doxorubicin-induced cardiotoxicity in patients treated for metastatic cancer in a phase II study. British Journal of Cancer, 97(8), 1084-1089. https://doi.org/10.1038/sj.bjc.6603994
  4. Published
    Schwitters, B., Achanta, G., van der Vlies, D., Morisset, H., Bast, A., & Hanekamp, J. C. (2007). The European regulation of food supplements and food fortification. Intended normal use ' The ultimate tool in organising level playing field markets and regulations or how to break the fairy ring around 'other substances'. Environmental Law and Management, 19, 19-29.
  5. Published
    Rietjens, S. J., Bast, A., Vente, J. D., & Haenen, G. (2007). The olive oil antioxidant hydroxytyrosol efficiently protects against the oxidative stress induced impairment of the NO{middle dot} response of isolated rat aorta. American Journal of Physiology-heart and Circulatory Physiology, 292(4), H1931-H1936. https://doi.org/10.1152/ajpheart.00755.2006
  6. Published
    Boots, A. W., Li, H., Schins, R. P., Heemskerk, J. W., Bast, A., & Haenen, G. R. (2007). The quercetin paradox. Toxicology and Applied Pharmacology, 222(1), 89-96. https://doi.org/10.1016/j.taap.2007.04.004
  7. Published
    Bast, A., & van den Berg, H. (2007). Voedingssupplementen. In J. J. E. V. Everdingen, & J. H. Glerum (Eds.), Diagnose en therapie Jaarboek 2007. (pp. 1179-1205). Bohn Stafleu van Loghum.
  8. 2006
  9. Published
    Willems, A. M., Bruynzeel, A. M., Kedde, M. A., van Groeningen, C. J., Bast, A., & van der Vijgh, W. J. F. (2006). A phase I study of monohydroxyethylrutoside in healthy volunteers. Cancer Chemotherapy and Pharmacology, 57(5), 678-684. https://doi.org/10.1007/s00280-005-0083-7
  10. Published
    Swennen, E. L. R., Dagnelie, P. C., & Bast, A. (2006). ATP inhibits hydroxyl radical formation and the inflammatory response of stimulated whole blood even under circumstances of severe oxidative stress. Free Radical Research, 40(1), 53-8. https://doi.org/10.1080/10715760500364298
  11. Published
    Geraets, L., Moonen, H. J., Wouters, E. F., Bast, A., & Hageman, G. J. (2006). Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations. Biochemical Pharmacology, 72(7), 902-910. https://doi.org/10.1016/j.bcp.2006.06.023
  12. Published
    Hanekamp, J. C., & Bast, A. (2006). Food supplements and fortified foods: the EC's patriarchal precautionary perspectives on public health. Environmental Liability, 5, 181-191.
  13. Published
    Rosias, P. P. R., den Hartog, G. J., Robroeks, C. M., Bast, A., Donckerwolcke, R. A., Heynens, J. W., ... Dompeling, E. D. (2006). Free radicals in exhaled breath condensate in cystic fibrosis and healthy subjects. Free Radical Research, 40(9), 901-909. https://doi.org/10.1080/10715760500522648
  14. Published
    Troost, F. J., Brummer, R. J., Haenen, G. R., Bast, A., van Haaften, R. I. M., Evelo, C. T., & Saris, W. H. (2006). Gene expression in human small intestinal mucosa in vivo is mediated by iron-induced oxidative stress. Physiological genomics, 25(2), 242-249. https://doi.org/10.1152/physiolgenomics.00114.2005
  15. Published
    Kaiserova, H., den Hartog, G. J., Simunek, T., Schroterova, L., Kvasnickova, E., & Bast, A. (2006). Iron is not involved in oxidative stress-mediated cytotoxicity of doxorubicin and bleomycin. British Journal of Pharmacology, 149(7), 920-930. https://doi.org/10.1038/sj.bjp.0706930
  16. Published
    Swennen, E. L. R., Bast, A., & Dagnelie, P. C. (2006). Purinergic receptors involved in the immunomodulatory effects of ATP in human blood. Biochemical and Biophysical Research Communications, 348(3), 1194-1199. https://doi.org/10.1016/j.bbrc.2006.07.177
  17. Published
    Haenen, G. R., Arts, M. J. T., Bast, A., & Coleman, M. D. (2006). Structure and activity in assessing antioxidant activity in vitro and in vivo. A critical appraisal illustrated with the flavenoids. Environmental Toxicology and Pharmacology, 21, 191-198. https://doi.org/10.1016/j.etap.2005.07.010
  18. Published
    Bruynzeel, A. M., Mul, P. P., Berkhof, J., Bast, A., Niessen, H. W. M., & van der Vijgh, W. J. F. (2006). The influence of the time interval between monoHER and doxorubicin administration on the protection against doxorubicin-induced cardiotoxicity in mice. Cancer Chemotherapy and Pharmacology, 58(5), 699-702. https://doi.org/10.1007/s00280-006-0206-9
  19. Published
    Puts, E. W. A., Lammerts, L., Bast, A., van Dieijen-Visser, M. P., & Kremer, B. (2006). Urea as a marker of dilution of nasal secretion in nasal lavage fluid. Allergologie, 29, 184-193. https://doi.org/10.5414/ALP29184
  20. Published
    Bast, A., & van den Berg, H. (2006). Voedingssuplementen. In E. E. V. Everdingen, & J. H. Glerum (Eds.), Diagnose en therapie Jaarboek 2006 (pp. 1147-1172). Bohn Stafleu van Loghum.
  21. 2005
  22. Published
    Gosker, H. R., Bast, A., Haenen, G. R. M. M., Fischer, M. A. J. G., van der Vusse, G. J., Wouters, E. F. M., & Schols, A. M. W. J. (2005). Altered antioxidant status in peripheral skeletal muscle of patients with COPD. Respiratory Medicine, 99, 118-125. https://doi.org/10.1016/j.rmed.2004.05.018
  23. Published
    Fischer, M. A. J. G., Gransier, T. J., Beckers, L. M., Bekers, O., Bast, A., & Haenen, G. R. (2005). Determination of the antioxidant capacity in blood. Clinical Chemistry and Laboratory Medicine, 43(7), 735-740. https://doi.org/10.1515/CCLM.2005.125
  24. Published
    Dambros, M., de Jongh, R., van Koeveringe, G. A., Bast, A., Beerens - Heijnen, C. G. M., & van Kerrebroeck, P. E. V. A. (2005). Flavonoid galangin prevents smooth muscle fatigue of pig urinary bladder. Journal of Pharmacy and Pharmacology, 57(5), 617-622. https://doi.org/10.1211/0022357055920
  25. Published
    Dambros, M., de Jongh, R., van Koeveringe, G. A., Bast, A., & van Kerrebroeck, P. E. V. A. (2005). Galangin protects pig detrusor nerves from repetitive field stimulation and anoxia/glucopenia injury. Urology, 66(6), 1327-1331. https://doi.org/10.1016/j.urology.2005.06.095
  26. Published
    Swennen, E. L. R., Bast, A., & Dagnelie, P. C. (2005). Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. European Journal of Immunology, 35(3), 852-858. https://doi.org/10.1002/eji.200425423
  27. Published
    Boots, A. W., Bast, A., & Haenen, G. R. (2005). No role of DT-diaphorase (NQO1) in the protection against oxidized quercetin. Febs Letters, 579(3), 677-682. https://doi.org/10.1016/j.febslet.2004.12.044
  28. Published
    Michels, G., Watjen, W., Niering, P., Steffan, B., Thi, Q. H., Chovolou, Y., ... Kahl, R. (2005). Pro-apoptotic effects of the flavonoid luteolin in rat H4IIE cells. Toxicology, 206(3), 337-348. https://doi.org/10.1016/j.tox.2004.07.022
  29. Published
    Mercken, E. M., Hageman, G. J., Schols, A. M., Akkermans, M. A., Bast, A., & Wouters, E. F. (2005). Rehabilitation Decreases Exercise-induced Oxidative Stress in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine, 172(8), 994-1001. https://doi.org/10.1164/rccm.200411-1580OC
  30. Published
    Boots, A. W., Balk, J. M., Bast, A., & Haenen, G. R. (2005). The reversibility of the glutathionyl-quercetin adduct spreads oxidized quercetin-induced toxicity. Biochemical and Biophysical Research Communications, 338(2), 923-929. https://doi.org/10.1016/j.bbrc.2005.10.031
  31. Published
    Moonen, H. J., Geraets, L., Vaarhorst, A., Bast, A., Wouters, E. F., & Hageman, G. J. (2005). Theophylline prevents NAD(+) depletion via PARP-1 inhibition in human pulmonary epithelial cells. Biochemical and Biophysical Research Communications, 338(4), 1805-1810. https://doi.org/10.1016/j.bbrc.2005.10.159
  32. 2004
  33. Published
    Arts, M. J. T. J., Dallinga, J. W., Voss, H. P., Haenen, G. R. M. M., & Bast, A. (2004). A new approach to assess the total antioxidant capacity using the TEAC assay. Food Chemistry, 88, 567-570. https://doi.org/10.1016/j.foodchem.2004.02.008
  34. Published
    Arts, M. J. T. J., Haenen, G. R., Voss, H. P., & Bast, A. (2004). Antioxidant capacity of reaction products limits the applicability of the Trolox Equivalent Antioxidant Capacity (TEAC) assay. Food and Chemical Toxicology, 42(1), 45-49. https://doi.org/10.1016/j.fct.2003.08.004
  35. Published
    Bast, A., & Haenen, G. R. M. M. (2004). Dose-response relationships with special refrence to antioxidants. In Commission Food Safety, & G. Eisenbrand (Eds.), Functional food: Safety aspects (pp. 98-111). Deutsche Forschungsgemeinschaft.
  36. Published
    de Franceschi, L., Turrini, F., Honczarenko, M., Ayi, K., Rivera, A., Fleming, M. D., ... Brugnara, C. (2004). In vivo reduction of erythrocyte oxidant stress in a murine model of beta-thalassemia. Haematologica-the Hematology Journal, 89(11), 1287-1298.
  37. Published
    den Hartog, G. J. M., Haenen, G. R. M. M., Boven, E., van der Vijgh, W. J. F., & Bast, A. (2004). Lecithinized copper,zinc-superoxide dismutase as a protector against doxorubicin-induced cardiotoxicity in mice. Toxicology and Applied Pharmacology, 194(2), 180-188. https://doi.org/10.1016/j.taap.2003.09.008
  38. Published
    Rezk, B. M., Haenen, G. R., van der Vijgh, W. J. F., & Bast, A. (2004). Lipoic acid protects efficiently only against a specific form of peroxynitrite-induced damage. Journal of Biological Chemistry, 279(11), 9693-9697. https://doi.org/10.1074/jbc.M312289200
  39. Published
    Verschraagen, M., Boven, E., Torun, E., Hausheer, F. H., Bast, A., & van der Vijgh, W. J. F. (2004). Possible (enzymatic) routes and biological sites for metabolic reduction of BNP7787, a new protector against cisplatin-induced side-effects. Biochemical Pharmacology, 68(3), 493-502. https://doi.org/10.1016/j.bcp.2004.04.005
  40. Published
    Dambros, M., van Koeveringe, G. A., Bast, A., & van Kerrebroeck, P. E. V. A. (2004). Relaxant effects of estradiol through non-genomic pathways in male and female pig bladder smooth muscle. Pharmacology, 72(2), 121-127. https://doi.org/10.1159/000080184
  41. Published
    De Celle, T., Heeringa, P., Strzelecka, A. E., Bast, A., Smits, J. F. M., & Janssen, B. J. A. (2004). Sustained protective effects of 7-monohydroxyethylrutoside in an in vivo model of cardiac ischemia-reperfusion. European Journal of Pharmacology, 494(2-3), 205-212. https://doi.org/10.1016/j.ejphar.2004.05.017
  42. Published
    Rezk, B. M., Haenen, G. R., van der Vijgh, W. J. F., & Bast, A. (2004). The extraordinary antioxidant activity of vitamin E phosphate. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1683(1-3), 16-21. https://doi.org/10.1016/j.bbalip.2004.03.005
  43. Published
    Michels, G., Haenen, G. R., Wätjen, W., Rietjens, S. J., & Bast, A. (2004). The thiol reactivity of the oxidation product of 3,5,7-trihydroxy-4H-chromen-4-one containing flavonoids. Toxicology Letters, 151(1), 105-111. https://doi.org/10.1016/j.toxlet.2004.01.017
  44. Published
    Bast, A., & van den Berg, H. (2004). Voedingssupplementen en vitamines. In Therapie Informatorium Houten: Bohn, Stafleu en Van Loghum.
  45. 2003
  46. Published
    Abou el Hassan, M. A., Rabelink, M. J., van der Vijgh, W. J. F., Bast, A., & Hoeben, R. C. (2003). A comparative study between catalase gene therapy and the cardioprotector monohydroxyethylrutoside (MonoHER) in protecting against doxorubicin-induced cardiotoxicity in vitro. British Journal of Cancer, 89(11), 2140-2146. https://doi.org/10.1038/sj.bjc.6601430
  47. Published
    Arts, M. J. T. J., Dallinga, J. W., Voss, H. P., Haenen, G. R. M. M., & Bast, A. (2003). A critical appraisal of the use of the antioxidant capacity (TEAC) assay in defining optimal structures. Food Chemistry, 80, 409-414. https://doi.org/10.1016/S0308-8146(02)00468-5
  48. Published
    Abou el Hassan, M. A., Kedde, M., Zwiers, U. T., Tourn, E., Haenen, G. R. M. M., Bast, A., & van der Vijgh, W. J. F. (2003). Bioavailability and pharmacokinetics of the cardioprotecting flavonoid 7-monohydroxyethylrutoside in mice. Cancer Chemotherapy and Pharmacology, 52(5), 371-376. https://doi.org/10.1007/s00280-003-0667-z
  49. Published
    Drent, M., Gorgels, A. P. M., & Bast, A. (2003). Cardiac failure associated with G6PD deficiency. Circulation Research, 93, [e75]. https://doi.org/10.1161/01.RES.0000096992.70384.4F
  50. Published
    van Haaften, R. I. M., Haenen, G. R. M. M., Evelo, C. T. A., & Bast, A. (2003). Effect of vitamin E on glutathione-dependent enzymes. Drug Metabolism Reviews, 35(2-3), 215-253. https://doi.org/10.1081/DMR-120024086
  51. Published
    van Haaften, R. I. M., Haenen, G. R. M. M., van Bladeren, P. J., Bogaards, J. J., Evelo, C. T. A., & Bast, A. (2003). Inhibition of various glutathione S-transferase isoenzymes by RRR-alpha-tocopherol. Toxicology in Vitro, 17(3), 245-251. https://doi.org/10.1016/S0887-2333(03)00038-9
  52. Published
    den Hartog, G. J. M., Boots, A. W., Haenen, G. R. M. M., van der Vijgh, W. J. F., & Bast, A. (2003). Lack of inhibition of endothelial nitric oxide synthase in the isolated rat aorta by doxorubicin. Toxicology in Vitro, 17(2), 165-167. https://doi.org/10.1016/S0887-2333(03)00007-9
  53. Published
    Bast, A., & Haenen, G. R. M. M. (2003). Lipoic acid: a multifunctional antioxidant. Biofactors, 17(1-4), 207-213. https://doi.org/10.1002/biof.5520170120
  54. Published
    Drent, M., & Bast, A. (2003). Longfibrose: stand van zaken. Modern Medicine, 8, 44-50.
  55. Published
    Troost, F. J. J., Saris, W. H. M., Haenen, G. R. M. M., Bast, A., & Brummer, R. J. M. (2003). New method to study oxidative damage and antioxidants in the human small bowel: effects of iron application. American Journal of Physiology-Gastrointestinal and Liver Physiology, 285(2), G354-G359. https://doi.org/10.1152/ajpgi.00422.2002
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