(-)-Epicatechin metabolites promote vascular health through epigenetic reprogramming of endothelial-immune cell signaling and reversing systemic low-grade inflammation

Dragan Milenkovic; Ken Declerck; Yelena Guttman; Zohar Kerem; Sylvain Claude; Antje R Weseler; Aalt Bast; Hagen Schroeter; Christine Morand; Wim Vanden Berghe

doi:10.1016/j.bcp.2019.113699

(-)-Epicatechin metabolites promote vascular health through epigenetic reprogramming of endothelial-immune cell signaling and reversing systemic low-grade inflammation

Dragan Milenkovic^*, Ken Declerck, Yelena Guttman, Zohar Kerem, Sylvain Claude, Antje R Weseler, Aalt Bast, Hagen Schroeter, Christine Morand, Wim Vanden Berghe^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Web of Science)

Original language	English
Article number	113699
Number of pages	16
Journal	Biochemical Pharmacology
Volume	173
DOIs	https://doi.org/10.1016/j.bcp.2019.113699
Publication status	Published - Mar 2020

Keywords

Epicatechin metabolite
Vascular health
Epigenetic
Endothelial-immune cell signaling
Systemic low-grade inflammation
INTRAGENIC DNA METHYLATION
C-REACTIVE PROTEIN
LYMPHOCYTE RATIO
OXIDATIVE STRESS
COCOA FLAVANOLS
BLOOD-PRESSURE
CHOCOLATE
RISK
HOMOCYSTEINE
FLAVONOIDS

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10.1016/j.bcp.2019.113699

Cite this

Milenkovic, D., Declerck, K., Guttman, Y., Kerem, Z., Claude, S., Weseler, A. R., Bast, A., Schroeter, H., Morand, C., & Vanden Berghe, W. (2020). (-)-Epicatechin metabolites promote vascular health through epigenetic reprogramming of endothelial-immune cell signaling and reversing systemic low-grade inflammation. Biochemical Pharmacology, 173, [113699]. https://doi.org/10.1016/j.bcp.2019.113699

Milenkovic, Dragan ; Declerck, Ken ; Guttman, Yelena ; Kerem, Zohar ; Claude, Sylvain ; Weseler, Antje R ; Bast, Aalt ; Schroeter, Hagen ; Morand, Christine ; Vanden Berghe, Wim. / (-)-Epicatechin metabolites promote vascular health through epigenetic reprogramming of endothelial-immune cell signaling and reversing systemic low-grade inflammation. In: Biochemical Pharmacology. 2020 ; Vol. 173.

@article{bc74dacca10847bdb78a6948b4771082,

title = "(-)-Epicatechin metabolites promote vascular health through epigenetic reprogramming of endothelial-immune cell signaling and reversing systemic low-grade inflammation",

keywords = "Epicatechin metabolite, Vascular health, Epigenetic, Endothelial-immune cell signaling, Systemic low-grade inflammation, INTRAGENIC DNA METHYLATION, C-REACTIVE PROTEIN, LYMPHOCYTE RATIO, OXIDATIVE STRESS, COCOA FLAVANOLS, BLOOD-PRESSURE, CHOCOLATE, RISK, HOMOCYSTEINE, FLAVONOIDS",

author = "Dragan Milenkovic and Ken Declerck and Yelena Guttman and Zohar Kerem and Sylvain Claude and Weseler, {Antje R} and Aalt Bast and Hagen Schroeter and Christine Morand and {Vanden Berghe}, Wim",

year = "2020",

month = mar,

doi = "10.1016/j.bcp.2019.113699",

language = "English",

volume = "173",

journal = "Biochemical Pharmacology",

issn = "0006-2952",

publisher = "Elsevier Science",

}

Milenkovic, D, Declerck, K, Guttman, Y, Kerem, Z, Claude, S, Weseler, AR, Bast, A, Schroeter, H, Morand, C & Vanden Berghe, W 2020, '(-)-Epicatechin metabolites promote vascular health through epigenetic reprogramming of endothelial-immune cell signaling and reversing systemic low-grade inflammation', Biochemical Pharmacology, vol. 173, 113699. https://doi.org/10.1016/j.bcp.2019.113699

(-)-Epicatechin metabolites promote vascular health through epigenetic reprogramming of endothelial-immune cell signaling and reversing systemic low-grade inflammation. / Milenkovic, Dragan; Declerck, Ken; Guttman, Yelena; Kerem, Zohar; Claude, Sylvain; Weseler, Antje R; Bast, Aalt; Schroeter, Hagen; Morand, Christine; Vanden Berghe, Wim.

In: Biochemical Pharmacology, Vol. 173, 113699, 03.2020.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Milenkovic, Dragan

AU - Declerck, Ken

AU - Guttman, Yelena

AU - Kerem, Zohar

AU - Claude, Sylvain

AU - Weseler, Antje R

AU - Bast, Aalt

AU - Schroeter, Hagen

AU - Morand, Christine

AU - Vanden Berghe, Wim

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KW - Systemic low-grade inflammation

KW - INTRAGENIC DNA METHYLATION

KW - C-REACTIVE PROTEIN

KW - LYMPHOCYTE RATIO

KW - OXIDATIVE STRESS

KW - COCOA FLAVANOLS

KW - BLOOD-PRESSURE

KW - CHOCOLATE

KW - RISK

KW - HOMOCYSTEINE

KW - FLAVONOIDS

U2 - 10.1016/j.bcp.2019.113699

DO - 10.1016/j.bcp.2019.113699

M3 - Article

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JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

SN - 0006-2952

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