TY - JOUR
T1 - Non-steroidal anti-inflammatory drugs increase urinary neutrophil gelatinase-associated lipocalin in recreational runners
AU - Semen, Khrystyna O.
AU - van der Doelen, Rick H. A.
AU - van der Lugt, Monique
AU - van Dam, Davy G. H. A.
AU - Reimer, Jurgen
AU - Stassen, Frank R. M.
AU - Janssen, Loes
AU - Janssen, Paddy K. C.
AU - Janssen, Marcel J. W.
AU - Bast, Aalt
AU - le Noble, Jos L. M. L.
PY - 2020/10
Y1 - 2020/10
N2 - Objectives To study the effects of running with/without the use of pain killers on urinary neutrophil gelatinase-associated lipocalin (uNGAL) and other parameters of kidney function in recreational runners. Methods Participants of the 10- and 21.1-km Weir Venloop race were enrolled and their urine samples collected before and after the run. Urine dipstick and other conventional tests used to assess kidney function were performed. The presence of ibuprofen, diclofenac, naproxen, and/or paracetamol was assessed by LC-MS/MS. uNGAL was measured with a two-step chemiluminescent immunoassay. Results NSAIDs/analgesics were detected in urine of 5 (14.4%) 10-km runners and 13 (28.9%) 21.1-km runners. Only half-marathon participants showed significant increases in uNGAL (pre: 11.7 [7.1-34.3] ng/mL; post: 33.4 [17.4-50.4] ng/mL;P = .0038). There was a significant effect of NSAID/analgesic use on uNGAL increase (F-2,F- 76 = 4.210,P = .004). Post hoc tests revealed that uNGAL increased significantly in runners who tested positive for ibuprofen/naproxen compared to runners who did not use any medications (P = .045) or those who tested positive for paracetamol (P = .033). Running distance had a significant influence on the increase in uNGAL (F-1,F- 53 = 4.741,P <.05), specific gravity (F-1,F- 60 = 9.231,P <.01), urinary creatinine (F-1,F- 61 = 10.574,P <.01), albumin (F-1,F- 59 = 4.888,P <.05), and development of hematuria (chi(2)(4) = 18.44,P = .001). Conclusions Running distance and use of ibuprofen/naproxen were identified as risk factors for uNGAL increase in recreational runners.
AB - Objectives To study the effects of running with/without the use of pain killers on urinary neutrophil gelatinase-associated lipocalin (uNGAL) and other parameters of kidney function in recreational runners. Methods Participants of the 10- and 21.1-km Weir Venloop race were enrolled and their urine samples collected before and after the run. Urine dipstick and other conventional tests used to assess kidney function were performed. The presence of ibuprofen, diclofenac, naproxen, and/or paracetamol was assessed by LC-MS/MS. uNGAL was measured with a two-step chemiluminescent immunoassay. Results NSAIDs/analgesics were detected in urine of 5 (14.4%) 10-km runners and 13 (28.9%) 21.1-km runners. Only half-marathon participants showed significant increases in uNGAL (pre: 11.7 [7.1-34.3] ng/mL; post: 33.4 [17.4-50.4] ng/mL;P = .0038). There was a significant effect of NSAID/analgesic use on uNGAL increase (F-2,F- 76 = 4.210,P = .004). Post hoc tests revealed that uNGAL increased significantly in runners who tested positive for ibuprofen/naproxen compared to runners who did not use any medications (P = .045) or those who tested positive for paracetamol (P = .033). Running distance had a significant influence on the increase in uNGAL (F-1,F- 53 = 4.741,P <.05), specific gravity (F-1,F- 60 = 9.231,P <.01), urinary creatinine (F-1,F- 61 = 10.574,P <.01), albumin (F-1,F- 59 = 4.888,P <.05), and development of hematuria (chi(2)(4) = 18.44,P = .001). Conclusions Running distance and use of ibuprofen/naproxen were identified as risk factors for uNGAL increase in recreational runners.
KW - half-marathon
KW - NSAIDs
KW - renal function
KW - running
KW - urinary neutrophil gelatinase-associated lipocalin (uNGAL)
KW - ACUTE KIDNEY INJURY
KW - RENAL-FUNCTION
KW - MARATHON
KW - BIOMARKERS
KW - NGAL
KW - ULTRAMARATHON
KW - IBUPROFEN
KW - ADMISSION
KW - EXERCISE
KW - MARKERS
U2 - 10.1111/sms.13755
DO - 10.1111/sms.13755
M3 - Article
C2 - 32585737
SN - 0905-7188
VL - 30
SP - 1888
EP - 1895
JO - Scandinavian Journal of Medicine & Science in Sports
JF - Scandinavian Journal of Medicine & Science in Sports
IS - 10
ER -