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Research Output

2016

The tobacco smoke component acrolein induces glucocorticoid resistant gene expression via inhibition of histone deacetylase

Randall, M., Haenen, G. R., Bouwman, F. G., Vliet, A. V. & Bast, A., 5 Jan 2016, In : Toxicology Letters. 240, 1, p. 43-49 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Time in Redox Adaptation Processes: From Evolution to Hormesis

Sthijns, M. M. J. P. E., Weseler, A. R., Bast, A. & Haenen, G. R. M. M., Oct 2016, In : International journal of molecular sciences. 17, 10, 1649.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway

Heyninck, K., Sabbe, L., Chirumamilla, C. S., Szic, K. S. V., Veken, P. V., Lemmens, K. J. A., Lahtela-Kakkonen, M., Naulaerts, S., de Beeck, K. O., Laukens, K., Van Camp, G., Weseler, A. R., Bast, A., Haenen, G. R. M. M., Haegeman, G. & Berghe, W. V., 1 Jun 2016, In : Biochemical Pharmacology. 109, p. 48-61

Research output: Contribution to journalArticleAcademicpeer-review

2015

Acute eosinophilic pneumonia associated with glyphosate-surfactant exposure

de Raadt, W. M., Wijnen, P. A., Bast, A., Bekers, O. & Drent, M., 2015, In : Sarcoidosis Vasculitis and Diffuse Lung Diseases. 32, 2, p. 172-175

Research output: Contribution to journalArticleAcademicpeer-review

Adverse food-drug interactions

de Boer, A., van Hunsel, F. & Bast, A., 19 Oct 2015, In : Regulatory Toxicology and Pharmacology. 73, 3, p. 859-865

Research output: Contribution to journalArticleAcademicpeer-review

Antibiotics exposure and health risks: Chloramphenicol

Hanekamp, J. C. & Bast, A., 1 Jan 2015, In : Environmental Toxicology and Pharmacology. 39, 1, p. 213-220

Research output: Contribution to journalArticleAcademicpeer-review

Anticholinergic Accumulation: A Slumbering Interaction between Drugs and Food Supplements

Vrolijk, M. F., Opperhuizen, A., Jansen, E. H., Bast, A. & Haenen, G. R., Dec 2015, In : Basic & Clinical Pharmacology & Toxicology. 117, 6, p. 427-432 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Chemical characteristics for optimizing CYP2E1 inhibition

van de Wier, B., Balk, J. M., Bast, A., Koek, G. H. & Haenen, G. R., 5 Dec 2015, In : Chemico-Biological Interactions. 242, p. 139-144 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Enforcement of the nutrition and health claim regulation

De Boer, A., Urlings, M., Vos, E. & Bast, A., 1 Dec 2015, In : European Food and Feed Law Review. 10, 5, p. 334-344 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Health effects of erythritol

Boesten, D. M. P. H. J., den Hartog, G. J. M., de Cock, P., Bosscher, D., Bonnema, A. & Bast, A., 1 Jan 2015, In : Nutrafoods. 14, p. 3-9

Research output: Contribution to journalArticleAcademicpeer-review

International legislation on nutrition and health claims

de Boer, A. & Bast, A., 1 Aug 2015, In : Food Policy. 55, p. 61-70 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Modulation of Glucokinase Regulatory Protein: A Double-Edged Sword?

Brouwers, M. C. G. J., Jacobs, C., Bast, A., Stehouwer, C. D. A. & Schaper, N. C., 1 Jan 2015, In : Trends in Molecular Medicine. 21, 10, p. 583-594

Research output: Contribution to journalArticleAcademicpeer-review

Nutritional Antioxidants: It Is Time to Categorise

Bast, A. & Haenen, G., 2015, Antioxidants in Sport Nutrition. Lamprecht, M. (ed.). Boca Raton: CRC Press, Taylor & Frances Group, p. 17-38

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Nutrition and health-transforming research traditions

Hanekamp, J. C., Bast, A. & Calabrese, E. J., 2015, In : Critical Reviews in Food Science and Nutrition. 55, 8, p. 1072-1078

Research output: Contribution to journalArticleAcademicpeer-review

Once-daily dose regimen of ribavirin is interchangeable with a twice-daily dose regimen: randomized open clinical trial

Balk, J. M., Haenen, G. R. M., Koc, O. M., Peters, R., Bast, A., van der Vijgh, W. J. F. & Koek, G. H., 1 Jan 2015, In : Pharmacogenomics and personalized medicine. 8, p. 137-144 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Paracetamol as a Post Prandial Marker for Gastric Emptying, A Food-Drug Interaction on Absorption

Bartholomé, R., Salden, B., Vrolijk, M. F., Troost, F. J., Masclee, A., Bast, A. & Haenen, G. R. M. M., 9 Sep 2015, In : PLOS ONE. 10, 9, 9 p., e0136618.

Research output: Contribution to journalArticleAcademicpeer-review

Protective Pleiotropic Effect of Flavonoids on NAD(+) Levels in Endothelial Cells Exposed to High Glucose

Boesten, D. M., von Ungern-Sternberg, S. N., den Hartog, G. J. & Bast, A., 1 Jan 2015, In : Oxidative Medicine and Cellular Longevity. 2015, 894597.

Research output: Contribution to journalArticleAcademicpeer-review

Stakeholders' perception of the nutrition and health claim regulation

de Boer, A. & Bast, A., May 2015, In : International Journal of Food Sciences and Nutrition. 66, 3, p. 321-328 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

The contribution of the major metabolite 4'-O-methylmonoHER to the antioxidant activity of the flavonoid monoHER

Lemmens, K. J., Herst, P. M., Housmans, B. A., Moalin, M., van der Vijgh, W. J., Bast, A. & Haenen, G. R., 5 Sep 2015, In : Chemico-Biological Interactions. 239, p. 146-152 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

The flavonoid monoHER promotes the adaption to oxidative stress during the onset of NAFLD

Lemmens, K., van de Wier, B., Koek, G. H., Köhler, E. S., Drittij, M. J., van der Vijgh, W., Bast, A. & Haenen, G. R., 1 Jan 2015, In : Biochemical and Biophysical Research Communications. 456, 1, p. 179-182

Research output: Contribution to journalArticleAcademicpeer-review

The oxidation of p-phenylenediamine, an ingredient used for permanent hair dyeing purposes, leads to the formation of hydroxyl radicals: Oxidative stress and DNA damage in human immortalized keratinocytes

Zanoni, T. B., Hudari, F., Munnia, A., Peluso, M., Godschalk, R. W., Zanoni, M. V., den Hartog, G. J., Bast, A., Barros, S. B., Maria-Engler, S. S., Hageman, G. J. & de Oliveira, D. P., 15 Dec 2015, In : Toxicology Letters. 239, 3, p. 194-204 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

The shifting perception on antioxidants: The case of vitamin E and beta-carotene

Vrolijk, M. F., Opperhuizen, A., Jansen, E. H., Godschalk, R. W., van Schooten, F. J., Bast, A. & Haenen, G. R., 1 Jan 2015, In : Redox Biology. 4C, p. 272-278

Research output: Contribution to journalArticleAcademic

The supplement-drug interaction of quercetin with tamsulosin on vasorelaxation

Vrolijk, M. F., Haenen, G. R., Opperhuizen, A., Jansen, E. H., Schiffers, P. M. & Bast, A., 5 Jan 2015, In : European Journal of Pharmacology. 746, p. 132-137 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Toxicity of Antioxidants

Rezk, B., van der Vijgh, W. J. F., Bast, A. & Haenen, G. R., 1 Jan 2015, In : Toxicology and Forensic Medicine. 1, 1, 1000TFMOJ1e002.

Research output: Contribution to journalArticleAcademic

Toxicity of the anti-oxidants

Rezk, B. M., van der Vijgh, W., Bast, A. & Haenen, G., 2015, In : Toxicology and Forensic Medicine. 1, 1, p. e3-e4

Research output: Contribution to journalArticleAcademicpeer-review

Apoptotic, inflammatory, and fibrogenic effects of two different types of multi-walled carbon nanotubes in mouse lung

van Berlo, D., Wilhelmi, V., Boots, A. W., Hullmann, M., Kuhlbusch, T. A., Bast, A., Schins, R. P. & Albrecht, C., Sep 2014, In : Archives of Toxicology. 88, 9, p. 1725-1737 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Basic Red 51, a permitted semi-permanent hair dye, is cytotoxic to human skin cells: Studies in monolayer and 3D skin model using human keratinocytes (HaCaT)

Zanoni, T. B., Tiago, M., Faiao-Flores, F., Moraes de Barros, S. B., Bast, A., Hageman, G., de Oliveira, D. P. & Maria-Engler, S. S., 1 Jan 2014, In : Toxicology Letters. 227, 2, p. 139-149

Research output: Contribution to journalArticleAcademicpeer-review

Critical appraisal of (13) C breath tests for microsomal liver function: aminopyrine revisited

Pijls, K. E., de Vries, H., Nikkessen, S., Bast, A., Wodzig, W. K. W. H. & Koek, G. H., 1 Jan 2014, In : Liver International. 34, 4, p. 487-494

Research output: Contribution to journalArticleAcademicpeer-review

Dietary Flavanols Modulate the Transcription of Genes Associated with Cardiovascular Pathology without Changes in Their DNA Methylation State

Milenkovic, D., Vanden Berghe, W., Boby, C., Leroux, C., Declerck, K., Szarc Vel Szic, K., Heyninck, K., Laukens, K., Bizet, M., Defrance, M., Dedeurwaerder, S., Calonne, E., Fuks, F., Haegeman, G., Haenen, G. R., Bast, A. & Weseler, A. R., 24 Apr 2014, In : PLOS ONE. 9, 4, 13 p., e95527.

Research output: Contribution to journalArticleAcademicpeer-review

Effect of Nɛ-carboxymethyllysine on oxidative stress and the glutathione system in beta cells

Boesten, D. M. P. H. J., Elie, A. G. I. M., Dritty-Reijnders, M. J. H. J., den Hartog, G. J. M. & Bast, A., 1 Jan 2014, In : Toxicology Reports. 1, p. 973-980

Research output: Contribution to journalArticleAcademicpeer-review

Glutathione revisited: a better scavenger than previously thought

Haenen, G. R. M. & Bast, A., 27 Nov 2014, In : Frontiers in Pharmacology. 5, 5 p., 260.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Implementation of the nutrition and health claim regulation - The case of antioxidants

de Boer, A., Vos, E. & Bast, A., Apr 2014, In : Regulatory Toxicology and Pharmacology. 68, 3, p. 475-487 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Nutritional components: How they enhance the ability to adapt.

Weseler, A. R. & Bast, A., 1 Jan 2014, Hormesis in health and disease. Rattan, S. I. S. & Le Bourg, E. (eds.). Boca Raton: CRC Press, Taylor & Frances Group, p. 45-78

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

'Oude' medicijnen kans voor zeldzame ziekten.

Drent, M., Bast, A. & Bootsma, H. P., 1 Jan 2014, In : Medisch Contact. 5 juni, 6, p. 1153-1155

Research output: Contribution to journalArticleAcademic

Protection against Chemotaxis in the Anti-Inflammatory Effect of Bioactives from Tomato Ketchup

Hazewindus, M., Haenen, G. R., Weseler, A. R. & Bast, A., 1 Jan 2014, In : PLOS ONE. 9, 12, e114387.

Research output: Contribution to journalArticleAcademicpeer-review

Superoxide anion radicals activate hepatic stellate cells after entry through chloride channels: A new target in liver fibrosis

den Hartog, G. J., Qi, S., van Tilburg, J. H., Koek, G. H. & Bast, A., 5 Feb 2014, In : European Journal of Pharmacology. 724, 5 February, p. 140-144 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

The cocoa flavanol (-)-epicatechin protects the cortisol response.

Ruijters, E. J., Haenen, G. R., Weseler, A. R. & Bast, A., 1 Jan 2014, In : Pharmacological Research. 79, p. 28-33 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

The effect of Amaranth oil on monolayers of artificial lipids and hepatocyte plasma membranes with adrenalin-induced stress

Yelisyeyeva, O. P., Semen, K. O., Ostrovska, G. V., Kaminskyy, D. V., Sirota, T. V., Zarkovic, N., Mazur, D., Lutsyk, O. D., Rybalchenko, K. & Bast, A., 15 Mar 2014, In : Food Chemistry. 147, p. 152-159 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

The flavonoid 7-mono-O-(beta-hydroxyethyl)-rutoside is able to protect endothelial cells by a direct antioxidant effect

Lemmens, K. J., van de Wier, B., Vaes, N., Ghosh, M., van Zandvoort, M. A., van der Vijgh, W., Bast, A. & Haenen, G. R., Jun 2014, In : Toxicology in Vitro. 28, 4, p. 538-543 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Minor Structural Difference between the Antioxidants Quercetin and 4'O-Methylquercetin Has a Major Impact on Their Selective Thiol

Lemmens, K. J., Vrolijk, M. F., Bouwman, F. G., van der Vijgh, W. J., Bast, A. & Haenen, G. R., 1 Jan 2014, In : International journal of molecular sciences. 15, 5, p. 7475-7484

Research output: Contribution to journalArticleAcademicpeer-review

"You Can't Always Get What You Want" - Linearity as the Golden Ratio of Toxicology

Bast, A. & Hanekamp, J. C., 1 Jan 2014, In : Dose-Response. 12, 4, p. 664-672 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2013

Accelerated aging during chronic oxidative stress: a role for PARP-1

Boesten, D. M., de Vos-Houben, J. M., Timmermans, L., den Hartog, G. J., Bast, A. & Hageman, G. J., 1 Jan 2013, In : Oxidative Medicine and Cellular Longevity. 2013, 10 p., 680414.

Research output: Contribution to journalArticleAcademicpeer-review

Astaxanthin supplementation does not augment fat use or improve endurance performance.

Res, P. T., Cermak, N. M., Stinkens, R. E., Tollakson, T. J., Haenen, G. R. M. M., Bast, A. & van Loon, L. J. C., Jun 2013, In : Medicine and Science in Sports and Exercise. 45, 6, p. 1158-1165 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

CHEMICALS AND HEALTH - THOUGHT FOR FOOD

Bast, A. & Hanekamp, J. C., 2013, In : Dose-Response. 11, 3, p. 295-300

Research output: Contribution to journalArticleAcademicpeer-review

Diffuse alveolar hemorrhage in coumarin users: a fibrosing interstitial pneumonia trigger?

Wijnen, P. A. H. M., Verschakelen, J. A., Bast, A., Bekers, O. & Drent, M., Feb 2013, In : Lung. 191, 1, p. 53-59 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effect of antioxidant supplementation on exercise-induced cardiac troponin release in cyclists: a randomized trial

Klinkenberg, L. J., Res, P. T., Haenen, G. R., Bast, A., van Loon, L. J., van Dieijen-Visser, M. P. & Meex, S. J., 1 Jan 2013, In : PLOS ONE. 8, 11, e79280.

Research output: Contribution to journalArticleAcademicpeer-review

Elevated citrate levels in non-alcoholic fatty liver disease: The potential of citrate to promote radical production

van de Wier, B., Balk, J. M., Haenen, G. R. M. M., Giamouridis, D., Bakker, J. A., Bast, B. C., den Hartog, G. J. M., Koek, G. H. & Bast, A., 2 Aug 2013, In : Febs Letters. 587, 15, p. 2461-2466 6 p.

Research output: Contribution to journalArticleAcademicpeer-review