Lubrication behavior of ex-vivo salivary pellicle influenced by tannins, gallic acid and mannoproteins

Georgios Agorastos; Olaf van Nielen; Emo van Halsema; Elke Scholten; Aalt Bast; Peter Klosse

doi:10.1016/j.heliyon.2022.e12347

Lubrication behavior of ex-vivo salivary pellicle influenced by tannins, gallic acid and mannoproteins

Georgios Agorastos^*, Olaf van Nielen, Emo van Halsema, Elke Scholten, Aalt Bast, Peter Klosse

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The objective of this study was to investigate the influence of tannins and gallic acid on the salivary lubrication behavior. Furthermore, the effects of pH and mannoproteins in combination with gallic acid on the lubrication of saliva were studied. The addition of gallic acid and tannins were found to increase friction caused by the removal of the saliva film. Tannins resulted in higher friction compared to gallic acid. Lowering pH increased friction of gallic acid mixtures with saliva, due to stronger interactions between gallic acid and saliva. The increased friction caused by gallic acid was inhibited by the addition of mannoproteins due to the hydrogen bond interactions between gallic acid and mannoproteins, thereby decreasing the complex formation between gallic acid and salivary proteins. A correlation of 0.96 was found between the hydrodynamic diameter of the aggregate and the delta friction suggesting that the formation of aggregates determined the lubrication behavior.

Original language	English
Article number	e12347
Number of pages	9
Journal	Heliyon
Volume	8
Issue number	12
DOIs	https://doi.org/10.1016/j.heliyon.2022.e12347
Publication status	Published - Dec 2022

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10.1016/j.heliyon.2022.e12347Licence: CC BY

Cite this

@article{4d5d0a2591d644319a19573ea3f5611b,

title = "Lubrication behavior of ex-vivo salivary pellicle influenced by tannins, gallic acid and mannoproteins",

abstract = "The objective of this study was to investigate the influence of tannins and gallic acid on the salivary lubrication behavior. Furthermore, the effects of pH and mannoproteins in combination with gallic acid on the lubrication of saliva were studied. The addition of gallic acid and tannins were found to increase friction caused by the removal of the saliva film. Tannins resulted in higher friction compared to gallic acid. Lowering pH increased friction of gallic acid mixtures with saliva, due to stronger interactions between gallic acid and saliva. The increased friction caused by gallic acid was inhibited by the addition of mannoproteins due to the hydrogen bond interactions between gallic acid and mannoproteins, thereby decreasing the complex formation between gallic acid and salivary proteins. A correlation of 0.96 was found between the hydrodynamic diameter of the aggregate and the delta friction suggesting that the formation of aggregates determined the lubrication behavior.",

author = "Georgios Agorastos and {van Nielen}, Olaf and {van Halsema}, Emo and Elke Scholten and Aalt Bast and Peter Klosse",

note = "{\textcopyright} 2022 The Author(s).",

year = "2022",

month = dec,

doi = "10.1016/j.heliyon.2022.e12347",

language = "English",

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journal = "Heliyon",

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T1 - Lubrication behavior of ex-vivo salivary pellicle influenced by tannins, gallic acid and mannoproteins

AU - Agorastos, Georgios

AU - van Nielen, Olaf

AU - van Halsema, Emo

AU - Scholten, Elke

AU - Bast, Aalt

AU - Klosse, Peter

PY - 2022/12

Y1 - 2022/12

N2 - The objective of this study was to investigate the influence of tannins and gallic acid on the salivary lubrication behavior. Furthermore, the effects of pH and mannoproteins in combination with gallic acid on the lubrication of saliva were studied. The addition of gallic acid and tannins were found to increase friction caused by the removal of the saliva film. Tannins resulted in higher friction compared to gallic acid. Lowering pH increased friction of gallic acid mixtures with saliva, due to stronger interactions between gallic acid and saliva. The increased friction caused by gallic acid was inhibited by the addition of mannoproteins due to the hydrogen bond interactions between gallic acid and mannoproteins, thereby decreasing the complex formation between gallic acid and salivary proteins. A correlation of 0.96 was found between the hydrodynamic diameter of the aggregate and the delta friction suggesting that the formation of aggregates determined the lubrication behavior.

AB - The objective of this study was to investigate the influence of tannins and gallic acid on the salivary lubrication behavior. Furthermore, the effects of pH and mannoproteins in combination with gallic acid on the lubrication of saliva were studied. The addition of gallic acid and tannins were found to increase friction caused by the removal of the saliva film. Tannins resulted in higher friction compared to gallic acid. Lowering pH increased friction of gallic acid mixtures with saliva, due to stronger interactions between gallic acid and saliva. The increased friction caused by gallic acid was inhibited by the addition of mannoproteins due to the hydrogen bond interactions between gallic acid and mannoproteins, thereby decreasing the complex formation between gallic acid and salivary proteins. A correlation of 0.96 was found between the hydrodynamic diameter of the aggregate and the delta friction suggesting that the formation of aggregates determined the lubrication behavior.

U2 - 10.1016/j.heliyon.2022.e12347

DO - 10.1016/j.heliyon.2022.e12347

M3 - Article

C2 - 36582694

SN - 2405-8440

VL - 8

JO - Heliyon

JF - Heliyon

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