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Research Output

2013

Method for the preparation of a dry composition comprising a stable ABTS radical.

Balk, J. M., Bast, A. & Haenen, G. R. M. M., 1 Jan 2013, Patent No. 12157763.9,2013

Research output: Patent

Multinational evidence-based World Association of Sarcoidosis and Other Granulomatous Disorders recommendations for the use of methotrexate in sarcoidosis: integrating systematic literature research and expert opinion of sarcoidologists worldwide

Cremers, J. P., Drent, M., Bast, A., Shigemitsu, H., Baughman, R. P., Valeyre, D., Sweiss, N. J. & Jansen, T. L., Sep 2013, In : Current Opinion in Pulmonary Medicine. 19, 5, p. 545-561

Research output: Contribution to journalArticleAcademicpeer-review

Multi-targeted mechanisms underlying the endothelial protective effects of the diabetic-safe sweetener erythritol

Boesten, D. M., Berger, A., de Cock, P., Dong, H., Hammock, B. D., den Hartog, G. J. M. & Bast, A., 5 Jun 2013, In : PLOS ONE. 8, 6, 12 p., e65741.

Research output: Contribution to journalArticleAcademicpeer-review

Olive juice extracts for promoting muscle health

Rietjens, S. J., Bast, A. & Haenen, G. R. M. M., 1 Jan 2013, Patent No. 20,130,330,431

Research output: Patent

Oxyphytosterol formation in humans: Identification of high vs. low oxidizers.

Baumgartner, S., Mensink, R. P., den Hartog, G. J., Bast, A., Bekers, O., Husche, C., Lutjohann, D. & Plat, J., 1 Jan 2013, In : Biochemical Pharmacology. 86, 1, p. 19-25

Research output: Contribution to journalArticleAcademicpeer-review

Redox Modulation by Amaranth Oil in Human Lung Fibroblasts

Semen, K. O., den Hartog, G. J. M., Kaminsky, D. V., Sirota, T. V., Maij, N. G. A. A., Yelisyeyeva, O. P. & Bast, A., 1 Jan 2013, In : Natural Products Chemistry & Research. December, 2013

Research output: Contribution to journalArticleAcademicpeer-review

Scientism, Legalism and Precaution - Contending with Regulating Nutrition and Health Claims in Europe

Bast, A., Briggs, W., Calabrese, E., Fenech, M., Hanekamp, J. C., Heaney, R., Rijkers, G., Schwitters, B. & Verhoeven, P., 1 Jan 2013, In : European Food and Feed Law Review. 6, 2013, p. 401-409

Research output: Contribution to journalArticleAcademicpeer-review

Ten misconceptions about antioxidants

Bast, A. & Haenen, G. R. M. M., 1 Jan 2013, In : Trends in Pharmacological Sciences. 34, 8, p. 430-436

Research output: Contribution to journalArticleAcademicpeer-review

The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice.

Bieghs, V., Hendrikx, T., van Gorp, P. J. J., Verheyen, F., Guichot, Y. D., Walenbergh, S. M., Gijbels, M. J. J., Rensen, S. S. M., Bast, A., Plat, J., Kalhan, S. C., Leitersdorf, E., Hofker, M. H., Lutjohann, D. & Shiri-Sverdlov, R., 1 Jan 2013, In : Gastroenterology. 144, 1, p. 167-178.e1

Research output: Contribution to journalArticleAcademicpeer-review

The flavanol (-)-epicatechin and its metabolites protect against oxidative stress in primary endothelial cells via a direct antioxidant effect.

Ruijters, E. J. B., Weseler, A. R., Kicken, C., Haenen, G. R. M. M. & Bast, A., 5 Sep 2013, In : European Journal of Pharmacology. 715, 1-3, p. 147-153 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

The use of complementary and alternative medicine by breast cancer patients

Martens, M. H., van Roozendaal, L. M., Schouten, L. J., Hermans, J. J. R. M., Bast, A., Weijenberg, M. P. & Smidt, M. L., 1 Jan 2013, In : Nederlands Tijdschrift voor Geneeskunde.

Research output: Contribution to journalArticleAcademicpeer-review

Zoet in de strijd tegen suiker

Bast, A., den Hartog, G. J. & Boesten, D. M., 26 Jun 2013, In : Dagblad de Limburger - Limburgs Dagblad. 2 p.

Research output: Contribution to journalArticlePopular

Open Access
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104 Downloads (Pure)
2012

Adenosine 5' -triphosphate (ATP) supplements are not orally bioavailable: a randomized, placebocontrolled cross-over trial in healthy humans

Arts, I. C. W., Coolen, E., Bours, M. J. L., Huyghebaert, N., Stuart, M. A. C., Bast, A. & Dagnelie, P. C., 1 Jan 2012, In : Journal of the International Society of Sports Nutrition. 9, 1, p. 16

Research output: Contribution to journalArticleAcademicpeer-review

Cat litter is a possible trigger for sarcoidosis

Drent, M., Wijnen, P. A. H. M., Boots, A. W. & Bast, A., 1 Jan 2012, In : European Respiratory Journal. 39, 1, p. 221-222 3 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Effects of flavonoids on the vascular endothelium: What is known and what is next?

Weseler, A. R. & Bast, A., 1 Jan 2012, Flavonoids and related compounds. Bioavailability and function.. Spencer, J. P. E. & Crozier, A. (eds.). CRC Press, p. 309-330

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Interstitial lung damage due to cocaine abuse: pathogenesis, pharmacogenomics and therapy.

Drent, M., Wijnen, P. & Bast, A., Nov 2012, In : Current Medicinal Chemistry. 19, 33, p. 5607-5611 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Management van longfibrose: Stand van zaken.

Drent, M. & Bast, A., 1 Jan 2012, In : Farmacotherapie Online. 1, p. 9

Research output: Contribution to journalArticleProfessional

Maximizing fruit's potential.

Dietrich, H., Zimmer, E., Pecoroni, S., Bast, A. & Brouns, F. J. P., 30 Jul 2012

Research output: Non-textual formWeb publication/siteAcademic

Neutrophils augment LPS-mediated pro-inflammatory signaling in human lung epithelial cells

Boots, A. W., Gerloff, K., Bartholomé, R., van Berlo, D., Ledermann, K., Haenen, G. R. M. M., Bast, A., van Schooten, F. J., Albrecht, C. & Schins, R. P., Jul 2012, In : Biochimica et Biophysica Acta-Molecular Cell Research. 1823, 7, p. 1151-1162 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Of reductionism and the pendulum swing: connecting toxicology and human health

Hanekamp, J. C., Bast, A. & Kwakman, J. H., 1 Jan 2012, In : Dose-Response. 10, 2, p. 155-76

Research output: Contribution to journalArticleAcademicpeer-review

Optimizing the bioactive potential of wheat bran by processing

Mateo Anson, N., Hemery, Y. M., Bast, A. & Haenen, G. R. M. M., 1 Jan 2012, In : Food & Function. 3, 4, p. 362-375

Research output: Contribution to journalArticleAcademicpeer-review

Pleiotropic-acting nutrients require integrative investigational approaches: the example of flavonoids.

Weseler, A. R. & Bast, A., 12 Sep 2012, In : Journal of Agricultural and Food Chemistry. 60, 36, p. 8941-8946 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Prediction of asthma exacerbations in children: results of a one-year prospective study

Robroeks, C. M. H. H. T., van Vliet, D., Jöbsis, Q., Braekers, R., Rijkers, G. T., Wodzig, K. W. H., Bast, A., Zimmermann, L. J. I. & Dompeling, E., May 2012, In : Clinical and Experimental Allergy. 42, 5, p. 792-798 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

The anti-inflammatory effect of lycopene complements the antioxidant action of ascorbic acid and alpha-tocopherol

Hazewindus, M., Haenen, G. R. M. M., Weseler, A. R. & Bast, A., 15 May 2012, In : Food Chemistry. 132, 2, p. 954-958 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

The Effect of Statins and Other Cardiovascular Medication on Ischemia-Reperfusion Damage in a Human DIEP Flap Model: Theoretical and Epidemiological Considerations

van den Heuvel, M. G., Bast, A., Ambergen, A. W. & van der Hulst, R. R., 1 Jan 2012, In : Journal of transplantation. 2012, p. 504081

Research output: Contribution to journalArticleAcademicpeer-review

The flavonoid monoHER prevents monocrotaline-induced hepatic sinusoidal injury in rats.

Ezzat, T., van den Broek, M. A., Davies, N., Dejong, C. H. C., Bast, A., Malago, M., Dhar, D. K. & Olde Damink, S., 1 Jan 2012, In : Journal of Surgical Oncology. 106, 1, p. 72-78

Research output: Contribution to journalArticleAcademicpeer-review

Therapeutic options for ILD: Food or pharma?

Bast, A., 1 Jan 2012, In : Ild Care Today. 10, p. 32-35

Research output: Contribution to journalArticleAcademic

The role of antioxidants in ischaemia-reperfusion in a human DIEP flap model

van den Heuvel, M. G. W., Bast, A., Haenen, G. R. M. M., Ambergen, A. W., Mermans, J. F. & van der Hulst, R. R. W. J., 1 Jan 2012, In : Journal of Plastic Reconstructive and Aesthetic Surgery. 65, 12, p. 1706-1711

Research output: Contribution to journalArticleAcademicpeer-review

2011

An essential difference in the reactivity of the glutathione adducts of the structurally closely related flavonoids monoher and quercetin

Jacobs, H., Moalin, M., van Gisbergen, M. W., Bast, A., van der Vijgh, W. J. F. & Haenen, G. R. M. M., 1 Dec 2011, In : Free Radical Biology and Medicine. 51, 11, p. 2118-2123 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

A planar conformation and the hydroxyl groups in the b and c rings play a pivotal role in the antioxidant capacity of quercetin and quercetin derivatives

Moalin, M., van Strijdonck, G. P., Beckers, M., Hageman, G., Borm, P., Bast, A. & Haenen, G. R. M. M., Nov 2011, In : Molecules. 16, 11, p. 9636-9650 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Bioprocessing of Wheat Bran in Whole Wheat Bread Increases the Bioavailability of Phenolic Acids in Men and Exerts Antiinflammatory Effects ex Vivo.

Mateo Anson, N., Aura, A. M., Selinheimo, E., Mattila, I., Poutanen, K., van den Berg, R., Havenaar, R., Bast, A. & Haenen, G. R. M. M., 1 Jan 2011, In : Journal of Nutrition. 141, 1, p. 137-143 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Differences in pharmacological activities of the antioxidant flavonoid monoher in humans and mice are caused by variations in its metabolic profile

Jacobs, H., Koek, G. H., Peters, R., Moalin, M., Tack, J., van der Vijgh, W. J. F., Bast, A. & Haenen, G. R. M. M., Dec 2011, In : Clinical Pharmacology & Therapeutics. 90, 6, p. 852-859 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Effect of bioprocessing of wheat bran in wholemeal wheat breads on the colonic SCFA production in vitro and postprandial plasma concentrations in men

Anson, N. M., Havenaar, R., Vaes, W., Coulier, L., Venema, K., Selinheimo, E., Bast, A. & Haenen, G. R. M. M., 15 Sep 2011, In : Food Chemistry. 128, 2, p. 404-409

Research output: Contribution to journalArticleAcademicpeer-review

Identification of the Metabolites of the Antioxidant Flavonoid 7-Mono-O-({beta}-hydroxyethyl)-rutoside in Mice.

Jacobs, H., Peters, R., den Hartog, G. J. M., van der Vijgh, W. J. F., Bast, A. & Haenen, G. R. M. M., 1 Jan 2011, In : Drug Metabolism and Disposition. 39, 5, p. 750-756

Research output: Contribution to journalArticleAcademicpeer-review

NADPH-oxidase but not inducible nitric oxide synthase contributes to resistance in a murine Staphylococcus aureus Newman pneumonia model.

Kohler, J., Breitbach, K., Renner, C., Heitsch, A. K., Bast, A., van Rooijen, N., Vogelgesang, S. & Steinmetz, I., Oct 2011, In : Microbes and Infection. 13, 11, p. 914-922 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Oral bioavailability of ATP after prolonged administration.

Coolen, E. J., Arts, I. C., Bekers, O., Vervaet, C., Bast, A. & Dagnelie, P. C., Feb 2011, In : British Journal of Nutrition. 105, 3, p. 357-366 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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PGD(2) and PGE(2) regulate gene expression of Prx 6 in primary macrophages via Nrf2

Erttmann, S. F., Bast, A., Seidel, J., Breitbach, K., Walther, R. & Steinmetz, I., 1 Aug 2011, In : Free Radical Biology and Medicine. 51, 3, p. 626-640 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Pleiotropic benefit of monomeric and oligomeric flavanols on vascular health - a randomized controlled clinical pilot study

Weseler, A. R., Ruijters, E. J. B., Reesink, K. D., Haenen, G. R. M. M. & Bast, A., 8 Dec 2011, In : PLOS ONE. 6, 12, 12 p., 28460.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis

Boots, A. W., Drent, M., de Boer, V. C., Bast, A. & Haenen, G. R. M. M., 1 Jan 2011, In : Clinical Nutrition. 30, 4, p. 506-512

Research output: Contribution to journalArticleAcademicpeer-review

The role of oxidative stress in non-alcoholic steatohepatitis

Koek, G. H., Liedorp, P. R. & Bast, A., 15 Jul 2011, In : Clinica Chimica Acta. 412, 15-16, p. 1297-1305 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The semisynthetic flavonoid monoHER sensitises human soft tissue sarcoma cells to doxorubicin-induced apoptosis via inhibition of nuclear factor-kappaB

Jacobs, H., Bast, A., Peters, G. J., van der Vijgh, W. J. F. & Haenen, G. R. M. M., 1 Feb 2011, In : British Journal of Cancer. 104, 3, p. 437-440 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

2010

An essential difference between the flavonoids monoHER and quercetin in their interplay with the endogenous antioxidant network

Jacobs, H., Moalin, M., Bast, A., van der Vijgh, W. J. & Haenen, G. R. M. M., 1 Jan 2010, In : PLOS ONE. 5, 11, 9 p., e13880.

Research output: Contribution to journalArticleAcademicpeer-review

Antioxidant and anti-inflammatory capacity of bioaccessible compounds from wheat fractions after gastrointestinal digestion

Anson, N. M., Havenaar, R., Bast, A. & Haenen, G. R. M. M., Jan 2010, In : Journal of Cereal Science. 51, 1, p. 110-114

Research output: Contribution to journalArticleAcademicpeer-review

Antioxidant moet vergoed blijven. N-acetylcysteïne belangrijk voor longfibrosepatiënten.

Drent, M., Dekhuijzen, P. N., Grutters, J. C., Bresser, P., van der Bij, W. & Bast, A., 1 Jan 2010, In : Medisch Contact. 65, 1, p. 30-33

Research output: Contribution to journalArticleAcademicpeer-review

ATP sensitizes H460 lung carcinoma cells to cisplatin-induced apoptosis

Swennen, E. L. R., Ummels, V., Buss, I., Jaehde, U., Bast, A. & Dagnelie, P. C., 30 Mar 2010, In : Chemico-Biological Interactions. 184, 3, p. 338-345 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Chorioamnionitis induced hepatic inflammation and disturbed lipid metabolism in fetal sheep.

Bieghs, V., Vlassaks, E., Custers, A., van Gorp, P. J. J., Gijbels, M. J. J., Bast, A., Bekers, O., Zimmermann, L. J. I., Lutjohann, D., Voncken, J. W., Gavilanes, A. W., Kramer, B. W. & Shiri-Sverdlov, R., Dec 2010, In : Pediatric Research. 68, 6, p. 466-472 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Deconjugation Kinetics of Glucuronidated Phase II Flavonoid Metabolites by beta-glucuronidase from Neutrophils

Bartholomé, R., Haenen, G. R. M. M., Hollman, C. H., Bast, A., Dagnelie, P. C., Roos, D., Keijer, J., Kroon, P. A., Needs, P. W. & Arts, C. W., 1 Jan 2010, In : Drug metabolism and pharmacokinetics. 25, 4, p. 379-87

Research output: Contribution to journalArticleAcademicpeer-review

De dosis telt

Bast, A., 1 Jan 2010, In : Nederlands Tijdschrift voor Geneeskunde. 154, p. B607

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review