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2020

(-)-Epicatechin metabolites promote vascular health through epigenetic reprogramming of endothelial-immune cell signaling and reversing systemic low-grade inflammation

Milenkovic, D., Declerck, K., Guttman, Y., Kerem, Z., Claude, S., Weseler, A. R., Bast, A., Schroeter, H., Morand, C. & Vanden Berghe, W., Mar 2020, In : Biochemical Pharmacology. 173, 16 p., 113699.

Research output: Contribution to journalArticleAcademicpeer-review

Gastrointestinal digestion of dietary advanced glycation endproducts using an in vitro model of the gastrointestinal tract (TIM-1)

van der Lugt, T., Venema, K., van Leeuwen, S., Vrolijk, M. F., Opperhuizen, A. & Bast, A., 1 Jul 2020, In : Food & Function. 11, 7, p. 6297-6307 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Haemodynamic effects of the flavonoid quercetin in rats revisited

Vrolijk, M. F., van Essen, H., Opperhuizen, A., Bast, A. & Janssen, B. J., Apr 2020, In : British Journal of Pharmacology. 177, 8, p. 1841-1852 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Inter-individual differences in pharmacokinetics of vitamin B6: A possible explanation of different sensitivity to its neuropathic effects

Vrolijk, M. F., Hageman, G. J., van de Koppel, S., van Hunsel, F. & Bast, A., Jun 2020, In : PharmaNutrition. 12, 7 p., 100188.

Research output: Contribution to journalArticleAcademicpeer-review

Tamsulosin Associated with Interstitial Lung Damage in CYP2D6 Variant Alleles Carriers

Jessurun, N. T., Wijnen, P. A., Bast, A., van Puijenbroek, E. P., Bekers, O. & Drent, M., Apr 2020, In : International journal of molecular sciences. 21, 8, 9 p., 2770.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The dietary antioxidant quercetin reduces hallmarks of bleomycin-induced lung fibrogenesis in mice

Boots, A. W., Veith, C., Albrecht, C., Bartholome, R., Drittij, M-J., Claessen, S. M. H., Bast, A., Rosenbruch, M., Jonkers, L., van Schooten, F-J. & Schins, R. P. F., 29 Apr 2020, In : BMC Pulmonary Medicine. 20, 1, 16 p., 112.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

Exploring the mechanism of within-meal variety and sensory-specific satiation

Hendriks, A. E. M., Havermans, R. C., Nederkoorn, C. & Bast, A., Dec 2019, In : Food Quality and Preference. 78, 6 p., 103740.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Protective role of c-Jun N-terminal kinase-2 (JNK2) in ibuprofen-induced acute liver injury

Zoubek, M. E., Woitok, M. M., Sydor, S., Nelson, L. J., Bechmann, L. P., Lucena, M. I., Andrade, R. J., Bast, A., Koek, G. H., Trautwein, C. & Cubero, F. J., Jan 2019, In : Journal of Pathology. 247, 1, p. 110-122 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Self-reported Gastrointestinal Side Effects of Antifibrotic Drugs in Dutch Idiopathic Pulmonary Fibrosis patients

Proesmans, V. L. J., Drent, M., Elfferich, M. D. P., Wijnen, P. A. H. M., Jessurun, N. T. & Bast, A., Oct 2019, In : Lung. 197, 5, p. 551-558 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Towards improved pharmacotherapy in pulmonary arterial hypertension. Can diet play a role?

Semen, K. O. & Bast, A., Apr 2019, In : Clinical Nutrition ESPEN. 30, p. 159-169 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

VKORC1 and CYP2C9 Polymorphisms: A Case Report in a Dutch Family with Pulmonary Fibrosis

Wijnen, P., Drent, M., Bekers, O., Verschakelen, J. & Bast, A., 1 Mar 2019, In : International journal of molecular sciences. 20, 5, 10 p., 1160.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Allergens of permanent hair dyes induces epidermal damage, skin barrier loss and IL-1 alpha increase in epidermal in vitro model

Zanoni, T. B., Pedrosa, T. N., Catarino, C. M., Spiekstra, S. W., de Oliveira, D. P., Den Hartog, G., Bast, A., Hagemann, G., Gibbs, S., de Moraes Barros, S. B. & Maria-Engler, S. S., Feb 2018, In : Food and Chemical Toxicology. 112, p. 265-272 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Clarifying the health claim assessment procedure of EFSA will benefit functional food innovation

Lenssen, K., Bast, A. & de Boer, A., Aug 2018, In : Journal of Functional Foods. 47, p. 386-396 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Dietary Advanced Glycation Endproducts Induce an Inflammatory Response in Human Macrophages in Vitro

van der Lugt, T., Weseler, A. R., Gebbink, W. A., Vrolijk, M. F., Opperhuizen, A. & Bast, A., 1 Dec 2018, In : Nutrients. 10, 12, 10 p., 1868.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Lipase diffusion in oil-filled, alginate micro- and macrobeads

van Leusden, P., den Hartog, G. J. M., Bast, A., Postema, M., van der Linden, E. & Sagis, L. M. C., 1 Dec 2018, In : Food Hydrocolloids. 85, p. 242-247 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro

Verissimo, G., Bast, A. & Weseler, A. R., 1 Aug 2018, In : Chemico-Biological Interactions. 291, p. 237-244 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

One-week cocoa flavanol intake increases prefrontal cortex oxygenation at rest and during moderate-intensity exercise in normoxia and hypoxia

Decroix, L., Tonoli, C., Lespagnol, E., Balestra, C., Descat, A., Drittij-Reijnders, M. J., Blackwell, J. R., Stahl, W., Jones, A. M., Weseler, A. R., Bast, A., Meeusen, R. & Heyman, E., 1 Jul 2018, In : Journal of Applied Physiology. 125, 1, p. 8-18 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

The direct and sustained consequences of severe placental hypoxia on vascular contractility

Vangrieken, P., Al-Nasiry, S., Janssen, G. M. J., Weseler, A. R., Spaanderman, M. E., Bast, A. & Schiffers, P. M. H., 24 Aug 2018, In : PLOS ONE. 13, 8, 15 p., e0202648.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017
Open Access

Acute cocoa Flavanols intake has minimal effects on exercise-induced oxidative stress and nitric oxide production in healthy cyclists: a randomized controlled trial

Decroix, L., Tonoli, C., Soares, D. D., Descat, A., Drittij-Reijnders, M-J., Weseler, A. R., Bast, A., Stahl, W., Heyman, E. & Meeusen, R., 10 Aug 2017, In : Journal of the International Society of Sports Nutrition. 14, 11 p., 28.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Paraquat disrupts the anti-inflammatory action of cortisol in human macrophages in vitro: therapeutic implications for paraquat intoxications

Verssimo, G., Bast, A. & Weseler, A. R., 1 Mar 2017, In : Toxicology Research. 6, 2, p. 232-241 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Permeation of probe molecules into alginate microbeads: Effect of salt and processing

van Leusden, P., den Hartog, G. J. M., Bast, A., Postema, M., van der Linden, E. & Sagis, L. M. C., Dec 2017, In : Food Hydrocolloids. 73, p. 255-261 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Silver nanoparticles induce hormesis in A549 human epithelial cells

Sthijns, M. M. J. P. E., Thongkam, W., Albrecht, C., Hellack, B., Bast, A., Haenen, G. R. M. M. & Schins, R. P. F., Apr 2017, In : Toxicology in Vitro. 40, p. 223-233 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The disturbed redox-balance in pulmonary fibrosis is modulated by the plant flavonoid quercetin

Veith, C., Drent, M., Bast, A., van Schooten, F. J. & Boots, A. W., 1 Dec 2017, In : Toxicology and Applied Pharmacology. 336, p. 40-48 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effects of vitamin E or lipoic acid supplementation on oxyphytosterols in subjects with elevated oxidative stress: a randomized trial

Baumgartner, S., Mensink, R. P., Haenen, G. R., Bast, A., Binder, C. J., Bekers, O., Husche, C., Luetjohann, D. & Plat, J., 10 Nov 2017, In : Scientific Reports. 7, 9 p., 15288.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The Potential of Flavonoids in the Treatment of Non-alcoholic Fatty Liver Disease

van de Wier, B., Koek, G. H., Bast, A. & Haenen, G. R. M., 2017, In : Critical Reviews in Food Science and Nutrition. 57, 4, p. 834-855 22 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function

Vrolijk, M. F., Opperhuizen, A., Jansen, E. H. J. M., Hageman, G. J., Bast, A. & Haenen, G. R. M. M., Oct 2017, In : Toxicology in Vitro. 44, p. 206-212 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

Active ingredients leading in health claims on functional foods

de Boer, A., Urlings, M. J. E. & Bast, A., 1 Jan 2016, In : Journal of Functional Foods. 20, p. 587-593 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Iron Supplements and Magnesium Peroxide: An Example of a Hazardous Combination in Self-Medication

Vrolijk, M. F., Opperhuizen, A., Jansen, E. H. J. M., Bast, A. & Haenen, G. R. M. M., Oct 2016, In : Basic & Clinical Pharmacology & Toxicology. 119, 4, p. 412-417

Research output: Contribution to journalArticleAcademicpeer-review

Is intestinal oxidative stress involved in patients with compensated liver cirrhosis?

Pijls, K., Jonkers, D., Elizalde Vilalta, M., Drittij - Reijnders, M. J., Haenen, G., Bast, A., Masclee, A. & Koek, G., 2016, In : Annals of Hepatology. 15, 3, p. 402-409 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

REPOSITIONING 'OLD' DRUGS TO TREAT RARE DISEASES: ARGUING FROM THE MECHANISM OF ACTION

Drent, M., Bast, A., Bootsma, H-P. & Deneer, V., 2016, In : Sarcoidosis Vasculitis and Diffuse Lung Diseases. 33, 2, p. 191-194

Research output: Contribution to journalArticleAcademicpeer-review

Strength of microbeads for the encapsulation of heat sensitive, hydrophobic components

van Leusden, P., den Hartog, G. J. M., Bast, A., Postema, M., van der Linden, E. & Sagis, L. M. C., May 2016, In : Food Hydrocolloids. 56, p. 318-324

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Structure engineering of filled protein microbeads to tailor release of oil droplets in gastric digestion

van Leusden, P., den Hartog, G. J. M., Bast, A., Postema, M., van der Linden, E. & Sagis, L. M. C., 1 Aug 2016, In : Food & Function. 7, 8, p. 3539-3547

Research output: Contribution to journalArticleAcademicpeer-review

The tobacco smoke component acrolein induces glucocorticoid resistant gene expression via inhibition of histone deacetylase

Randall, M., Haenen, G. R., Bouwman, F. G., Vliet, A. V. & Bast, A., 5 Jan 2016, In : Toxicology Letters. 240, 1, p. 43-49 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Time in Redox Adaptation Processes: From Evolution to Hormesis

Sthijns, M. M. J. P. E., Weseler, A. R., Bast, A. & Haenen, G. R. M. M., Oct 2016, In : International journal of molecular sciences. 17, 10, 1649.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway

Heyninck, K., Sabbe, L., Chirumamilla, C. S., Szic, K. S. V., Veken, P. V., Lemmens, K. J. A., Lahtela-Kakkonen, M., Naulaerts, S., de Beeck, K. O., Laukens, K., Van Camp, G., Weseler, A. R., Bast, A., Haenen, G. R. M. M., Haegeman, G. & Berghe, W. V., 1 Jun 2016, In : Biochemical Pharmacology. 109, p. 48-61

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
2015

Acute eosinophilic pneumonia associated with glyphosate-surfactant exposure

de Raadt, W. M., Wijnen, P. A., Bast, A., Bekers, O. & Drent, M., 2015, In : Sarcoidosis Vasculitis and Diffuse Lung Diseases. 32, 2, p. 172-175

Research output: Contribution to journalArticleAcademicpeer-review

Adverse food-drug interactions

de Boer, A., van Hunsel, F. & Bast, A., 19 Oct 2015, In : Regulatory Toxicology and Pharmacology. 73, 3, p. 859-865

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Antibiotics exposure and health risks: Chloramphenicol

Hanekamp, J. C. & Bast, A., 1 Jan 2015, In : Environmental Toxicology and Pharmacology. 39, 1, p. 213-220

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Anticholinergic Accumulation: A Slumbering Interaction between Drugs and Food Supplements

Vrolijk, M. F., Opperhuizen, A., Jansen, E. H., Bast, A. & Haenen, G. R., Dec 2015, In : Basic & Clinical Pharmacology & Toxicology. 117, 6, p. 427-432 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Chemical characteristics for optimizing CYP2E1 inhibition

van de Wier, B., Balk, J. M., Bast, A., Koek, G. H. & Haenen, G. R., 5 Dec 2015, In : Chemico-Biological Interactions. 242, p. 139-144 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Enforcement of the nutrition and health claim regulation

De Boer, A., Urlings, M., Vos, E. & Bast, A., 1 Dec 2015, In : European Food and Feed Law Review. 10, 5, p. 334-344 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Health effects of erythritol

Boesten, D. M. P. H. J., den Hartog, G. J. M., de Cock, P., Bosscher, D., Bonnema, A. & Bast, A., 1 Jan 2015, In : Nutrafoods. 14, p. 3-9

Research output: Contribution to journalArticleAcademicpeer-review

International legislation on nutrition and health claims

de Boer, A. & Bast, A., 1 Aug 2015, In : Food Policy. 55, p. 61-70 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)