Simone van Breda

Research output

Research output per year 2000 2015 2016 2018 2021 2022 2023 2024

• 41 Article
• 6 (Systematic) Review article
• 5 Conference Abstract/Poster in journal
• 2 Erratum / corrigendum / retractions
• 3 More
  • 1 Editorial
  • 1 Comment/Letter to the editor
  • 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2023

  Analysis of cell-specific transcriptional responses in human colon tissue using CIBERSORTx

  He, Y., De Benedictis, J. N., Caiment, F., van Breda, S. G. J. & de Kok, T. M. C. M., 25 Oct 2023, In: Scientific Reports. 13, 1, 10 p., 18281.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Impact of Processing Method and Storage Time on Phytochemical Concentrations in an Antioxidant-Rich Food Mixture

  DeBenedictis, J. N., de Kok, T. M. & van Breda, S. G., 1 Jun 2023, In: Antioxidants. 12, 6, 18 p., 1252.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2022

  The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer

  Bischoff, N. S., Proquin, H., Jetten, M. J., Schrooders, Y., Jonkhout, M. C. M., Briede, J. J., van Breda, S. G., Jennen, D. G. J., Medina-Reyes, E. I., Delgado-Buenrostro, N. L., Chirino, Y. I., van Loveren, H. & de Kok, T. M., 1 Apr 2022, In: Nanomaterials. 12, 8, 28 p., 1256.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2021

  Effects of processed meat and drinking water nitrate on oral and fecal microbial populations in a controlled feeding study

  Sinha, R., Zhao, N., Goedert, J. J., Byrd, D. A., Wan, Y. H., Hua, X., Hullings, A. G., Knight, R., van Breda, S., Mathijs, K., de Kok, T. M., Ward, M. H. & PHYTOME Consortium Members, 1 Jun 2021, In: Environmental Research. 197, 9 p., 111084.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Replacement of Nitrite in Meat Products by Natural Bioactive Compounds Results in Reduced Exposure to N-Nitroso Compounds: The PHYTOME Project

  van Breda, S. G., Mathijs, K., Pieters, H. J., Sagi-Kiss, V., Kuhnle, G. G., Georgiadis, P., Saccani, G., Parolari, G., Virgili, R., Sinha, R., Hemke, G., Hung, Y., Verbeke, W., Masclee, A. A., Vleugels-Simon, C. B., van Bodegraven, A. A., de Kok, T. M. & PHYTOME consortium, Oct 2021, In: Molecular Nutrition & Food Research. 65, 20, 17 p., 2001214.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2019

  Consumption of Nitrate-Rich Beetroot Juice with or without Vitamin C Supplementation Increases the Excretion of Urinary Nitrate, Nitrite, and N-nitroso Compounds in Humans

  Berends, J. E., van den Berg, L. M. M., Guggeis, M. A., Henckens, N. F. T., Hossein, I. J., de Joode, M. E. J. R., Zamani, H., van Pelt, K. A. A. J., Beelen, N. A., Kuhnle, G. G., de Kok, T. M. C. M. & Van Breda, S. G. J., 1 May 2019, In: International Journal of Molecular Sciences. 20, 9, 15 p., 2277.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Impact of high drinking water nitrate levels on the endogenous formation of apparent N-nitroso compounds in combination with meat intake in healthy volunteers

  van Breda, S. G., Mathijs, K., Sagi-Kiss, V., Kuhnle, G. G., Van der Veer, B., Jones, R. R., Sinha, R., Ward, M. H. & de Kok, T. M., 17 Oct 2019, In: Environmental Health. 18, 1, 12 p., 87.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Improved Preventive Effects of Combined Bioactive Compounds Present in Different Blueberry Varieties as Compared to Single Phytochemicals

  van Breda, S. G. J., Briede, J. J. & de Kok, T. M. C. M., Jan 2019, In: Nutrients. 11, 1, 14 p., 61.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2018

  A cross-omics approach to investigate temporal gene expression regulation by 5-hydroxymethylcytosine via TBH-derived oxidative stress showed involvement of different regulatory kinases

  Briede, J. J., Deferme, L., Wolters, J. E. J., Claessen, S. M. H., van den Beucken, T., Wagner, R. J., van Breda, S. G. & Kleinjans, J. C. S., 1 Apr 2018, In: Toxicology in Vitro. 48, p. 318-328 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Data on novel DNA methylation changes induced by valproic acid in human hepatocytes

  Wolters, JJ., van Breda, SJ., Claessen, S., de Kok, TCM. & Kleinjans, JS., Feb 2018, In: Data in brief. 16, p. 161-171 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes

  Wolters, J. E. J., van Breda, S. G. J., Grossmann, J., Fortes, C., Caiment, F. & Kleinjans, J. C. S., 1 Jun 2018, In: Toxicology Letters. 289, p. 1-13 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction

  van Breda, S. G. J., Claessen, S. M. H., van Herwijnen, M., Theunissen, D. H. J., Jennen, D. G. J., de Kok, T. M. C. M. & Kleinjans, J. C. S., 15 Jan 2018, In: Toxicology. 393, p. 160-170 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens

  Limonciel, A., van Breda, S. G., Jiang, X., Tredwell, G. D., Wilmes, A., Aschauer, L., Siskos, A. P., Sachinidis, A., Keun, H. C., Kopp-Schneider, A., de Kok, T. M., Kleinjans, J. C. S. & Jennings, P., 3 Dec 2018, In: Frontiers in Genetics. 9, 15 p., 558.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2017

  Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes

  Wolters, J. E. J., van Breda, S. G. J., Caiment, F., Claessen, S. M., de Kok, T. M. C. M. & Kleinjans, J. C. S., Oct 2017, In: Chemical Research in Toxicology. 30, 10, p. 1847-1854 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2016

  Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma

  Rieswijk, L., Claessen, S. M. H., Bekers, O., van Herwijnen, M., Theunissen, D. H. J., Jennen, D. G. J., de Kok, T., Kleinjans, J. C. S. & van Breda, S. G. J., 28 Mar 2016, In: Toxicology. 350, p. 31-39 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Consumer awareness and credibility factors of health claims on innovative meat products in a cross-sectional population study in the Netherlands

  Strijbos, C., Schluck, M., Bui, T., de Jong, I., van Leeuwen, M., von Tottleben, M. & van Breda, S. G., Dec 2016, In: Food Quality and Preference. 54, p. 13-22

  Research output: Contribution to journal › Article › Academic › peer-review

• Dynamic Interplay between the Transcriptome and Methylome in Response to Oxidative and Alkylating Stress

  Deferme, L., Wolters, J. E. J., Claessen, S. M. H., Theunissen, D., van den Beucken, T., Wagner, J. R., van Breda, S. G., Kleinjans, J. C. S. & Briede, J. J., Sept 2016, In: Chemical Research in Toxicology. 29, 9, p. 1428-1438

  Research output: Contribution to journal › Article › Academic › peer-review

• Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity

  Rieswijk, L., Brauers, K. J. J., Coonen, M. L. J., Jennen, D. G. J., van Breda, S. G. J. & Kleinjans, J. C. S., Sept 2016, In: Mutagenesis. 31, 5, p. 603-615

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis

  Wolters, J. E. J., van Herwijnen, M. H. M., Theunissen, D. H. J., Jennen, D. G. J., Van den Hof, W. F. P. M., de Kok, T., Schaap, F. G., van Breda, S. G. J. & Kleinjans, J. C. S., Dec 2016, In: Chemical Research in Toxicology. 29, 12, p. 2164-2174

  Research output: Contribution to journal › Article › Academic › peer-review

• "Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015

  Fernando, R. N., Chaudhari, U., Escher, S. E., Hengstler, J. G., Hescheler, J., Jennings, P., Keun, H. C., Kleinjans, J. C. S., Kolde, R., Kollipara, L., Kopp-Schneider, A., Limonciel, A., Nemade, H., Nguemo, F., Peterson, H., Prieto, P., Rodrigues, R. M., Sachinidis, A., Schaefer, C., Sickmann, A., & 8 othersSpitkovsky, D., Stoeber, R., van Breda, S. G. J., van de Water, B., Vivier, M., Zahedi, R. P., Vinken, M. & Rogiers, V., Jun 2016, In: Archives of Toxicology. 90, 6, p. 1529-1539

  Research output: Contribution to journal › Article › Academic › peer-review
• 2015

  Development of novel tools for the in vitro investigation of drug-induced liver injury

  Jiang, J., Wolters, J. EJ., van Breda, S. G., Kleinjans, J. C. & de Kok, T. M., 3 Oct 2015, In: Expert Opinion on Drug Metabolism & Toxicology. 11, 10, p. 1523-1537 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis

  van Breda, S. G. J., Claessen, S. M. H., Lo, K., van Herwijnen, M., Brauers, K. J. J., Lisanti, S., Theunissen, D. H. J., Jennen, D. G. J., Gaj, S., de Kok, T. & Kleinjans, J. C. S., Nov 2015, In: Archives of Toxicology. 89, 11, p. 1959-1969

  Research output: Contribution to journal › Article › Academic › peer-review

• Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes

  Rieswijk, L., Brauers, K. J. J., Coonen, M. L. J., Van Breda, S. G. J., Jennen, D. G. J. & Kleinjans, J. C. S., 2015, In: Mutagenesis. 30, 6, p. 771-784 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• The exposome concept in a human nutrigenomics study: Evaluating the impact of exposure to a complex mixture of phytochemicals using transcriptomics signatures

  Van Breda, S. G. J., Wilms, L. C., Gaj, S., Jennen, D. G. J., Bried, J. J., Kleinjans, J. C. S. & De Kok, T. M. C. M., 2015, In: Mutagenesis. 30, 6, p. 723-731 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2014

  Selenoprotein Gene Variants, Toenail Selenium Levels, and Risk for Advanced Prostate Cancer

  Geybels, M. S., van den Brandt, P. A., Schouten, L. J., van Schooten, F. J., van Breda, S. G., Rayman, M. P., Green, F. R. & Verhage, B. A. J., 1 Jan 2014, In: Journal of the National Cancer Institute. 106, 3, dju003.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2012

  Genomics-Based Identification of Molecular Mechanisms behind the Cancer Preventive Action of Phytochemicals: Potential and Challenges

  de Kok, T. M. C. M., van Breda, S. G. J. & Briede, J. J., Jan 2012, In: Current Pharmaceutical Biotechnology. 13, 1, p. 255-264

  Research output: Contribution to journal › Article › Academic › peer-review
• 2011

  A Lyophilized Red Grape Pomace Containing Proanthocyanidin-Rich Dietary Fiber Induces Genetic and Metabolic Alterations in Colon Mucosa of Female C57BL/6J Mice

  Lizarraga, D., Vinardell, M. P., Noe, V., van Delft, J. H., Alcarraz-Vizan, G., van Breda, S. G., Staal, Y., Guenther, U. L., Reed, M. A., Ciudad, C. J., Torres, J. L. & Cascante, M., Sept 2011, In: Journal of Nutrition. 141, 9, p. 1597-1604

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2010

  Antioxidative and antigenotoxic properties of vegetables and dietary phytochemicals: The value of genomics biomarkers in molecular epidemiology.

  de Kok, T. M., de Waard, P., Wilms, L. C. & van Breda, S. G., Feb 2010, In: Molecular Nutrition & Food Research. 54, 2, p. 208-217

  Research output: Contribution to journal › Article › Academic › peer-review

• Dietary acrylamide intake and risk of breast cancer in the UK women's cohort

  Burley, V. J., Greenwood, D. C., Hepworth, S. J., Fraser, L. K., de Kok, T. M., van Breda, S. G. J., Kyrtopoulos, S. A., Botsivali, M., Kleinjans, J., McKinney, P. A. & Cade, J. E., 23 Nov 2010, In: British Journal of Cancer. 103, 11, p. 1749-1754 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2009

  Methylation status of CpG islands in the promoter region of genes differentially expressed in colonic mucosa from adenoma patients and controls in response to altered vegetable intake

  van Breda, S. G., van Delft, J. H., Engels, L. G., Kleinjans, J. C. & Mathers, J. C., 1 Jan 2009, In: British Journal of Nutrition. 101, 9, p. 1295-9

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2008

  Mechanisms of colorectal and lung cancer prevention by vegetables: a genomic approach.

  van Breda, S. G., de Kok, T. & van Delft, J. H., 1 Jan 2008, In: Journal of Nutritional Biochemistry. 19, 3, p. 139-157

  Research output: Contribution to journal › Article › Academic › peer-review

• Mechanisms of combined action of different chemopreventive dietary compounds: a review

  de Kok, T. M., van Breda, S. G. & Manson, M. M., 1 Jan 2008, In: European Journal of Nutrition. 47, Suppl 2, p. 51-9

  Research output: Contribution to journal › Article › Academic › peer-review

• Proton pump inhibitor therapy in gastro-oesophageal reflux disease decreases the oesophageal immune response but does not reduce the formation of DNA adducts

  De Jonge, P. J., Siersema, P. D., van Breda, S. G., Van Zoest, K. P., Bac, D. J., Leeuwenburgh, I., Ouwendijk, R. J., van Dekken, H., Kusters, J. G. & Kuipers, E. J., 1 Jan 2008, In: Alimentary Pharmacology & Therapeutics. 28, 1, p. 127-36

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2006

  Potential protein markers for nutritional health effects on colorectal cancer in the mouse as revealed by proteomics analysis

  Breikers, G., van Breda, S. G., Bouwman, F. G., van Herwijnen, M. H. M., Renes, J., Mariman, E. C., Kleinjans, J. C. & van Delft, J. H., 1 Jan 2006, In: Proteomics. 6, 9, p. 2844-2852

  Research output: Contribution to journal › Article › Academic › peer-review
• 2005

  Comparison of supervised clustering methods to discriminate genotoxic from non-genotoxic carcinogens by gene expression profiling

  van Delft, J. H., van Agen, E., van Breda, S. G. J., van Herwijnen, M. H. M., Staal, Y. & Kleinjans, J. C., 1 Jan 2005, In: Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis. 575, 1-2, p. 17-33

  Research output: Contribution to journal › Article › Academic › peer-review

• Vegetables affect the expression of genes involved in anticarcinogenic processes in the colonic mucosa of C57BL/6 female mice

  van Breda, S. G. J., van Agen, E., van Sanden, S., Burzykowski, T., Kienhuis, A. S., Kleinjans, J. C. & van Delft, J. H., 1 Jan 2005, In: Journal of Nutrition. 135, 8, p. 1879-1888

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Vegetables affect the expression of genes involved in carcinogenic and anticarcinogenic processes in the lungs of female C57BL/6 mice

  van Breda, S. G. J., van Agen, E., van Sanden, S., Burzykowski, T., Kleinjans, J. C. & van Delft, J. H., 1 Jan 2005, In: Journal of Nutrition. 135, 11, p. 2546-2552

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2004

  Altered vegetable intake affects pivotal carcinogenesis pathways in colon mucosa from adenoma patients and controls

  van Breda, S. G. J., van Agen, E., Engels, L. G. B., Moonen, E. J. C., Kleinjans, J. C. & van Delft, J. H., 1 Jan 2004, In: Carcinogenesis. 25, 11, p. 2207-2216

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

• Discrimination of genotoxic from non-genotoxic carcinogens by gene expression profiling

  van Delft, J. H., van Agen, E., van Breda, S. G. J., van Herwijnen, M. H. M., Staal, Y. & Kleinjans, J. C., 1 Jan 2004, In: Carcinogenesis. 25, 7, p. 1265-1276

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access
• 2000

  Applicability of induced sputum for molecular dosimetry of exposure to inhalatory carcinogens: P-32-postlabeling of lipophilic DNA adducts in smokers and nonsmokers

  Nia, A. B., Maas, L. M., van Breda, S. G. J., Curfs, D. M. J., Kleinjans, J. C. S., Wouters, E. F. M. & van Schooten, F. J., 1 Jan 2000, In: Cancer Epidemiology Biomarkers & Prevention. 9, 4, p. 367-372 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Does the risk of childhood diabetes mellitus require revision of the guideline values for nitrate in drinking water?

  van Maanen, J. M. S., Albering, H. J., de Kok, T. M. C. M., van Breda, S. G. J., Curfs, D. M. J., Vermeer, I. T. M., Ambergen, A. W., Wolffenbuttel, B. H. R., Kleinjans, J. C. S. & Reeser, H. M., 1 Jan 2000, In: Environmental Health Perspectives. 108, 5, p. 457-461 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access