Dietary acrylamide intake and risk of breast cancer in the UK women's cohort

V.J. Burley, D.C. Greenwood, S.J. Hepworth, L.K. Fraser, T.M. de Kok, S.G.J. van Breda, S.A. Kyrtopoulos, M. Botsivali, J. Kleinjans, P.A. McKinney, J.E. Cade

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    Abstract

    Background:No studies to date have demonstrated a clear association with breast cancer risk and dietary exposure to acrylamide.Methods:A 217-item food frequency questionnaire was used to estimate dietary acrylamide intake in 33 731 women aged 35-69 years from the UK Women's Cohort Study followed up for a median of 11 years.Results:In all, 1084 incident breast cancers occurred during follow-up. There was no evidence of an overall association between acrylamide intake and breast cancer (hazard ratio=1.08 per 10 mug day(-1), 95% CI: 0.98-1.18, P(trend)=0.1). There was a suggestion of a possible weak positive association between dietary acrylamide intake and premenopausal breast cancer after adjustment for potential confounders (hazard ratio=1.2, 95% CI: 1.0-1.3, P(trend)=0.008). There was no suggestion of any association for postmenopausal breast cancer (hazard ratio=1.0, 95% CI: 0.9-1.1, P(trend)=0.99).Conclusions:There is no evidence of an association between dietary acrylamide intake and breast cancer. A weak association may exist with premenopausal breast cancer, but requires further investigation.British Journal of Cancer advance online publication, 19 October 2010; doi:10.1038/sj.bjc.6605956 www.bjcancer.com.
    Original languageEnglish
    Pages (from-to)1749-1754
    Number of pages6
    JournalBritish Journal of Cancer
    Volume103
    Issue number11
    DOIs
    Publication statusPublished - 23 Nov 2010

    Keywords

    • cohort study
    • acrylamide
    • diet
    • breast cancer
    • FOOD-FREQUENCY QUESTIONNAIRES
    • HEMOGLOBIN ADDUCTS
    • SWEDISH WOMEN
    • EPIC PROJECT
    • VALIDATION
    • EXPOSURE
    • DESIGN
    • HEALTH
    • CARCINOGENICITY
    • ONCOGENICITY

    Cite this

    Burley, V. J., Greenwood, D. C., Hepworth, S. J., Fraser, L. K., de Kok, T. M., van Breda, S. G. J., Kyrtopoulos, S. A., Botsivali, M., Kleinjans, J., McKinney, P. A., & Cade, J. E. (2010). Dietary acrylamide intake and risk of breast cancer in the UK women's cohort. British Journal of Cancer, 103(11), 1749-1754. https://doi.org/10.1038/sj.bjc.6605956