Background:No studies to date have demonstrated a clear association with breast cancer risk and dietary exposure to acrylamide.Methods:A 217-item food frequency questionnaire was used to estimate dietary acrylamide intake in 33 731 women aged 35-69 years from the UK Women's Cohort Study followed up for a median of 11 years.Results:In all, 1084 incident breast cancers occurred during follow-up. There was no evidence of an overall association between acrylamide intake and breast cancer (hazard ratio=1.08 per 10 mug day(-1), 95% CI: 0.98-1.18, P(trend)=0.1). There was a suggestion of a possible weak positive association between dietary acrylamide intake and premenopausal breast cancer after adjustment for potential confounders (hazard ratio=1.2, 95% CI: 1.0-1.3, P(trend)=0.008). There was no suggestion of any association for postmenopausal breast cancer (hazard ratio=1.0, 95% CI: 0.9-1.1, P(trend)=0.99).Conclusions:There is no evidence of an association between dietary acrylamide intake and breast cancer. A weak association may exist with premenopausal breast cancer, but requires further investigation.British Journal of Cancer advance online publication, 19 October 2010; doi:10.1038/sj.bjc.6605956 www.bjcancer.com.
- cohort study
- breast cancer
- FOOD-FREQUENCY QUESTIONNAIRES
- HEMOGLOBIN ADDUCTS
- SWEDISH WOMEN
- EPIC PROJECT
Burley, V. J., Greenwood, D. C., Hepworth, S. J., Fraser, L. K., de Kok, T. M., van Breda, S. G. J., Kyrtopoulos, S. A., Botsivali, M., Kleinjans, J., McKinney, P. A., & Cade, J. E. (2010). Dietary acrylamide intake and risk of breast cancer in the UK women's cohort. British Journal of Cancer, 103(11), 1749-1754. https://doi.org/10.1038/sj.bjc.6605956