Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma

Linda Rieswijk; Sandra M. H. Claessen; Otto Bekers; Marcel van Herwijnen; Daniël H.J. Theunissen; Danyel G. J. Jennen; Theodorus de Kok; Jos C. S. Kleinjans; Simone G. J. van Breda

doi:10.1016/j.tox.2016.05.002

Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma

Linda Rieswijk, Sandra M. H. Claessen, Otto Bekers, Marcel van Herwijnen, Daniël H.J. Theunissen, Danyel G. J. Jennen, Theodorus de Kok, Jos C. S. Kleinjans, Simone G. J. van Breda

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

Original language	English
Pages (from-to)	31-39
Number of pages	9
Journal	Toxicology
Volume	350
DOIs	https://doi.org/10.1016/j.tox.2016.05.002
Publication status	Published - 28 Mar 2016

Keywords

Aflatoxin B1
Epigenomics
Hepatocellular carcinoma
Persistence
Wash-out
PROMOTER HYPERMETHYLATION
DIFFERENTIAL EXPRESSION
CANCER
CYCLIN K
P53 MUTATION
EPIGENETICS
MUTATIONAL HOTSPOT
GENE
CELL-CYCLE
RAB GTPASES

Cite this

Rieswijk, L., Claessen, S. M. H., Bekers, O., van Herwijnen, M., Theunissen, D. H. J., Jennen, D. G. J., de Kok, T., Kleinjans, J. C. S., & van Breda, S. G. J. (2016). Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology, 350, 31-39. https://doi.org/10.1016/j.tox.2016.05.002

Rieswijk, Linda ; Claessen, Sandra M. H. ; Bekers, Otto ; van Herwijnen, Marcel ; Theunissen, Daniël H.J. ; Jennen, Danyel G. J. ; de Kok, Theodorus ; Kleinjans, Jos C. S. ; van Breda, Simone G. J. / Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. In: Toxicology. 2016 ; Vol. 350. pp. 31-39.

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title = "Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma",

keywords = "Aflatoxin B1, Epigenomics, Hepatocellular carcinoma, Persistence, Wash-out, PROMOTER HYPERMETHYLATION, DIFFERENTIAL EXPRESSION, CANCER, CYCLIN K, P53 MUTATION, EPIGENETICS, MUTATIONAL HOTSPOT, GENE, CELL-CYCLE, RAB GTPASES",

author = "Linda Rieswijk and Claessen, {Sandra M. H.} and Otto Bekers and {van Herwijnen}, Marcel and Theunissen, {Dani{\"e}l H.J.} and Jennen, {Danyel G. J.} and {de Kok}, Theodorus and Kleinjans, {Jos C. S.} and {van Breda}, {Simone G. J.}",

year = "2016",

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day = "28",

doi = "10.1016/j.tox.2016.05.002",

language = "English",

volume = "350",

pages = "31--39",

journal = "Toxicology",

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publisher = "Elsevier Ireland Ltd",

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Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. / Rieswijk, Linda ; Claessen, Sandra M. H.; Bekers, Otto ; van Herwijnen, Marcel ; Theunissen, Daniël H.J.; Jennen, Danyel G. J.; de Kok, Theodorus ; Kleinjans, Jos C. S.; van Breda, Simone G. J.

In: Toxicology, Vol. 350, 28.03.2016, p. 31-39.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma

AU - Rieswijk, Linda

AU - Claessen, Sandra M. H.

AU - Bekers, Otto

AU - van Herwijnen, Marcel

AU - Theunissen, Daniël H.J.

AU - Jennen, Danyel G. J.

AU - de Kok, Theodorus

AU - Kleinjans, Jos C. S.

AU - van Breda, Simone G. J.

PY - 2016/3/28

Y1 - 2016/3/28

KW - Aflatoxin B1

KW - Epigenomics

KW - Hepatocellular carcinoma

KW - Persistence

KW - Wash-out

KW - PROMOTER HYPERMETHYLATION

KW - DIFFERENTIAL EXPRESSION

KW - CANCER

KW - CYCLIN K

KW - P53 MUTATION

KW - EPIGENETICS

KW - MUTATIONAL HOTSPOT

KW - GENE

KW - CELL-CYCLE

KW - RAB GTPASES

U2 - 10.1016/j.tox.2016.05.002

DO - 10.1016/j.tox.2016.05.002

M3 - Article

VL - 350

SP - 31

EP - 39

JO - Toxicology

JF - Toxicology

SN - 0300-483X

ER -

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10.1016/j.tox.2016.05.002