Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes

Jarno E. J. Wolters*, Simone G. J. van Breda, Jonas Grossmann, Claudia Fortes, Florian Caiment, Jos C. S. Kleinjans

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalToxicology Letters
Volume289
DOIs
Publication statusPublished - 1 Jun 2018

Keywords

  • Steatosis
  • Mitochondrial dysfunction
  • Primary human hepatocytes
  • Epigenomics
  • Transcriptomics
  • Proteomics
  • VALPROIC ACID METABOLISM
  • HISTONE DEACETYLASE
  • DNA METHYLATION
  • HEPATOCELLULAR-CARCINOMA
  • OXIDATIVE STRESS
  • QUALITY-CONTROL
  • NUCLEAR
  • CELLS
  • DYSFUNCTION
  • MECHANISMS

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