Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction

Simone G. J. van Breda*, Sandra M. H. Claessen, Marcel van Herwijnen, Daniel H. J. Theunissen, Danyel G. J. Jennen, Theo M. C. M. de Kok, Jos C. S. Kleinjans

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Web of Science)
Original languageEnglish
Pages (from-to)160-170
Number of pages11
JournalToxicology
Volume393
DOIs
Publication statusPublished - 15 Jan 2018

Keywords

  • Valproic acid
  • Integrative omics data analyses
  • Human liver
  • Adverse outcome pathway
  • Primary human hepatocytes
  • Genomics
  • FATTY LIVER-DISEASE
  • HEPATIC GENE-EXPRESSION
  • NONALCOHOLIC STEATOHEPATITIS
  • OXIDATIVE STRESS
  • LIPID-METABOLISM
  • STEM-CELLS
  • BILE-ACID
  • DRUG
  • HEPATOCYTES
  • APOPTOSIS

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