A cross-omics approach to investigate temporal gene expression regulation by 5-hydroxymethylcytosine via TBH-derived oxidative stress showed involvement of different regulatory kinases

Jacob J. Briede*, Lize Deferme, Jarno E. J. Wolters, Sandra M. H. Claessen, Twan van den Beucken, Richard J. Wagner, Simone G. van Breda, Jos C. S. Kleinjans

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)318-328
Number of pages11
JournalToxicology in Vitro
Volume48
DOIs
Publication statusPublished - 1 Apr 2018

Keywords

  • tert-Butyl hydroperoxide
  • 5-Hydroxymethylcytosine
  • 5-Methylcytosine
  • Differentially expressed genes
  • Serine-threonine kinases
  • HepG2 cells
  • EMBRYONIC STEM-CELLS
  • HEPATOCELLULAR-CARCINOMA
  • DNA-DAMAGE
  • LIVER CARCINOGENESIS
  • DETOXIFYING ENZYMES
  • TET PROTEINS
  • 5-METHYLCYTOSINE
  • METHYLATION
  • SURVIVAL
  • CANCER

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