Simone van Breda

2025

Food-grade titanium dioxide exposure between age groups and in global regions: a systematic review and meta-analysis

Bischoff, N. S., Bussi, M. R., Van Breda, S. G., Jolani, S., Sijm, D. T. H. M., de Kok, T. M. & Briede, J. J., 1 Feb 2025, In: Critical Reviews in Food Science and Nutrition. 11 p.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

Investigating the ROS Formation and Particle Behavior of Food-Grade Titanium Dioxide (E171) in the TIM-1 Dynamic Gastrointestinal Digestion Model

Bischoff, N. S., Undas, A. K., van Bemmel, G., Briedé, J. J., van Breda, S. G., Verhoeven, J., Verbruggen, S., Venema, K., Sijm, D. T. H. M. & de Kok, T. M., 2025, In: Nanomaterials. 15, 1, 18 p., 8.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

The Role of Genetic Variation in Modulating the Effects of Blended Fruits and Vegetables Versus Fruit- and Vegetable-Coated Food Products on Antioxidant Capacity, DNA Protection, and Vascular Health: A Randomized Controlled Trial

DeBenedictis, J. N., Xu, N., de Kok, T. M. & van Breda, S. G., 18 Jun 2025, In: Nutrients. 17, 12, 26 p., 2036.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2024

Author Correction: Analysis of cell-specific transcriptional responses in human colon tissue using CIBERSORTx (Scientific Reports, (2023), 13, 1, (18281), 10.1038/s41598-023-45582-6)

He, Y., DeBenedictis, J. N., Caiment, F., van Breda, S. G. J. & de Kok, T. M. C. M., Mar 2024, In: Scientific Reports. 14, 1, 1 p., 5096.

Research output: Contribution to journal › Erratum / corrigendum / retractions › Academic

Open Access

Effects of Different Combinations of Phytochemical-Rich Fruits and Vegetables on Chronic Disease Risk Markers and Gene Expression Changes: Insights from the MiBLEND Study, a Randomized Trial

DeBenedictis, J. N., Murrell, C., Hauser, D., van Herwijnen, M., Elen, B., de Kok, T. M. & van Breda, S. G., 1 Aug 2024, In: Antioxidants. 13, 8, 37 p., 915.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Genetic Variability Impacts Genotoxic and Transcriptome Responses in the Human Colon after the Consumption of Processed Red Meat Products and Those with Added Phytochemical Extracts

DeBenedictis, J. N., Baars, E., Ochoteco-Asensio, J., van Breda, S. G. & de Kok, T. M., 31 Jan 2024, In: Nutrients. 16, 3, 30 p., 425.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

Nitrate: "the source makes the poison"

Bowles, E. F., Burleigh, M., Mira, A., Van Breda, S. G. J., Weitzberg, E. & Rosier, B. T., 1 Aug 2024, (E-pub ahead of print) In: Critical Reviews in Food Science and Nutrition. 27 p.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

2023

Analysis of cell-specific transcriptional responses in human colon tissue using CIBERSORTx

He, Y., De Benedictis, J. N., Caiment, F., van Breda, S. G. J. & de Kok, T. M. C. M., 25 Oct 2023, In: Scientific Reports. 13, 1, 10 p., 18281.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Correction: Bischoff et al. The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer. Nanomaterials 2022, 12, 1256

Bischoff, N. S., Proquin, H., Jetten, M. J., Schrooders, Y., Jonkhout, M. C. M., Briedé, J. J., van Breda, S. G., Jennen, D. G. J., Medina-Reyes, E. I., Delgado-Buenrostro, N. L., Chirino, Y. I., van Loveren, H. & de Kok, T. M., 31 Oct 2023, In: Nanomaterials. 13, 21, 2888.

Research output: Contribution to journal › Erratum / corrigendum / retractions › Academic

Open Access

Impact of Processing Method and Storage Time on Phytochemical Concentrations in an Antioxidant-Rich Food Mixture

DeBenedictis, J. N., de Kok, T. M. & van Breda, S. G., 1 Jun 2023, In: Antioxidants. 12, 6, 18 p., 1252.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Reply to Kaminski, NE; Cohen, SM Comment on "Bischoff et al. The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer. Nanomaterials 2022, 12, 1256"

Bischoff, N. S., Proquin, H., Jetten, M. J., Schrooders, Y., Jonkhout, M. C. M., Briede, J. J., van Breda, S. G., Jennen, D. G. J., Medina-Reyes, E. I., Delgado-Buenrostro, N. L., Chirino, Y. I., van Loveren, H. & de Kok, T. M., 5 May 2023, In: Nanomaterials. 13, 9, 5 p., 1552.

Research output: Contribution to journal › Editorial › Academic › peer-review

Open Access

2022

Establishment and validation of co-culture system of human colon organoids and THP-1 derived macrophages

He, Y., de Kok, T. M. & van Breda, S. G., 1 Sept 2022, In: Toxicology Letters. 368, p. S74-S75 2 p.

Research output: Contribution to journal › Conference Abstract/Poster in journal › Academic

Impact of genetic variability on health effects of red meat products containing phytochemicals and reduced levels of nitrite

van Breda, S. G., Baars, E., DeBenedictis, J. & de Kok, T. M., 1 Sept 2022, In: Toxicology Letters. 368, p. S256-S256 1 p.

Research output: Contribution to journal › Conference Abstract/Poster in journal › Academic

Polysaccharide purified from Morchella effectively prevents doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress

Xu, N., Lu, Y., van Breda, S. G. & de Kok, T. M., 1 Sept 2022, In: Toxicology Letters. 368, p. S166-S166 1 p.

Research output: Contribution to journal › Conference Abstract/Poster in journal › Academic

The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer

Bischoff, N. S., Proquin, H., Jetten, M. J., Schrooders, Y., Jonkhout, M. C. M., Briede, J. J., van Breda, S. G., Jennen, D. G. J., Medina-Reyes, E. I., Delgado-Buenrostro, N. L., Chirino, Y. I., van Loveren, H. & de Kok, T. M., 1 Apr 2022, In: Nanomaterials. 12, 8, 28 p., 1256.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

The Importance of Nitrate Reduction for Oral Health

Rosier, B. T., Takahashi, N., Zaura, E., Krom, B. P., MartÍnez-Espinosa, R. M., van Breda, S. G. J., Marsh, P. D. & Mira, A., Jul 2022, In: Journal of Dental Research. 101, 8, p. 887-897 11 p., 00220345221080982.

Research output: Contribution to journal › (Systematic) Review article › peer-review

2021

Effects of processed meat and drinking water nitrate on oral and fecal microbial populations in a controlled feeding study

Sinha, R., Zhao, N., Goedert, J. J., Byrd, D. A., Wan, Y. H., Hua, X., Hullings, A. G., Knight, R., van Breda, S., Mathijs, K., de Kok, T. M., Ward, M. H. & PHYTOME Consortium Members, 1 Jun 2021, In: Environmental Research. 197, 9 p., 111084.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Health effects of red meat products containing phytochemicals and reduced levels of nitrite: the PHYTOME project

van Breda, S. G., de Kok, T. M. & PHYTOME consortium, 1 Sept 2021, In: Toxicology Letters. 350, p. S78-S78 1 p.

Research output: Contribution to journal › Conference Abstract/Poster in journal › Academic

Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System

Bischoff, N. S., de Kok, T. M., Sijm, D. T. H. M., van Breda, S. G., Briede, J. J., Castenmiller, J. J. M., Opperhuizen, A., Chirino, Y. I., Dirven, H., Gott, D., Houdeau, E., Oomen, A. G., Poulsen, M., Rogler, G. & van Loveren, H., 1 Jan 2021, In: International Journal of Molecular Sciences. 22, 1, 35 p., 207.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

Replacement of Nitrite in Meat Products by Natural Bioactive Compounds Results in Reduced Exposure to N-Nitroso Compounds: The PHYTOME Project

van Breda, S. G., Mathijs, K., Pieters, H. J., Sagi-Kiss, V., Kuhnle, G. G., Georgiadis, P., Saccani, G., Parolari, G., Virgili, R., Sinha, R., Hemke, G., Hung, Y., Verbeke, W., Masclee, A. A., Vleugels-Simon, C. B., van Bodegraven, A. A., de Kok, T. M. & PHYTOME consortium, Oct 2021, In: Molecular Nutrition & Food Research. 65, 20, 17 p., 2001214.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

The benefits and risks of beetroot juice consumption: a systematic review

Zamani, H., de Joode, M. E. J. R., Hossein, I. J., Henckens, N. F. T., Guggeis, M. A., Berends, J. E., de Kok, T. M. C. M. & van Breda, S. G. J., 9 Mar 2021, In: Critical Reviews in Food Science and Nutrition. 61, 5, p. 788-804 17 p.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

2019

Consumption of Nitrate-Rich Beetroot Juice with or without Vitamin C Supplementation Increases the Excretion of Urinary Nitrate, Nitrite, and N-nitroso Compounds in Humans

Berends, J. E., van den Berg, L. M. M., Guggeis, M. A., Henckens, N. F. T., Hossein, I. J., de Joode, M. E. J. R., Zamani, H., van Pelt, K. A. A. J., Beelen, N. A., Kuhnle, G. G., de Kok, T. M. C. M. & Van Breda, S. G. J., 1 May 2019, In: International Journal of Molecular Sciences. 20, 9, 15 p., 2277.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Impact of high drinking water nitrate levels on the endogenous formation of apparent N-nitroso compounds in combination with meat intake in healthy volunteers

van Breda, S. G., Mathijs, K., Sagi-Kiss, V., Kuhnle, G. G., Van der Veer, B., Jones, R. R., Sinha, R., Ward, M. H. & de Kok, T. M., 17 Oct 2019, In: Environmental Health. 18, 1, 12 p., 87.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Improved Preventive Effects of Combined Bioactive Compounds Present in Different Blueberry Varieties as Compared to Single Phytochemicals

van Breda, S. G. J., Briede, J. J. & de Kok, T. M. C. M., Jan 2019, In: Nutrients. 11, 1, 14 p., 61.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2018

A cross-omics approach to investigate temporal gene expression regulation by 5-hydroxymethylcytosine via TBH-derived oxidative stress showed involvement of different regulatory kinases

Briede, J. J., Deferme, L., Wolters, J. E. J., Claessen, S. M. H., van den Beucken, T., Wagner, R. J., van Breda, S. G. & Kleinjans, J. C. S., 1 Apr 2018, In: Toxicology in Vitro. 48, p. 318-328 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Data on novel DNA methylation changes induced by valproic acid in human hepatocytes

Wolters, J., van Breda, S., Claessen, S., de Kok, T. & Kleinjans, J., Feb 2018, In: Data in brief. 16, p. 161-171 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Drinking Water Nitrate and Human Health: An Updated Review

Ward, M. H., Jones, R. R., Brender, J. D., de Kok, T. M., Weyer, P. J., Nolan, B. T., Villanueva, C. M. & van Breda, S. G., 23 Jul 2018, In: International Journal of Environmental Research and Public Health. 15, 7, 31 p., 1557.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

Health effects of red meat products containing phytochemicals and reduced levels of nitrite: the PHYTOME project

PHYTOME consortium, 10 Oct 2018, In: Toxicology Letters. 295, p. S141-S142 2 p.

Research output: Contribution to journal › Conference Abstract/Poster in journal › Academic

Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes

Wolters, J. E. J., van Breda, S. G. J., Grossmann, J., Fortes, C., Caiment, F. & Kleinjans, J. C. S., 1 Jun 2018, In: Toxicology Letters. 289, p. 1-13 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction

van Breda, S. G. J., Claessen, S. M. H., van Herwijnen, M., Theunissen, D. H. J., Jennen, D. G. J., de Kok, T. M. C. M. & Kleinjans, J. C. S., 15 Jan 2018, In: Toxicology. 393, p. 160-170 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens

Limonciel, A., van Breda, S. G., Jiang, X., Tredwell, G. D., Wilmes, A., Aschauer, L., Siskos, A. P., Sachinidis, A., Keun, H. C., Kopp-Schneider, A., de Kok, T. M., Kleinjans, J. C. S. & Jennings, P., 3 Dec 2018, In: Frontiers in Genetics. 9, 15 p., 558.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Smart Combinations of Bioactive Compounds in Fruits and Vegetables May Guide New Strategies for Personalized Prevention of Chronic Diseases

van Breda, S. G. J. & de Kok, T. M. C. M., 1 Jan 2018, In: Molecular Nutrition & Food Research. 62, 1, 12 p., 1700597.

Research output: Contribution to journal › (Systematic) Review article › peer-review

2017

Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes

Wolters, J. E. J., van Breda, S. G. J., Caiment, F., Claessen, S. M., de Kok, T. M. C. M. & Kleinjans, J. C. S., Oct 2017, In: Chemical Research in Toxicology. 30, 10, p. 1847-1854 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2016

Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma

Rieswijk, L., Claessen, S. M. H., Bekers, O., van Herwijnen, M., Theunissen, D. H. J., Jennen, D. G. J., de Kok, T., Kleinjans, J. C. S. & van Breda, S. G. J., 28 Mar 2016, In: Toxicology. 350, p. 31-39 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Consumer awareness and credibility factors of health claims on innovative meat products in a cross-sectional population study in the Netherlands

Strijbos, C., Schluck, M., Bui, T., de Jong, I., van Leeuwen, M., von Tottleben, M. & van Breda, S. G., Dec 2016, In: Food Quality and Preference. 54, p. 13-22

Research output: Contribution to journal › Article › Academic › peer-review

Dynamic Interplay between the Transcriptome and Methylome in Response to Oxidative and Alkylating Stress

Deferme, L., Wolters, J. E. J., Claessen, S. M. H., Theunissen, D., van den Beucken, T., Wagner, J. R., van Breda, S. G., Kleinjans, J. C. S. & Briede, J. J., Sept 2016, In: Chemical Research in Toxicology. 29, 9, p. 1428-1438

Research output: Contribution to journal › Article › Academic › peer-review

Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity

Rieswijk, L., Brauers, K. J. J., Coonen, M. L. J., Jennen, D. G. J., van Breda, S. G. J. & Kleinjans, J. C. S., Sept 2016, In: Mutagenesis. 31, 5, p. 603-615

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis

Wolters, J. E. J., van Herwijnen, M. H. M., Theunissen, D. H. J., Jennen, D. G. J., Van den Hof, W. F. P. M., de Kok, T., Schaap, F. G., van Breda, S. G. J. & Kleinjans, J. C. S., Dec 2016, In: Chemical Research in Toxicology. 29, 12, p. 2164-2174

Research output: Contribution to journal › Article › Academic › peer-review

"Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015

Fernando, R. N., Chaudhari, U., Escher, S. E., Hengstler, J. G., Hescheler, J., Jennings, P., Keun, H. C., Kleinjans, J. C. S., Kolde, R., Kollipara, L., Kopp-Schneider, A., Limonciel, A., Nemade, H., Nguemo, F., Peterson, H., Prieto, P., Rodrigues, R. M., Sachinidis, A., Schaefer, C. & Sickmann, A. & 8 others, Spitkovsky, D., Stoeber, R., van Breda, S. G. J., van de Water, B., Vivier, M., Zahedi, R. P., Vinken, M. & Rogiers, V., Jun 2016, In: Archives of Toxicology. 90, 6, p. 1529-1539

Research output: Contribution to journal › Article › Academic › peer-review

2015

Development of novel tools for the in vitro investigation of drug-induced liver injury

Jiang, J., Wolters, J. E., van Breda, S. G., Kleinjans, J. C. & de Kok, T. M., 3 Oct 2015, In: Expert Opinion on Drug Metabolism & Toxicology. 11, 10, p. 1523-1537 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis

van Breda, S. G. J., Claessen, S. M. H., Lo, K., van Herwijnen, M., Brauers, K. J. J., Lisanti, S., Theunissen, D. H. J., Jennen, D. G. J., Gaj, S., de Kok, T. & Kleinjans, J. C. S., Nov 2015, In: Archives of Toxicology. 89, 11, p. 1959-1969

Research output: Contribution to journal › Article › Academic › peer-review

Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes

Rieswijk, L., Brauers, K. J. J., Coonen, M. L. J., Van Breda, S. G. J., Jennen, D. G. J. & Kleinjans, J. C. S., 2015, In: Mutagenesis. 30, 6, p. 771-784 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

The exposome concept in a human nutrigenomics study: Evaluating the impact of exposure to a complex mixture of phytochemicals using transcriptomics signatures

Van Breda, S. G. J., Wilms, L. C., Gaj, S., Jennen, D. G. J., Bried, J. J., Kleinjans, J. C. S. & De Kok, T. M. C. M., 2015, In: Mutagenesis. 30, 6, p. 723-731 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2014

Selenoprotein Gene Variants, Toenail Selenium Levels, and Risk for Advanced Prostate Cancer

Geybels, M. S., van den Brandt, P. A., Schouten, L. J., van Schooten, F. J., van Breda, S. G., Rayman, M. P., Green, F. R. & Verhage, B. A. J., 1 Jan 2014, In: Journal of the National Cancer Institute. 106, 3, dju003.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2012

Genomics-Based Identification of Molecular Mechanisms behind the Cancer Preventive Action of Phytochemicals: Potential and Challenges

de Kok, T. M. C. M., van Breda, S. G. J. & Briede, J. J., Jan 2012, In: Current Pharmaceutical Biotechnology. 13, 1, p. 255-264

Research output: Contribution to journal › Article › Academic › peer-review

2011

A Lyophilized Red Grape Pomace Containing Proanthocyanidin-Rich Dietary Fiber Induces Genetic and Metabolic Alterations in Colon Mucosa of Female C57BL/6J Mice

Lizarraga, D., Vinardell, M. P., Noe, V., van Delft, J. H., Alcarraz-Vizan, G., van Breda, S. G., Staal, Y., Guenther, U. L., Reed, M. A., Ciudad, C. J., Torres, J. L. & Cascante, M., Sept 2011, In: Journal of Nutrition. 141, 9, p. 1597-1604

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2010

Antioxidative and antigenotoxic properties of vegetables and dietary phytochemicals: The value of genomics biomarkers in molecular epidemiology.

de Kok, T. M., de Waard, P., Wilms, L. C. & van Breda, S. G., Feb 2010, In: Molecular Nutrition & Food Research. 54, 2, p. 208-217

Research output: Contribution to journal › Article › Academic › peer-review

Dietary acrylamide intake and risk of breast cancer in the UK women's cohort

Burley, V. J., Greenwood, D. C., Hepworth, S. J., Fraser, L. K., de Kok, T. M., van Breda, S. G. J., Kyrtopoulos, S. A., Botsivali, M., Kleinjans, J., McKinney, P. A. & Cade, J. E., 23 Nov 2010, In: British Journal of Cancer. 103, 11, p. 1749-1754 6 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2009

Methylation status of CpG islands in the promoter region of genes differentially expressed in colonic mucosa from adenoma patients and controls in response to altered vegetable intake

van Breda, S. G., van Delft, J. H., Engels, L. G., Kleinjans, J. C. & Mathers, J. C., 1 Jan 2009, In: British Journal of Nutrition. 101, 9, p. 1295-9

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2008

Mechanisms of colorectal and lung cancer prevention by vegetables: a genomic approach.

van Breda, S. G., de Kok, T. & van Delft, J. H., 1 Jan 2008, In: Journal of Nutritional Biochemistry. 19, 3, p. 139-157

Research output: Contribution to journal › Article › Academic › peer-review

Simone van Breda

Research output

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