20142019

Research output per year

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Research Output

A concise tutorial review of TOF-SIMS based molecular and cellular imaging

Massonnet, P. & Heeren, R. M. A., 1 Nov 2019, In : Journal of Analytical Atomic Spectrometry. 34, 11, p. 2217-2228 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

A critical evaluation of the current state-of-the-art in quantitative imaging mass spectrometry

Ellis, S. R., Bruinen, A. L. & Heeren, R. M. A., Feb 2014, In : Analytical and Bioanalytical Chemistry. 406, 5, p. 1275-1289

Research output: Contribution to journalArticleAcademicpeer-review

42 Citations (Scopus)

Advances in mass spectrometry imaging enabling observation of localised lipid biochemistry within tissues

Bowman, A. P., Heeren, R. M. A. & Ellis, S. R., Nov 2019, In : Trac-Trends in Analytical Chemistry. 120, 10 p., 115197.

Research output: Contribution to journalReview articleAcademicpeer-review

"Afterlife Experiment": Use of MALDI-MS and SIMS Imaging for the Study of the Nitrogen Cycle within Plants

Seaman, C., Flinders, B., Eijkel, G., Heeren, R. M. A., Bricklebank, N. & Clench, M. R., 21 Oct 2014, In : Analytical Chemistry. 86, 20, p. 10071-10077

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

A micropixelated ion-imaging detector for mass resolution enhancement of a QMS instrument

Syed, S. U. A. H., Eijkel, G. B., Maher, S., Kistemaker, P., Taylor, S. & Heeren, R. M. A., Mar 2015, In : Analytical and Bioanalytical Chemistry. 407, 8, p. 2055-2062

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

An ambient detection system for visualization of charged particles generated with ionization methods at atmospheric pressure

Hommersom, B., Syed, S. U. A. H., Eijkel, G. B., Kilgour, D. P. A., Goodlett, D. R. & Heeren, R. M. A., 15 Feb 2016, In : Rapid Communications in Mass Spectrometry. 30, 3, p. 352-358

Research output: Contribution to journalArticleAcademicpeer-review

A New Method and Mass Spectrometer Design for TOF-SIMS Parallel Imaging MS/MS

Fisher, G. L., Bruinen, A. L., Potocnik, N. O., Hammond, J. S., Bryan, S. R., Larson, P. E. & Heeren, R. M. A., 21 Jun 2016, In : Analytical Chemistry. 88, 12, p. 6433-6440

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

A patch-based super resolution algorithm for improving image resolution in clinical mass spectrometry

Scupakova, K., Terzopoulos, V., Jain, S., Smeets, D. & Heeren, R. M. A., 27 Feb 2019, In : Scientific Reports. 9, 11 p., 2915.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Automated, parallel mass spectrometry imaging and structural identification of lipids

Ellis, S. R., Paine, M. R. L., Eijkel, G. B., Pauling, J. K., Husen, P., Jervelund, M. W., Hermansson, M., Ejsing, C. S. & Heeren, R. M. A., Jul 2018, In : Nature Methods. 15, 7, p. 515–518 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Automatic Generic Registration of Mass Spectrometry Imaging Data to Histology Using Nonlinear Stochastic Embedding

Abdelmoula, W. M., Skraskova, K., Balluff, B., Carreira, R. J., Tolner, E. A., Lelieveldt, B. P. F., van der Maaten, L., Morreau, H., van den Maagdenberg, A. M. J. M., Heeren, R. M. A., McDonnell, L. A. & Dijkstra, J., 16 Sep 2014, In : Analytical Chemistry. 86, 18, p. 9204-9211

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Characterization of lipidic markers of chondrogenic differentiation using mass spectrometry imaging

Rocha, B., Cillero-Pastor, B., Eijkel, G., Bruinen, A. L., Ruiz-Romero, C., Heeren, R. M. A. & Blanco, F. J., Feb 2015, In : Proteomics. 15, 4, p. 702-13 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Class-specific depletion of lipid ion signals in tissues upon formalin fixation

Vos, D. R. N., Bowman, A. P., Heeren, R. M. A., Balluff, B. & Ellis, S. R., Dec 2019, In : International Journal of Mass Spectrometry. 446, p. 1-9 9 p., 116212.

Research output: Contribution to journalArticleAcademicpeer-review

Combined X-ray CT and mass spectrometry for biomedical imaging applications

Schioppa, E. . J., Ellis, S., Bruinen, A. L., Visser, J., Heeren, R. M. A., Uher, J. & Koffeman, E., Apr 2014, In : Journal of Instrumentation. 9

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Combining Time-of-Flight Secondary Ion Mass Spectrometry Imaging Mass Spectrometry and CARS Microspectroscopy Reveals Lipid Patterns Reminiscent of Gene Expression Patterns in the Wing Imaginal Disc of Drosophila melanogaster

Marty, F., Rago, G., Smith, D. F., Gao, X., Eijkel, G. B., MacAleese, L., Bonn, M., Brunner, E., Basler, K. & Heeren, R. M. A., 19 Sep 2017, In : Analytical Chemistry. 89, 18, p. 9664-9670 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Complexiteit in beeld : samen naar de moleculaire ‘selfie’

Heeren, R. M. A., 19 Jun 2015, Maastricht: Maastricht University.

Research output: Book/ReportInaugural speechPopular

Consequences of Decontamination Procedures in Forensic Hair Analysis Using Metal-Assisted Secondary Ion Mass Spectrometry Analysis

Cuypers, E., Flinders, B., Boone, C. M., Bosman, I. J., Lusthof, K. J., Van Asten, A. C., Tytgat, J. & Heeren, R. M. A., 15 Mar 2016, In : Analytical Chemistry. 88, 6, p. 3091-3097

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Cross-Species Molecular Imaging of Bile Salts and Lipids in Liver: Identification of Molecular Structural Markers in Health and Disease

Flinders, B., Huizing, L. R. S., van Heerden, M., Cuyckens, F., Neumann, U. P., van der Laan, L. J. W., Damink, S. W. M. O., Heeren, R. M. A., Schaap, F. G. & Vreeken, R. J., 16 Oct 2018, In : Analytical Chemistry. 90, 20, p. 11835-11846 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Deciphering Metabolic Heterogeneity by Single-Cell Analysis

Evers, T. M. J., Hochane, M., Tans, S. J., Heeren, R. M. A., Semrau, S., Nemes, P. & Mashaghi, A., 5 Nov 2019, In : Analytical Chemistry. 91, 21, p. 13314-13323 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Derivatization Strategies for the Detection of Triamcinolone Acetonide in Cartilage by Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Barre, F. P. Y., Flinders, B., Garcia, J. P., Jansen, I., Huizing, L. R. S., Porta, T., Creemers, L. B., Heeren, R. M. A. & Cillero-Pastor, B., 20 Dec 2016, In : Analytical Chemistry. 88, 24, p. 12051-12059

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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Design and Performance of a Novel Interface for Combined Matrix-Assisted Laser Desorption Ionization at Elevated Pressure and Electrospray Ionization with Orbitrap Mass Spectrometry

Belov, M. E., Ellis, S. R., Dilillo, M., Paine, M. R. L., Danielson, W. F., Anderson, G. A., de Graaf, E. L., Eijkel, G. B., Heeren, R. M. A. & McDonnell, L. A., 18 Jul 2017, In : Analytical Chemistry. 89, 14, p. 7493-7501 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Differentiation of Mesenchymal Stem Cells under Hypoxia and Normoxia: Lipid Profiles Revealed by Time-of-Flight Secondary Ion Mass Spectrometry and Multivariate Analysis

Georgi, N., Cillero-Pastor, B., Eijkel, G. B., Periyasamy, P. C., Kiss, A., van Blitterswijk, C., Post, J. N., Heeren, R. M. A. & Karperien, M., 7 Apr 2015, In : Analytical Chemistry. 87, 7, p. 3981-3988

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Digestion-Free Analysis of Peptides from 30-year-old Formalin-Fixed, Paraffin-Embedded Tissue by Mass Spectrometry Imaging

Paine, M. R. L., Ellis, S. R., Maloney, D., Heeren, R. M. A. & Verhaert, P. D. E. M., 7 Aug 2018, In : Analytical Chemistry. 90, 15, p. 9272-9280 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Direct Analysis and Quantification of Metaldehyde in Water using Reactive Paper Spray Mass Spectrometry

Maher, S., Jjunju, F. P. M., Damon, D. E., Gorton, H., Maher, Y. S., Syed, S. U., Heeren, R. M. A., Young, I. S., Taylor, S. & Badu-Tawiah, A. K., 21 Oct 2016, In : Scientific Reports. 6, 35643.

Research output: Contribution to journalArticleAcademicpeer-review

Direct Analysis of Thin-Layer Chromatography Separations of Petroleum Samples by Laser Desorption Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Imaging

Smith, D. F., McKenna, A. M., Corilo, Y. E., Rodgers, R. P., Marshall, A. G. & Heeren, R. M. A., Oct 2014, In : Energy & Fuels. 28, 10, p. 6284-6288

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Direct Ion Imaging Approach for Investigation of Ion Dynamics in Multipole Ion Guides

Syed, S. U. A. H., Maher, S., Eijkel, G. B., Ellis, S. R., Jjunju, F., Taylor, S. & Heeren, R. M. A., 7 Apr 2015, In : Analytical Chemistry. 87, 7, p. 3714-3720

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Discussion point: reporting guidelines for mass spectrometry imaging

McDonnell, L. A., Roempp, A., Balluff, B., Heeren, R. M. A., Albar, J. P., Andren, P. E., Corthals, G. L., Walch, A. & Stoeckli, M., Mar 2015, In : Analytical and Bioanalytical Chemistry. 407, 8, p. 2035-2045

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Distinguishing core from penumbra by lipid profiles using Mass Spectrometry Imaging in a transgenic mouse model of ischemic stroke

Mulder, I. A., Potocnik, N. O., Broos, L. A. M., Prop, A., Wermer, M. J. H., Heeren, R. M. A. & van den Maagdenberg, A. M. J. M., 31 Jan 2019, In : Scientific Reports. 9, p. 1-10 10 p., 1090.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Distributed computing strategies for processing of FT-ICR MS imaging datasets for continuous mode data visualization

Smith, D. F., Schulz, C., Konijnenburg, M., Kilic, M. & Heeren, R. M. A., Mar 2015, In : Analytical and Bioanalytical Chemistry. 407, 8, p. 2321-2327

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Efficient Functionalization of Additives at Supramolecular Material Surfaces

Goor, O. J. G. M., Keizer, H. M., Bruinen, A. L., Schmitz, M. G. J., Versteegen, R. M., Janssen, H. M., Heeren, R. M. A. & Dankers, P. Y. W., 2 Feb 2017, In : Advanced Materials. 29, 5, 8 p., 1604652.

Research output: Contribution to journalArticleAcademicpeer-review

Enhanced capabilities for imaging gangliosides in murine brain with matrix-assisted laser desorption/ionization and desorption electrospray ionization mass spectrometry coupled to ion mobility separation

Skraskova, K., Claude, E., Jones, E. A., Towers, M., Ellis, S. R. & Heeren, R. M. A., 15 Jul 2016, In : Methods. 104, p. 69-78

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Enhanced Sensitivity Using MALDI Imaging Coupled with Laser Postionization (MALDI-2) for Pharmaceutical Research

Barre, F. P. Y., Paine, M. R. L., Flinders, B., Trevitt, A. J., Kelly, P. D., Ait-Belkacem, R., Garcia, J. P., Creemers, L. B., Stauber, J., Vreeken, R. J., Cillero-Pastor, B., Ellis, S. R. & Heeren, R. M. A., 20 Aug 2019, In : Analytical Chemistry. 91, 16, p. 10840-10848 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Evaluation of Thin-Layer Chromatography-Laser Desorption Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometric Imaging for Visualization of Crude Oil Interactions

Zahraei, A., Arisz, P. W. F., van Bawl, A. P. & Heeren, R. M. A., Jul 2018, In : Energy & Fuels. 32, 7, p. 7347-7357 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Experimental Investigation of the 2D Ion Beam Profile Generated by an ESI Octopole-QMS System

Syed, S. U. A. H., Eijkel, G. B., Kistemaker, P., Ellis, S., Maher, S., Smith, D. F. & Heeren, R. M. A., Oct 2014, In : Journal of the American Society for Mass Spectrometry. 25, 10, p. 1780-1787

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Faster raster matrix-assisted laser desorption/ionization mass spectrometry imaging of lipids at high lateral resolution

Barre, F., Rocha, B., Dewez, F., Towers, M., Murray, P., Claude, E., Cillero-Pastor, B., Heeren, R. & Siegel, T. P., Mar 2019, In : International Journal of Mass Spectrometry. 437, p. 38-48 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Fast image-charge calculations for multi-particle simulations in FT-ICR analyzer cells of arbitrary geometry

Driver, J. A., Kharchenko, A., Heeren, R. M. A. & Amster, I. J., 1 Feb 2015, In : International Journal of Mass Spectrometry. 377, p. 432-439

Research output: Contribution to journalArticleAcademicpeer-review

Getting the picture: The coming of age of imaging MS

Heeren, R. M. A., 1 Feb 2015, In : International Journal of Mass Spectrometry. 377, p. 672-680

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Gold Sputtered Fiducial Markers for Combined Secondary Ion Mass Spectrometry and MALDI Imaging of Tissue Samples

Potocnik, N. O., Skraskova, K., Flinders, B., Pelicon, P. & Heeren, R. M. A., 15 Jul 2014, In : Analytical Chemistry. 86, 14, p. 6781-6785

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Hand-Held Portable Desorption Atmospheric Pressure Chemical Ionization Ion Source for in Situ Analysis of Nitroaromatic Explosives

Jjunju, F. P. M., Maher, S., Li, A., Syed, S. U., Smith, B., Heeren, R. M. A., Taylor, S. & Cooks, R. G., 6 Oct 2015, In : Analytical Chemistry. 87, 19, p. 10047-10055

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Host-based lipid inflammation drives pathogenesis in Francisella infection

Scott, A. J., Post, J. M., Lerner, R., Ellis, S. R., Lieberman, J., Shirey, K. A., Heeren, R. M. A., Bindila, L. & Ernst, R. K., 21 Nov 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 47, p. 12596-12601 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hydrogen peroxide reactions on cocaine in hair using imaging mass spectrometry

Cuypers, E., Flinders, B., Bosman, I. J., Lusthof, K. J., Van Asten, A. C., Tytgat, J. & Heeren, R. M. A., Sep 2014, In : Forensic Science International. 242, p. 103-110

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Identification and High-Resolution Imaging of alpha-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry

Bruinen, A. L., Fisher, G. L., Balez, R., van der Sar, A. M., Ooi, L. & Heeren, R. M. A., Aug 2018, In : Journal of the American Society for Mass Spectrometry. 29, 8, p. 1571-1581 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Imaging Isomers on a Biological Surface: A Review

Claes, B. S. R., Takeo, E., Fukusaki, E., Shimma, S. & Heeren, R. M. A., 2019, In : Mass spectrometry (Tokyo, Japan). 8, 1, p. A0078 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Increased throughput and ultra-high mass resolution in DESI FT-ICR MS imaging through new-generation external data acquisition system and advanced data processing approaches

Kooijman, P. C., Nagornov, K. O., Kozhinov, A. N., Kilgour, D. P. A., Tsybin, Y. O., Heeren, R. M. A. & Ellis, S. R., 9 Jan 2019, In : Scientific Reports. 9, p. 1-11 11 p., 8.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Integration of Ion Mobility MS(E) after Fully Automated, Online, High-Resolution Liquid Extraction Surface Analysis Micro-Liquid Chromatography

Lamont, L., Baumert, M., Potocnik, N. O., Allen, M., Vreeken, R., Heeren, R. M. A. & Porta, T., 17 Oct 2017, In : Analytical Chemistry. 89, 20, p. 11143-11150 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Integrative Clustering in Mass Spectrometry Imaging for Enhanced Patient Stratification

Balluff, B., Buck, A., Martin-Lorenzo, M., Dewez, F., Langer, R., McDonnell, L. A., Walch, A. & Heeren, R. M. A., Jan 2019, In : Proteomics Clinical Applications. 13, 1, 5 p., 1800137.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Ion mobility spectrometry combined with multivariate statistical analysis: revealing the effects of a drug candidate for Alzheimer's disease on A beta 1-40 peptide early assembly

Lazzaro, S., Ogrinc, N., Lamont, L., Vecchio, G., Pappalardo, G. & Heeren, R. M. A., Sep 2019, In : Analytical and Bioanalytical Chemistry. 411, 24, p. 6353-6363 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Ion mobility spectrometry reveals intermediate states in temperature-resolved DNA unfolding

Hommersom, B., Porta, T. & Heeren, R. M. A., Aug 2017, In : International Journal of Mass Spectrometry. 419, p. 52-55 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Label-free characterization of biomembranes: from structure to dynamics

Mashaghi, A., Mashaghi, S., Reviakine, I., Heeren, R. M. A., Sandoghdar, V. & Bonn, M., 2014, In : Chemical Society Reviews. 43, 3, p. 887-900

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)