20142020

Research output per year

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Research Output

2020

Cellular resolution in clinical MALDI mass spectrometry imaging: the latest advancements and current challenges

Ščupáková, K., Balluff, B., Tressler, C., Adelaja, T., Heeren, R. M. A., Glunde, K. & Ertaylan, G., Jun 2020, In : Clinical Chemistry and Laboratory Medicine. 58, 6, p. 914-929 16 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Clinical use of mass spectrometry (imaging) for hard tissue analysis in abnormal fracture healing

Nauta, S. P., Poeze, M., Heeren, R. M. A. & Siegel, T. P., Jun 2020, In : Clinical Chemistry and Laboratory Medicine. 58, 6, p. 897-913 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Evaluation of lipid coverage and high spatial resolution MALDI-imaging capabilities of oversampling combined with laser post-ionisation

Bowman, A. P., Bogie, J. F. J., Hendriks, J. J. A., Haidar, M., Belov, M., Heeren, R. M. A. & Ellis, S. R., Apr 2020, In : Analytical and Bioanalytical Chemistry. 412, 10, p. 2277-2289 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Glutamine deprivation courteracts hypoxia-induced chemoresistance

Wapplera, J., Arts, M., Roeth, A., Heeren, R. M. A., Neumann, U. P., Damink, S. W. O., Soons, Z. & Cramer, T., Jan 2020, In : Neoplasia (Online). 22, 1, p. 22-32 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Integrative Metabolic Pathway Analysis Reveals Novel Therapeutic Targets in Osteoarthritis

Rocha, B., Cillero-Pastor, B., Eijkel, G., Calamia, V., Fernandez-Puente, P., Paine, M. R. L., Ruiz-Romero, C., Heeren, R. M. A. & Blanco, F. J., Apr 2020, In : Molecular & Cellular Proteomics. 19, 4, p. 574-588 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Simultaneous Detection of Zinc and Its Pathway Metabolites Using MALDI MS Imaging of Prostate Tissue

Andersen, M. K., Krossa, S., Hoiem, T. S., Buchholz, R., Claes, B. S. R., Balluff, B., Ellis, S. R., Richardsen, E., Bertilsson, H., Heeren, R. M. A., Bathen, T. F., Karst, U., Giskeodegard, G. F. & Tessem, M-B., 18 Feb 2020, In : Analytical Chemistry. 92, 4, p. 3171-3179 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Spatial Localization of Vitamin D Metabolites in Mouse Kidney by Mass Spectrometry Imaging

Smith, K. W., Flinders, B., Thompson, P. D., Cruickshank, F. L., Mackay, C. L., Heeren, R. M. A. & Cobice, D. F., 9 Jun 2020, In : Acs omega. 5, 22, p. 13430-13437 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Spatially resolved proteomics in osteoarthritis: State of the art and new perspectives

Eveque-Mourroux, M. R., Rocha, B., Barre, F. P. Y., Heeren, R. M. A. & Cillero-Pastor, B., 20 Mar 2020, In : Journal of Proteomics. 215, 7 p., 103637.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Ultra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS

Bowman, A. P., Blakney, G. T., Hendrickson, C. L., Ellis, S. R., Heeren, R. M. A. & Smith, D. F., 18 Feb 2020, In : Analytical Chemistry. 92, 4, p. 3133-3142 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

A concise tutorial review of TOF-SIMS based molecular and cellular imaging

Massonnet, P. & Heeren, R. M. A., 1 Nov 2019, In : Journal of Analytical Atomic Spectrometry. 34, 11, p. 2217-2228 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Advances in mass spectrometry imaging enabling observation of localised lipid biochemistry within tissues

Bowman, A. P., Heeren, R. M. A. & Ellis, S. R., Nov 2019, In : Trac-Trends in Analytical Chemistry. 120, 10 p., 115197.

Research output: Contribution to journalReview articleAcademicpeer-review

A patch-based super resolution algorithm for improving image resolution in clinical mass spectrometry

Scupakova, K., Terzopoulos, V., Jain, S., Smeets, D. & Heeren, R. M. A., 27 Feb 2019, In : Scientific Reports. 9, 11 p., 2915.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Class-specific depletion of lipid ion signals in tissues upon formalin fixation

Vos, D. R. N., Bowman, A. P., Heeren, R. M. A., Balluff, B. & Ellis, S. R., Dec 2019, In : International Journal of Mass Spectrometry. 446, p. 1-9 9 p., 116212.

Research output: Contribution to journalArticleAcademicpeer-review

Deciphering Metabolic Heterogeneity by Single-Cell Analysis

Evers, T. M. J., Hochane, M., Tans, S. J., Heeren, R. M. A., Semrau, S., Nemes, P. & Mashaghi, A., 5 Nov 2019, In : Analytical Chemistry. 91, 21, p. 13314-13323 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Development and evaluation of matrix application techniques for high throughput mass spectrometry imaging of tissues in the clinic

Huizing, L. R. S., Ellis, S. R., Beulen, B. W. A. M. M., Barre, F. P. Y., Kwant, P. B., Vreeken, R. J. & Heeren, R. M. A., Apr 2019, In : Clinical mass spectrometry. 12, p. 7-15 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Distinguishing core from penumbra by lipid profiles using Mass Spectrometry Imaging in a transgenic mouse model of ischemic stroke

Mulder, I. A., Potocnik, N. O., Broos, L. A. M., Prop, A., Wermer, M. J. H., Heeren, R. M. A. & van den Maagdenberg, A. M. J. M., 31 Jan 2019, In : Scientific Reports. 9, p. 1-10 10 p., 1090.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Enhanced Sensitivity Using MALDI Imaging Coupled with Laser Postionization (MALDI-2) for Pharmaceutical Research

Barre, F. P. Y., Paine, M. R. L., Flinders, B., Trevitt, A. J., Kelly, P. D., Ait-Belkacem, R., Garcia, J. P., Creemers, L. B., Stauber, J., Vreeken, R. J., Cillero-Pastor, B., Ellis, S. R. & Heeren, R. M. A., 20 Aug 2019, In : Analytical Chemistry. 91, 16, p. 10840-10848 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Faster raster matrix-assisted laser desorption/ionization mass spectrometry imaging of lipids at high lateral resolution

Barre, F., Rocha, B., Dewez, F., Towers, M., Murray, P., Claude, E., Cillero-Pastor, B., Heeren, R. & Siegel, T. P., Mar 2019, In : International Journal of Mass Spectrometry. 437, p. 38-48 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Imaging Isomers on a Biological Surface: A Review

Claes, B. S. R., Takeo, E., Fukusaki, E., Shimma, S. & Heeren, R. M. A., 2019, In : Mass spectrometry (Tokyo, Japan). 8, 1, p. A0078 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Increased throughput and ultra-high mass resolution in DESI FT-ICR MS imaging through new-generation external data acquisition system and advanced data processing approaches

Kooijman, P. C., Nagornov, K. O., Kozhinov, A. N., Kilgour, D. P. A., Tsybin, Y. O., Heeren, R. M. A. & Ellis, S. R., 9 Jan 2019, In : Scientific Reports. 9, p. 1-11 11 p., 8.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Integrative Clustering in Mass Spectrometry Imaging for Enhanced Patient Stratification

Balluff, B., Buck, A., Martin-Lorenzo, M., Dewez, F., Langer, R., McDonnell, L. A., Walch, A. & Heeren, R. M. A., Jan 2019, In : Proteomics Clinical Applications. 13, 1, 5 p., 1800137.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Ion mobility spectrometry combined with multivariate statistical analysis: revealing the effects of a drug candidate for Alzheimer's disease on A beta 1-40 peptide early assembly

Lazzaro, S., Ogrinc, N., Lamont, L., Vecchio, G., Pappalardo, G. & Heeren, R. M. A., Sep 2019, In : Analytical and Bioanalytical Chemistry. 411, 24, p. 6353-6363 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Maintenance of Deep Lung Architecture and Automated Airway Segmentation for 3D Mass Spectrometry Imaging

Scott, A. J., Chandler, C. E., Ellis, S. R., Heeren, R. M. A. & Ernst, R. K., 27 Dec 2019, In : Scientific Reports. 9, p. 1-12 12 p., 20160.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

MALDI-Mass Spectrometry Imaging to Investigate Lipid and Bile Acid Modifications Caused by Lentil Extract Used as a Potential Hypocholesterolemic Treatment

Genangeli, M., Heijens, A. M. M., Rustichelli, A., Schuit, N. D., Di Bonaventura, M. V. M., Cifani, C., Vittori, S., Siegel, T. P. & Heeren, R. M. A., Oct 2019, In : Journal of the American Society for Mass Spectrometry. 30, 10, p. 2041-2050 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mass Spectrometry-Based Tissue Imaging: The Next Frontier in Clinical Diagnostics?

Leung, F., Eberlin, L. S., Schwamborn, K., Heeren, R. M. A., Winograd, N. & Cooks, R. G., Apr 2019, In : Clinical Chemistry. 65, 4, p. 510-513 4 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Mass Spectrometry Imaging:Enabling Comprehensive Local Analysis of Molecular Biomarkers in Tissue for Personalized Medicine

Porta, T., Olde Damink, S. & Heeren, R., 2019, Handbook of Biomarkers and Precision Medicine. Chapman and Hall/CRC, p. 439-445 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Precise co-registration of mass spectrometry imaging, histology, and laser microdissection-based omics

Dewez, F., Martin-Lorenzo, M., Herfs, M., Baiwir, D., Mazzucchelli, G., De Pauw, E., Heeren, R. M. A. & Balluff, B., Sep 2019, In : Analytical and Bioanalytical Chemistry. 411, 22, p. 5647-5653 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis: A Potential Role for Plant Sterols

van Gorp, C., de Lange, I. H., Spiller, O. B., Dewez, F., Pastor, B. C., Heeren, R. M. A., Kessels, L., Kloosterboer, N., van Gemert, W. G., Beeton, M. L., Stock, S. J., Jobe, A. H., Payne, M. S., Kemp, M. W., Zimmermann, L. J., Kramer, B. W., Plat, J. & Wolfs, T. G. A. M., May 2019, In : Nutrients. 11, 5, p. 1-21 21 p., 968.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Rapid Identification of Ischemic Injury in Renal Tissue by Mass-Spectrometry Imaging

van Smaalen, T. C., Ellis, S. R., Mascini, N. E., Siegel, T. P., Cillero-Pastor, B., Hillen, L. M., van Heurn, L. W. E., Peutz-Kootstra, C. J. & Heeren, R. M. A., 5 Mar 2019, In : Analytical Chemistry. 91, 5, p. 3575-3581 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Recent technological developments in MALDI-MSI based hair analysis

Flinders, B., Bassindale, T. & Heeren, R., 2019, Emerging Technologies for the Analysis of Forensic Traces. Springer, Cham, p. 133-149 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Stigmatic imaging of secondary ions in MeV-SIMS spectrometry by linear Time-of-Flight mass spectrometer and the TimePix detector

Jencic, B., Sepec, L., Vavpetic, P., Kelemen, M., Rupnik, Z., Vencelj, M., Vogel-Mikus, K., Potocnik, N. O., Ellis, S. R., Heeren, R. & Pelicon, P., 1 Aug 2019, In : Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms. 452, p. 1-6 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Strategies for managing multi-patient 3D mass spectrometry imaging data

Vos, D. R. N., Jansen, R. L., Lucas, M., Paine, M. R. L., de Boer, O. J., Meijer, S. L., Savci-Heijink, C. D., Marquering, H. A., de Bruin, D. M., Heeren, R. M. A., Ellis, S. R. & Balluff, B., 20 Feb 2019, In : Journal of Proteomics. 193, p. 184-191 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The importance of clinical tissue imaging

Spraggins, J. M., Schwamborn, K., Heeren, R. M. A. & Eberlin, L. S., Apr 2019, In : Clinical mass spectrometry. 12, p. 47-49 3 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Three-Dimensional Mass Spectrometry Imaging Identifies Lipid Markers of Medulloblastoma Metastasis

Paine, M. R. L., Liu, J., Huang, D., Ellis, S. R., Trede, D., Kobarg, J. H., Heeren, R. M. A., Fernandez, F. M. & MacDonald, T. J., 18 Feb 2019, In : Scientific Reports. 9, p. 1-10 10 p., 2205.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Trends in mass spectrometry imaging for cardiovascular diseases

Mezger, S. T. P., Mingels, A. M. A., Bekers, O., Cillero-Pastor, B. & Heeren, R. M. A., Jul 2019, In : Analytical and Bioanalytical Chemistry. 411, 17, p. 3709-3720 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Automated, parallel mass spectrometry imaging and structural identification of lipids

Ellis, S. R., Paine, M. R. L., Eijkel, G. B., Pauling, J. K., Husen, P., Jervelund, M. W., Hermansson, M., Ejsing, C. S. & Heeren, R. M. A., Jul 2018, In : Nature Methods. 15, 7, p. 515–518 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cross-Species Molecular Imaging of Bile Salts and Lipids in Liver: Identification of Molecular Structural Markers in Health and Disease

Flinders, B., Huizing, L. R. S., van Heerden, M., Cuyckens, F., Neumann, U. P., van der Laan, L. J. W., Damink, S. W. M. O., Heeren, R. M. A., Schaap, F. G. & Vreeken, R. J., 16 Oct 2018, In : Analytical Chemistry. 90, 20, p. 11835-11846 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Digestion-Free Analysis of Peptides from 30-year-old Formalin-Fixed, Paraffin-Embedded Tissue by Mass Spectrometry Imaging

Paine, M. R. L., Ellis, S. R., Maloney, D., Heeren, R. M. A. & Verhaert, P. D. E. M., 7 Aug 2018, In : Analytical Chemistry. 90, 15, p. 9272-9280 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Evaluation of Thin-Layer Chromatography-Laser Desorption Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometric Imaging for Visualization of Crude Oil Interactions

Zahraei, A., Arisz, P. W. F., van Bawl, A. P. & Heeren, R. M. A., Jul 2018, In : Energy & Fuels. 32, 7, p. 7347-7357 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification and High-Resolution Imaging of alpha-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry

Bruinen, A. L., Fisher, G. L., Balez, R., van der Sar, A. M., Ooi, L. & Heeren, R. M. A., Aug 2018, In : Journal of the American Society for Mass Spectrometry. 29, 8, p. 1571-1581 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mass Spectrometry Imaging with Isomeric Resolution Enabled by Ozone-Induced Dissociation

Paine, M. R. L., Poad, B. L. J., Eijkel, G. B., Marshall, D. L., Blanksby, S. J., Heeren, R. M. A. & Ellis, S. R., 13 Aug 2018, In : Angewandte Chemie-International Edition. 57, 33, p. 10530-10534 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

NF-kappa B-mediated metabolic remodelling in the inflamed heart in acute viral myocarditis

Remels, A. H. V., Derks, W. J. A., Cillero-Pastor, B., Verhees, K. J. P., Kelders, M. C., Heggermont, W., Carai, P., Summer, G., Ellis, S. R., de Theije, C. C., Heeren, R. M. A., Heymans, S., Papageorgiou, A. P. & van Bilsen, M., Aug 2018, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1864, 8, p. 2579-2589 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Round robin study of formalin-fixed paraffin-embedded tissues in mass spectrometry imaging

Buck, A., Heijs, B., Beine, B., Schepers, J., Cassese, A., Heeren, R. M. A., McDonnell, L. A., Henkel, C., Walch, A. & Balluff, B., Sep 2018, In : Analytical and Bioanalytical Chemistry. 410, 23, p. 5969–5980 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Simultaneous lipidomic and transcriptomic profiling in mouse brain punches of acute epileptic seizure model compared to controls

Lerner, R., Post, J. M., Ellis, S. R., Vos, D. R. N., Heeren, R. M. A., Lutz, B. & Bindila, L., Feb 2018, In : Journal of Lipid Research. 59, 2, p. 283-297 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Solvent effects on differentiation of mouse brain tissue using laser microdissection 'cut and drop' sampling with direct mass spectral analysis

Cahill, J. F., Kertesz, V., Porta, T., LeBlanc, J. C. Y., Heeren, R. M. A. & Van Berkel, G. J., 15 Mar 2018, In : Rapid Communications in Mass Spectrometry. 32, 5, p. 414-422 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Spatial Systems Lipidomics Reveals Nonalcoholic Fatty Liver Disease Heterogeneity

Scupakova, K., Soons, Z., Ertaylan, G., Pierzchalski, K. A., Eijkel, G. B., Ellis, S. R., Greve, J. W., Driessen, A., Verheij, J., De Kok, T. M., Damink, S. W. M. O., Rensen, S. S. & Heeren, R. M. A., 17 Apr 2018, In : Analytical Chemistry. 90, 8, p. 5130-5138 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Specific Lipid and Metabolic Profiles of R-CHOP-Resistant Diffuse Large B-Cell Lymphoma Elucidated by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging and in Vivo Imaging

Barre, F. P. Y., Claes, B. S. R., Dewez, F., Peutz-Kootstra, C., Munch-Petersen, H. F., Gronbaek, K., Lund, A. H., Heeren, R. M. A., Come, C. & Cillero-Pastor, B., 18 Dec 2018, In : Analytical Chemistry. 90, 24, p. 14198-14206 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access