20142019

Research output per year

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Research Output

2019

A concise tutorial review of TOF-SIMS based molecular and cellular imaging

Massonnet, P. & Heeren, R. M. A., 1 Nov 2019, In : Journal of Analytical Atomic Spectrometry. 34, 11, p. 2217-2228 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Advances in mass spectrometry imaging enabling observation of localised lipid biochemistry within tissues

Bowman, A. P., Heeren, R. M. A. & Ellis, S. R., Nov 2019, In : Trac-Trends in Analytical Chemistry. 120, 10 p., 115197.

Research output: Contribution to journalReview articleAcademicpeer-review

A patch-based super resolution algorithm for improving image resolution in clinical mass spectrometry

Scupakova, K., Terzopoulos, V., Jain, S., Smeets, D. & Heeren, R. M. A., 27 Feb 2019, In : Scientific Reports. 9, 11 p., 2915.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Class-specific depletion of lipid ion signals in tissues upon formalin fixation

Vos, D. R. N., Bowman, A. P., Heeren, R. M. A., Balluff, B. & Ellis, S. R., Dec 2019, In : International Journal of Mass Spectrometry. 446, p. 1-9 9 p., 116212.

Research output: Contribution to journalArticleAcademicpeer-review

Deciphering Metabolic Heterogeneity by Single-Cell Analysis

Evers, T. M. J., Hochane, M., Tans, S. J., Heeren, R. M. A., Semrau, S., Nemes, P. & Mashaghi, A., 5 Nov 2019, In : Analytical Chemistry. 91, 21, p. 13314-13323 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Distinguishing core from penumbra by lipid profiles using Mass Spectrometry Imaging in a transgenic mouse model of ischemic stroke

Mulder, I. A., Potocnik, N. O., Broos, L. A. M., Prop, A., Wermer, M. J. H., Heeren, R. M. A. & van den Maagdenberg, A. M. J. M., 31 Jan 2019, In : Scientific Reports. 9, p. 1-10 10 p., 1090.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Enhanced Sensitivity Using MALDI Imaging Coupled with Laser Postionization (MALDI-2) for Pharmaceutical Research

Barre, F. P. Y., Paine, M. R. L., Flinders, B., Trevitt, A. J., Kelly, P. D., Ait-Belkacem, R., Garcia, J. P., Creemers, L. B., Stauber, J., Vreeken, R. J., Cillero-Pastor, B., Ellis, S. R. & Heeren, R. M. A., 20 Aug 2019, In : Analytical Chemistry. 91, 16, p. 10840-10848 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Faster raster matrix-assisted laser desorption/ionization mass spectrometry imaging of lipids at high lateral resolution

Barre, F., Rocha, B., Dewez, F., Towers, M., Murray, P., Claude, E., Cillero-Pastor, B., Heeren, R. & Siegel, T. P., Mar 2019, In : International Journal of Mass Spectrometry. 437, p. 38-48 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Imaging Isomers on a Biological Surface: A Review

Claes, B. S. R., Takeo, E., Fukusaki, E., Shimma, S. & Heeren, R. M. A., 2019, In : Mass spectrometry (Tokyo, Japan). 8, 1, p. A0078 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Increased throughput and ultra-high mass resolution in DESI FT-ICR MS imaging through new-generation external data acquisition system and advanced data processing approaches

Kooijman, P. C., Nagornov, K. O., Kozhinov, A. N., Kilgour, D. P. A., Tsybin, Y. O., Heeren, R. M. A. & Ellis, S. R., 9 Jan 2019, In : Scientific Reports. 9, p. 1-11 11 p., 8.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Integrative Clustering in Mass Spectrometry Imaging for Enhanced Patient Stratification

Balluff, B., Buck, A., Martin-Lorenzo, M., Dewez, F., Langer, R., McDonnell, L. A., Walch, A. & Heeren, R. M. A., Jan 2019, In : Proteomics Clinical Applications. 13, 1, 5 p., 1800137.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Ion mobility spectrometry combined with multivariate statistical analysis: revealing the effects of a drug candidate for Alzheimer's disease on A beta 1-40 peptide early assembly

Lazzaro, S., Ogrinc, N., Lamont, L., Vecchio, G., Pappalardo, G. & Heeren, R. M. A., Sep 2019, In : Analytical and Bioanalytical Chemistry. 411, 24, p. 6353-6363 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Maintenance of Deep Lung Architecture and Automated Airway Segmentation for 3D Mass Spectrometry Imaging

Scott, A. J., Chandler, C. E., Ellis, S. R., Heeren, R. M. A. & Ernst, R. K., 27 Dec 2019, In : Scientific Reports. 9, p. 1-12 12 p., 20160.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

MALDI-Mass Spectrometry Imaging to Investigate Lipid and Bile Acid Modifications Caused by Lentil Extract Used as a Potential Hypocholesterolemic Treatment

Genangeli, M., Heijens, A. M. M., Rustichelli, A., Schuit, N. D., Di Bonaventura, M. V. M., Cifani, C., Vittori, S., Siegel, T. P. & Heeren, R. M. A., Oct 2019, In : Journal of the American Society for Mass Spectrometry. 30, 10, p. 2041-2050 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mass Spectrometry-Based Tissue Imaging: The Next Frontier in Clinical Diagnostics?

Leung, F., Eberlin, L. S., Schwamborn, K., Heeren, R. M. A., Winograd, N. & Cooks, R. G., Apr 2019, In : Clinical Chemistry. 65, 4, p. 510-513 4 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Mass Spectrometry Imaging:Enabling Comprehensive Local Analysis of Molecular Biomarkers in Tissue for Personalized Medicine

Porta, T., Olde Damink, S. & Heeren, R., 2019, Handbook of Biomarkers and Precision Medicine. Chapman and Hall/CRC, p. 439-445 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Precise co-registration of mass spectrometry imaging, histology, and laser microdissection-based omics

Dewez, F., Martin-Lorenzo, M., Herfs, M., Baiwir, D., Mazzucchelli, G., De Pauw, E., Heeren, R. M. A. & Balluff, B., Sep 2019, In : Analytical and Bioanalytical Chemistry. 411, 22, p. 5647-5653 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis: A Potential Role for Plant Sterols

van Gorp, C., de Lange, I. H., Spiller, O. B., Dewez, F., Pastor, B. C., Heeren, R. M. A., Kessels, L., Kloosterboer, N., van Gemert, W. G., Beeton, M. L., Stock, S. J., Jobe, A. H., Payne, M. S., Kemp, M. W., Zimmermann, L. J., Kramer, B. W., Plat, J. & Wolfs, T. G. A. M., May 2019, In : Nutrients. 11, 5, p. 1-21 21 p., 968.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Rapid Identification of Ischemic Injury in Renal Tissue by Mass-Spectrometry Imaging

van Smaalen, T. C., Ellis, S. R., Mascini, N. E., Siegel, T. P., Cillero-Pastor, B., Hillen, L. M., van Heurn, L. W. E., Peutz-Kootstra, C. J. & Heeren, R. M. A., 5 Mar 2019, In : Analytical Chemistry. 91, 5, p. 3575-3581 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Recent technological developments in MALDI-MSI based hair analysis

Flinders, B., Bassindale, T. & Heeren, R., 2019, Emerging Technologies for the Analysis of Forensic Traces. Springer, Cham, p. 133-149 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Stigmatic imaging of secondary ions in MeV-SIMS spectrometry by linear Time-of-Flight mass spectrometer and the TimePix detector

Jencic, B., Sepec, L., Vavpetic, P., Kelemen, M., Rupnik, Z., Vencelj, M., Vogel-Mikus, K., Potocnik, N. O., Ellis, S. R., Heeren, R. & Pelicon, P., 1 Aug 2019, In : Nuclear Instruments & Methods in Physics Research Section B-Beam Interactions with Materials and Atoms. 452, p. 1-6 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Strategies for managing multi-patient 3D mass spectrometry imaging data

Vos, D. R. N., Jansen, R. L., Lucas, M., Paine, M. R. L., de Boer, O. J., Meijer, S. L., Savci-Heijink, C. D., Marquering, H. A., de Bruin, D. M., Heeren, R. M. A., Ellis, S. R. & Balluff, B., 20 Feb 2019, In : Journal of Proteomics. 193, p. 184-191 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The importance of clinical tissue imaging

Spraggins, J. M., Schwamborn, K., Heeren, R. M. A. & Eberlin, L. S., Apr 2019, In : Clinical mass spectrometry. 12, p. 47-49 3 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Three-Dimensional Mass Spectrometry Imaging Identifies Lipid Markers of Medulloblastoma Metastasis

Paine, M. R. L., Liu, J., Huang, D., Ellis, S. R., Trede, D., Kobarg, J. H., Heeren, R. M. A., Fernandez, F. M. & MacDonald, T. J., 18 Feb 2019, In : Scientific Reports. 9, p. 1-10 10 p., 2205.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Trends in mass spectrometry imaging for cardiovascular diseases

Mezger, S. T. P., Mingels, A. M. A., Bekers, O., Cillero-Pastor, B. & Heeren, R. M. A., Jul 2019, In : Analytical and Bioanalytical Chemistry. 411, 17, p. 3709-3720 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Automated, parallel mass spectrometry imaging and structural identification of lipids

Ellis, S. R., Paine, M. R. L., Eijkel, G. B., Pauling, J. K., Husen, P., Jervelund, M. W., Hermansson, M., Ejsing, C. S. & Heeren, R. M. A., Jul 2018, In : Nature Methods. 15, 7, p. 515–518 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cross-Species Molecular Imaging of Bile Salts and Lipids in Liver: Identification of Molecular Structural Markers in Health and Disease

Flinders, B., Huizing, L. R. S., van Heerden, M., Cuyckens, F., Neumann, U. P., van der Laan, L. J. W., Damink, S. W. M. O., Heeren, R. M. A., Schaap, F. G. & Vreeken, R. J., 16 Oct 2018, In : Analytical Chemistry. 90, 20, p. 11835-11846 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Digestion-Free Analysis of Peptides from 30-year-old Formalin-Fixed, Paraffin-Embedded Tissue by Mass Spectrometry Imaging

Paine, M. R. L., Ellis, S. R., Maloney, D., Heeren, R. M. A. & Verhaert, P. D. E. M., 7 Aug 2018, In : Analytical Chemistry. 90, 15, p. 9272-9280 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Evaluation of Thin-Layer Chromatography-Laser Desorption Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometric Imaging for Visualization of Crude Oil Interactions

Zahraei, A., Arisz, P. W. F., van Bawl, A. P. & Heeren, R. M. A., Jul 2018, In : Energy & Fuels. 32, 7, p. 7347-7357 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Identification and High-Resolution Imaging of alpha-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry

Bruinen, A. L., Fisher, G. L., Balez, R., van der Sar, A. M., Ooi, L. & Heeren, R. M. A., Aug 2018, In : Journal of the American Society for Mass Spectrometry. 29, 8, p. 1571-1581 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mass Spectrometry Imaging with Isomeric Resolution Enabled by Ozone-Induced Dissociation

Paine, M. R. L., Poad, B. L. J., Eijkel, G. B., Marshall, D. L., Blanksby, S. J., Heeren, R. M. A. & Ellis, S. R., 13 Aug 2018, In : Angewandte Chemie-International Edition. 57, 33, p. 10530-10534 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

NF-kappa B-mediated metabolic remodelling in the inflamed heart in acute viral myocarditis

Remels, A. H. V., Derks, W. J. A., Cillero-Pastor, B., Verhees, K. J. P., Kelders, M. C., Heggermont, W., Carai, P., Summer, G., Ellis, S. R., de Theije, C. C., Heeren, R. M. A., Heymans, S., Papageorgiou, A. P. & van Bilsen, M., Aug 2018, In : Biochimica et Biophysica Acta-Molecular Basis of Disease. 1864, 8, p. 2579-2589 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Round robin study of formalin-fixed paraffin-embedded tissues in mass spectrometry imaging

Buck, A., Heijs, B., Beine, B., Schepers, J., Cassese, A., Heeren, R. M. A., McDonnell, L. A., Henkel, C., Walch, A. & Balluff, B., Sep 2018, In : Analytical and Bioanalytical Chemistry. 410, 23, p. 5969–5980 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Simultaneous lipidomic and transcriptomic profiling in mouse brain punches of acute epileptic seizure model compared to controls

Lerner, R., Post, J. M., Ellis, S. R., Vos, D. R. N., Heeren, R. M. A., Lutz, B. & Bindila, L., Feb 2018, In : Journal of Lipid Research. 59, 2, p. 283-297 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Solvent effects on differentiation of mouse brain tissue using laser microdissection 'cut and drop' sampling with direct mass spectral analysis

Cahill, J. F., Kertesz, V., Porta, T., LeBlanc, J. C. Y., Heeren, R. M. A. & Van Berkel, G. J., 15 Mar 2018, In : Rapid Communications in Mass Spectrometry. 32, 5, p. 414-422 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Spatial Systems Lipidomics Reveals Nonalcoholic Fatty Liver Disease Heterogeneity

Scupakova, K., Soons, Z., Ertaylan, G., Pierzchalski, K. A., Eijkel, G. B., Ellis, S. R., Greve, J. W., Driessen, A., Verheij, J., De Kok, T. M., Damink, S. W. M. O., Rensen, S. S. & Heeren, R. M. A., 17 Apr 2018, In : Analytical Chemistry. 90, 8, p. 5130-5138 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Targeted Drug and Metabolite Imaging: Desorption Electrospray Ionization Combined with Triple Quadrupole Mass Spectrometry

Lamont, L., Eijkel, G. B., Jones, E. A., Flinders, B., Ellis, S. R., Porta Siegel, T., Heeren, R. M. A. & Vreeken, R. J., 20 Nov 2018, In : Analytical Chemistry. 90, 22, p. 13229-13235 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Tumor classification with MALDI-MSI data of tissue microarrays: A case study

Mascini, N. E., Teunissen, J., Noorlag, R., Willems, S. M. & Heeren, R. M. A., 1 Dec 2018, In : Methods. 151, p. 21-27 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Understanding Detrimental and Beneficial Grain Boundary Effects in Halide Perovskites

Adhyaksa, G. W. P., Brittman, S., Abolins, H., Lof, A., Li, X., Keelor, J. D., Luo, Y., Duevski, T., Heeren, R. M. A., Ellis, S. R., Fenning, D. P. & Garnett, E. C., 27 Dec 2018, In : Advanced Materials. 30, 52, 9 p., 1804792.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Combining Time-of-Flight Secondary Ion Mass Spectrometry Imaging Mass Spectrometry and CARS Microspectroscopy Reveals Lipid Patterns Reminiscent of Gene Expression Patterns in the Wing Imaginal Disc of Drosophila melanogaster

Marty, F., Rago, G., Smith, D. F., Gao, X., Eijkel, G. B., MacAleese, L., Bonn, M., Brunner, E., Basler, K. & Heeren, R. M. A., 19 Sep 2017, In : Analytical Chemistry. 89, 18, p. 9664-9670 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Design and Performance of a Novel Interface for Combined Matrix-Assisted Laser Desorption Ionization at Elevated Pressure and Electrospray Ionization with Orbitrap Mass Spectrometry

Belov, M. E., Ellis, S. R., Dilillo, M., Paine, M. R. L., Danielson, W. F., Anderson, G. A., de Graaf, E. L., Eijkel, G. B., Heeren, R. M. A. & McDonnell, L. A., 18 Jul 2017, In : Analytical Chemistry. 89, 14, p. 7493-7501 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Efficient Functionalization of Additives at Supramolecular Material Surfaces

Goor, O. J. G. M., Keizer, H. M., Bruinen, A. L., Schmitz, M. G. J., Versteegen, R. M., Janssen, H. M., Heeren, R. M. A. & Dankers, P. Y. W., 2 Feb 2017, In : Advanced Materials. 29, 5, 8 p., 1604652.

Research output: Contribution to journalArticleAcademicpeer-review

Host-based lipid inflammation drives pathogenesis in Francisella infection

Scott, A. J., Post, J. M., Lerner, R., Ellis, S. R., Lieberman, J., Shirey, K. A., Heeren, R. M. A., Bindila, L. & Ernst, R. K., 21 Nov 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 47, p. 12596-12601 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Integration of Ion Mobility MS(E) after Fully Automated, Online, High-Resolution Liquid Extraction Surface Analysis Micro-Liquid Chromatography

Lamont, L., Baumert, M., Potocnik, N. O., Allen, M., Vreeken, R., Heeren, R. M. A. & Porta, T., 17 Oct 2017, In : Analytical Chemistry. 89, 20, p. 11143-11150 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Ion mobility spectrometry reveals intermediate states in temperature-resolved DNA unfolding

Hommersom, B., Porta, T. & Heeren, R. M. A., Aug 2017, In : International Journal of Mass Spectrometry. 419, p. 52-55 4 p.

Research output: Contribution to journalArticleAcademicpeer-review