A micropixelated ion-imaging detector for mass resolution enhancement of a QMS instrument

Sarfaraz U. A. H. Syed, Gert B. Eijkel, Simon Maher, Piet Kistemaker, Stephen Taylor, Ron M. A. Heeren*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


An in-vacuum position-sensitive micropixelated detector (Timepix) is used to investigate the time-dependent spatial distribution of different charge state (and hence different mass-to-charge (m/z)) ions exiting an electrospray ionization (ESI)-based quadrupole mass spectrometer (QMS) instrument. Ion images obtained from the Timepix detector provide a detailed insight into the positions of stable and unstable ions of the mass peak as they exit the QMS. With the help of image processing algorithms and by selecting areas on the ion images where more stable ions impact the detector, an improvement in mass resolution by a factor of 5 was obtained for certain operating conditions. Moreover, our experimental approach of mass resolution enhancement was confirmed by in-house-developed novel QMS instrument simulation software. Utilizing the imaging-based mass resolution enhancement approach, the software predicts instrument mass resolution of ?1,0000 for a single-filter QMS instrument with a 210-mm long mass filter and a low operating frequency (880?kHz) of the radio frequency (RF) voltage.
Original languageEnglish
Pages (from-to)2055-2062
JournalAnalytical and Bioanalytical Chemistry
Issue number8
Publication statusPublished - Mar 2015


  • Mass spectrometry
  • Imaging
  • Spectroscopy/instrumentation

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