Deciphering Metabolic Heterogeneity by Single-Cell Analysis

Tom M. J. Evers, Mazene Hochane, Sander J. Tans, Ron M. A. Heeren, Stefan Semrau, Peter Nemes, Alireza Mashaghi*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Web of Science)

Abstract

Single-cell analysis provides insights into cellular heterogeneity and dynamics of individual cells. This Feature highlights recent developments in key analytical techniques suited for single-cell metabolic analysis with a special focus on mass spectrometry-based analytical platforms and RNA-seq as well as imaging techniques that reveal stochasticity in metabolism.
Original languageEnglish
Pages (from-to)13314-13323
Number of pages10
JournalAnalytical Chemistry
Volume91
Issue number21
DOIs
Publication statusPublished - 5 Nov 2019

Keywords

  • IONIZATION MASS-SPECTROMETRY
  • CAPILLARY-ELECTROPHORESIS
  • RNA-SEQ
  • EMBRYONIC-CELLS
  • LIVE CELLS
  • DYNAMICS
  • REVEALS
  • PROTEOMICS
  • CYTOMETRY
  • PROTEIN

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