Detection of Localized Hepatocellular Amino Acid Kinetics by using Mass Spectrometry Imaging of Stable Isotopes

Martijn Arts; Zita Soons; Shane R. Ellis; Keely A. Pierzchalski; Benjamin Balluff; Gert B. Eijkel; Ludwig J. Dubois; Natasja G. Lieuwes; Stijn M. Agten; Tilman M. Hackeng; Luc J. C. van Loon; Ron M. A. Heeren; Steven W. M. Olde Damink

doi:10.1002/anie.201702669

Detection of Localized Hepatocellular Amino Acid Kinetics by using Mass Spectrometry Imaging of Stable Isotopes

Martijn Arts, Zita Soons^*, Shane R. Ellis, Keely A. Pierzchalski, Benjamin Balluff, Gert B. Eijkel, Ludwig J. Dubois, Natasja G. Lieuwes, Stijn M. Agten, Tilman M. Hackeng, Luc J. C. van Loon, Ron M. A. Heeren, Steven W. M. Olde Damink

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	7146-7150
Number of pages	5
Journal	Angewandte Chemie-International Edition
Volume	56
Issue number	25
DOIs	https://doi.org/10.1002/anie.201702669
Publication status	Published - 12 Jun 2017

Keywords

amino acids
dynamics
isotopic labeling
mass spectrometry imaging
metabolism
EXPRESSION
CANCER
PHENYLALANINE
TRANSPORTER
METABOLISM
TUMORS
C-13
TOOL

Cite this

Arts, M., Soons, Z., Ellis, S. R., Pierzchalski, K. A., Balluff, B., Eijkel, G. B., Dubois, L. J., Lieuwes, N. G., Agten, S. M., Hackeng, T. M., van Loon, L. J. C., Heeren, R. M. A., & Damink, S. W. M. O. (2017). Detection of Localized Hepatocellular Amino Acid Kinetics by using Mass Spectrometry Imaging of Stable Isotopes. Angewandte Chemie-International Edition, 56(25), 7146-7150. https://doi.org/10.1002/anie.201702669

Arts, Martijn ; Soons, Zita ; Ellis, Shane R. ; Pierzchalski, Keely A. ; Balluff, Benjamin ; Eijkel, Gert B. ; Dubois, Ludwig J. ; Lieuwes, Natasja G. ; Agten, Stijn M. ; Hackeng, Tilman M. ; van Loon, Luc J. C. ; Heeren, Ron M. A. ; Damink, Steven W. M. Olde. / Detection of Localized Hepatocellular Amino Acid Kinetics by using Mass Spectrometry Imaging of Stable Isotopes. In: Angewandte Chemie-International Edition. 2017 ; Vol. 56, No. 25. pp. 7146-7150.

@article{bd407e7233f94f7e99a409e98a915b6f,

title = "Detection of Localized Hepatocellular Amino Acid Kinetics by using Mass Spectrometry Imaging of Stable Isotopes",

keywords = "amino acids, dynamics, isotopic labeling, mass spectrometry imaging, metabolism, EXPRESSION, CANCER, PHENYLALANINE, TRANSPORTER, METABOLISM, TUMORS, C-13, TOOL",

author = "Martijn Arts and Zita Soons and Ellis, {Shane R.} and Pierzchalski, {Keely A.} and Benjamin Balluff and Eijkel, {Gert B.} and Dubois, {Ludwig J.} and Lieuwes, {Natasja G.} and Agten, {Stijn M.} and Hackeng, {Tilman M.} and {van Loon}, {Luc J. C.} and Heeren, {Ron M. A.} and Damink, {Steven W. M. Olde}",

year = "2017",

month = jun

day = "12",

doi = "10.1002/anie.201702669",

language = "English",

volume = "56",

pages = "7146--7150",

journal = "Angewandte Chemie-International Edition",

issn = "1433-7851",

publisher = "Wiley-VCH Verlag",

number = "25",

}

Arts, M , Soons, Z , Ellis, SR, Pierzchalski, KA, Balluff, B, Eijkel, GB, Dubois, LJ , Lieuwes, NG , Agten, SM , Hackeng, TM , van Loon, LJC , Heeren, RMA & Damink, SWMO 2017, 'Detection of Localized Hepatocellular Amino Acid Kinetics by using Mass Spectrometry Imaging of Stable Isotopes', Angewandte Chemie-International Edition, vol. 56, no. 25, pp. 7146-7150. https://doi.org/10.1002/anie.201702669

Detection of Localized Hepatocellular Amino Acid Kinetics by using Mass Spectrometry Imaging of Stable Isotopes. / Arts, Martijn ; Soons, Zita ; Ellis, Shane R.; Pierzchalski, Keely A.; Balluff, Benjamin; Eijkel, Gert B.; Dubois, Ludwig J.; Lieuwes, Natasja G.; Agten, Stijn M.; Hackeng, Tilman M.; van Loon, Luc J. C.; Heeren, Ron M. A.; Damink, Steven W. M. Olde.

In: Angewandte Chemie-International Edition, Vol. 56, No. 25, 12.06.2017, p. 7146-7150.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Detection of Localized Hepatocellular Amino Acid Kinetics by using Mass Spectrometry Imaging of Stable Isotopes

AU - Arts, Martijn

AU - Soons, Zita

AU - Ellis, Shane R.

AU - Pierzchalski, Keely A.

AU - Balluff, Benjamin

AU - Eijkel, Gert B.

AU - Dubois, Ludwig J.

AU - Lieuwes, Natasja G.

AU - Agten, Stijn M.

AU - Hackeng, Tilman M.

AU - van Loon, Luc J. C.

AU - Heeren, Ron M. A.

AU - Damink, Steven W. M. Olde

PY - 2017/6/12

Y1 - 2017/6/12

KW - amino acids

KW - dynamics

KW - isotopic labeling

KW - mass spectrometry imaging

KW - metabolism

KW - EXPRESSION

KW - CANCER

KW - PHENYLALANINE

KW - TRANSPORTER

KW - METABOLISM

KW - TUMORS

KW - C-13

KW - TOOL

U2 - 10.1002/anie.201702669

DO - 10.1002/anie.201702669

M3 - Article

VL - 56

SP - 7146

EP - 7150

JO - Angewandte Chemie-International Edition

JF - Angewandte Chemie-International Edition

SN - 1433-7851

IS - 25

ER -

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10.1002/anie.201702669