Lucas van Loon

2025

Aerobic Exercise Preconditioning Does Not Augment Muscle Hypertrophy During Subsequent Resistance Exercise Training in Healthy Older Adults

Betz, M. W., Monsegue, A. P., Houben, L. H. P., Hendriks, F. K., van Kranenburg, J., Aussieker, T., Adriaans, B. P., Houben, A. J. H. M., Verdijk, L. B., van Loon, L. J. C. & Snijders, T., 23 Apr 2025, (E-pub ahead of print) In: Sports Medicine. 110723.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

A Well-Balanced Vegan Diet Does not Compromise Daily Mixed Muscle Protein Synthesis Rates when Compared with an Omnivorous Diet in Active Older Adults: A Randomized Controlled Cross-Over Trial

Domic, J., Pinckaers, P. J., Grootswagers, P., Siebelink, E., Gerdessen, J. C., van Loon, L. J. & de Groot, L. C., Apr 2025, In: Journal of Nutrition. 155, 4, p. 1141-1150 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Bone Health of Female Elite Cyclists Is Characterized by Impaired Cortical and Trabecular Microarchitecture

Hilkens, L., Bevers, M. S. A. M., Wyers, C. E., van Loon, L. J. C., van den Bergh, J. P. & van Dijk, J.-W., 3 Apr 2025, (E-pub ahead of print) In: Medicine and Science in Sports and Exercise.

Research output: Contribution to journal › Article › Academic › peer-review

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Daily blood flow restriction does not affect muscle fiber capillarization and satellite cell content during 2 wk of bed rest in healthy young men

Aussieker, T., Fuchs, C. J., Zorenc, A., Verdijk, L. B., van Loon, L. J. C. & Snijders, T., Jan 2025, In: Journal of Applied Physiology. 138, 1, p. 89-98 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

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Ingestion of a Whey Plus Collagen Protein Blend Increases Myofibrillar and Muscle Connective Protein Synthesis Rates

Aussieker, T., Kaiser, J., Hermans, W. J. H., Hendriks, F. K., Holwerda, A. M., Senden, J. M., van Kranenburg, J. M. X., Goessens, J. P. B., Braun, U., Baar, K., Snijders, T. & van Loon, L. J. C., Mar 2025, In: Medicine and Science in Sports and Exercise. 57, 3, p. 544-554

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Measured and predicted resting metabolic rate of Dutch and Norwegian Paralympic athletes

Weijer, V. C. R., Jonvik, K. L., van Dam, L., Risvang, L., Raastad, T., van Loon, L. J. C. & van Dijk, J.-W., Feb 2025, In: Journal of the Academy of Nutrition and Dietetics. 125, 2, p. 217-227.e5

Research output: Contribution to journal › Article › Academic › peer-review

Oleuropein supplementation increases resting skeletal muscle fractional PDH activity but does not influence whole-body metabolism: A randomized, double-blind, placebo-controlled trial in healthy, older males

Pinckaers, P. J., Petrick, H. L., Horstman, A. M., Moreno-Asso, A., De Marchi, U., Hendriks, F. K., Kuin, L. M., Fuchs, C. J., Grathwohl, D., Verdijk, L. B., Zorenc, A. H., Senden, J. M., Migliavacca, E., Metairon, S., Poquet, L., Morin-Rivron, D., Karagounis, L. G., Holloway, G. P., Feige, J. N. & van Loon, L. J., May 2025, In: Journal of Nutrition. 155, 5, p. 1373-1386 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Post-Exercise Cooling Lowers Skeletal Muscle Microvascular Perfusion and Blunts Amino Acid Incorporation into Muscle Tissue in Active Young Adults

Betz, M. W., Fuchs, C. J., Chedd, F., Monsegue, A. P., Hendriks, F. K., van Kranenburg, J. M. X., Goessens, J., Houben, A. J. H. M., Verdijk, L. B., van Loon, L. J. C. & Snijders, T., 18 Apr 2025, (E-pub ahead of print) In: Medicine and Science in Sports and Exercise.

Research output: Contribution to journal › Article › Academic › peer-review

Postprandial plasma amino acid and appetite responses to a low protein breakfast supplemented with whey or pea protein in middle-to-older aged adults

Korzepa, M., Marshall, R. N., Rogers, L. M., Belfield, A. E., Quinlan, J. I., Huang, Y., Gritsas, A., Churchward-Venne, T. A., Glover, E. I., van Loon, L. J. C., Wallis, G. A. & Breen, L., 11 Feb 2025, In: European Journal of Nutrition. 64, 2, p. 86 1 p., 86.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Protein glycation compromises the bioavailability of milk protein-derived lysine in vivo in healthy adult males: a double-blind randomized cross-over trial

van Lieshout, G. A., Trommelen, J., Nyakayiru, J., van Kranenburg, J., Senden, J. M., Gijsen, A. P., Verdijk, L. B., Pellikaan, W. F., Bragt, M. C. & van Loon, L. J., Apr 2025, In: American Journal of Clinical Nutrition. 121, 4, p. 804-815 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Quantifying Leg Muscle Disuse Atrophy During Bed Rest Using DXA, CT, and MRI

Fuchs, C. J., Hermans, W. J. H., van den Hurk, J., Wiggins, C. J., Widholm, P., Dahlqvist Leinhard, O., Veeraiah, P., Wildberger, J. E., Prompers, J. J. & van Loon, L. J. C., May 2025, In: European Journal of Sport Science. 25, 5, 11 p., e12299.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Repeated passive heat treatment increases muscle tissue capillarization, but does not affect postprandial muscle protein synthesis rates in healthy older adults

Fuchs, C. J., Betz, M. W., Petrick, H. L., Weber, J., Senden, J. M., Hendriks, F. K., Bels, J. L. M., van Loon, L. J. C. & Snijders, T., 1 Jan 2025, In: Journal of Physiology. 603, 1, p. 167-186 20 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Resistance training increases myofibrillar protein synthesis in middle-to-older aged adults consuming a typical diet with no influence of protein source: a randomized controlled trial

Korzepa, M., Quinlan, J. I., Marshall, R. N., Rogers, L. M., Belfield, A. E., Elhassan, Y. S., Lawson, A., Ayre, C., Senden, J. M., Goessens, J. P., Glover, E. I., Wallis, G. A., van Loon, L. J. & Breen, L., 25 Apr 2025, (E-pub ahead of print) In: American Journal of Clinical Nutrition.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Turning over new ideas in human skeletal muscle proteostasis: What do we know and where to from here?

Lim, C., Mckendry, J., Lees, M., Atherton, P. J., Burd, N. A., Holwerda, A. M., van Loon, L. J. C., Mcglory, C., Mitchell, C. J., Smith, K., Wilkinson, D. J., Stokes, T. & Phillips, S. M., 1 Feb 2025, (E-pub ahead of print) In: Experimental Physiology. 9 p., EP092353.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

2024

Access to a pre-sleep protein snack increases daily energy and protein intake in surgical hospitalized patients

Weijzen, M. E. G., Kohlen, M., Monsegue, A., Houtvast, D. C. J., Nyakayiru, J., Beijer, S., Geerlings, P., Verdijk, L. B. & van Loon, L. J. C., 1 May 2024, In: Clinical Nutrition. 43, 5, p. 1073-1078 6 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Administration of Free Amino Acids Improves Exogenous Amino Acid Availability when Compared with Intact Protein in Critically Ill Patients: A Randomized Controlled Study

van Gassel, R. J., Weijzen, M. E., Kouw, I. W., Senden, J. M., Wodzig, W. K., Olde Damink, S. W., van de Poll, M. C. & van Loon, L. J., Feb 2024, In: Journal of Nutrition. 154, 2, p. 554-564 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

A Low or High Physical Activity Level Does Not Modulate Prostate Tumor Tissue Protein Synthesis Rates

Houben, L. H. P., Tuytten, T., Holwerda, A. M., Wisanto, E., Senden, J., Wodzig, W. K. W. H., Olde Damink, S. W. M., Beelen, M., Beijer, S., van Renterghem, K. & van Loon, L. J. C., Apr 2024, In: Medicine and Science in Sports and Exercise. 56, 4, p. 635-643 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

A single bout of jumping exercise does not modulate serum markers of bone formation or bone resorption throughout a 24 h period

Hilkens, L., Bons, J., Nyakayiru, J., van Loon, L. J. C. & van Dijk, J.-W., Nov 2024, In: Bone. 188, 117216.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

A single sauna session does not improve postprandial blood glucose handling in individuals with type 2 diabetes mellitus: a cross-over, randomized, controlled trial

Schenaarts, L., Hendriks, F. K., Fuchs, C. J., Sluijsmans, W. E., Snijders, T. & van Loon, L. J., 29 Aug 2024, (E-pub ahead of print) In: Experimental and clinical endocrinology & diabetes.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Assessing muscle protein synthesis rates in vivo in humans: the deuterated water (2H2O) method

Holwerda, A. M., Atherton, P. J., Smith, K., Wilkinson, D. J., Phillips, S. M. & van Loon, L. J. C., Nov 2024, In: Journal of Nutrition. 154, 11, p. 3177-3189 13 p.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

Becoming a World Champion Powerlifter at 71 Years of Age: It Is Never Too Late to Start Exercising

Fuchs, C. J., Trommelen, J., Weijzen, M. E. G., Smeets, J. S. J., van Kranenburg, J., Verdijk, L. B. & van Loon, L. J. C., Jul 2024, In: International Journal of Sport Nutrition and Exercise Metabolism. 34, 4, p. 223-231 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Benefits of resistance training are not preserved after cessation of supervised training in prostate cancer patients on androgen deprivation therapy

Houben, L. H. P., Overkamp, M., Senden, J. M. G., van Roermund, J. G. H., de Vries, P., de Laet, K., van der Meer, S., van Loon, L. J. C., Beelen, M. & Beijer, S., 1 Jan 2024, In: European Journal of Sport Science. 24, 1, p. 116-126 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Coingestion of Collagen With Whey Protein Prevents Postexercise Decline in Plasma Glycine Availability in Recreationally Active Men

Aussieker, T., Janssen, T. A. H., Hermans, W. J. H., Holwerda, A. M., Senden, J. M., van Kranenburg, J. M. X., Goessens, J. P. B., Snijders, T. & van Loon, L. J. C., Jul 2024, In: International Journal of Sport Nutrition and Exercise Metabolism. 34, 4, p. 189-198 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Collagen Peptide Supplementation during Training Does Not Further Increase Connective Tissue Protein Synthesis Rates

Kirmse, M., Lottmann, T. M., Volk, N. R., de Marées, M., Holwerda, A. M., van Loon, L. J. C. & Platen, P., 1 Dec 2024, In: Medicine and Science in Sports and Exercise. 56, 12, p. 2296-2304 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Comparison of intramyocellular lipid metabolism in patients with diabetes and male athletes

Mezincescu, A. M., Rudd, A., Cheyne, L., Horgan, G., Philip, S., Cameron, D., van Loon, L., Whitfield, P., Gribbin, R., Hu, M. K., Delibegovic, M., Fielding, B., Lobley, G., Thies, F., Newby, D. E., Gray, S., Henning, A. & Dawson, D., 1 Dec 2024, In: Nature Communications. 15, 1, 14 p., 3690.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Continuous glucose monitoring in para cyclists: An observational study

Weijer, V., van der Werf, R., van der Haijden, M., Jeukendrup, A., van Loon, L. J. C. & van Dijk, J.-W., Dec 2024, In: European Journal of Sport Science. 24, 12, p. 1809-1819 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Daily blood flow restriction does not preserve muscle mass and strength during 2 weeks of bed rest

Fuchs, C. J., Hermans, W. J. H., Nyakayiru, J., Weijzen, M. E. G., Smeets, J. S. J., Aussieker, T., Senden, J. M., Wodzig, W. K. H. W., Snijders, T., Verdijk, L. B. & van Loon, L. J. C., 27 Feb 2024, (E-pub ahead of print) In: The Journal of Physiology.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Do Paralympic athletes suffer from brittle bones? Prevalence and risk factors of low bone mineral density in Paralympic athletes

Weijer, V. C. R., van Dijk, J. W., van Dam, L., Risvang, L., Bons, J., Raastad, T., van Loon, L. J. C. & Jonvik, K. L., 1 Jun 2024, In: Bone Reports. 21, 9 p., 101767.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Energy expenditure and dietary intake in professional female football players in the Dutch Women's League: Implications for nutritional counselling

Brinkmans, N., Plasqui, G., van Loon, L. & van Dijk, J.-W., 2024, In: Journal of Sports Sciences. 42, 4, p. 313-322 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Energy Requirements of Paralympic Athletes: Insights from the Doubly Labeled Water Approach

Weijer, V. C. R., Jonvik, K. L., van Dam, L., Risvang, L., Plasqui, G., Sandbakk, Ø., Raastad, T., van Loon, L. J. C. & van Dijk, J.-W., 1 May 2024, In: Medicine and Science in Sports and Exercise. 56, 5, p. 963-971 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Graded Replacement of Carbohydrate-Rich Breakfast Products with Dairy Products: Effects on Postprandial Aminoacidemia, Glycemic Control, Bone Metabolism, and Satiety

Hilkens, L., Praster, F., van Overdam, J., Nyakayiru, J., Singh-Povel, C. M., Bons, J., van Loon, L. J. & van Dijk, J.-W., Feb 2024, In: Journal of Nutrition. 154, 2, p. 479-490 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Hemodialysis does not lower circulating testosterone concentrations

Hendriks, F. K., Wiersma, J., van der Sande, F. M., Alexander, S. E., Kooman, J. P., Bons, J. A. P. & van Loon, L. J. C., May 2024, In: Journal of Nephrology. 37, 4, p. 1125-1127 3 p.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Higher muscle protein synthesis rates following ingestion of an omnivorous meal compared with an isocaloric and isonitrogenous vegan meal in healthy, older adults

Pinckaers, P. J. M., Domic, J., Petrick, H. L., Holwerda, A. M., Trommelen, J., Hendriks, F. K., Houben, L. H. P., Goessens, J. P. B., van Kranenburg, J. M. X., Senden, J. M., de Groot, L. C. P. G. M., Verdijk, L. B., Snijders, T. & van Loon, L. J. C., Jul 2024, In: The Journal of nutrition. 154, 7, p. 2120-2132 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Jumping Exercise Combined With Collagen Supplementation Preserves Bone Mineral Density in Elite Cyclists

Hilkens, L., van Schijndel, N., Weijer, V. C. R., Decroix, L., Bons, J., van Loon, L. J. C. & van Dijk, J.-W., 2024, In: International Journal of Sport Nutrition and Exercise Metabolism. 34, 1, p. 38-47 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT

Hengist, A., Davies, R. G., Walhin, J.-P., Buniam, J., Merrell, L. H., Rogers, L., Bradshaw, L., Moreno-Cabañas, A., Rogers, P. J., Brunstrom, J. M., Hodson, L., van Loon, L. J. C., Barton, W., O'Donovan, C., Crispie, F., O'Sullivan, O., Cotter, P. D., Proctor, K., Betts, J. A. & Koumanov, F. & 2 others, Thompson, D. & Gonzalez, J. T., 20 Aug 2024, In: Cell Reports Medicine. 5, 8, 101667.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Mitochondrial bioenergetics are not associated with myofibrillar protein synthesis rates

Holwerda, A. M., Dirks, M. L., Barbeau, P.-A., Goessens, J., Gijsen, A., van Loon, L. J. C. & Holloway, G. P., Oct 2024, In: Journal of cachexia, sarcopenia and muscle. 15, 5, p. 1811-1822 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Muscle fibre satellite cells are located at a greater distance from capillaries in patients with COPD compared with healthy controls

Betz, M. W., De Brandt, J., Aussieker, T., Monsegue, A. P., Houtvast, D. C. J., Gehlert, S., Verdijk, L. B., van Loon, L. J. C., Gosker, H. R., Langen, R. J. C., Derave, W., Burtin, C., Spruit, M. A. & Snijders, T., 30 Sept 2024, In: ERJ Open Research. 10, 5, 00203-2024.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Muscle Mass and Strength Gains Following Resistance Exercise Training in Older Adults 65-75 Years and Older Adults Above 85 Years

Marzuca-Nassr, G. N., Alegría-Molina, A., SanMartín-Calísto, Y., Artigas-Arias, M., Huard, N., Sapunar, J., Salazar, L. A., Verdijk, L. B. & van Loon, L. J. C., Jan 2024, In: International Journal of Sport Nutrition and Exercise Metabolism. 34, 1, p. 11-19 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

One Week of Single Leg Immobilization Lowers Muscle Connective Protein Synthesis Rates in Healthy, Young Adults

Holwerda, A. M., Weijzen, M. E. G., Zorenc, A., Senden, J., Jetten, G. H. J., Houben, L. H. P., Verdijk, L. B. & van Loon, L. J. C., Apr 2024, In: Medicine and Science in Sports and Exercise. 56, 4, p. 612-622 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Post-prandial muscle protein synthesis rates following the ingestion of pea-derived protein do not differ from ingesting an equivalent amount of milk-derived protein in healthy, young males

Pinckaers, P. J. M., Smeets, J. S. J., Kouw, I. W. K., Goessens, J. P. B., Gijsen, A. P. B., de Groot, L. C. P. G. M., Verdijk, L. B., van Loon, L. J. C. & Snijders, T., Apr 2024, In: European Journal of Nutrition. 63, 3, p. 893-904 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Protein Intake Distribution: Beneficial, Detrimental, or Inconsequential for Muscle Anabolism? Response to Witard & Mettler

Trommelen, J., Holwerda, A. M. & van Loon, L. J. C., Sept 2024, In: International Journal of Sport Nutrition and Exercise Metabolism. 34, 5, p. 325-328 4 p.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Quantification and interpretation of postprandial whole-body protein metabolism using stable isotope methodology: a narrative review

Trommelen, J. & van Loon, L. J. C., 15 May 2024, In: Frontiers in nutrition. 11, 12 p., 1391750.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

Reply - Letter to the editor: Access to a pre-sleep protein snack increases daily energy and protein intake in surgical hospitalized patients

Weijzen, M. E. G. & van Loon, L. J. C., 1 Aug 2024, In: Clinical Nutrition. 43, 8, p. 1888-1889 2 p.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Resistance Exercise Training, a Simple Intervention to Preserve Muscle Mass and Strength in Prostate Cancer Patients on Androgen Deprivation Therapy

Houben, L. H. P., Beelen, M., van Loon, L. J. C. & Beijer, S., 1 Mar 2024, In: International Journal of Sport Nutrition and Exercise Metabolism. 34, 2, p. 122-134 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

Resistance exercise training to improve post-operative rehabilitation in knee arthroplasty patients: A narrative review

Monsegue, A. P., Emans, P., van Loon, L. J. C. & Verdijk, L. B., Jul 2024, In: European Journal of Sport Science. 24, 7, p. 938-949 12 p.

Research output: Contribution to journal › (Systematic) Review article › peer-review

Open Access

Short-term intermittent fasting and energy restriction do not impair rates of muscle protein synthesis: A randomised, controlled dietary intervention

Kouw, I. W. K., Parr, E. B., Wheeler, M. J., Radford, B. E., Hall, R. C., Senden, J. M., Goessens, J. P. B., van Loon, L. J. C. & Hawley, J. A., 1 Nov 2024, In: Clinical Nutrition. 43, 11, p. 174-184 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

The muscle protein synthetic response following corn protein ingestion does not differ from milk protein in healthy, young adults

Pinckaers, P. J. M., Weijzen, M. E. G., Houben, L. H. P., Zorenc, A. H., Kouw, I. W. K., de Groot, L. C. P. G. M., Verdijk, L. B., Snijders, T. & van Loon, L. J. C., 5 Feb 2024, In: Amino Acids. 56, 1, 14 p., 8.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Type II Muscle Fiber Capillarization Is an Important Determinant of Post-Exercise Microvascular Perfusion in Older Adults

Betz, M. W., Hendriks, F. K., Houben, A. J. H. M., Van Den Eynde, M. D. G., Verdijk, L. B., Van Loon, L. J. C. & Snijders, T., 1 Mar 2024, In: Gerontology. 70, 3, p. 290-301 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Underpowered Studies in Muscle Metabolism Research: Determinants and Considerations

Houtvast, D. C. J., Betz, M. W., Van Hooren, B., Vanbelle, S., Verdijk, L. B., van Loon, L. J. C. & Trommelen, J., Dec 2024, In: Clinical Nutrition ESPEN. 64, p. 334-343 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

“It gave me a sense of achievement and a sense of purpose”—a qualitative study of patient experiences of a virtually supervised exercise program for adults with advanced cancer and cachexia

Bland, K. A., France-Ratcliffe, M., Krishnasamy, M., Nandi, A., Parr, E. B., Martin, P., Cormie, P., van Loon, L. J. C. & Zopf, E. M., 1 May 2024, In: Supportive Care in Cancer. 32, 5, 325.

Research output: Contribution to journal › Article › Academic › peer-review

Lucas van Loon

Research output

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