TY - JOUR
T1 - Post-prandial muscle protein synthesis rates following the ingestion of pea-derived protein do not differ from ingesting an equivalent amount of milk-derived protein in healthy, young males
AU - Pinckaers, Philippe J.M.
AU - Smeets, Joey S.J.
AU - Kouw, Imre W.K.
AU - Goessens, Joy P.B.
AU - Gijsen, Annemarie P.B.
AU - de Groot, Lisette C.P.G.M.
AU - Verdijk, Lex B.
AU - van Loon, Luc J.C.
AU - Snijders, Tim
N1 - Funding Information:
PJMP, IWKK, JPBG, LCPGMdG, LBV, TS and LJCvL have the following interests: This study was funded by TiFN, Wageningen, The Netherlands. The sponsors Tereos Syral (Marckolsheim, France), Cargill (Minneapolis, MN, USA), and Kellogg (Battle Creek, MI, USA) partly financed the project. The researchers are responsible for the study design, data collection and analysis, decision to publish, and preparation of the manuscript. The industrial partners have contributed to the project through regular discussion, and were involved in the study design. More specifically, the choice of interventional products were produced by these sponsors. The funders had no role in data collection and analysis, decision to publish, or preparation of the manuscript. In addition, LJCvL and LBV have received research grants, consulting fees, speaking honoraria, or a combination of these from Friesland Campina, Tereos Syral, and Pepsico. A full overview on research funding is provided at: https://www.maastrichtuniversity.nl/l.vanloon . The other authors report no conflicts of interest.
Funding Information:
The project is organized by and executed under the auspices of TiFN (Wageningen, The Netherlands), a public–private partnership on precompetitive research in food and nutrition. Funding for this research was obtained from Tereos (Marckolsheim, France), Cargill (Minneapolis, MN, USA), Kellogg (Battle Creek, MI, USA), and the Top-sector Agri&Food.
Publisher Copyright:
© 2024, The Author(s).
PY - 2024/4
Y1 - 2024/4
N2 - Purpose: Plant-derived proteins have received considerable attention as an alternative to animal-derived proteins. However, plant-derived proteins are considered to have less anabolic properties when compared with animal-derived proteins. The lower muscle protein synthesis rates following ingestion of plant- compared with animal-derived protein have been attributed to the lower essential amino acid content of plant-derived proteins and/or their specific amino acid deficiencies. This study aimed to compare post-prandial muscle protein synthesis rates following the ingestion of 30 g pea-derived protein with 30 g milk-derived protein in healthy, young males. Methods: In a randomized, double-blind, parallel-group design, 24 young males (24 ± 3 y) received a primed continuous L-[ring-13C6]-phenylalanine infusion after which they ingested 30 g pea (PEA) or 30 g milk-derived protein (MILK). Blood and muscle biopsies were collected frequently for 5 h to assess post-prandial plasma amino acid profiles and subsequent post-prandial muscle protein synthesis rates. Results: MILK increased plasma essential amino acid concentrations more than PEA over the 5 h post-prandial period (incremental area under curve 151 ± 31 vs 102 ± 15 mmol * 300 min L-1, respectively; P < 0.001). Ingestion of both MILK and PEA showed a robust muscle protein synthetic response with no significant differences between treatments (0.053 ± 0.013 and 0.053 ± 0.017% h-1, respectively; P = 0.96). Conclusion: Post-prandial muscle protein synthesis rates following the ingestion of 30 g pea-derived protein do not differ from the response following ingestion of an equivalent amount of milk-derived protein. International Clinical Trials Registry Platform (NTR6548; 27-06-2017).
AB - Purpose: Plant-derived proteins have received considerable attention as an alternative to animal-derived proteins. However, plant-derived proteins are considered to have less anabolic properties when compared with animal-derived proteins. The lower muscle protein synthesis rates following ingestion of plant- compared with animal-derived protein have been attributed to the lower essential amino acid content of plant-derived proteins and/or their specific amino acid deficiencies. This study aimed to compare post-prandial muscle protein synthesis rates following the ingestion of 30 g pea-derived protein with 30 g milk-derived protein in healthy, young males. Methods: In a randomized, double-blind, parallel-group design, 24 young males (24 ± 3 y) received a primed continuous L-[ring-13C6]-phenylalanine infusion after which they ingested 30 g pea (PEA) or 30 g milk-derived protein (MILK). Blood and muscle biopsies were collected frequently for 5 h to assess post-prandial plasma amino acid profiles and subsequent post-prandial muscle protein synthesis rates. Results: MILK increased plasma essential amino acid concentrations more than PEA over the 5 h post-prandial period (incremental area under curve 151 ± 31 vs 102 ± 15 mmol * 300 min L-1, respectively; P < 0.001). Ingestion of both MILK and PEA showed a robust muscle protein synthetic response with no significant differences between treatments (0.053 ± 0.013 and 0.053 ± 0.017% h-1, respectively; P = 0.96). Conclusion: Post-prandial muscle protein synthesis rates following the ingestion of 30 g pea-derived protein do not differ from the response following ingestion of an equivalent amount of milk-derived protein. International Clinical Trials Registry Platform (NTR6548; 27-06-2017).
KW - Amino acids
KW - Dairy
KW - Fractional synthesis rate
KW - Plant-based proteins
U2 - 10.1007/s00394-023-03295-6
DO - 10.1007/s00394-023-03295-6
M3 - Article
SN - 1436-6207
VL - 63
SP - 893
EP - 904
JO - European Journal of Nutrition
JF - European Journal of Nutrition
IS - 3
ER -