Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates: A randomized control trial

Evelyn B Parr*, Imre W K Kouw, Michael J Wheeler, Bridget E Radford, Rebecca C Hall, Joan M Senden, Joy P B Goessens, Luc J C van Loon, John A Hawley

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: This study aimed to assess the impact of time-restricted eating (TRE) on integrated skeletal muscle myofibrillar protein synthesis (MyoPS) rates in males with overweight/obesity.Methods: A total of 18 healthy males (age 46 +/- 5 years; BMI: 30 +/- 2 kg/m(2)) completed this exploratory, parallel, randomized dietary intervention after a 3-day lead-in diet. Participants then consumed an isoenergetic diet (protein: similar to 1.0 g/kg body mass per day) following either TRE (10:00 a.m. to 6:00 p.m.) or an extended eating control (CON; 8:00 a.m. to 8:00 p.m.) protocol for 10 days. Integrated MyoPS rates were measured using deuterated water administration with repeated saliva, blood, and muscle sampling. Secondary measures included continuous glucose monitoring and body composition (dual-energy x-ray absorptiometry).Results: There were no differences in daily integrated MyoPS rates (TRE: 1.28% +/- 0.18% per day, CON: 1.26% +/- 0.22% per day; p = 0.82) between groups. From continuous glucose monitoring, 24-hour total area under the curve was reduced following TRE (-578 +/- 271 vs. CON: 12 +/- 272 mmol/L x 24 hours; p = 0.001). Total body mass declined (TRE: 1.6 +/- 0.9 and CON: 1.1 +/- 0.7 kg; p < 0.001) with no differences between groups (p = 0.22). Lean mass loss was greater following TRE compared with CON ( 1.0 2.. 0.7 vs. 0.2 _ 0.5 kg, respectively; p = 0.01). Conclusion: Consuming food within an 8-hour time-restricted period does not lower daily MyoPS rates when compared with an isoenergetic diet consumed over 12 hours. Future research should investigate whether these results translate to free-living TRE.
Original languageEnglish
Pages (from-to)116-126
Number of pages11
JournalObesity
Volume31
Issue numberS1
Early online date22 Dec 2022
DOIs
Publication statusPublished - Feb 2023

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