TY - JOUR
T1 - Resistance Exercise Training Increases Muscle Mass and Strength in Prostate Cancer Patients on Androgen Deprivation Therapy
AU - Houben, Lisanne H P
AU - Overkamp, Maarten
AU - van Kraaij, Puck
AU - Trommelen, Jorn
AU - van Roermund, Joep G H
AU - de Vries, Peter
AU - de Laet, Kevin
AU - van der Meer, Saskia
AU - Mikkelsen, Ulla R
AU - Verdijk, Lex B
AU - van Loon, Luc J C
AU - Beijer, Sandra
AU - Beelen, Milou
N1 - Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine.
PY - 2023/4
Y1 - 2023/4
N2 - PURPOSE: To assess the effects of 20 weeks resistance exercise training with or without protein supplementation on body composition, muscle mass, muscle strength, physical performance and aerobic capacity in prostate cancer patients receiving androgen deprivation therapy (ADT).METHODS: Sixty prostate cancer patients receiving ADT were randomly assigned to perform 20 weeks of resistance exercise training with supplementation of 31 g whey protein (EX+PRO, n = 30) or placebo (EX+PLA, n = 30), consumed immediately after exercise and every night before sleep. A separate control group (CON, n = 36) only received usual care. At baseline and after 20 weeks, body composition (dual-energy X-ray absorptiometry), muscle mass (computed tomography scan), muscle strength (1-repetition maximum strength tests), physical performance (Timed Up and Go Test, 30-second Chair Stand Test, Stair Climb Test), aerobic capacity (cardiopulmonary exercise test) and habitual dietary intake (food diary), were assessed. Data were analyzed using a two-factor repeated-measures ANOVA.RESULTS: Over time, muscle mass and strength increased in EX+PRO and EX+PLA and decreased in CON. Total fat mass and fat percentage increased in EX+PRO and CON, but not in EX+PLA. Physical performance did not significantly change over time in either group. Aerobic capacity was maintained in EX+PLA, while it decreased in EX+PRO and CON. Habitual protein intake (without supplements) averaged >1.0 g·kg body weight-1·day-1, with no differences over time or between groups.CONCLUSIONS: In prostate cancer patients, resistance exercise training counteracts the adverse effects of ADT on body composition, muscle mass, muscle strength and aerobic capacity, with no additional benefits of protein supplementation.
AB - PURPOSE: To assess the effects of 20 weeks resistance exercise training with or without protein supplementation on body composition, muscle mass, muscle strength, physical performance and aerobic capacity in prostate cancer patients receiving androgen deprivation therapy (ADT).METHODS: Sixty prostate cancer patients receiving ADT were randomly assigned to perform 20 weeks of resistance exercise training with supplementation of 31 g whey protein (EX+PRO, n = 30) or placebo (EX+PLA, n = 30), consumed immediately after exercise and every night before sleep. A separate control group (CON, n = 36) only received usual care. At baseline and after 20 weeks, body composition (dual-energy X-ray absorptiometry), muscle mass (computed tomography scan), muscle strength (1-repetition maximum strength tests), physical performance (Timed Up and Go Test, 30-second Chair Stand Test, Stair Climb Test), aerobic capacity (cardiopulmonary exercise test) and habitual dietary intake (food diary), were assessed. Data were analyzed using a two-factor repeated-measures ANOVA.RESULTS: Over time, muscle mass and strength increased in EX+PRO and EX+PLA and decreased in CON. Total fat mass and fat percentage increased in EX+PRO and CON, but not in EX+PLA. Physical performance did not significantly change over time in either group. Aerobic capacity was maintained in EX+PLA, while it decreased in EX+PRO and CON. Habitual protein intake (without supplements) averaged >1.0 g·kg body weight-1·day-1, with no differences over time or between groups.CONCLUSIONS: In prostate cancer patients, resistance exercise training counteracts the adverse effects of ADT on body composition, muscle mass, muscle strength and aerobic capacity, with no additional benefits of protein supplementation.
U2 - 10.1249/MSS.0000000000003095
DO - 10.1249/MSS.0000000000003095
M3 - Article
C2 - 36534950
SN - 0195-9131
VL - 55
SP - 614
EP - 624
JO - Medicine and Science in Sports and Exercise
JF - Medicine and Science in Sports and Exercise
IS - 4
ER -