Resistance Exercise Training Increases Muscle Mass and Strength in Prostate Cancer Patients on Androgen Deprivation Therapy

Lisanne H P Houben, Maarten Overkamp, Puck van Kraaij, Jorn Trommelen, Joep G H van Roermund, Peter de Vries, Kevin de Laet, Saskia van der Meer, Ulla R Mikkelsen, Lex B Verdijk, Luc J C van Loon*, Sandra Beijer, Milou Beelen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


PURPOSE: To assess the effects of 20 weeks resistance exercise training with or without protein supplementation on body composition, muscle mass, muscle strength, physical performance and aerobic capacity in prostate cancer patients receiving androgen deprivation therapy (ADT).

METHODS: Sixty prostate cancer patients receiving ADT were randomly assigned to perform 20 weeks of resistance exercise training with supplementation of 31 g whey protein (EX+PRO, n = 30) or placebo (EX+PLA, n = 30), consumed immediately after exercise and every night before sleep. A separate control group (CON, n = 36) only received usual care. At baseline and after 20 weeks, body composition (dual-energy X-ray absorptiometry), muscle mass (computed tomography scan), muscle strength (1-repetition maximum strength tests), physical performance (Timed Up and Go Test, 30-second Chair Stand Test, Stair Climb Test), aerobic capacity (cardiopulmonary exercise test) and habitual dietary intake (food diary), were assessed. Data were analyzed using a two-factor repeated-measures ANOVA.

RESULTS: Over time, muscle mass and strength increased in EX+PRO and EX+PLA and decreased in CON. Total fat mass and fat percentage increased in EX+PRO and CON, but not in EX+PLA. Physical performance did not significantly change over time in either group. Aerobic capacity was maintained in EX+PLA, while it decreased in EX+PRO and CON. Habitual protein intake (without supplements) averaged >1.0 g·kg body weight-1·day-1, with no differences over time or between groups.

CONCLUSIONS: In prostate cancer patients, resistance exercise training counteracts the adverse effects of ADT on body composition, muscle mass, muscle strength and aerobic capacity, with no additional benefits of protein supplementation.

Original languageEnglish
Pages (from-to)614-624
Number of pages11
JournalMedicine and Science in Sports and Exercise
Issue number4
Early online date14 Dec 2022
Publication statusPublished - Apr 2023

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