20092020

Research output per year

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Research Output

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Article
2020

Both Prediabetes and Type 2 Diabetes Are Associated With Lower Heart Rate Variability: The Maastricht Study

Coopmans, C., Zhou, T. L., Henry, R. M. A., Heijman, J., Schaper, N. C., Koster, A., Schram, M. T., van der Kallen, C. J. H., Wesselius, A., den Engelsman, R. J. A., Crijns, H. J. G. M. & Stehouwer, C. D. A., May 2020, In : Diabetes Care. 43, 5, p. 1126-1133 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

2019

Maastricht antiarrhythmic drug evaluator (MANTA): a computational tool for better understanding of antiarrhythmic drugs

Sutanto, H., Laudy, L., Clerx, M., Dobrev, D., Crijns, H. J. G. M. & Heijman, J., Oct 2019, In : Pharmacological Research. 148, p. 104444 14 p., 104444.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

A left bundle branch block activation sequence and ventricular pacing influence voltage amplitudes: an in vivo and in silico study

Uyen Chau Nguyen, N. V., Potse, M., Vernooy, K., Mafi-Rad, M., Heijman, J., Caputo, M. L., Conte, G., Regoli, F., Krause, R., Moccetti, T., Auricchio, A., Prinzen, F. W. & Maffessanti, F., Nov 2018, In : EP Europace. 20, p. 77-86 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Muscarinic type-1 receptors contribute to I-K,I-ACh in human atrial cardiomyocytes and are upregulated in patients with chronic atrial fibrillation

Heijman, J., Kirchner, D., Kunze, F., Chretien, E. M., Michel-Reher, M. B., Voigt, N., Knaut, M., Michel, M. C., Ravens, U. & Dobrev, D., 15 Mar 2018, In : International Journal of Cardiology. 255, p. 61-68 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Predicting changes to I-Na from missense mutations in human SCN5A

Clerx, M., Heijman, J., Collins, P. & Volders, P. G. A., 24 Aug 2018, In : Scientific Reports. 8, 1, 13 p., 12797.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation

Molina, C. E., Abu-Taha, I. H., Wang, Q., Rosello-Diez, E., Kamler, M., Nattel, S., Ravens, U., Wehrens, X. H. T., Hove-Madsen, L., Heijman, J. & Dobrev, D., 9 Oct 2018, In : Frontiers in physiology. 9, 18 p., 1383.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update

Abu-Taha, I. H., Heijman, J., Feng, Y., Vettel, C., Dobrev, D. & Wieland, T., 1 Feb 2018, In : Laboratory Investigation. 98, 2, p. 190-197 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2017

beta-Adrenergic receptor stimulation inhibits proarrhythmic alternans in postinfarction border zone cardiomyocytes: a computational analysis

Tomek, J., Rodriguez, B., Bub, G. & Heijman, J., Aug 2017, In : American Journal of Physiology-heart and Circulatory Physiology. 313, 2, p. H338-H353 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity

Neef, S., Heijman, J., Otte, K., Dewenter, M., Saadatmand, A. R., Meyer-Roxlau, S., Antos, C. L., Backs, J., Dobrev, D., Wagner, M., Maier, L. S. & El-Armouche, A., Aug 2017, In : Naunyn-Schmiedebergs Archives of Pharmacology. 390, 8, p. 857-862 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Inverse remodelling of K(2P)3.1 K(+) channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy

Schmidt, C., Wiedmann, F., Zhou, X-B., Heijman, J., Voigt, N., Ratte, A., Lang, S., Kallenberger, S. M., Campana, C., Weymann, A., De Simone, R., Szabo, G., Ruhparwar, A., Kallenbach, K., Karck, M., Ehrlich, J. R., Baczko, I., Borggrefe, M., Ravens, U., Dobrev, D. & 2 others, Katus, H. A. & Thomas, D., 7 Jun 2017, In : European Heart Journal. 38, 22, p. 1764-1774 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Potassium channels in the heart: structure, function and regulation

Grandi, E., Sanguinetti, M. C., Bartos, D. C., Bers, D. M., Ye Chen-Izu, Chiamvimonvat, N., Colecraft, H. M., Delisle, B. P., Heijman, J., Navedo, M. F., Noskov, S., Proenza, C., Vandenberg, J. I. & Yarov-Yarovoy, V., 1 Apr 2017, In : Journal of Physiology. 595, 7, p. 2209-2228 20 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics

Chiamvimonvat, N., Ye Chen-Izu, U., Clancy, C. E., Deschenes, I., Dobrev, D., Heijman, J., Izu, L., Qu, Z., Ripplinger, C. M., Vandenberg, J. I., Weiss, J. N., Koren, G., Banyasz, T., Grandi, E., Sanguinetti, M. C., Bers, D. M. & Nerbonne, J. M., 1 Apr 2017, In : Journal of Physiology. 595, 7, p. 2229-2252 24 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Serine/Threonine Phosphatases in Atrial Fibrillation

Heijman, J., Ghezelbash, S., Wehrens, X. H. T. & Dobrev, D., Feb 2017, In : Journal of Molecular and Cellular Cardiology. 103, p. 110-120 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation

Heijman, J., Abdoust, P. E., Voigt, N., Nattel, S. & Dobrev, D., 1 Feb 2016, In : Journal of Physiology. 594, 3, p. 537-553

Research output: Contribution to journalArticleAcademicpeer-review

Differences in Left Versus Right Ventricular Electrophysiological Properties in Cardiac Dysfunction and Arrhythmogenesis

Molina, C. E., Heijman, J. & Dobrev, D., 2016, In : Arrhythmia & Electrophysiology Review. 5, 1, p. 14-9

Research output: Contribution to journalArticleAcademicpeer-review

The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis

Heijman, J., Algalarrondo, V., Voigt, N., Melka, J., Wehrens, X. H. T., Dobrev, D. & Nattel, S., 1 Apr 2016, In : Cardiovascular Research. 109, 4, p. 467-479

Research output: Contribution to journalArticleAcademicpeer-review

2015

Calcium Handling Abnormalities as a Target for Atrial Fibrillation Therapeutics: How Close to Clinical Implementation?

Heijman, J., Voigt, N., Ghezelbash, S., Schirmer, I. & Dobrev, D., Dec 2015, In : Journal of Cardiovascular Pharmacology. 66, 6, p. 515-522

Research output: Contribution to journalArticleAcademicpeer-review

Irregular rhythm and atrial metabolism are key for the evolution of proarrhythmic atrial remodeling in atrial fibrillation

Heijman, J. & Dobrev, D., Jul 2015, In : Basic Research in Cardiology. 110, 4, 41.

Research output: Contribution to journalArticleAcademicpeer-review

New antiarrhythmic targets in atrial fibrillation

Voigt, N., Heijman, J. & Dobrev, D., 1 Jan 2015, In : Future Cardiology. 11, 6

Research output: Contribution to journalArticleAcademicpeer-review

Tools to Keep the Clock Ticking: Molecular Approaches to Treat Sinus Node Dysfunction

Heijman, J., Heusch, G. & Dobrev, D., 2015, In : Cardiology. 132, 1, p. 45-48

Research output: Contribution to journalArticleAcademicpeer-review

T-wave Right Slope Provides a New Angle in the Prediction of Drug-Induced Ventricular Arrhythmias

Heijman, J. & Crijns, H. J. G. M., Oct 2015, In : Cardiovascular Drugs and Therapy. 29, 5, p. 411-413

Research output: Contribution to journalArticleAcademicpeer-review

Upregulation of K(2P)3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation

Schmidt, C., Wiedmann, F., Voigt, N., Zhou, X-B., Heijman, J., Lang, S., Albert, V., Kallenberger, S., Ruhparwar, A., Szabo, G., Kallenbach, K., Karck, M., Borggrefe, M., Biliczki, P., Ehrlich, J. R., Baczko, I., Lugenbiel, P., Schweizer, P. A., Donner, B. C., Katus, H. A. & 2 others, Dobrev, D. & Thomas, D., 14 Jul 2015, In : Circulation. 132, 2, p. 82-92

Research output: Contribution to journalArticleAcademicpeer-review

2014

Long-QT mutation p.K557E-Kv7.1: dominant-negative suppression of I-Ks, but preserved cAMP-dependent up-regulation

Spätjens, R., Bebarova, M., Seyen, S. R. M., Lentink, V., Jongbloed, R. J., Arens, Y. H. J. M., Heijman, J. & Volders, P. G. A., 1 Oct 2014, In : Cardiovascular Research. 104, 1, p. 216-225

Research output: Contribution to journalArticleAcademicpeer-review

Diastolic Spontaneous Calcium Release From the Sarcoplasmic Reticulum Increases Beat-to-Beat Variability of Repolarization in Canine Ventricular Myocytes After beta-Adrenergic Stimulation

Johnson, D. M., Heijman, J., Bode, E. F., Greensmith, D. J., van der Linde, H., Abi-Gerges, N., Eisner, D. A., Trafford, A. W. & Volders, P. G. A., 18 Jan 2013, In : Circulation Research. 112, 2, p. 246-+

Research output: Contribution to journalArticleAcademicpeer-review

2012

Dominant-Negative Control of cAMP-Dependent I-Ks Upregulation in Human Long-QT Syndrome Type 1

Heijman, J., Spätjens, R., Seyen, S. R. M., Lentink, V., Kuijpers, H. J. H., Boulet, I. R., de Windt, L. J., David, M. & Volders, P. G. A., 20 Jan 2012, In : Circulation Research. 110, 2, p. 211-+

Research output: Contribution to journalArticleAcademicpeer-review

2011

Local control of β-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca2+-transient

Heijman, J., Volders, P. G. A., Westra, R. L. & Rudy, Y., May 2011, In : Journal of Molecular and Cellular Cardiology. 50, 5, p. 863-871 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2010

I(Ks) restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation

Johnson, D. M., Heijman, J., Pollard, C. E., Valentin, J. P., Crijns, H. J., Abi-Gerges, N. & Volders, P. G. A., Jan 2010, In : Journal of Molecular and Cellular Cardiology. 48, 1, p. 122-130 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2009

Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium

Decker, K. F., Heijman, J., Silva, J. R., Hund, T. J. & Rudy, Y., Apr 2009, In : American Journal of Physiology-heart and Circulatory Physiology. 296, 4, p. H1017-H1026 10 p.

Research output: Contribution to journalArticleAcademicpeer-review