Abstract

OBJECTIVE Low heart rate variability (HRV), a marker for cardiac autonomic dysfunction, is a known feature of type 2 diabetes, but it remains incompletely understood whether this also applies to prediabetes or across the whole glycemic spectrum. Therefore, we investigated the association among prediabetes, type 2 diabetes, and measures of glycemia and HRV. RESEARCH DESIGN AND METHODS In the population-based Maastricht Study (n = 2,107; mean +/- SD age 59 +/- 8 years; 52% men; normal glucose metabolism [n = 1,226], prediabetes [n = 331], and type 2 diabetes [n = 550, oversampled]), we determined 24-h electrocardiogram-derived HRV in time and frequency domains (individual z-scores, based upon seven and six variables, respectively). We used linear regression with adjustments for age, sex, and major cardiovascular risk factors. RESULTS After adjustments, both time and frequency domain HRV were lower in prediabetes and type 2 diabetes as compared with normal glucose metabolism (standardized beta [95% CI] for time domain: -0.15 [-0.27; -0.03] and -0.34 [-0.46; -0.22], respectively, P for trend

Original languageEnglish
Pages (from-to)1126-1133
Number of pages8
JournalDiabetes Care
Volume43
Issue number5
DOIs
Publication statusPublished - May 2020

Keywords

  • ATHEROSCLEROTIC CARDIOVASCULAR-DISEASE
  • SUDDEN CARDIAC DEATH
  • GLUCOSE-TOLERANCE
  • MICROVASCULAR DYSFUNCTION
  • AUTONOMIC FUNCTION
  • ALL-CAUSE
  • HYPERGLYCEMIA
  • DETERMINANTS
  • MECHANISMS
  • FAILURE

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