Cumulative hydropathic topology of a voltage-gated sodium channel at atomic resolution

Markos N. Xenakis; Dimos Kapetis; Yang Yang; Jordi Heijman; Stephen G. Waxman; Giuseppe Lauria; Catharina G. Faber; Hubert J. Smeets; Ronald L. Westra; Patrick J. Lindsey

doi:10.1002/prot.25951

Cumulative hydropathic topology of a voltage-gated sodium channel at atomic resolution

Markos N. Xenakis^*, Dimos Kapetis, Yang Yang, Jordi Heijman, Stephen G. Waxman, Giuseppe Lauria, Catharina G. Faber, Hubert J. Smeets, Ronald L. Westra, Patrick J. Lindsey

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	1319-1328
Number of pages	10
Journal	Proteins-structure Function and Bioinformatics
Volume	88
Issue number	10
DOIs	https://doi.org/10.1002/prot.25951
Publication status	Published - Oct 2020

Keywords

cumulative hydropathic effects
hydrophobic gating
NavAb
scaling
topology
voltage-gated sodium channels
EXTREME PAIN DISORDER
OF-FUNCTION MUTATION
HYDROPHOBIC MOMENTS
SCN9A MUTATIONS
ALPHA-SUBUNIT
ERYTHROMELALGIA
NA(V)1.7
STATE
WATER
ERYTHERMALGIA

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Cite this

Xenakis, Markos N. ; Kapetis, Dimos ; Yang, Yang ; Heijman, Jordi ; Waxman, Stephen G. ; Lauria, Giuseppe ; Faber, Catharina G. ; Smeets, Hubert J. ; Westra, Ronald L. ; Lindsey, Patrick J. / Cumulative hydropathic topology of a voltage-gated sodium channel at atomic resolution. In: Proteins-structure Function and Bioinformatics. 2020 ; Vol. 88, No. 10. pp. 1319-1328.

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title = "Cumulative hydropathic topology of a voltage-gated sodium channel at atomic resolution",

keywords = "cumulative hydropathic effects, hydrophobic gating, NavAb, scaling, topology, voltage-gated sodium channels, EXTREME PAIN DISORDER, OF-FUNCTION MUTATION, HYDROPHOBIC MOMENTS, SCN9A MUTATIONS, ALPHA-SUBUNIT, ERYTHROMELALGIA, NA(V)1.7, STATE, WATER, ERYTHERMALGIA",

author = "Xenakis, {Markos N.} and Dimos Kapetis and Yang Yang and Jordi Heijman and Waxman, {Stephen G.} and Giuseppe Lauria and Faber, {Catharina G.} and Smeets, {Hubert J.} and Westra, {Ronald L.} and Lindsey, {Patrick J.}",

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language = "English",

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Cumulative hydropathic topology of a voltage-gated sodium channel at atomic resolution. / Xenakis, Markos N.; Kapetis, Dimos; Yang, Yang; Heijman, Jordi; Waxman, Stephen G.; Lauria, Giuseppe; Faber, Catharina G.; Smeets, Hubert J.; Westra, Ronald L.; Lindsey, Patrick J.

In: Proteins-structure Function and Bioinformatics, Vol. 88, No. 10, 10.2020, p. 1319-1328.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Cumulative hydropathic topology of a voltage-gated sodium channel at atomic resolution

AU - Xenakis, Markos N.

AU - Kapetis, Dimos

AU - Yang, Yang

AU - Heijman, Jordi

AU - Waxman, Stephen G.

AU - Lauria, Giuseppe

AU - Faber, Catharina G.

AU - Smeets, Hubert J.

AU - Westra, Ronald L.

AU - Lindsey, Patrick J.

PY - 2020/10

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KW - hydrophobic gating

KW - NavAb

KW - scaling

KW - topology

KW - voltage-gated sodium channels

KW - EXTREME PAIN DISORDER

KW - OF-FUNCTION MUTATION

KW - HYDROPHOBIC MOMENTS

KW - SCN9A MUTATIONS

KW - ALPHA-SUBUNIT

KW - ERYTHROMELALGIA

KW - NA(V)1.7

KW - STATE

KW - WATER

KW - ERYTHERMALGIA

U2 - 10.1002/prot.25951

DO - 10.1002/prot.25951

M3 - Article

C2 - 32447794

VL - 88

SP - 1319

EP - 1328

JO - Proteins-structure Function and Bioinformatics

JF - Proteins-structure Function and Bioinformatics

SN - 0887-3585

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