Treatment of atrial fibrillation with doxapram: TASK-1 potassium channel inhibition as a novel pharmacological strategy

Felix Wiedmann, Christoph Beyersdorf, Xiao-Bo Zhou, Manuel Kraft, Amelie Paasche, Natasa Jávorszky, Susanne Rinné, Henry Sutanto, Antonius Büscher, Kathrin I Foerster, Antje Blank, Ibrahim El-Battrawy, Xin Li, Siegfried Lang, Ursula Tochtermann, Jamila Kremer, Rawa Arif, Matthias Karck, Niels Decher, Gunther van LoonIbrahim Akin, Martin Borggrefe, Stefan Kallenberger, Jordi Heijman, Walter E Haefeli, Hugo A Katus, Constanze Schmidt*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Web of Science)
Original languageEnglish
Number of pages14
JournalCardiovascular Research
DOIs
Publication statusE-pub ahead of print - 24 May 2021

Keywords

  • Antiarrhythmic pharmacotherapy
  • Arrhythmia
  • Atrial fibrillation
  • Doxapram
  • Electrical remodelling
  • Potassium channel
  • Rhythm control
  • TASK-1
  • ACTION-POTENTIAL DURATION
  • SINOATRIAL CONDUCTION
  • K+ CHANNEL
  • LEAK
  • MECHANISMS

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