Treatment of atrial fibrillation with doxapram: TASK-1 potassium channel inhibition as a novel pharmacological strategy

Felix Wiedmann; Christoph Beyersdorf; Xiao-Bo Zhou; Manuel Kraft; Amelie Paasche; Natasa Jávorszky; Susanne Rinné; Henry Sutanto; Antonius Büscher; Kathrin I Foerster; Antje Blank; Ibrahim El-Battrawy; Xin Li; Siegfried Lang; Ursula Tochtermann; Jamila Kremer; Rawa Arif; Matthias Karck; Niels Decher; Gunther van Loon; Ibrahim Akin; Martin Borggrefe; Stefan Kallenberger; Jordi Heijman; Walter E Haefeli; Hugo A Katus; Constanze Schmidt

doi:10.1093/cvr/cvab177

Treatment of atrial fibrillation with doxapram: TASK-1 potassium channel inhibition as a novel pharmacological strategy

Felix Wiedmann, Christoph Beyersdorf, Xiao-Bo Zhou, Manuel Kraft, Amelie Paasche, Natasa Jávorszky, Susanne Rinné, Henry Sutanto, Antonius Büscher, Kathrin I Foerster, Antje Blank, Ibrahim El-Battrawy, Xin Li, Siegfried Lang, Ursula Tochtermann, Jamila Kremer, Rawa Arif, Matthias Karck, Niels Decher, Gunther van LoonIbrahim Akin, Martin Borggrefe, Stefan Kallenberger, Jordi Heijman, Walter E Haefeli, Hugo A Katus, Constanze Schmidt^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Web of Science)

Original language	English
Number of pages	14
Journal	Cardiovascular Research
DOIs	https://doi.org/10.1093/cvr/cvab177
Publication status	E-pub ahead of print - 24 May 2021

Keywords

Antiarrhythmic pharmacotherapy
Arrhythmia
Atrial fibrillation
Doxapram
Electrical remodelling
Potassium channel
Rhythm control
TASK-1
ACTION-POTENTIAL DURATION
SINOATRIAL CONDUCTION
K+ CHANNEL
LEAK
MECHANISMS

Access to Document

10.1093/cvr/cvab177

Cite this

Wiedmann, F., Beyersdorf, C., Zhou, X-B., Kraft, M., Paasche, A., Jávorszky, N., Rinné, S., Sutanto, H., Büscher, A., Foerster, K. I., Blank, A., El-Battrawy, I., Li, X., Lang, S., Tochtermann, U., Kremer, J., Arif, R., Karck, M., Decher, N., ... Schmidt, C. (2021). Treatment of atrial fibrillation with doxapram: TASK-1 potassium channel inhibition as a novel pharmacological strategy. Cardiovascular Research. https://doi.org/10.1093/cvr/cvab177

Wiedmann, Felix ; Beyersdorf, Christoph ; Zhou, Xiao-Bo ; Kraft, Manuel ; Paasche, Amelie ; Jávorszky, Natasa ; Rinné, Susanne ; Sutanto, Henry ; Büscher, Antonius ; Foerster, Kathrin I ; Blank, Antje ; El-Battrawy, Ibrahim ; Li, Xin ; Lang, Siegfried ; Tochtermann, Ursula ; Kremer, Jamila ; Arif, Rawa ; Karck, Matthias ; Decher, Niels ; van Loon, Gunther ; Akin, Ibrahim ; Borggrefe, Martin ; Kallenberger, Stefan ; Heijman, Jordi ; Haefeli, Walter E ; Katus, Hugo A ; Schmidt, Constanze. / Treatment of atrial fibrillation with doxapram : TASK-1 potassium channel inhibition as a novel pharmacological strategy. In: Cardiovascular Research. 2021.

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title = "Treatment of atrial fibrillation with doxapram: TASK-1 potassium channel inhibition as a novel pharmacological strategy",

keywords = "Antiarrhythmic pharmacotherapy, Arrhythmia, Atrial fibrillation, Doxapram, Electrical remodelling, Potassium channel, Rhythm control, TASK-1, ACTION-POTENTIAL DURATION, SINOATRIAL CONDUCTION, K+ CHANNEL, LEAK, MECHANISMS",

author = "Felix Wiedmann and Christoph Beyersdorf and Xiao-Bo Zhou and Manuel Kraft and Amelie Paasche and Natasa J{\'a}vorszky and Susanne Rinn{\'e} and Henry Sutanto and Antonius B{\"u}scher and Foerster, {Kathrin I} and Antje Blank and Ibrahim El-Battrawy and Xin Li and Siegfried Lang and Ursula Tochtermann and Jamila Kremer and Rawa Arif and Matthias Karck and Niels Decher and {van Loon}, Gunther and Ibrahim Akin and Martin Borggrefe and Stefan Kallenberger and Jordi Heijman and Haefeli, {Walter E} and Katus, {Hugo A} and Constanze Schmidt",

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month = may,

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doi = "10.1093/cvr/cvab177",

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journal = "Cardiovascular Research",

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Wiedmann, F, Beyersdorf, C, Zhou, X-B, Kraft, M, Paasche, A, Jávorszky, N, Rinné, S, Sutanto, H, Büscher, A, Foerster, KI, Blank, A, El-Battrawy, I, Li, X, Lang, S, Tochtermann, U, Kremer, J, Arif, R, Karck, M, Decher, N, van Loon, G, Akin, I, Borggrefe, M, Kallenberger, S, Heijman, J, Haefeli, WE, Katus, HA & Schmidt, C 2021, 'Treatment of atrial fibrillation with doxapram: TASK-1 potassium channel inhibition as a novel pharmacological strategy', Cardiovascular Research. https://doi.org/10.1093/cvr/cvab177

Treatment of atrial fibrillation with doxapram : TASK-1 potassium channel inhibition as a novel pharmacological strategy. / Wiedmann, Felix; Beyersdorf, Christoph; Zhou, Xiao-Bo; Kraft, Manuel; Paasche, Amelie; Jávorszky, Natasa; Rinné, Susanne; Sutanto, Henry; Büscher, Antonius; Foerster, Kathrin I; Blank, Antje; El-Battrawy, Ibrahim; Li, Xin; Lang, Siegfried; Tochtermann, Ursula; Kremer, Jamila; Arif, Rawa; Karck, Matthias; Decher, Niels; van Loon, Gunther; Akin, Ibrahim; Borggrefe, Martin; Kallenberger, Stefan; Heijman, Jordi; Haefeli, Walter E; Katus, Hugo A; Schmidt, Constanze.

In: Cardiovascular Research, 24.05.2021.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Treatment of atrial fibrillation with doxapram

T2 - TASK-1 potassium channel inhibition as a novel pharmacological strategy

AU - Wiedmann, Felix

AU - Beyersdorf, Christoph

AU - Zhou, Xiao-Bo

AU - Kraft, Manuel

AU - Paasche, Amelie

AU - Jávorszky, Natasa

AU - Rinné, Susanne

AU - Sutanto, Henry

AU - Büscher, Antonius

AU - Foerster, Kathrin I

AU - Blank, Antje

AU - El-Battrawy, Ibrahim

AU - Li, Xin

AU - Lang, Siegfried

AU - Tochtermann, Ursula

AU - Kremer, Jamila

AU - Arif, Rawa

AU - Karck, Matthias

AU - Decher, Niels

AU - van Loon, Gunther

AU - Akin, Ibrahim

AU - Borggrefe, Martin

AU - Kallenberger, Stefan

AU - Heijman, Jordi

AU - Haefeli, Walter E

AU - Katus, Hugo A

AU - Schmidt, Constanze

PY - 2021/5/24

Y1 - 2021/5/24

KW - Antiarrhythmic pharmacotherapy

KW - Arrhythmia

KW - Atrial fibrillation

KW - Doxapram

KW - Electrical remodelling

KW - Potassium channel

KW - Rhythm control

KW - TASK-1

KW - ACTION-POTENTIAL DURATION

KW - SINOATRIAL CONDUCTION

KW - K+ CHANNEL

KW - LEAK

KW - MECHANISMS

U2 - 10.1093/cvr/cvab177

DO - 10.1093/cvr/cvab177

M3 - Article

C2 - 34028533

JO - Cardiovascular Research

JF - Cardiovascular Research

SN - 0008-6363

ER -