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Jordi Heijman

20092019

Research output per year

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Research Output

2019

Bayesian network analyses in atrial fibrillation - A path to better therapies?

Heijman, J. & Dobrev, D., Mar 2019, In : IJC Heart and Vasculature. 22, p. 210-211 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Computational modeling: What does it tell us about atrial fibrillation therapy?

Grandi, E., Dobrev, D. & Heijman, J., 15 Jul 2019, In : International Journal of Cardiology. 287, p. 155-161 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Genome-wide association studies of atrial fibrillation: Finding meaning in the life of risk loci

Sutanto, H., Dobrev, D. & Heijman, J., Sep 2019, In : IJC Heart and Vasculature. 24, p. 100397 3 p., 100397.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia management

Thomas, D., Christ, T., Fabritz, L., Goette, A., Hammwoehner, M., Heijman, J., Kockskaemper, J., Linz, D., Odening, K. E., Schweizer, P. A., Wakili, R. & Voigt, N., Jun 2019, In : Clinical research in cardiology. 108, 6, p. 577-599 23 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Highlights from the International Journal of Cardiology Heart & Vasculature: Heart failure, atrial fibrillation, coronary artery disease and myocardial infarction

Linz, D., Ammirati, E., Dan, G-A., Heijman, J. & Dobrev, D., Dec 2019, In : IJC Heart and Vasculature. 25, 4 p., 100443.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access

Maastricht antiarrhythmic drug evaluator (MANTA): a computational tool for better understanding of antiarrhythmic drugs

Sutanto, H., Laudy, L., Clerx, M., Dobrev, D., Crijns, H. J. G. M. & Heijman, J., Oct 2019, In : Pharmacological Research. 148, p. 104444 14 p., 104444.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Personalized Ventricular Arrhythmia Simulation Framework to Study Vulnerable Trigger Locations on Top of Scar Substrate

Lau, K., Groth, A., Waechter-Stehle, I., Nguyen, U., Volders, P., Heijman, J., Weese, J. & Cluitmans, M., 2019, Computing in Cardiology (CinC). Vol. 46. p. 1-4 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingAcademicpeer-review

Open Access

Postoperative atrial fibrillation: mechanisms, manifestations and management

Dobrev, D., Aguilar, M., Heijman, J., Guichard, J-B. & Nattel, S., Jul 2019, In : Nature Reviews Cardiology. 16, 7, p. 417-436 20 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The Role of Calcium in the Human Heart: With Great Power Comes Great Responsibility

Sutanto, H. & Heijman, J., 10 May 2019, In : Frontiers for Young Minds. 7, 65

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2018

A left bundle branch block activation sequence and ventricular pacing influence voltage amplitudes: an in vivo and in silico study

Uyen Chau Nguyen, N. V., Potse, M., Vernooy, K., Mafi-Rad, M., Heijman, J., Caputo, M. L., Conte, G., Regoli, F., Krause, R., Moccetti, T., Auricchio, A., Prinzen, F. W. & Maffessanti, F., Nov 2018, In : EP Europace. 20, p. 77-86 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Electrocardiographic characteristics associated with atrial fibrillation - What do they tell us?

Heijman, J., Dobrev, D. & Crijns, H. J. G. M., 1 Sep 2018, In : International Journal of Cardiology. 266, p. 143-144 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Ion channels as part of macromolecular multiprotein complexes: Clinical significance

Heijman, J. & Dobrev, D., Mar 2018, In : Herzschrittmachertherapie und Elektrophysiologie. 29, 1, p. 30-35 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Muscarinic type-1 receptors contribute to I-K,I-ACh in human atrial cardiomyocytes and are upregulated in patients with chronic atrial fibrillation

Heijman, J., Kirchner, D., Kunze, F., Chretien, E. M., Michel-Reher, M. B., Voigt, N., Knaut, M., Michel, M. C., Ravens, U. & Dobrev, D., 15 Mar 2018, In : International Journal of Cardiology. 255, p. 61-68 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Predicting changes to I-Na from missense mutations in human SCN5A

Clerx, M., Heijman, J., Collins, P. & Volders, P. G. A., 24 Aug 2018, In : Scientific Reports. 8, 1, 13 p., 12797.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation

Molina, C. E., Abu-Taha, I. H., Wang, Q., Rosello-Diez, E., Kamler, M., Nattel, S., Ravens, U., Wehrens, X. H. T., Hove-Madsen, L., Heijman, J. & Dobrev, D., 9 Oct 2018, In : Frontiers in physiology. 9, 18 p., 1383.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update

Abu-Taha, I. H., Heijman, J., Feng, Y., Vettel, C., Dobrev, D. & Wieland, T., 1 Feb 2018, In : Laboratory Investigation. 98, 2, p. 190-197 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Resveratrol: an effective pharmacological agent to prevent inflammation-induced atrial fibrillation?

Sutanto, H., Dobrev, D. & Heijman, J., Nov 2018, In : Naunyn-Schmiedebergs Archives of Pharmacology. 391, 11, p. 1163-1167 5 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Translational Challenges in Atrial Fibrillation

Heijman, J., Guichard, J-B., Dobrev, D. & Nattel, S., 2 Mar 2018, In : Circulation Research. 122, 5, p. 752-773 22 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2017

beta-Adrenergic receptor stimulation inhibits proarrhythmic alternans in postinfarction border zone cardiomyocytes: a computational analysis

Tomek, J., Rodriguez, B., Bub, G. & Heijman, J., Aug 2017, In : American Journal of Physiology-heart and Circulatory Physiology. 313, 2, p. H338-H353 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity

Neef, S., Heijman, J., Otte, K., Dewenter, M., Saadatmand, A. R., Meyer-Roxlau, S., Antos, C. L., Backs, J., Dobrev, D., Wagner, M., Maier, L. S. & El-Armouche, A., Aug 2017, In : Naunyn-Schmiedebergs Archives of Pharmacology. 390, 8, p. 857-862 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Inhibition of Small-Conductance Ca2+-Activated K+ Channels The Long-Awaited Breakthrough for Antiarrhythmic Drug Therapy of Atrial Fibrillation?

Heijman, J. & Dobrev, D., Oct 2017, In : Circulation-Arrhythmia and Electrophysiology. 10, 10, 5 p., e005776.

Research output: Contribution to journalEditorialAcademicpeer-review

Inverse remodelling of K(2P)3.1 K(+) channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy

Schmidt, C., Wiedmann, F., Zhou, X-B., Heijman, J., Voigt, N., Ratte, A., Lang, S., Kallenberger, S. M., Campana, C., Weymann, A., De Simone, R., Szabo, G., Ruhparwar, A., Kallenbach, K., Karck, M., Ehrlich, J. R., Baczko, I., Borggrefe, M., Ravens, U., Dobrev, D. & 2 others, Katus, H. A. & Thomas, D., 7 Jun 2017, In : European Heart Journal. 38, 22, p. 1764-1774 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Investigational antiarrhythmic agents: promising drugs in early clinical development

Heijman, J., Ghezelbash, S. & Dobrev, D., 2017, In : Expert Opinion on Investigational Drugs. 26, 8, p. 897-907 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Potassium channels in the heart: structure, function and regulation

Grandi, E., Sanguinetti, M. C., Bartos, D. C., Bers, D. M., Ye Chen-Izu, Chiamvimonvat, N., Colecraft, H. M., Delisle, B. P., Heijman, J., Navedo, M. F., Noskov, S., Proenza, C., Vandenberg, J. I. & Yarov-Yarovoy, V., 1 Apr 2017, In : Journal of Physiology. 595, 7, p. 2209-2228 20 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics

Chiamvimonvat, N., Ye Chen-Izu, U., Clancy, C. E., Deschenes, I., Dobrev, D., Heijman, J., Izu, L., Qu, Z., Ripplinger, C. M., Vandenberg, J. I., Weiss, J. N., Koren, G., Banyasz, T., Grandi, E., Sanguinetti, M. C., Bers, D. M. & Nerbonne, J. M., 1 Apr 2017, In : Journal of Physiology. 595, 7, p. 2229-2252 24 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Serine/Threonine Phosphatases in Atrial Fibrillation

Heijman, J., Ghezelbash, S., Wehrens, X. H. T. & Dobrev, D., Feb 2017, In : Journal of Molecular and Cellular Cardiology. 103, p. 110-120 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Targeting supraventricular ectopic complexes: Which approach should be used and how does it affect atrial fibrillation?

Heijman, J., Dobrev, D. & Crijns, H. J. G. M., 1 Oct 2017, In : International Journal of Cardiology. 244, p. 202-203 2 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access
2016

Challenges to the translation of basic science findings to atrial fibrillation therapies

Heijman, J. & Dobrev, D., May 2016, In : Future Cardiology. 12, 3, p. 251-254

Research output: Contribution to journalEditorialAcademicpeer-review

Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation

Heijman, J., Abdoust, P. E., Voigt, N., Nattel, S. & Dobrev, D., 1 Feb 2016, In : Journal of Physiology. 594, 3, p. 537-553

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Differences in Left Versus Right Ventricular Electrophysiological Properties in Cardiac Dysfunction and Arrhythmogenesis

Molina, C. E., Heijman, J. & Dobrev, D., 2016, In : Arrhythmia & Electrophysiology Review. 5, 1, p. 14-9

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Response to Letter Regarding Article, "Upregulation of K 2P 3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation"

Schmidt, C., Wiedmann, F., Voigt, N., Zhou, X-B., Heijman, J., Lang, S., Albert, V., Kallenberger, S., Ruhparwar, A., Szabo, G., Kallenbach, K., Karck, M., Borggrefe, M., Biliczki, P., Ehrlich, J. R., Baczko, I., Lugenbiel, P., Schweizer, P. A., Donner, B. C., Katus, H. A. & 2 others, Dobrev, D. & Thomas, D., 15 Mar 2016, In : Circulation. 133, 11, p. E440-E441

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

The multiple proarrhythmic roles of cardiac calcium-handling abnormalities: triggered activity, conduction abnormalities, beat-to-beat variability, and adverse remodelling

Heijman, J., Schirmer, I. & Dobrev, D., Oct 2016, In : EP Europace. 18, 10, p. 1452-1454

Research output: Contribution to journalEditorialAcademicpeer-review

The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis

Heijman, J., Algalarrondo, V., Voigt, N., Melka, J., Wehrens, X. H. T., Dobrev, D. & Nattel, S., 1 Apr 2016, In : Cardiovascular Research. 109, 4, p. 467-479

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)
2015

Calcium Handling Abnormalities as a Target for Atrial Fibrillation Therapeutics: How Close to Clinical Implementation?

Heijman, J., Voigt, N., Ghezelbash, S., Schirmer, I. & Dobrev, D., Dec 2015, In : Journal of Cardiovascular Pharmacology. 66, 6, p. 515-522

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Irregular rhythm and atrial metabolism are key for the evolution of proarrhythmic atrial remodeling in atrial fibrillation

Heijman, J. & Dobrev, D., Jul 2015, In : Basic Research in Cardiology. 110, 4, 41.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

New antiarrhythmic targets in atrial fibrillation

Voigt, N., Heijman, J. & Dobrev, D., 1 Jan 2015, In : Future Cardiology. 11, 6

Research output: Contribution to journalArticleAcademicpeer-review

Tools to Keep the Clock Ticking: Molecular Approaches to Treat Sinus Node Dysfunction

Heijman, J., Heusch, G. & Dobrev, D., 2015, In : Cardiology. 132, 1, p. 45-48

Research output: Contribution to journalArticleAcademicpeer-review

T-wave Right Slope Provides a New Angle in the Prediction of Drug-Induced Ventricular Arrhythmias

Heijman, J. & Crijns, H. J. G. M., Oct 2015, In : Cardiovascular Drugs and Therapy. 29, 5, p. 411-413

Research output: Contribution to journalArticleAcademicpeer-review

Upregulation of K(2P)3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation

Schmidt, C., Wiedmann, F., Voigt, N., Zhou, X-B., Heijman, J., Lang, S., Albert, V., Kallenberger, S., Ruhparwar, A., Szabo, G., Kallenbach, K., Karck, M., Borggrefe, M., Biliczki, P., Ehrlich, J. R., Baczko, I., Lugenbiel, P., Schweizer, P. A., Donner, B. C., Katus, H. A. & 2 others, Dobrev, D. & Thomas, D., 14 Jul 2015, In : Circulation. 132, 2, p. 82-92

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)
2014

Long-QT mutation p.K557E-Kv7.1: dominant-negative suppression of I-Ks, but preserved cAMP-dependent up-regulation

Spätjens, R., Bebarova, M., Seyen, S. R. M., Lentink, V., Jongbloed, R. J., Arens, Y. H. J. M., Heijman, J. & Volders, P. G. A., 1 Oct 2014, In : Cardiovascular Research. 104, 1, p. 216-225

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
2013
38 Citations (Scopus)

Diastolic Spontaneous Calcium Release From the Sarcoplasmic Reticulum Increases Beat-to-Beat Variability of Repolarization in Canine Ventricular Myocytes After beta-Adrenergic Stimulation

Johnson, D. M., Heijman, J., Bode, E. F., Greensmith, D. J., van der Linde, H., Abi-Gerges, N., Eisner, D. A., Trafford, A. W. & Volders, P. G. A., 18 Jan 2013, In : Circulation Research. 112, 2, p. 246-+

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)
2012
Open Access
File
438 Downloads (Pure)

Dominant-Negative Control of cAMP-Dependent I-Ks Upregulation in Human Long-QT Syndrome Type 1

Heijman, J., Spätjens, R., Seyen, S. R. M., Lentink, V., Kuijpers, H. J. H., Boulet, I. R., de Windt, L. J., David, M. & Volders, P. G. A., 20 Jan 2012, In : Circulation Research. 110, 2, p. 211-+

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)
2011

Local control of β-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca2+-transient

Heijman, J., Volders, P. G. A., Westra, R. L. & Rudy, Y., May 2011, In : Journal of Molecular and Cellular Cardiology. 50, 5, p. 863-871 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

I(Ks) restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation

Johnson, D. M., Heijman, J., Pollard, C. E., Valentin, J. P., Crijns, H. J., Abi-Gerges, N. & Volders, P. G. A., Jan 2010, In : Journal of Molecular and Cellular Cardiology. 48, 1, p. 122-130 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

2009

Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium

Decker, K. F., Heijman, J., Silva, J. R., Hund, T. J. & Rudy, Y., Apr 2009, In : American Journal of Physiology-heart and Circulatory Physiology. 296, 4, p. H1017-H1026 10 p.

Research output: Contribution to journalArticleAcademicpeer-review