TY - JOUR
T1 - ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research
AU - Odening, K.E.
AU - Gomez, A.M.
AU - Dobrev, D.
AU - Fabritz, L.
AU - Heinzel, F.R.
AU - Mangoni, M.E.
AU - Molina, C.E.
AU - Sacconi, L.
AU - Smith, G.
AU - Stengl, M.
AU - Thomas, D.
AU - Zaza, A.
AU - Remme, C.A.
AU - Heijman, J.
N1 - Publisher Copyright:
© 2021 Published on behalf of the European Society of Cardiology. All rights reserved.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Cardiac arrhythmias are a major cause of death and disability. A large number of experimental cell and animal models have been developed to study arrhythmogenic diseases. These models have provided important insights into the underlying arrhythmia mechanisms and translational options for their therapeutic management. This position paper from the ESC Working Group on Cardiac Cellular Electrophysiology provides an overview of (i) currently available in vitro, ex vivo, and in vivo electrophysiological research methodologies, (ii) the most commonly used experimental (cellular and animal) models for cardiac arrhythmias including relevant species differences, (iii) the use of human cardiac tissue, induced pluripotent stem cell (hiPSC)-derived and in silico models to study cardiac arrhythmias, and (iv) the availability, relevance, limitations, and opportunities of these cellular and animal models to recapitulate specific acquired and inherited arrhythmogenic diseases, including atrial fibrillation, heart failure, cardiomyopathy, myocarditis, sinus node, and conduction disorders and channelopathies. By promoting a better understanding of these models and their limitations, this position paper aims to improve the quality of basic research in cardiac electrophysiology, with the ultimate goal to facilitate the clinical translation and application of basic electrophysiological research findings on arrhythmia mechanisms and therapies.
AB - Cardiac arrhythmias are a major cause of death and disability. A large number of experimental cell and animal models have been developed to study arrhythmogenic diseases. These models have provided important insights into the underlying arrhythmia mechanisms and translational options for their therapeutic management. This position paper from the ESC Working Group on Cardiac Cellular Electrophysiology provides an overview of (i) currently available in vitro, ex vivo, and in vivo electrophysiological research methodologies, (ii) the most commonly used experimental (cellular and animal) models for cardiac arrhythmias including relevant species differences, (iii) the use of human cardiac tissue, induced pluripotent stem cell (hiPSC)-derived and in silico models to study cardiac arrhythmias, and (iv) the availability, relevance, limitations, and opportunities of these cellular and animal models to recapitulate specific acquired and inherited arrhythmogenic diseases, including atrial fibrillation, heart failure, cardiomyopathy, myocarditis, sinus node, and conduction disorders and channelopathies. By promoting a better understanding of these models and their limitations, this position paper aims to improve the quality of basic research in cardiac electrophysiology, with the ultimate goal to facilitate the clinical translation and application of basic electrophysiological research findings on arrhythmia mechanisms and therapies.
KW - Animal models
KW - Experimental models
KW - Arrhythmias
KW - Atrial fibrillation
KW - Mechanisms
KW - Cardiac electrophysiology
KW - Cellular electrophysiology
KW - Ion channels
KW - Position paper
KW - TORSADE-DE-POINTES
KW - LONG-QT SYNDROME
KW - TRANSGENIC RABBIT MODEL
KW - PLURIPOTENT STEM-CELLS
KW - SINUS NODE DYSFUNCTION
KW - PRESERVED EJECTION FRACTION
KW - LEFT-VENTRICULAR WALL
KW - HEART-FAILURE
KW - ATRIAL-FIBRILLATION
KW - SINOATRIAL NODE
U2 - 10.1093/europace/euab142
DO - 10.1093/europace/euab142
M3 - Article
C2 - 34313298
SN - 1099-5129
VL - 23
SP - 1795
EP - 1814
JO - EP Europace
JF - EP Europace
IS - 11
ER -