TY - JOUR
T1 - Association of low-voltage areas with the regional wall deformation and the left atrial shape in patients with atrial fibrillation
T2 - A proof of concept study
AU - Nedios, Sotirios
AU - Sanatkhani, Soroosh
AU - Oladosu, Michael
AU - Seewoester, Timm
AU - Richter, Sergio
AU - Arya, Arash
AU - Heijman, Jordi
AU - Crijns, Harry J. G. M.
AU - Hindricks, Gerhard
AU - Bollmann, Andreas
AU - Menon, Prahlad G.
N1 - Publisher Copyright:
© 2021 The Authors
PY - 2021/4
Y1 - 2021/4
N2 - Background: Left atrium (LA) remodeling is associated with atrial fibrillation (AF) and reduced success after AF ablation, but its relation with low-voltage areas (LVA) is not known. This study aimed to evaluate the relation between regional LA changes and LVAs in AF patients.Methods: Pre-interventional CT data of patients (n = 24) with LA-LVA (Results: The roof, posterior and septal regions had negative local deviations. There was a correlation between roof and septum (r = 0.42, p = 0.04), lateral and inferior-posterior (r = 0.48, p = 0.02) as well as posterior and inferior-septal deviations (r = -0.41, p = 0.046). ASI correlated with septum deformation (r = -0.43, p = 0.04). LAS correlated with dilatation (LAV, r = 0.49, p = 0.02), roof (r = 0.52, p = 0.009) and posterior deformation (r = -0.56, p = 0.005). Extended LVA correlated with local deformation of all LA walls, except the roof and the septum. LVA association with LAV, ASI and LAS did not reach statistical significance.Conclusion: Extended LVA correlates with local wall deformations better than other remodeling surrogates. Therefore, their calculation could help predict LVA presence and deserve further evaluation in clinical studies. (C) 2021 The Authors. Published by Elsevier B.V.
AB - Background: Left atrium (LA) remodeling is associated with atrial fibrillation (AF) and reduced success after AF ablation, but its relation with low-voltage areas (LVA) is not known. This study aimed to evaluate the relation between regional LA changes and LVAs in AF patients.Methods: Pre-interventional CT data of patients (n = 24) with LA-LVA (Results: The roof, posterior and septal regions had negative local deviations. There was a correlation between roof and septum (r = 0.42, p = 0.04), lateral and inferior-posterior (r = 0.48, p = 0.02) as well as posterior and inferior-septal deviations (r = -0.41, p = 0.046). ASI correlated with septum deformation (r = -0.43, p = 0.04). LAS correlated with dilatation (LAV, r = 0.49, p = 0.02), roof (r = 0.52, p = 0.009) and posterior deformation (r = -0.56, p = 0.005). Extended LVA correlated with local deformation of all LA walls, except the roof and the septum. LVA association with LAV, ASI and LAS did not reach statistical significance.Conclusion: Extended LVA correlates with local wall deformations better than other remodeling surrogates. Therefore, their calculation could help predict LVA presence and deserve further evaluation in clinical studies. (C) 2021 The Authors. Published by Elsevier B.V.
KW - Atrial fibrillation
KW - Atrial remodeling
KW - Computer tomography
KW - Voltage mapping
KW - Sphericity
U2 - 10.1016/j.ijcha.2021.100730
DO - 10.1016/j.ijcha.2021.100730
M3 - Article
C2 - 33718586
SN - 2352-9067
VL - 33
JO - IJC Heart & Vasculature
JF - IJC Heart & Vasculature
M1 - 100730
ER -