Association of low-voltage areas with the regional wall deformation and the left atrial shape in patients with atrial fibrillation: A proof of concept study

Sotirios Nedios*, Soroosh Sanatkhani, Michael Oladosu, Timm Seewoester, Sergio Richter, Arash Arya, Jordi Heijman, Harry J. G. M. Crijns, Gerhard Hindricks, Andreas Bollmann, Prahlad G. Menon

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background: Left atrium (LA) remodeling is associated with atrial fibrillation (AF) and reduced success after AF ablation, but its relation with low-voltage areas (LVA) is not known. This study aimed to evaluate the relation between regional LA changes and LVAs in AF patients.

Methods: Pre-interventional CT data of patients (n = 24) with LA-LVA (

Results: The roof, posterior and septal regions had negative local deviations. There was a correlation between roof and septum (r = 0.42, p = 0.04), lateral and inferior-posterior (r = 0.48, p = 0.02) as well as posterior and inferior-septal deviations (r = -0.41, p = 0.046). ASI correlated with septum deformation (r = -0.43, p = 0.04). LAS correlated with dilatation (LAV, r = 0.49, p = 0.02), roof (r = 0.52, p = 0.009) and posterior deformation (r = -0.56, p = 0.005). Extended LVA correlated with local deformation of all LA walls, except the roof and the septum. LVA association with LAV, ASI and LAS did not reach statistical significance.

Conclusion: Extended LVA correlates with local wall deformations better than other remodeling surrogates. Therefore, their calculation could help predict LVA presence and deserve further evaluation in clinical studies. (C) 2021 The Authors. Published by Elsevier B.V.

Original languageEnglish
Article number100730
Number of pages5
JournalIJC Heart & Vasculature
Publication statusPublished - Apr 2021


  • Atrial fibrillation
  • Atrial remodeling
  • Computer tomography
  • Voltage mapping
  • Sphericity

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