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Harald Schmidt

20102019

Research output per year

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Research Output

2019

Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke

Casas, A. I., Kleikers, P. W. M., Geuss, E., Langhauser, F., Adler, T., Busch, D. H., Gailus-Durner, V., de Angelis, M. H., Egea, J., Lopez, M. G., Kleinschnitz, C. & Schmidt, H. H. H. W., 1 Apr 2019, In : Journal of Clinical Investigation. 129, 4, p. 1772-1778 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

E. coli gene regulatory networks are inconsistent with gene expression data

Larsen, S. J., Rottger, R., Schmidt, H. H. H. W. & Baumbach, J., 10 Jan 2019, In : Nucleic Acids Research. 47, 1, p. 85-92 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

From single drug targets to synergistic network pharmacology in ischemic stroke

Casas, A. I., Hassan, A. A., Larsen, S. J., Gomez-Rangel, V., Elbatreek, M., Kleikers, P. W. M., Guney, E., Egea, J., Lopez, M. G., Baumbach, J. & Schmidt, H. H. H. W., 2 Apr 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 14, p. 7129-7136 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Reactive Oxygen Comes of Age: Mechanism-Based Therapy of Diabetic End-Organ Damage

Elbatreek, M. H., Pachado, M. P., Cuadrado, A., Jandeleit-Dahm, K. & Schmidt, H. H. H. W., May 2019, In : Trends in Endocrinology and Metabolism. 30, 5, p. 312-327 16 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Receptor guanylyl cyclase (RGC) family (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Beuve, A., Brouckaert, P., Burnett, J. C., Friebe, A., Garthwaite, J., Hobbs, A. J., Koesling, D., Kuhn, M., Potter, L. R., Russwurm, M., Schmidt, H., Stasch, J-P. & Waldman, S. A., 2019, In : IUPHAR/BPS Guide to Pharmacology CITE. 2019, 4, p. 1-5 5 p.

Research output: Contribution to journalConference Abstract/Poster in journalAcademic

Red Blood Cell-Derived Nitric Oxide Bioactivity and Hypoxic Vasodilation To beta 93 or not to beta 93?

Schmidt, H. H. H. W. & Feelisch, M., 4 Jun 2019, In : Circulation. 139, 23, p. 2664-2667 4 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Time-Resolved Systems Medicine Reveals Viral Infection-Modulating Host Targets

Wiwie, C., Kuznetsova, I., Mostafa, A., Rauch, A., Haakonsson, A., Barrio-Hernandez, I., Blagoev, B., Mandrup, S., Schmidt, H. H. H. W., Pleschka, S., Röttger, R. & Baumbach, J., 2019, In : Systems medicine (New Rochelle, N.Y.). 2, 1, p. 1-9 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection

Langhauser, F., Casas, A. I., Dao, V-T-V., Guney, E., Menche, J., Geuss, E., Kleikers, P. W. M., López, M. G., Barabási, A-L., Kleinschnitz, C. & Schmidt, H. H. H. W., 5 Feb 2018, In : NPJ systems biology and applications. 4, 13 p., 8.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) (vol 13, pg 94, 2017)

Egea, J., Fabregat, I., Frapart, Y. M., Ghezzi, P., Gorlach, A., Kietzmann, T., Kubaichuk, K., Knaus, U. G., Lopez, M. G., Olaso-Gonzalez, G., Petry, A., Schulz, R., Vina, J., Winyard, P., Abbas, K., Ademowo, O. S., Afonso, C. B., Andreadou, I., Antelmann, H., Antunes, F. & 131 others, Aslan, M., Bachschmid, M. M., Barbosa, R. M., Belousov, V., Berndt, C., Bernlohr, D., Bertran, E., Bindoli, A., Bottari, S. P., Brito, P. M., Carrara, G., Casas, A. I., Chatzi, A., Chondrogiannni, N., Conrad, M., Cooke, M. S., Costa, J. G., Cuadrado, A., Dang, P. M-C., De Smet, B., Debelec-Butuner, B., Dias, I. H. K., Dunn, J. D., Edson, A. J., El Assar, M., El-Benna, J., Ferdinandy, P., Fernandes, A. S., Fladmark, K. E., Forstermann, U., Giniatullin, R., Giricz, Z., Gorbe, A., Griffiths, H., Hampl, V., Hanf, A., Herget, J., Hernansanz-Agustin, P., Hillion, M., Huang, J., Ilikay, S., Jansen-Durr, P., Jaquet, V., Joles, J. A., Kalyanaraman, B., Kaminskyy, D., Karbaschi, M., Kleanthous, M., Klotz, L. O., Korac, B., Korkmaz, K. S., Koziel, R., Kracun, D., Krause, K. H., Kren, V., Krieg, T., Laranjinha, J., Lazou, A., Li, H., Martinez-Ruiz, A., Matsui, R., McBean, G. J., Meredith, S. P., Messens, J., Miguel, V., Mikhed, Y., Milisav, I., Milkovic, L., Miranda-Vizuete, A., Mojovic, M., Monsalve, M., Mouthuay, P. A., Mulvey, J., Munzel, T., Muzykantov, V., Nguyen, I. T. N., Oelze, M., Oliveira, N. G., Palmeira, C. M., Papaevgeniou, N., Pavicevic, A., Pedre, B., Peyrot, F., Phylactides, M., Pircalabioru, G. G., Pitt, A. R., Poulsen, H. E., Prieto, I., Rigobello, M. P., Robledinos-Anton, N., Rodriguez-Manas, L., Rolo, A. P., Rousset, F., Ruskovska, T., Saraiva, N., Sasson, S., Schroder, K., Semen, K., Seredenina, T., Shakirzyanova, A., Smith, G. L., Soldati, T., Sousa, B. C., Spickett, C. M., Stancic, A., Stasia, M. J., Steinbrenner, H., Stepanic, V., Steven, S., Tokatlidis, K., Tuncay, E., Turan, B., Ursini, F., Vacek, J., Vanjnerova, O., Valentova, K., Van Breusegem, F., Varisli, L., Veal, E. A., Yalcin, A. S., Yelisyeyeva, O., Zarkovic, N., Zatloukalova, M., Zielonka, J., Touyz, R. M., Papapetropoulos, A., Grune, T., Lamas, S., Schmidt, H. H. H. W., Di Lisa, F. & Daiber, A., 1 Apr 2018, In : Redox Biology. 14, p. 694-696 3 p.

Research output: Contribution to journalErratum / corrigendumAcademic

Open Access

Proximal Pathway Enrichment Analysis for Targeting Comorbid Diseases via Network Endopharmacology

Aguirre-Plans, J., Pinero, J., Menche, J., Sanz, F., Furlong, L. I., Schmidt, H. H. H. W., Oliva, B. & Guney, E., Sep 2018, In : Pharmaceuticals. 11, 3, 18 p., 61.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

Cuadrado, A., Manda, G., Hassan, A., Alcaraz, M., Barbas, C., Daiber, A., Ghezzi, P., Leon, R., Lopez, M. G., Oliva, B., Pajares, M., Rojo, A. I., Robledinos-Anton, N., Valverde, A. M., Guney, E. & Schmidt, H. H. H. W., 1 Apr 2018, In : Pharmacological Reviews. 70, 2, p. 348-383 36 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
2017

Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease

Gray, S. P., Jha, J. C., Kennedy, K., van Bommel, E., Chew, P., Szyndralewiez, C., Touyz, R. M., Schmidt, H. H. H. W., Cooper, M. E. & Jandeleit-Dahm, K. A. M., May 2017, In : Diabetologia. 60, 5, p. 927-937 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Comprehensive efforts to increase adherence to statin therapy

Vonbank, A., Agewall, S., Kjeldsen, K. P., Lewis, B. S., Torp-Pedersen, C., Ceconi, C., Funck-Brentano, C., Kaski, J. C., Niessner, A., Tamargo, J., Walther, T., Wassmann, S., Rosano, G., Schmidt, H., Saely, C. H. & Drexel, H., 21 Aug 2017, In : European Heart Journal. 38, 32, p. 2473-2477b 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Egea, J., Fabregat, I., Frapart, Y. M., Ghezzi, P., Gorlach, A., Kietzmann, T., Kubaichuk, K., Knaus, U. G., Lopez, M. G., Olaso-Gonzalez, G., Petry, A., Schulz, R., Vinal, J., Winyard, P., Abbas, K., Ademowo, O. S., Afonso, C. B., Andreadou, I., Antelmann, H., Antunes, F. & 131 others, Aslan, M., Bachschmid, M. M., Barbosa, R. M., Belousov, V., Berndt, C., Bernlohr, D., Bertran, E., Bindoli, A., Bottari, S. P., Brito, P. M., Carrara, G., Casas, A. I., Chatzi, A., Chondrogianni, N., Conrad, M., Cooke, M. S., Costa, J. G., Cuadrado, A., Dang, P. M-C., De Smet, B., Butuner, B. D., Dias, I. H. K., Dunn, J. D., Edson, A. J., El Assar, M., El-Benna, J., Ferdinandy, P., Fernandes, A. S., Fladmark, K. E., Forstermann, U., Giniatullin, R., Giricz, Z., Gorbe, A., Griffiths, H., Hampl, V., Hanf, A., Herget, J., Hernansanz-Agustin, P., Hillion, M., Huang, J., Ilikay, S., Jansen-Durr, P., Jaquet, V., Joles, J. A., Kalyanaraman, B., Kaminskyy, D., Karbaschi, M., Kleanthous, M., Klotz, L-O., Korac, B., Sami Korkmaz, K., Koziel, R., Kracun, D., Krause, K-H., Kren, V., Krieg, T., Laranjinha, J., Lazou, A., Li, H., Martinez-Ruiz, A., Matsui, R., McBean, G. J., Meredith, S. P., Messens, J., Miguel, V., Mikhed, Y., Milisav, I., Milkovic, L., Miranda-Vizuete, A., Mojovic, M., Monsalve, M., Mouthuy, P-A., Mulvey, J., Munzel, T., Muzykantov, V., Nguyen, I. T. N., Oelze, M., Oliveira, N. G., Palmeira, C. M., Papaevgeniou, N., Pavicevic, A., Pedre, B., Peyrot, F., Phylactides, M., Pircalabioru, G. G., Pitt, A. R., Poulsen, H. E., Prieto, I., Pia Rigobello, M., Robledinos-Anton, N., Rodriguez-Manas, L., Rolo, A. P., Rousset, F., Ruskovska, T., Saraiva, N., Sasson, S., Schroeder, K., Semen, K., Seredenina, T., Shakirzyanova, A., Smith, G. L., Soldati, T., Sousa, B. C., Spickett, C. M., Stancic, A., Stasia, M. J., Steinbrenner, H., Stepanic, V., Steven, S., Tokatlidis, K., Tuncay, E., Turan, B., Ursini, F., Vacek, J., Vajnerova, O., Valentova, K., Van Breusegem, F., Varisli, L., Veal, E. A., Yalcin, A. S., Yelisyeyeva, O., Zarkovic, N., Zatloukalova, M., Zielonka, J., Touyz, R. M., Papapetropoulos, A., Grune, T., Lamas, S., Schmidt, H. H. H. W., Di Lisa, F. & Daiber, A., Oct 2017, In : Redox Biology. 13, p. 94-162 69 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage

Casas, A. I., Geuss, E., Kleikers, P. W. M., Mencl, S., Herrmann, A. M., Buendia, I., Egea, J., Meuth, S. G., Lopez, M. G., Kleinschnitz, C. & Schmidt, H. H. H. W., 14 Nov 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 46, p. 12315-12320 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

NOX4 is an early initiator of neuropathic pain

Geis, C., Geuss, E., Sommer, C., Schmidt, H. H. H. W. & Kleinschnitz, C., Feb 2017, In : Experimental Neurology. 288, p. 94-103 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

The oxidative stress theory of disease: levels of evidence and epistemological aspects

Ghezzi, P., Jaquet, V., Marcucci, F. & Schmidt, H. H. H. W., Jun 2017, In : British Journal of Pharmacology. 174, 12, p. 1784-1796 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

2016

Betere kwaliteit en vertaalbaarheid van pre-klinisch wetenschappelijk onderzoek noodzakelijk. Een pleidooi voor een expliciete wereldwijde doelstelling

Ritskes-Hoitinga, M. & Schmidt, H., 2016, In : Podium voor Bio-ethiek. 23, 3, p. 14-17

Research output: Contribution to journalArticleAcademicpeer-review

Clinical Relevance of Cyclic GMP Modulators: A Translational Success Story of Network Pharmacology

Oettrich, J. M., Dao, V. T., Frijhoff, J., Kleikers, P. W. M., Casas Guijarro, A., Hobbs, A. J. & Schmidt, H. H. H. W., Apr 2016, In : Clinical Pharmacology & Therapeutics. 99, 4, p. 360-362

Research output: Contribution to journalArticleAcademicpeer-review

Differential effects of NOX4 and NOX1 on immune cell-mediated inflammation in the aortic sinus of diabetic ApoE(-/-) mice

Di Marco, E., Gray, S. P., Chew, P., Kennedy, K., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K. A. M., 1 Aug 2016, In : Clinical Science. 130, 15, p. 1363-1374

Research output: Contribution to journalArticleAcademicpeer-review

Imaging Reactive Oxygen Species-Induced Modifications in Living Systems

Maulucci, G., Bacic, G., Bridal, L., Schmidt, H. H. H. W., Tavitian, B., Viel, T., Utsumi, H., Yalcin, A. S. & De Spirito, M., 1 Jun 2016, In : Antioxidants & Redox Signaling. 24, 16, p. 939-958

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage

Kleinschnitz, C., Mencl, S., Kleikers, P. W. M., Schuhmann, M. K., Lopez, M. G., Casas, A. I., Surun, B., Reif, A. & Schmidt, H. H. H. W., Sep 2016, In : Journal of Cerebral Blood Flow and Metabolism. 36, 9, p. 1508-1512

Research output: Contribution to journalArticleAcademicpeer-review

NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis

Di Marco, E., Gray, S. P., Kennedy, K., Szyndralewiez, C., Lyle, A. N., Lassegue, B., Griendling, K. K., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K. A. M., Aug 2016, In : Free Radical Biology and Medicine. 97, p. 556-567

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy

Jha, J. C., Thallas-Bonke, V., Banal, C., Gray, S. P., Chow, B. S. M., Ramm, G., Quaggin, S. E., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K. A., Feb 2016, In : Diabetologia. 59, 2, p. 379-389

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling

Gray, S. P., Di Marco, E., Kennedy, K., Chew, P., Okabe, J., El-Osta, A., Calkin, A. C., Biessen, E. A. L., Touyz, R. M., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K. A. M., Feb 2016, In : Arteriosclerosis Thrombosis and Vascular Biology. 36, 2, p. 295-307

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Response to I. Batinic-Haberle et al.

Schmidt, H. H. H. W., Stocker, R., Paulsen, G., Ghezzi, P., Riley, D., Daiber, A. & Cuadrado, A., 20 Mar 2016, In : Antioxidants & Redox Signaling. 24, 9, p. 525-526

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

2015

A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation

Kleikers, P. W. M., Hooijmans, C., Goeb, E., Langhauser, F., Rewell, S. S. J., Radermacher, K., Ritskes-Hoitinga, M., Howells, D. W., Kleinschnitz, C. & Schmidt, H. H. H. W., 27 Aug 2015, In : Scientific Reports. 5, 13428.

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Antioxidants in Translational Medicine

Schmidt, H. H. H. W., Stocker, R., Vollbracht, C., Paulsen, G., Riley, D., Daiber, A. & Cuadrado, A., 10 Nov 2015, In : Antioxidants & Redox Signaling. 23, 14, p. 1130-1143

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)

Clinical Relevance of Biomarkers of Oxidative Stress

Frijhoff, J., Winyard, P. G., Zarkovic, N., Davies, S. S., Stocker, R., Cheng, D., Knight, A. R., Taylor, E. L., Oettrich, J., Ruskovska, T., Gasparovic, A. C., Cuadrado, A., Weber, D., Poulsen, H. E., Grune, T., Schmidt, H. H. H. W. & Ghezzi, P., 10 Nov 2015, In : Antioxidants & Redox Signaling. 23, 14, p. 1144-1170

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

Altenhofer, S., Radermacher, K. A., Kleikers, P. W. M., Wingler, K. & Schmidt, H. H. H. W., 10 Aug 2015, In : Antioxidants & Redox Signaling. 23, 5, p. 406-427

Research output: Contribution to journalArticleAcademicpeer-review

43 Citations (Scopus)

Gender differences in the effect of cardiovascular drugs: a position document of the Working Group on Pharmacology and Drug Therapy of the ESC

Rosano, G. M. C., Lewis, B., Agewall, S., Wassmann, S., Vitale, C., Schmidt, H., Drexel, H., Patak, A., Torp-Pedersen, C., Kjeldsen, K. P. & Tamargo, J., 21 Oct 2015, In : European Heart Journal. 36, 40, p. 2677-80 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

NOX4 in Mitochondria: Yeast Two-Hybrid-Based Interaction with Complex I Without Relevance for Basal Reactive Oxygen Species?

Hirschhaeuser, C., Bornbaum, J., Reis, A., Boehme, S., Kaludercic, N., Menabo, R., Di Lisa, F., Boengler, K., Shah, A. M., Schulz, R. & Schmidt, H. H. H. W., 10 Nov 2015, In : Antioxidants & Redox Signaling. 23, 14, p. 1106-1112

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Pharmacology and Clinical Drug Candidates in Redox Medicine

Dao, V. T-V., Casas, A. I., Maghzal, G. J., Seredenina, T., Kaludercic, N., Robledinos-Anton, N., Di Lisa, F., Stocker, R., Ghezzi, P., Jaquet, V., Cuadrado, A. & Schmidt, H. H. H. W., 10 Nov 2015, In : Antioxidants & Redox Signaling. 23, 14, p. 1113-1129

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications

Casas, A. I., Dao, V. T-V., Daiber, A., Maghzal, G. J., Di Lisa, F., Kaludercic, N., Leach, S., Cuadrado, A., Jaquet, V., Seredenina, T., Krause, K. H., Lopez, M. G., Stocker, R., Ghezzi, P. & Schmidt, H. H. H. W., 1 Nov 2015, In : Antioxidants & Redox Signaling. 23, 14, p. 1171-1185

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)
2014

Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

Jha, J. C., Gray, S. P., Barit, D., Okabe, J., El-Osta, A., Namikoshi, T., Thallas-Bonke, V., Wingler, K., Szyndralewiez, C., Heitz, F., Touyz, R. M., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K. A., Jun 2014, In : Journal of the American Society of Nephrology. 25, 6, p. 1237-1254

Research output: Contribution to journalArticleAcademicpeer-review

78 Citations (Scopus)

NADPH Oxidase, NOX1, Mediates Vascular Injury in Ischemic Retinopathy

Wilkinson-Berka, J. L., Deliyanti, D., Rana, I., Miller, A. G., Agrotis, A., Armani, R., Szyndralewiez, C., Wingler, K., Touyz, R. M., Cooper, M. E., Jandeleit-Dahm, K. A. & Schmidt, H. H. H. W., 10 Jun 2014, In : Antioxidants & Redox Signaling. 20, 17, p. 2726-2740

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)

Nox-4 deletion reduces oxidative stress and injury by PKC-α-associated mechanisms in diabetic nephropathy

Thallas-Bonke, V., Jha, J. C., Gray, S. P., Barit, D., Haller, H., Schmidt, H. H. H. W., Coughlan, M. T., Cooper, M. E., Forbes, J. M. & Jandeleit-Dahm, K. A. M., 1 Nov 2014, In : Physiological Reports. 2, 11, e12192.

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune-inflammatory responses in diabetic Apoe (-/-) mice

Di Marco, E., Gray, S. P., Chew, P., Koulis, C., Ziegler, A., Szyndralewiez, C., Touyz, R. M., Schmidt, H. H. H. W., Cooper, M. E., Slattery, R. & Jandeleit-Dahm, K. A., Mar 2014, In : Diabetologia. 57, 3, p. 633-642

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)
2013

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus-Accelerated Atherosclerosis

Gray, S. P., Di Marco, E., Okabe, J., Szyndralewiez, C., Heitz, F., Montezano, A. C., de Haan, J. B., Koulis, C., El-Osta, A., Andrews, K. L., Chin-Dusting, J. P. F., Touyz, R. M., Wingler, K., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K. A., 7 May 2013, In : Circulation. 127, 18, p. 1888-+

Research output: Contribution to journalArticleAcademicpeer-review

134 Citations (Scopus)

Neuroprotection After Stroke by Targeting NOX4 As a Source of Oxidative Stress

Radermacher, K. A., Wingler, K., Langhauser, F., Altenhofer, S., Kleikers, P., Hermans, J. J. R., de Angelis, M. H., Kleinschnitz, C. & Schmidt, H. H. H. W., Apr 2013, In : Antioxidants & Redox Signaling. 18, 12, p. 1418-1427

Research output: Contribution to journalArticleAcademicpeer-review

2012

Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice

Weissmann, N., Sydykov, A., Kalwa, H., Storch, U., Fuchs, B., Mederos y Schnitzler, M., Brandes, R. P., Grimminger, F., Meissner, M., Freichel, M., Offermanns, S., Veit, F., Pak, O., Krause, K-H., Schermuly, R. T., Brewer, A. C., Schmidt, H. H. H. W., Seeger, W., Shah, A. M., Gudermann, T. & 2 others, Ghofrani, H. A. & Dietrich, A., Jan 2012, In : Nature Communications. 3, p. 649

Research output: Contribution to journalArticleAcademicpeer-review

NADPH oxidases as a source of oxidative stress and molecular target in ischemia/reperfusion injury

Kleikers, P. W. M., Wingler, K., Hermans, J. J. R., Diebold, I., Altenhofer, S., Radermacher, K. A., Janssen, B., Goerlach, A. & Schmidt, H. H. H. W., Dec 2012, In : Journal of Molecular Medicine. 90, 12, p. 1391-1406

Research output: Contribution to journalArticleAcademicpeer-review

The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

Altenhofer, S., Kleikers, P. W. M., Radermacher, K. A., Scheurer, P., Hermans, J. J. R., Schiffers, P., Ho, H., Wingler, K. & Schmidt, H. H. H. W., Jul 2012, In : Cellular and Molecular Life Sciences. 69, 14, p. 2327-2343

Research output: Contribution to journalArticleAcademicpeer-review

VAS2870 is a pan-NADPH oxidase inhibitor

Wingler, K., Altenhoefer, S. A., Kleikers, P. W. M., Radermacher, K. A., Kleinschnitz, C. & Schmidt, H. H. H. W., Sep 2012, In : Cellular and Molecular Life Sciences. 69, 18, p. 3159-3160

Research output: Contribution to journalArticleAcademicpeer-review

2011

Fluorescence Dequenching Makes Haem-Free Soluble Guanylate Cyclase Detectable in Living Cells

Hoffmann, L. S., Schmidt, P. M., Keim, Y., Hoffmann, C., Schmidt, H. H. H. W. & Stasch, J-P., 17 Aug 2011, In : PLOS ONE. 6, 8, p. 10

Research output: Contribution to journalArticleAcademicpeer-review

Measuring oxidative burden and predicting pharmacological response in coronary artery disease patients with a novel direct activator of haem-free/oxidiseds GC

Ahrens, I., Habersberger, J., Baumlin, N., Qian, H., Smith, B. K., Stasch, J-P., Bode, C., Schmidt, H. H. H. W. & Peter, K., Oct 2011, In : Atherosclerosis. 218, 2, p. 431-434

Research output: Contribution to journalArticleAcademicpeer-review

Modulating endothelial nitric oxide synthase: a new cardiovascular therapeutic strategy

Zhang, Y., Janssens, S. P., Wingler, K., Schmidt, H. H. H. W. & Moens, A. L., Sep 2011, In : American Journal of Physiology-heart and Circulatory Physiology. 301, 3, p. H634-H646

Research output: Contribution to journalArticleAcademicpeer-review

NOX1, 2, 4, 5: counting out oxidative stress

Wingler, K., Hermans, J. J. R., Schiffers, P., Moens, A. L., Paul, M. & Schmidt, H. H. H. W., Oct 2011, In : British Journal of Pharmacology. 164, 3, p. 866-883

Research output: Contribution to journalArticleAcademicpeer-review

Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders

Gielis, J. F., Lin, J. Y., Wingler, K., Van Schil, P. E. Y., Schmidt, H. H. & Moens, A. L., 1 Apr 2011, In : Free Radical Biology and Medicine. 50, 7, p. 765-776

Research output: Contribution to journalArticleAcademicpeer-review

2010

Comparative pharmacology of chemically distinct NADPH oxidase inhibitors

Wind, S., Beuerlein, K., Eucker, T., Mueller, H., Scheurer, P., Armitage, M. E., Ho, H., Schmidt, H. H. H. W. & Wingler, K., Oct 2010, In : British Journal of Pharmacology. 161, 4, p. 885-898

Research output: Contribution to journalArticleAcademicpeer-review