Receptor guanylyl cyclase (RGC) family in GtoPdb v.2021.3

A. Beuve*, Peter Brouckaert, J.C. Burnett, Andreas Friebe, John Garthwaite, Adrian J Hobbs, Doris Koesling, Michaela Kuhn, L.R. Potter, Michael Russwurm, Harald Schmidt, Johannes-Peter Stasch, Scott A. Waldman

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review


The mammalian genome encodes seven guanylyl cyclases, GC-A to GC-G, that are homodimeric transmembrane receptors activated by a diverse range of endogenous ligands. These enzymes convert guanosine-5'-triphosphate to the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP). GC-A, GC-B and GC-C are expressed predominantly in the cardiovascular system, skeletal system and intestinal epithelium, respectively. GC-D and GC-G are found in the olfactory neuropepithelium and Grueneberg ganglion of rodents, respectively. GC-E and GC-F are expressed in retinal photoreceptors.
Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalIUPHAR/BPS Guide to Pharmacology CITE
Publication statusPublished - 2021

Cite this