TY - JOUR
T1 - Network pharmacology
T2 - curing causal mechanisms instead of treating symptoms
AU - Nogales, Cristian
AU - Mamdouh, Zeinab M
AU - List, Markus
AU - Kiel, Christina
AU - Casas, Ana I
AU - Schmidt, Harald H H W
N1 - Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2022/2
Y1 - 2022/2
N2 - For complex diseases, most drugs are highly ineffective, and the success rate of drug discovery is in constant decline. While low quality, reproducibility issues, and translational irrelevance of most basic and preclinical research have contributed to this, the current organ-centricity of medicine and the 'one disease-one target-one drug' dogma obstruct innovation in the most profound manner. Systems and network medicine and their therapeutic arm, network pharmacology, revolutionize how we define, diagnose, treat, and, ideally, cure diseases. Descriptive disease phenotypes are replaced by endotypes defined by causal, multitarget signaling modules that also explain respective comorbidities. Precise and effective therapeutic intervention is achieved by synergistic multicompound network pharmacology and drug repurposing, obviating the need for drug discovery and speeding up clinical translation.
AB - For complex diseases, most drugs are highly ineffective, and the success rate of drug discovery is in constant decline. While low quality, reproducibility issues, and translational irrelevance of most basic and preclinical research have contributed to this, the current organ-centricity of medicine and the 'one disease-one target-one drug' dogma obstruct innovation in the most profound manner. Systems and network medicine and their therapeutic arm, network pharmacology, revolutionize how we define, diagnose, treat, and, ideally, cure diseases. Descriptive disease phenotypes are replaced by endotypes defined by causal, multitarget signaling modules that also explain respective comorbidities. Precise and effective therapeutic intervention is achieved by synergistic multicompound network pharmacology and drug repurposing, obviating the need for drug discovery and speeding up clinical translation.
KW - NADPH OXIDASE
KW - PREDICTIVE BIOMARKERS
KW - CLINICAL-RELEVANCE
KW - DRUG DISCOVERY
KW - ANIMAL-MODELS
KW - INHIBITION
KW - CANCER
KW - COMBINATION
KW - BRAIN
KW - ATHEROPROTECTION
U2 - 10.1016/j.tips.2021.11.004
DO - 10.1016/j.tips.2021.11.004
M3 - (Systematic) Review article
C2 - 34895945
SN - 0165-6147
VL - 43
SP - 136
EP - 150
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 2
ER -