From single drug targets to synergistic network pharmacology in ischemic stroke

Ana I. Casas; Ahmed A. Hassan; Simon J. Larsen; Vanessa Gomez-Rangel; Mahmoud Elbatreek; Pamela W. M. Kleikers; Emre Guney; Javier Egea; Manuela G. Lopez; Jan Baumbach; Harald H. H. W. Schmidt

doi:10.1073/pnas.1820799116

From single drug targets to synergistic network pharmacology in ischemic stroke

Ana I. Casas^*, Ahmed A. Hassan, Simon J. Larsen, Vanessa Gomez-Rangel, Mahmoud Elbatreek, Pamela W. M. Kleikers, Emre Guney, Javier Egea, Manuela G. Lopez, Jan Baumbach, Harald H. H. W. Schmidt^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Original language	English
Pages (from-to)	7129-7136
Number of pages	8
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	116
Issue number	14
DOIs	https://doi.org/10.1073/pnas.1820799116
Publication status	Published - 2 Apr 2019

Keywords

network pharmacology
stroke
NOX4
network analysis
HYDROGEN-PEROXIDE
NITRIC-OXIDE
OFF-TARGET
OXYGEN
SIMILARITY
PREDICTION
EXPRESSION
BIOLOGY
BRAIN
CELLS

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Casas, A. I., Hassan, A. A., Larsen, S. J., Gomez-Rangel, V., Elbatreek, M., Kleikers, P. W. M., Guney, E., Egea, J., Lopez, M. G., Baumbach, J., & Schmidt, H. H. H. W. (2019). From single drug targets to synergistic network pharmacology in ischemic stroke. Proceedings of the National Academy of Sciences of the United States of America, 116(14), 7129-7136. https://doi.org/10.1073/pnas.1820799116

Casas, Ana I. ; Hassan, Ahmed A. ; Larsen, Simon J. ; Gomez-Rangel, Vanessa ; Elbatreek, Mahmoud ; Kleikers, Pamela W. M. ; Guney, Emre ; Egea, Javier ; Lopez, Manuela G. ; Baumbach, Jan ; Schmidt, Harald H. H. W. / From single drug targets to synergistic network pharmacology in ischemic stroke. In: Proceedings of the National Academy of Sciences of the United States of America. 2019 ; Vol. 116, No. 14. pp. 7129-7136.

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title = "From single drug targets to synergistic network pharmacology in ischemic stroke",

keywords = "network pharmacology, stroke, NOX4, network analysis, HYDROGEN-PEROXIDE, NITRIC-OXIDE, OFF-TARGET, OXYGEN, SIMILARITY, PREDICTION, EXPRESSION, BIOLOGY, BRAIN, CELLS",

author = "Casas, {Ana I.} and Hassan, {Ahmed A.} and Larsen, {Simon J.} and Vanessa Gomez-Rangel and Mahmoud Elbatreek and Kleikers, {Pamela W. M.} and Emre Guney and Javier Egea and Lopez, {Manuela G.} and Jan Baumbach and Schmidt, {Harald H. H. W.}",

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doi = "10.1073/pnas.1820799116",

language = "English",

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Casas, AI , Hassan, AA, Larsen, SJ, Gomez-Rangel, V, Elbatreek, M, Kleikers, PWM, Guney, E, Egea, J, Lopez, MG, Baumbach, J & Schmidt, HHHW 2019, 'From single drug targets to synergistic network pharmacology in ischemic stroke', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 14, pp. 7129-7136. https://doi.org/10.1073/pnas.1820799116

From single drug targets to synergistic network pharmacology in ischemic stroke. / Casas, Ana I.; Hassan, Ahmed A.; Larsen, Simon J.; Gomez-Rangel, Vanessa; Elbatreek, Mahmoud; Kleikers, Pamela W. M.; Guney, Emre; Egea, Javier; Lopez, Manuela G.; Baumbach, Jan; Schmidt, Harald H. H. W.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 14, 02.04.2019, p. 7129-7136.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - From single drug targets to synergistic network pharmacology in ischemic stroke

AU - Casas, Ana I.

AU - Hassan, Ahmed A.

AU - Larsen, Simon J.

AU - Gomez-Rangel, Vanessa

AU - Elbatreek, Mahmoud

AU - Kleikers, Pamela W. M.

AU - Guney, Emre

AU - Egea, Javier

AU - Lopez, Manuela G.

AU - Baumbach, Jan

AU - Schmidt, Harald H. H. W.

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KW - stroke

KW - NOX4

KW - network analysis

KW - HYDROGEN-PEROXIDE

KW - NITRIC-OXIDE

KW - OFF-TARGET

KW - OXYGEN

KW - SIMILARITY

KW - PREDICTION

KW - EXPRESSION

KW - BIOLOGY

KW - BRAIN

KW - CELLS

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DO - 10.1073/pnas.1820799116

M3 - Article

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VL - 116

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EP - 7136

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

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