NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage

Ana I. Casas, Eva Geuss, Pamela W. M. Kleikers, Stine Mencl, Alexander M. Herrmann, Izaskun Buendia, Javier Egea, Sven G. Meuth, Manuela G. Lopez, Christoph Kleinschnitz, Harald H. H. W. Schmidt

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)12315-12320
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume114
Issue number46
DOIs
Publication statusPublished - 14 Nov 2017

Keywords

  • NOX4
  • stroke
  • BBB
  • neurotoxicity
  • endothelium
  • NADPH OXIDASE
  • OXIDATIVE STRESS
  • ISCHEMIA/REPERFUSION INJURY
  • THERAPEUTIC TARGETS
  • UP-REGULATION
  • NEUROPROTECTION
  • ANGIOGENESIS
  • INHIBITION
  • STROKE

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