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Aaron Isaacs

 https://orcid.org/0000-0001-5037-4834
20102024

Research activity per year

  • 123 Article
  • 5 Comment/Letter to the editor
  • 3 Erratum / corrigendum / retractions
  • 1 (Systematic) Review article

Search results

  • 2024

    Circulating BMP10 Levels Associate With Late Postoperative Atrial Fibrillation and Left Atrial Endomysial Fibrosis

    Winters, J., Kawczynski, M. J., Gilbers, M. D., Isaacs, A., Zeemering, S., Bidar, E., Maesen, B., Rienstra, M., van Gelder, I., Verheule, S., Maessen, J. G. & Schotten, U., 1 Jan 2024, (E-pub ahead of print) In: JACC: Clinical Electrophysiology.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Clinical Predictors of Device-Detected Atrial Fibrillation During 2.5 Years After Cardiac Surgery: Prospective RACE V Cohort

    Gilbers, M. D., Kawczynski, M. J., Bidar, E., Maesen, B., Isaacs, A., Winters, J., Linz, D., Rienstra, M., van Gelder, I., Maessen, J. G. & Schotten, U., 2024, (E-pub ahead of print) In: JACC: Clinical Electrophysiology. 15 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naïve T cells

    Christ, A., Maas, S. L., Jin, H., Lu, C., Legein, B., Wijnands, E., Temmerman, L., Otten, J., Isaacs, A., Zenke, M., Stoll, M., Biessen, E. A. L. & van der Vorst, E. P. C., 5 Jan 2024, In: Free Radical Biology and Medicine. 210, p. 406-415 10 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
  • 2023

    Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

    Young, W. J., Haessler, J., Benjamins, J. W., Repetto, L., Yao, J., Isaacs, A., Harper, A. R., Ramirez, J., Garnier, S., van Duijvenboden, S., Baldassari, A. R., Concas, M. P., Duong, T. V., Foco, L., Isaksen, J. L., Mei, H., Noordam, R., Nursyifa, C., Richmond, A., Santolalla, M. L., & 33 othersSitlani, C. M., Soroush, N., Thériault, S., Trompet, S., Aeschbacher, S., Ahmadizar, F., Alonso, A., Brody, J. A., Campbell, A., Correa, A., Darbar, D., De Luca, A., Deleuze, J. F., Ellervik, C., Fuchsberger, C., Goel, A., Grace, C., Guo, X., Hansen, T., Heckbert, S. R., Jackson, R. D., Kors, J. A., Lima-Costa, M. F., Linneberg, A., Macfarlane, P. W., Morrison, A. C., Navarro, P., Porteous, D. J., Schotten, U., Stoll, M., Tereshchenko, L. G., Munroe, P. B. & Et al., 1 Dec 2023, In: Nature Communications. 14, 1, 16 p., 1411.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Genetic insights into resting heart rate and its role in cardiovascular disease

    van de Vegte, Y. J., Eppinga, R. N., van der Ende, M. Y., Hagemeijer, Y. P., Mahendran, Y., Salfati, E., Smith, A. V., Tan, V. Y., Arking, D. E., Ntalla, I., Appel, E. V., Schurmann, C., Brody, J. A., Rueedi, R., Polasek, O., Sveinbjornsson, G., Lecoeur, C., Ladenvall, C., Zhao, J. H., Isaacs, A., & 32 othersWang, L., Luan, J., Hwang, S. J., Mononen, N., Auro, K., Jackson, A. U., Bielak, L. F., Zeng, L., Shah, N., Nethander, M., Campbell, A., Rankinen, T., Pechlivanis, S., Qi, L., Zhao, W., Rizzi, F., Tanaka, T., Robino, A., Cocca, M., Lange, L., Müller-Nurasyid, M., Roselli, C., Zhang, W., Kleber, M. E., Guo, X., Lin, H. J., Pavani, F., Galesloot, T. E., Noordam, R., Milaneschi, Y., Van der Harst, P. & The DCCT/EDIC Research Group, 2 Aug 2023, In: Nature Communications. 14, 1, 21 p., 4646.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

    Lagou, V., Jiang, L., Ulrich, A., Zudina, L., González, K. S. G., Balkhiyarova, Z., Faggian, A., Maina, J. G., Chen, S., Todorov, P. V., Sharapov, S., David, A., Marullo, L., Mägi, R., Rujan, R. M., Ahlqvist, E., Thorleifsson, G., Gao, H., ?vangelou, ., Benyamin, B., & 35 othersScott, R. A., Isaacs, A., Zhao, J. H., Willems, S. M., Johnson, T., Gieger, C., Grallert, H., Meisinger, C., Müller-Nurasyid, M., Strawbridge, R. J., Goel, A., Rybin, D., Albrecht, E., Jackson, A. U., Stringham, H. M., Corrêa, I. R., Farber-Eger, E., Steinthorsdottir, V., Uitterlinden, A. G., Munroe, P. B., Brown, M. J., Schmidberger, J., Holmen, O., Thorand, B., Hveem, K., Wilsgaard, T., Mohlke, K. L., Wang, Z., den Hoed, M., Shmeliov, A., Kaakinen, M., Jones, B., Prokopenko, I., Et al. & Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), Sept 2023, In: Nature Genetics. 55, 9, p. 1448-1461 14 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Heart Failure, Female Sex, and Atrial Fibrillation Are the Main Drivers of Human Atrial Cardiomyopathy: Results From the CATCH ME Consortium

    Winters, J., Isaacs, A., Zeemering, S., Kawczynski, M., Maesen, B., Maessen, J., Bidar, E., Boukens, B., Hermans, B., van Hunnik, A., Casadei, B., Fabritz, L., Chua, W., Sommerfeld, L., Guasch, E., Mont, L., Batlle, M., Hatem, S., Kirchhof, P., Wakili, R., & 5 othersSinner, M., Stoll, M., Goette, A., Verheule, S. & Schotten, U., 21 Nov 2023, In: Journal of the American Heart Association. 12, 22, 15 p., e031220.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    1 Downloads (Pure)

  • Standing genetic variation affects phenotypic heterogeneity in an SCN5A-mutation founder population with excess sudden cardiac death

    Isaacs, A., Barysenka, A., ter Bekke, R. M. A., den Enden, A. T. J. M. H., van den Wijngaard, A., Volders, P. G. A. & Stoll, M., 1 May 2023, In: Heart Rhythm. 20, 5, p. 720-727 8 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • 2022

    Atrial fibrillation in the presence and absence of heart failure enhances expression of genes involved in cardiomyocyte structure, conduction properties, fibrosis, inflammation, and endothelial dysfunction

    Zeemering, S., Isaacs, A., Winters, J., Maesen, B., Bidar, E., Dimopoulou, C., Guasch, E., Batlle, M., Haase, D., Hatem, S. N., Kara, M., Kääb, S., Mont, L., Sinner, M. F., Wakili, R., Maessen, J., Crijns, H. J. G. M., Fabritz, L., Kirchhof, P., Stoll, M., & 1 othersSchotten, U., Dec 2022, In: Heart Rhythm. 19, 12, p. 2115-2124 10 p.

    Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

    Open Access

  • Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

    Young, W. J., Lahrouchi, N., Isaacs, A., Duong, T., Foco, L., Ahmed, F., Brody, J. A., Salman, R., Noordam, R., Benjamins, J-W., Haessler, J., Lyytikäinen, L-P., Repetto, L., Concas, M. P., van den Berg, M. E., Weiss, S., Baldassari, A. R., Bartz, T. M., Cook, J. P., Evans, D. S., & 146 othersFreudling, R., Hines, O., Isaksen, J. L., Lin, H., Mei, H., Moscati, A., Müller-Nurasyid, M., Nursyifa, C., Qian, Y., Richmond, A., Roselli, C., Ryan, K. A., Tarazona-Santos, E., Thériault, S., van Duijvenboden, S., Warren, H. R., Yao, J., Raza, D., Aeschbacher, S., Ahlberg, G., Alonso, A., Andreasen, L., Bis, J. C., Boerwinkle, E., Campbell, A., Catamo, E., Cocca, M., Cutler, M. J., Darbar, D., De Grandi, A., De Luca, A., Ding, J., Ellervik, C., Ellinor, P. T., Felix, S. B., Froguel, P., Fuchsberger, C., Gögele, M., Graff, C., Graff, M., Guo, X., Hansen, T., Heckbert, S. R., Huang, P. L., Huikuri, H. V., Hutri-Kähönen, N., Ikram, M. A., Jackson, R. D., Junttila, J., Kavousi, M., Kors, J. A., Leal, T. P., Lemaitre, R. N., Lin, H. J., Lind, L., Linneberg, A., Liu, S., MacFarlane, P. W., Mangino, M., Meitinger, T., Mezzavilla, M., Mishra, P. P., Mitchell, R. N., Mononen, N., Montasser, M. E., Morrison, A. C., Nauck, M., Nauffal, V., Navarro, P., Nikus, K., Pare, G., Patton, K. K., Pelliccione, G., Pittman, A., Porteous, D. J., Pramstaller, P. P., Preuss, M. H., Raitakari, O. T., Reiner, A. P., Ribeiro, A. L. P., Rice, K. M., Risch, L., Schlessinger, D., Schotten, U., Schurmann, C., Shen, X., Shoemaker, M. B., Sinagra, G., Sinner, M. F., Soliman, E. Z., Stoll, M., Strauch, K., Tarasov, K., Taylor, K. D., Tinker, A., Trompet, S., Uitterlinden, A., Völker, U., Völzke, H., Waldenberger, M., Weng, L-C., Whitsel, E. A., Wilson, J. G., Avery, C. L., Conen, D., Correa, A., Cucca, F., Dörr, M., Gharib, S. A., Girotto, G., Grarup, N., Hayward, C., Jamshidi, Y., Järvelin, M-R., Jukema, J. W., Kääb, S., Kähönen, M., Kanters, J. K., Kooperberg, C., Lehtimäki, T., Lima-Costa, M. F., Liu, Y., Loos, R. J. F., Lubitz, S. A., Mook-Kanamori, D. O., Morris, A. P., O'Connell, J. R., Olesen, M. S., Orini, M., Padmanabhan, S., Pattaro, C., Peters, A., Psaty, B. M., Rotter, J. I., Stricker, B., van der Harst, P., van Duijn, C. M., Verweij, N., Wilson, J. F., Arking, D. E., Ramirez, J., Lambiase, P. D., Sotoodehnia, N., Mifsud, B., Newton-Cheh, C. & Munroe, P. B., 1 Sept 2022, In: Nature Communications. 13, 1, 18 p., 5144.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Low Density Lipoprotein Exposure of Plasmacytoid Dendritic Cells Blunts Toll-like Receptor 7/9 Signaling via NUR77

    Christ, A., Goossens, P. G., Wijnands, E., Jin, H., Legein, B., Oth, T., Isaacs, A., Stoll, M., Vanderlocht, J., Lutgens, E., Daemen, M. J. A. P., Zenke, M. & Biessen, E. A. L., 17 May 2022, In: Biomedicines. 10, 5, 17 p., 1152.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • New-onset perioperative atrial fibrillation in cardiac surgery patients: transient trouble or persistent problem?-Authors' reply

    Kawczynski, M. J., Zeemering, S., Gilbers, M., Isaacs, A., Verheule, S., Zink, M. D., Maesen, B., Bramer, S., Van Gelder, I. C., Crijns, H. J. G. M., Schotten, U. & Bidar, E., 1 Jun 2022, In: EP Europace. 24, 6, p. 1037-1038 1 p., 317.

    Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

    Open Access

  • Preoperative P-wave parameters and risk of atrial fibrillation after cardiac surgery: a meta-analysis of 20,201 patients

    Kawczynski, M. J., Van De Walle, S., Maesen, B., Isaacs, A., Zeemering, S., Hermans, B., Vernooy, K., Maessen, J. G., Schotten, U. & Bidar, E., 1 Oct 2022, In: Interactive Cardiovascular and Thoracic Surgery. 35, 4, 12 p., ivac220.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Rationale and Design of the ISOLATION Study: A Multicenter Prospective Cohort Study Identifying Predictors for Successful Atrial Fibrillation Ablation in an Integrated Clinical Care and Research Pathway

    Verhaert, D. V. M., Linz, D., Chaldoupi, S. M., Westra, S. W., den Uijl, D. W., Philippens, S., Kerperien, M., Habibi, Z., Vorstermans, B., ter Bekke, R. M. A., Beukema, R. J., Evertz, R., Hemels, M. E. W., Luermans, J. G. L. M., Manusama, R., Lankveld, T. A. R., van der Heijden, C. A. J., Bidar, E., Hermans, B. M., Zeemering, S., & 15 othersBijvoet, G. P., Habets, J., Holtackers, R. J., Mihl, C., Nijveldt, R., van Empel, V. P. M., Knackstedt, C., Simons, S. O., Buhre, W. F. F. A., Tijssen, J. G. P., Isaacs, A., Crijns, H. J. G. M., Maesen, B., Vernooy, K. & Schotten, U., 30 Jun 2022, In: Frontiers in Cardiovascular Medicine. 9, 10 p., 879139.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
  • 2021

    Clinical and electrophysiological predictors of device-detected new-onset atrial fibrillation during 3 years after cardiac surgery

    Bidar, E., Zeemering, S., Gilbers, M., Isaacs, A., Verheule, S., Zink, M. D., Maesen, B., Bramer, S., Kawczynski, M., Van Gelder, I. C., Crijns, H. J. G. M., Maessen, J. G. & Schotten, U., 1 Dec 2021, In: EP Europace. 23, 12, p. 1922-1930 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Considerations for the Assessment of Substrates, Genetics and Risk Factors in Patients with Atrial Fibrillation

    Linz, D., Verheule, S., Isaacs, A. & Schotten, U., 1 Sept 2021, In: Arrhythmia & Electrophysiology Review. 10, 3, p. 132-139 8 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Dynamic risk assessment to improve quality of care in patients with atrial fibrillation: the 7th AFNET/EHRA Consensus Conference

    Fabritz, L., Crijns, H. J. G. M., Guasch, E., Goette, A., Häusler, K. G., Kotecha, D., Lewalter, T., Meyer, C., Potpara, T. S., Rienstra, M., Schnabel, R. B., Willems, S., Breithardt, G., Camm, A. J., Chan, A., Chua, W., de Melis, M., Dimopoulou, C., Dobrev, D., Easter, C., & 38 othersEckardt, L., Haase, D., Hatem, S., Healey, J. S., Heijman, J., Hohnloser, S. H., Huebner, T., Ilyas, B. S., Isaacs, A., Kutschka, I., Leclercq, C., Lip, G. Y. H., Marinelli, E. A., Merino, J. L., Mont, L., Nabauer, M., Oldgren, J., Pürerfellner, H., Ravens, U., Savelieva, I., Sinner, M. F., Sitch, A., Smolnik, R., Steffel, J., Stein, K., Stoll, M., Svennberg, E., Thomas, D., Van Gelder, I. C., Vardar, B., Wakili, R., Wieloch, M., Zeemering, S., Ziegler, P. D., Heidbuchel, H., Hindricks, G., Schotten, U. & Kirchhof, P., Mar 2021, In: EP Europace. 23, 3, p. 329-344 16 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Leukocyte gene expression in post-thrombotic syndrome

    Iding, A. F. J., Witten, A., Isaacs, A., Castoldi, E., ten Cate, H., Stoll, M. & ten Cate-Hoek, A. J., Jun 2021, In: Thrombosis Research. 202, p. 40-42 3 p.

    Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

    Open Access
    File
    99 Downloads (Pure)

  • Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

    Lagou, V., Mägi, R., Hottenga, J. J., Grallert, H., Perry, J. R. B., Bouatia-Naji, N., Marullo, L., Rybin, D., Jansen, R., Min, J. L., Dimas, A. S., Ulrich, A., Zudina, L., Gådin, J. R., Jiang, L., Faggian, A., Bonnefond, A., Fadista, J., Stathopoulou, M. G., Isaacs, A., & 32 othersWillems, S. M., Navarro, P., Tanaka, T., Jackson, A. U., Montasser, M. E., O'Connell, J. R., Bielak, L. F., Webster, R. J., Saxena, R., Stafford, J. M., Pourcain, B. S., Timpson, N. J., Salo, P., Shin, S-Y., Amin, N., Smith, A. V., Li, G., Verweij, N., Goel, A., Ford, I., Johnson, P. C. D., Johnson, T., Kapur, K., Thorleifsson, G., Strawbridge, R. J., Rasmussen-Torvik, L. J., Esko, T., Mihailov, E., Fall, T., Wolffenbuttel, B. H. R., Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) & Prokopenko, I., 8 Feb 2021, In: Nature Communications. 12, 1, 2 p., 995.

    Research output: Contribution to journal › Erratum / corrigendum / retractions › Academic

    Open Access

  • Reappraisal of Atrial fibrillation: interaction between hyperCoagulability, Electrical remodelling and Vascular destabilisation in the progression of AF (RACE V) Tissue Bank Project: study design

    Gilbers, M. D., Bidar, E., Maesen, B., Zeemering, S., Isaacs, A., Crijns, H., van Gelder, I., Rienstra, M., Verheule, S., Maessen, J., Stoll, M. & Schotten, U., May 2021, In: Netherlands Heart Journal. 29, 5, p. 280-287 8 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

    Lagou, V., Mägi, R., Hottenga, J. J., Grallert, H., Perry, J. R. B., Bouatia-Naji, N., Marullo, L., Rybin, D., Jansen, R., Min, J. L., Dimas, A. S., Ulrich, A., Zudina, L., Gådin, J. R., Jiang, L., Faggian, A., Bonnefond, A., Fadista, J., Stathopoulou, M. G., Isaacs, A., & 32 othersWillems, S. M., Navarro, P., Tanaka, T., Jackson, A. U., Montasser, M. E., O'Connell, J. R., Bielak, L. F., Webster, R. J., Saxena, R., Stafford, J. M., Pourcain, B. S., Timpson, N. J., Salo, P., Shin, S-Y., Amin, N., Smith, A. V., Li, G., Verweij, N., Goel, A., Ford, I., Johnson, P. C. D., Johnson, T., Kapur, K., Thorleifsson, G., Strawbridge, R. J., Rasmussen-Torvik, L. J., Esko, T., Mihailov, E., Fall, T., Wolffenbuttel, B. H. R., Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) & Morris, A. P., 5 Jan 2021, In: Nature Communications. 12, 1, 18 p., 24.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
  • 2020

    A characterization of cis- and trans-heritability of RNA-Seq-based gene expression

    Ouwens, K. G., Jansen, R., Nivard, M. G., van Dongen, J., Frieser, M. J., Hottenga, J-J., Arindrarto, W., Claringbould, A., van Iterson, M., Mei, H., Franke, L., Heijmans, B. T., 't Hoen, P. A. C., van Meurs, J., Brooks, A., Penninx, B. W. J. H., Boomsma, D., Isaacs, A., Pool, R., Hottenga, J. J., & 31 othersvan Greevenbroek, M. M. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Wijmenga, C., Zhernakova, S., Tigchelaar, E. F., Slagboom, P. E., Beekman, M., Deelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., van Galen, M., Bot, J., Zhernakova, D., van't Hof, P., Deelen, P., Nooren, I., Moed, M. & BIOS Consortium, Feb 2020, In: European Journal of Human Genetics. 28, 2, p. 253-263 11 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
    File
    58 Downloads (Pure)

  • Genetic Determinants of Electrocardiographic P-Wave Duration and Relation to Atrial Fibrillation

    Weng, L-C., Hall, A. W., Choi, S. H., Jurgens, S. J., Haessler, J., Bihlmeyer, N. A., Grarup, N., Lin, H., Teumer, A., Li-Gao, R., Yao, J., Guo, X., Brody, J. A., Mueller-Nurasyid, M., Schramm, K., Verweij, N., van den Berg, M. E., van Setten, J., Isaacs, A., Ramirez, J., & 40 othersWarren, H. R., Padmanabhan, S., Kors, J. A., de Boer, R. A., van der Meer, P., Sinner, M. F., Waldenberger, M., Psaty, B. M., Taylor, K. D., Voelker, U., Kanters, J. K., Li, M., Alonso, A., Perez, M. V., Vaartjes, I., Bots, M. L., Huang, P. L., Heckbert, S. R., Lin, H. J., Kornej, J., Munroe, P. B., van Duijn, C. M., Asselbergs, F. W., Stricker, B. H., van der Harst, P., Kaeaeb, S., Peters, A., Sotoodehnia, N., Rotter, J. I., Mook-Kanamori, D. O., Doerr, M., Felix, S. B., Linneberg, A., Hansen, T., Arking, D. E., Kooperberg, C., Benjamin, E. J., Lunetta, K. L., Ellinor, P. T. & Lubitz, S. A., Oct 2020, In: Circulation: Genomic and Precision Medicine. 13, 5, p. 387-395 9 p., 002874.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Genome-wide analysis of constitutional DNA methylation in familial melanoma

    Salgado, C., Gruis, N., Heijmans, B. T., Oosting, J., van Doorn, R., BIOS Consortium & Isaacs, A., 6 Mar 2020, In: Clinical epigenetics. 12, 1, 7 p., 43.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • JavaCyte, a novel open-source tool for automated quantification of key hallmarks of cardiac structural remodeling

    Winters, J., von Braunmuhl, M. E., Zeemering, S., Gilbers, M., Ten Brink, T., Scaf, B., Guasch, E., Mont, L., Batlle, M., Sinner, M., Hatem, S., Mansour, M. K., Fabritz, L., Sommerfeld, L. C., Kirchhof, P., Isaacs, A., Stoll, M., Schotten, U. & Verheule, S., 18 Nov 2020, In: Scientific Reports. 10, 1, 15 p., 20074.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

    Ntalla, I., Weng, L-C., Cartwright, J. H., Hall, A. W., Sveinbjornsson, G., Tucker, N. R., Choi, S. H., Chaffin, M. D., Roselli, C., Barnes, M. R., Mifsud, B., Warren, H. R., Hayward, C., Marten, J., Cranley, J. J., Concas, M. P., Gasparini, P., Boutin, T., Kolcic, I., Polasek, O., & 167 othersRudan, I., Araujo, N. M., Lima-Costa, M. F., Ribeiro, A. L. P., Souza, R. P., Tarazona-Santos, E., Giedraitis, V., Ingelsson, E., Mahajan, A., Morris, A. P., Del Greco, F. M., Foco, L., Gogele, M., Hicks, A. A., Cook, J. P., Lind, L., Lindgren, C. M., Sundstrom, J., Nelson, C. P., Riaz, M. B., Samani, N. J., Sinagra, G., Ulivi, S., Kahonen, M., Mishra, P. P., Mononen, N., Nikus, K., Caulfield, M. J., Dominiczak, A., Padmanabhan, S., Montasser, M. E., O'Connell, J. R., Ryan, K., Shuldiner, A. R., Aeschbacher, S., Conen, D., Risch, L., Theriault, S., Hutri-Kahonen, N., Lehtimaki, T., Lyytikainen, L-P., Raitakari, O. T., Barnes, C. L. K., Campbell, H., Joshi, P. K., Wilson, J. F., Isaacs, A., Kors, J. A., van Duijn, C. M., Huang, P. L., Gudnason, V., Harris, T. B., Launer, L. J., Smith, A., Bottinger, E. P., Loos, R. J. F., Nadkarni, G. N., Preuss, M. H., Correa, A., Mei, H., Wilson, J., Meitinger, T., Mueller-Nurasyid, M., Peters, A., Waldenberger, M., Mangino, M., Spector, T. D., Rienstra, M., van de Vegte, Y. J., van der Harst, P., Verweij, N., Kaab, S., Schramm, K., Sinner, M. F., Strauch, K., Cutler, M. J., Fatkin, D., London, B., Olesen, M., Roden, D. M., Shoemaker, M. B., Smith, J. G., Biggs, M. L., Bis, J. C., Brody, J. A., Psaty, B. M., Rice, K., Sotoodehnia, N., De Grandi, A., Fuchsberger, C., Pattaro, C., Pramstaller, P. P., Ford, I., Jukema, J. W., Macfarlane, P. W., Trompet, S., Doerr, M., Felix, S. B., Voelker, U., Weiss, S., Havulinna, A. S., Jula, A., Saaksjarvi, K., Salomaa, V., Guo, X., Heckbert, S. R., Lin, H. J., Rotter, J., Taylor, K. D., Yao, J., de Mutsert, R., Maan, A. C., Mook-Kanamori, D. O., Noordam, R., Cucca, F., Ding, J., Lakatta, E. G., Qian, Y., Tarasov, K., Levy, D., Lin, H., Newton-Cheh, C. H., Lunetta, K. L., Murray, A. D., Porteous, D. J., Smith, B. H., Stricker, B. H., Uitterlinden, A., van den Berg, M. E., Haessler, J., Jackson, R. D., Kooperberg, C., Peters, U., Reiner, A. P., Whitsel, E. A., Alonso, A., Arking, D. E., Boerwinkle, E., Ehret, G. B., Soliman, E. Z., Avery, C. L., Gogarten, S. M., Kerr, K. F., Laurie, C. C., Seyerle, A. A., Stilp, A., Assa, S., Said, M. A., van der Ende, M. Y., Lambiase, P. D., Orini, M., Ramirez, J., Van Duijvenboden, S., Arnar, D. O., Gudbjartsson, D. F., Holm, H., Sulem, P., Thorleifsson, G., Thorolfsdottir, R. B., Thorsteinsdottir, U., Benjamin, E. J., Tinker, A., Stefansson, K., Ellinor, P. T., Jamshidi, Y., Lubitz, S. A. & Munroe, P. B., 21 May 2020, In: Nature Communications. 11, 1, 12 p., 2542.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Non-alcoholic fatty liver disease and cardiovascular disease: assessing the evidence for causality

    Brouwers, M. C. G. J., Simons, N., Stehouwer, C. D. A. & Isaacs, A., Feb 2020, In: Diabetologia. 63, 2, p. 253-260 8 p.

    Research output: Contribution to journal › (Systematic) Review article › peer-review

    Open Access

  • Refining Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Genetic Loci by Integrating Summary Data From Genome-wide Association, Gene Expression, and DNA Methylation Studies

    Hammerschlag, A. R., Byrne, E. M., Bartels, M., Wray, N. R., Middeldorp, C. M., eQTLgen Consortium, Stehouwer, C., BIOS Consortium, Isaacs, A., van der Kallen, C. & Schalkwijk, C., 15 Sept 2020, In: Biological Psychiatry. 88, 6, p. 470-479 10 p.

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  • 2019

    An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

    Liu, J., Carnero-Montoro, E., van Dongen, J., Lent, S., Nedeljkovic, I., Ligthart, S., Tsai, P-C., Martin, T. C., Mandaviya, P. R., Jansen, R., Peters, M. J., Duijts, L., Jaddoe, V. W. V., Tiemeier, H., Felix, J. F., Willemsen, G., de Geus, E. J. C., Chu, A. Y., Levy, D., Hwang, S-J., & 37 othersBressler, J., Gondalia, R., Salfati, E. L., Herder, C., Hidalgo, B. A., Tanaka, T., Moore, A. Z., Lemaitre, R. N., Jhun, M. A., Smith, J. A., Sotoodehnia, N., Bandinelli, S., Ferrucci, L., Arnett, D. K., Grallert, H., Assimes, T. L., Hou, L., Baccarelli, A., Whitsel, E. A., van Dijk, K. W., Amin, N., Uitterlinden, A. G., Sijbrands, E. J. G., Franco, O. H., Dehghan, A., Spector, T. D., Dupuis, J., Hivert, M-F., Rotter, J., Meigs, J. B., Pankow, J. S., van Meurs, J. B. J., Isaacs, A., Boomsma, D., Bell, J. T., Demirkan, A. & van Duijn, C. M., 13 Jun 2019, In: Nature Communications. 10, 11 p., 2581.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults

    van Dongen, J., Zilhao, N. R., Sugden, K., Hannon, E. J., Mill, J., Caspi, A., Agnew-Blais, J., Arseneault, L., Corcoran, D. L., Moffitt, T. E., Poulton, R., Franke, B., Boomsma, D., Heijmans, B. T., t'Hoen, P. A. G., van Meurs, J., Isaacs, A., Jansen, R., Franke, L., Pool, R., & 31 othersHottenga, J. J., van Greevenbroek, M. M. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Wijmenga, C., Zhernakova, S., Tigchelaar, E. F., Slagboom, P. E., Beekman, M., Deelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., van Iterson, M., van Galen, M., Bot, J., Zhernakova, D., van t'Hof, P. & BIOS Consortium, 15 Oct 2019, In: Biological Psychiatry. 86, 8, p. 599-607 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

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  • Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits

    van Setten, J., Verweij, N., Mbarek, H., Niemeijer, M. N., Trompet, S., Arking, D. E., Brody, J. A., Gandin, I., Grarup, N., Hall, L. M., Hemerich, D., Lyytikainen, L-P., Mei, H., Mueller-Nurasyid, M., Prins, B. P., Robino, A., Smith, A. V., Warren, H. R., Asselbergs, F. W., Boomsma, D. I., & 41 othersCaulfield, M. J., Eijgelsheim, M., Ford, I., Hansen, T., Harris, T. B., Heckbert, S. R., Hottenga, J-J., Iorio, A., Kors, J. A., Linneberg, A., MacFarlane, P. W., Meitinger, T., Nelson, C. P., Raitakari, O. T., Aldana, C. T. S., Sinagra, G., Sinner, M., Soliman, E. Z., Stoll, M., Uitterlinden, A., van Duijn, C. M., Waldenberger, M., Alonso, A., Gasparini, P., Gudnason, V., Jamshidi, Y., Kaab, S., Kanters, J. K., Lehtimaki, T., Munroe, P. B., Peters, A., Samani, N. J., Sotoodehnia, N., Ulivi, S., Wilson, J. G., de Geus, E. J. C., Jukema, J. W., Stricker, B., van der Harst, P., de Bakker, P. I. W. & Isaacs, A., Jun 2019, In: European Journal of Human Genetics. 27, 6, p. 952-962 11 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals

    Liu, C-T., Merino, J., Rybin, D., DiCorpo, D., Benke, K. S., Bragg-Gresham, J. L., Canouil, M., Corre, T., Grallert, H., Isaacs, A., Kutalik, Z., Lahti, J., Marullo, L., Marzi, C., Rasmussen-Torvik, L. J., Rocheleau, G., Rueedi, R., Scapoli, C., Verweij, N., Vogelzangs, N., & 30 othersWillems, S. M., Yengo, L., Bakker, S. J. L., Beilby, J., Hui, J., Kajantie, E., Müller-Nurasyid, M., Rathmann, W., Balkau, B., Bergmann, S., Eriksson, J. G., Florez, J. C., Froguel, P., Harris, T., Hung, J., James, A. L., Kavousi, M., Miljkovic, I., Musk, A. W., Palmer, L. J., Peters, A., Roussel, R., van der Harst, P., van Duijn, C. M., Vollenweider, P., Barroso, I., Prokopenko, I., Dupuis, J., Meigs, J. B. & Bouatia-Naji, N., 1 Jul 2019, In: Scientific Reports. 9, 1, 8 p., 9439.

    Research output: Contribution to journal › Article › Academic › peer-review

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  • Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

    Porcu, E., Rueger, S., Lepik, K., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Arindrarto, W., Awadalla, P., Battle, A., Beutner, F., Bonder, M. J., Boomsma, D., Christiansen, M., Claringbould, A., Deelen, P., Esko, T., Fave, M-J., Franke, L., Frayling, T., & 32 othersGharib, S. A., Gibson, G., Heijmans, B. T., Hemani, G., Jansen, R., Kahonen, M., Kalnapenkis, A., Kasela, S., Kettunen, J., Kim, Y., Kirsten, H., Kovacs, P., Krohn, K., Kronberg-Guzman, J., Kukushkina, V., Lee, B., Lehtimaki, T., Loeffler, M., Marigorta, U. M., Mei, H., Milani, L., Montgomery, G. W., Mueler-Nurasyid, M., Nauck, M., Stehouwer, C. D. A., Isaacs, A., Schalkwijk, C. G., van der Kallen, C. J. H., van Greevenbroek, M. M. J., eQTLgen Consortium, BIOS Consortium & Kutalik, Z., 24 Jul 2019, In: Nature Communications. 10, 12 p., 3300.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

    van der Spek, A., Broer, L., Draisma, H. H. M., Pool, R., Albrecht, E., Beekman, M., Mangino, M., Raag, M., Nyholt, D. R., Dharuri, H. K., Codd, V., Amin, N., de Geus, E. J. C., Deelen, J., Demirkan, A., Yet, I., Fischer, K., Haller, T., Henders, A. K., Isaacs, A., & 19 othersMedland, S. E., Montgomery, G. W., Mooijaart, S. P., Strauch, K., Suchiman, H. E. D., Vaarhorst, A. A. M., van Heemst, D., Wang-Sattler, R., Whitfield, J. B., Willemsen, G., Wright, M. J., Martin, N. G., Samani, N. J., Metspalu, A., Slagboom, P. E., Spector, T. D., Boomsma, D., van Duijn, C. M. & Gieger, C., 12 Aug 2019, In: Scientific Reports. 9, 12 p., 11623.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression

    van Der Plaat, D., Vonk, J. M., Terzikhan, N., de Jong, K., de Vries, M., La Bastide-van Gemert, S., van Diemen, C. C., Lahousse, L., Brusselle, G., Nedeljkovic, I., Amin, N., Kromhout, H., Vermeulen, R. C. H., Postma, D. S., van Duijn, C. M., Boezen, H. M., Heijmans, B. T., Hoen, P. A. C. T., van Meurs, J., Isaacs, A., & 31 othersJansen, R., Franke, L., Boomsma, D., Pool, R., van Dongen, J., Hottenga, J. J., van Greevenbroek, M. M. J., Stehouwer, C. D. A., van Der Kallen, C. J. H., Schalkwijk, C. G., Wijmenga, C., Zhernakova, S., Tigchelaar, E. E., Slagboom, P. E., Beekman, M., Deelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van Der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., van Iterson, M. & BIOS Consortium, 1 Aug 2019, In: Human Molecular Genetics. 28, 15, p. 2477-2485 9 p.

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  • Relationship Between Nonalcoholic Fatty Liver Disease Susceptibility Genes and Coronary Artery Disease

    Brouwers, M. C. G. J., Simons, N., Stehouwer, C. D. A., Koek, G. H., Schaper, N. C. & Isaacs, A., Apr 2019, In: Hepatology communications. 3, 4, p. 587-596 10 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Skewed X-inactivation is common in the general female population

    Shvetsova, E., Sofronova, A., Monajemi, R., Gagalova, K., Draisma, H. H. M., White, S. J., Santen, G. W. E., Lopes, S. M. C. D. S., Heijmans, B. T., van Meurs, J., Jansen, R., Franke, L., Kielbasa, S. M., den Dunnen, J. T., 't Hoen, P. A. C., Boomsma, D. I., Pool, R., van Dongen, J., Hottenga, J. J., Van Greevenbroek, M. M. J., & 31 othersDa Stehouwer, C., van der Kallen, C. J. H., Schalkwijk, C. G., Wijmenga, C., Zhernakova, S., Tigchelaar, E. F., Slagboom, P. E., Beekman, M., Deelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., Isaacs, A., van Dijk, F., Li, M., Cox, D. R., Li, Y., Chen, R., Li, N., Wang, J., van Ommen, G. J., BIOS Consortium & GoNL consortium, Mar 2019, In: European Journal of Human Genetics. 27, 3, p. 455-465 11 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene

    Nersisyan, L., Nikoghosyan, M., Arakelyan, A., Genome of the Netherlands Consortium & Isaacs, A., 10 Dec 2019, In: Scientific Reports. 9, 1, 9 p., 18758.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
  • 2018

    A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy

    Silva, C. T., Zorkoltseva, I. V., Niemeijer, M. N., van den Berg, M. E., Amin, N., Demirkan, A., van Leeuwen, E., Iglesias, A. I., Pineros-Hernandez, L. B., Restrepo, C. M., Kors, J. A., Kirichenko, A. V., Willemsen, R., Oostra, B. A., Stricker, B. H., Uitterlinden, A. G., Axenovich, T. I., van Duijn, C. M. & Isaacs, A., 5 Mar 2018, In: BMC Medical Genomics. 11, 10 p., 22.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • A SNP panel for identification of DNA and RNA specimens

    Yousefi, S., Abbassi-Daloii, T., Kraaijenbrink, T., Vermaat, M., Mei, H., van't Hof, P., van Iterson, M., Zhernakova, D. V., Claringbould, A., Franke, L., 't Hart, L. M., Slieker, R. C., van der Heijden, A., de Knijff, P., 't Hoen, P. A. C., BIOS Consortium, Jansen, R., van Meurs, J., Heijmans, B. T., Boomsma, D. I., & 45 othersvan Dongen, J., Hottenga, J-J., Slagboom, P. E., Suchiman, H. E. D., van Iterson, M., van Zwet, E. W., 't Hoen, P., Pool, R., van Greevenbroek, M., Stehouwer, C., van der Kallen, C., Schalkwijk, C., Wijmenga, C., Zhernakova, A., Tigchelaar, E. F., Beekman, M., Deelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., Bot, J., Zhernakova, D. V., Van't Hof, P., Deelen, P., Nooren, I., Moed, M., Vermaat, M., Bonder, M. J., van Dijk, F., van Galen, M., Arindrarto, W., Kielbasa, S. M., Swertz, M. A., Isaacs, A. & Franke, L., 25 Jan 2018, In: BMC Genomics. 19, 90, 12 p., 90.

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    Open Access

  • Author Correction: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

    UK10K Consortium, Dec 2018, In: Nature Genetics. 50, 12, p. 1752

    Research output: Contribution to journal › Erratum / corrigendum / retractions › Academic

    Open Access

  • Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval

    Lin, H., van Setten, J., Smith, A. V., Bihlmeyer, N. A., Warren, H. R., Brody, J. A., Radmanesh, F., Hall, L., Grarup, N., Muller-Nurasyid, M., Boutin, T., Verweij, N., Lin, H. J., Li-Gao, R., van den Berg, M. E., Marten, J., Weiss, S., Prins, B. P., Haessler, J., Lyytikainen, L-P., & 78 othersMei, H., Harris, T. B., Launer, L. J., Li, M., Alonso, A., Soliman, E. Z., Connell, J. M., Huang, P. L., Weng, L-C., Jameson, H. S., Hucker, W., Hanley, A., Tucker, N. R., Chen, Y-D. I., Bis, J. C., Rice, K. M., Sitlani, C. M., Kors, J. A., Xie, Z., Wen, C., Magnani, J. W., Nelson, C. P., Kanters, J. K., Sinner, M. F., Strauch, K., Peters, A., Waldenberger, M., Meitinger, T., Bork-Jensen, J., Pedersen, O., Linneberg, A., Rudan, I., de Boer, R. A., van der Meer, P., Yao, J., Guo, X., Taylor, K. D., Sotoodehnia, N., Rotter, J. I., Mook-Kanamori, D. O., Trompet, S., Rivadeneira, F., Uitterlinden, A., Eijgelsheim, M., Padmanabhan, S., Smith, B. H., Volzke, H., Mangino, M., Spector, T. D., Bots, M. L., Perez, M., Kahonen, M., Raitakari, O. T., Gudnason, V., Arking, D. E., Munroe, P. B., Psaty, B. M., van Duijn, C. M., Benjamin, E. J., Rosand, J., Samani, N. J., Hansen, T., Kaab, S., Polasek, O., van der Harst, P., Heckbert, S. R., Jukema, J. W., Stricker, B. H., Hayward, C., Dorr, M., Jamshidi, Y., Asselbergs, F. W., Kooperberg, C., Lehtimaki, T., Wilson, J. G., Ellinor, P. T., Lubitz, S. A. & Isaacs, A., 1 May 2018, In: Circulation: Genomic and Precision Medicine. 11, 5, 11 p., e002037   .

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

    Prins, B. P., Mead, T. J., Brody, J. A., Sveinbjornsson, G., Ntalla, I., Bihlmeyer, N. A., van den Berg, M., Bork-Jensen, J., Cappellani, S., Van Duijvenboden, S., Klena, N. T., Gabriel, G. C., Liu, X., Gulec, C., Grarup, N., Haessler, J., Hall, L. M., Iorio, A., Isaacs, A., Li-Gao, R., & 93 othersLin, H., Liu, C-T., Lyytikainen, L-P., Marten, J., Mei, H., Muller-Nurasyid, M., Orini, M., Padmanabhan, S., Radmanesh, F., Ramirez, J., Robino, A., Schwartz, M., van Setten, J., Smith, A. V., Verweij, N., Warren, H. R., Weiss, S., Alonso, A., Arnar, D. O., Bots, M. L., de Boer, R. A., Dominiczak, A. F., Eijgelsheim, M., Ellinor, P. T., Guo, X., Felix, S. B., Harris, T. B., Hayward, C., Heckbert, S. R., Huang, P. L., Jukema, J. W., Kahonen, M., Kors, J. A., Lambiase, P. D., Launer, L. J., Li, M., Linneberg, A., Nelson, C. P., Pedersen, O., Perez, M., Peters, A., Polasek, O., Psaty, B. M., Raitakari, O. T., Rice, K. M., Rotter, J. I., Sinner, M. F., Soliman, E. Z., Spector, T. D., Strauch, K., Thorsteinsdottir, U., Tinker, A., Trompet, S., Uitterlinden, A., Vaartjes, I., van der Meer, P., Volker, U., Volzke, H., Waldenberger, M., Wilson, J. G., Xie, Z., Asselbergs, F. W., Dorr, M., van Duijn, C. M., Gasparini, P., Gudbjartsson, D. F., Gudnason, V., Hansen, T., Kaab, S., Kanters, J. K., Kooperberg, C., Lehtimaki, T., Lin, H. J., Lubitz, S. A., Mook-Kanamori, D. O., Conti, F. J., Newton-Cheh, C. H., Rosand, J., Rudan, I., Samani, N. J., Sinagra, G., Smith, B. H., Holm, H., Stricker, B. H., Ulivi, S., Sotoodehnia, N., Apte, S. S., van der Harst, P., Stefansson, K., Munroe, P. B., Arking, D. E., Lo, C. W. & Jamshidi, Y., 17 Jul 2018, In: Genome Biology. 19, 17 p., 87.

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    Open Access

  • ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals

    Bihlmeyer, N. A., Brody, J. A., Smith, A. V., Warren, H. R., Lin, H., Isaacs, A., Liu, C-T., Marten, J., Radmanesh, F., Hall, L. M., Grarup, N., Mei, H., Muller-Nurasyid, M., Huffman, J. E., Verweij, N., Guo, X., Yao, J., Li-Gao, R., van den Berg, M., Weiss, S., & 80 othersPrins, B. P., van Setten, J., Haessler, J., Lyytikainen, L-P., Li, M., Alonso, A., Soliman, E. Z., Bis, J. C., Austin, T., Chen, Y-D. I., Psaty, B. M., Harrris, T. B., Launer, L. J., Padmanabhan, S., Dominiczak, A., Huang, P. L., Xie, Z., Ellinor, P. T., Kors, J. A., Campbell, A., Murray, A. D., Nelson, C. P., Tobin, M. D., Bork-Jensen, J., Hansen, T., Pedersen, O., Linneberg, A., Sinner, M. F., Peters, A., Waldenberger, M., Meitinger, T., Perz, S., Kolcic, I., Rudan, I., de Boer, R. A., van der Meer, P., Lin, H. J., Taylor, K. D., de Mutsert, R., Trompet, S., Jukema, J. W., Maan, A. C., Stricker, B. H. C., Rivadeneira, F., Uitterlinden, A., Volker, U., Homuth, G., Volzke, H., Felix, S. B., Mangino, M., Spector, T. D., Bots, M. L., Perez, M., Raitakari, O. T., Kahonen, M., Mononen, N., Gudnason, V., Munroe, P. B., Lubitz, S. A., van Duijn, C. M., Newton-Cheh, C. H., Hayward, C., Rosand, J., Samani, N. J., Kanters, J. K., Wilson, J. G., Kaab, S., Polasek, O., van der Harst, P., Heckbert, S. R., Rotter, J. I., Mook-Kanamori, D. O., Eij-Gelsheim, M., Dorr, M., Jamshidi, Y., Asselbergs, F. W., Kooperberg, C., Lehtimaki, T., Arking, D. E. & Sotoodehnia, N., 1 Jan 2018, In: Circulation : Cardiovascular Genetics. 11, 1, 63 p., e001758.

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  • GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

    Franceschini, N., Giambartolomei, C., de Vries, P. S., Finan, C., Bis, J. C., Huntley, R. P., Lovering, R. C., Tajuddin, S. M., Winkler, T. W., Graff, M., Kavousi, M., Dale, C., Smith, A. V., Hofer, E., van Leeuwen, E. M., Nolte, I. M., Lu, L., Scholz, M., Sargurupremraj, M., Pitkanen, N., & 44 othersFranzen, O., Joshi, P. K., Noordam, R., Marioni, R. E., Hwang, S-J., Musani, S. K., Schminke, U., Palmas, W., Isaacs, A., Correa, A., Zonderman, A. B., Hofman, A., Teumer, A., Cox, A. J., Uitterlinden, A. G., Wong, A., Smit, A. J., Newman, A. B., Britton, A., Ruusalepp, A., Sennblad, B., Hedblad, B., Pasaniuc, B., Penninx, B. W., Langefeld, C. D., Wassel, C. L., Tzourio, C., Fava, C., Baldassarre, D., O'Leary, D. H., Teupser, D., Kuh, D., Tremoli, E., Mannarino, E., Grossi, D., Boerwinkle, E., Schadt, E. E., Ingelsson, E., Veglia, F., Rivadeneira, F., Beutner, F., MEGASTROKE Consortium, Bjorkegren, J. L. M. & O'Donnell, C. J., 3 Dec 2018, In: Nature Communications. 9, 14 p., 5141.

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  • Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology

    Seyerle, A. A., Sitlani, C. M., Noordam, R., Gogarten, S. M., Li, J., Li, X., Evans, D. S., Sun, F., Laaksonen, M. A., Isaacs, A., Kristiansson, K., Highland, H. M., Stewart, J. D., Harris, T. B., Trompet, S., Bis, J. C., Peloso, G. M., Brody, J. A., Broer, L., Busch, E. L., & 54 othersDuan, Q., Stilp, A. M., O'Donnell, C. J., Macfarlane, P. W., Floyd, J. S., Kors, J. A., Lin, H. J., Li-Gao, R., Sofer, T., Mendez-Giraldez, R., Cummings, S. R., Heckbert, S. R., Hofman, A., Ford, I., Li, Y., Launer, L. J., Porthan, K., Newton-Cheh, C., Napier, M. D., Kerr, K. F., Reiner, A. P., Rice, K. M., Roach, J., Buckley, B. M., Soliman, E. Z., de Mutsert, R., Sotoodehnia, N., Uitterlinden, A. G., North, K. E., Lee, C. R., Gudnason, V., Sturmer, T., Rosendaal, F. R., Taylor, K. D., Wiggins, K. L., Wilson, J. G., Chen, Y-D., Kaplan, R. C., Wilhelmsen, K., Cupples, L. A., Salomaa, V., van Duijn, C., Jukema, J. W., Liu, Y., Mook-Kanamori, D. O., Lange, L. A., Vasan, R. S., Smith, A., Stricker, B. H., Laurie, C. C., Rotter, J., Whitsel, E. A., Psaty, B. M. & Avery, C. L., 1 Mar 2018, In: Pharmacogenomics Journal. 18, 2, p. 215-226 12 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

    van Setten, J., Brody, J. A., Jamshidi, Y., Swenson, B. R., Butler, A. M., Campbell, H., Del Greco, F. M., Evans, D. S., Gibson, Q., Gudbjartsson, D. F., Kerr, K. F., Krijthe, B. P., Lyytikainen, L-P., Muller, C., Muller-Nurasyid, M., Nolte, I. M., Padmanabhan, S., Ritchie, M. D., Robino, A., Smith, A. V., & 106 othersSteri, M., Tanaka, T., Teumer, A., Trompet, S., Ulivi, S., Verweij, N., Yin, X., Arnar, D. O., Asselbergs, F. W., Bader, J. S., Barnard, J., Bis, J., Blankenberg, S., Boerwinkle, E., Bradford, Y., Buckley, B. M., Chung, M. K., Crawford, D., den Hoed, M., Denny, J. C., Dominiczak, A. F., Ehret, G. B., Eijgelsheim, M., Ellinor, P. T., Felix, S. B., Franco, O. H., Franke, L., Harris, T. B., Holm, H., Ilaria, G., Iorio, A., Kahonen, M., Kolcic, I., Kors, J. A., Lakatta, E. G., Launer, L. J., Lin, H., Lin, H. J., Loos, R. J. F., Lubitz, S. A., Macfarlane, P. W., Magnani, J. W., Leach, I. M., Meitinger, T., Mitchell, B. D., Munzel, T., Papanicolaou, G. J., Peters, A., Pfeufer, A., Pramstaller, P. P., Raitakari, O. T., Rotter, J. I., Rudan, I., Samani, N. J., Schlessinger, D., Aldana, C. T. S., Sinner, M. F., Smith, J. D., Snieder, H., Soliman, E. Z., Spector, T. D., Stott, D. J., Strauch, K., Tarasov, K. V., Thorsteinsdottir, U., Uitterlinden, A. G., Van Wagoner, D. R., Volker, U., Volzke, H., Waldenberger, M., Westra, H. J., Wild, P. S., Zeller, T., Alonso, A., Avery, C. L., Bandinelli, S., Benjamin, E. J., Cucca, F., Dorr, M., Ferrucci, L., Gasparini, P., Gudnason, V., Hayward, C., Heckbert, S. R., Hicks, A. A., Jukema, J. W., Kaab, S., Lehtimaki, T., Liu, Y., Munroe, P. B., Parsa, A., Polasek, O., Psaty, B. M., Roden, D. M., Schnabel, R. B., Sinagra, G., Stefansson, K., Stricker, B. H., van der Harst, P., van Duijn, C. M., Wilson, J. F., Gharib, S. A., de Bakker, P. I. W., Isaacs, A., Arking, D. E. & Sotoodehnia, N., 25 Jul 2018, In: Nature Communications. 9, 11 p., 2904.

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  • 2017

    A systematic SNP selection approach to identify mechanisms underlying disease aetiology: linking height to post-menopausal breast and colorectal cancer risk

    Elands, R. J. J., Simons, C. C. J. M., Riemenschneider, M., Isaacs, A., Schouten, L. J., Verhage, B. A., Van Steen, K., Godschalk, R. W. L., van den Brandt, P. A., Stoll, M. & Weijenberg, M. P., 24 Jan 2017, In: Scientific Reports. 7, 11 p., 41034.

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    Open Access

  • Discovery of novel heart rate-associated loci using the Exome Chip

    van den Berg, M. E., Warren, H. R., Cabrera, C. P., Verweij, N., Mifsud, B., Haessler, J., Bihlmeyer, N. A., Fu, Y-P., Weiss, S., Lin, H. J., Grarup, N., Li-Gao, R., Pistis, G., Shah, N., Brody, J. A., Mueller-Nurasyid, M., Lin, H., Mei, H., Smith, A. V., Lyytikainen, L-P., & 101 othersHall, L. M., van Setten, J., Trompet, S., Prins, B. P., Isaacs, A., Radmanesh, F., Marten, J., Entwistle, A., Kors, J. A., Silva, C. T., Alonso, A., Bis, J. C., de Boer, R., de Haan, H. G., de Mutsert, R., Dedoussis, G., Dominiczak, A. F., Doney, A. S. F., Ellinor, P. T., Eppinga, R. N., Felix, S. B., Guo, X., Hagemeijer, Y., Hansen, T., Harris, T. B., Heckbert, S. R., Huang, P. L., Hwang, S-J., Kahonen, M., Kanters, J. K., Kolcic, I., Launer, L. J., Li, M., Yao, J., Linneberg, A., Liu, S., Macfarlane, P. W., Mangino, M., Morris, A. D., Mulas, A., Murray, A. D., Nelson, C. P., Orru, M., Padmanabhan, S., Peters, A., Porteous, D. J., Poulter, N., Psaty, B. M., Qi, L., Raitakari, O. T., Rivadeneira, F., Roselli, C., Rudan, I., Sattar, N., Sever, P., Sinner, M. F., Soliman, E. Z., Spector, T. D., Stanton, A. V., Stirrups, K. E., Taylor, K. D., Tobin, M. D., Uitterlinden, A., Vaartjes, I., Hoes, A. W., van der Meer, P., Voelker, U., Waldenberger, M., Xie, Z., Zoledziewska, M., Tinker, A., Polasek, O., Rosand, J., Jamshidi, Y., van Duijn, C. M., Zeggini, E., Jukema, J. W., Asselbergs, F. W., Samani, N. J., Lehtimaki, T., Gudnason, V., Wilson, J., Lubitz, S. A., Kaeaeb, S., Sotoodehnia, N., Caulfield, M. J., Palmer, C. N. A., Sanna, S., Mook-Kanamori, D. O., Deloukas, P., Pedersen, O., Rotter, J. I., Doerr, M., O'Donnell, C. J., Hayward, C., Arking, D. E., Kooperberg, C., van der Harst, P., Eijgelsheim, M., Stricker, B. H. & Munroe, P. B., 15 Jun 2017, In: Human Molecular Genetics. 26, 12, p. 2346-2363 18 p.

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  • Disease variants alter transcription factor levels and methylation of their binding sites

    Bonder, M. J., Luijk, R., Zhernakova, D. V., Moed, M., Deelen, P., Vermaat, M., van Iterson, M., van Dijk, F., van Galen, M., Bot, J., Slieker, R. C., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Arindrarto, W., Kielbasa, S. M., & 33 othersJonkers, I., van 't Hof, P., Nooren, I., Beekman, M., Deelen, J., van Heemst, D., Zhernakova, A., Tigchelaar, E. F., Swertz, M. A., Hofman, A., Uitterlinden, A. G., Pool, R., van Dongen, J., Hottenga, J. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., van den Berg, L. H., van Zwet, E. W., Mei, H., Li, Y., Lemire, M., Hudson, T. J., Slagboom, P. E., Wijmenga, C., Veldink, J. H., van Greevenbroek, M. M. J., van Duijn, C. M., Boomsma, D. I., Isaacs, A., BIOS Consortium, Heijmans, B. T. & Franke, L., Jan 2017, In: Nature Genetics. 49, 1, p. 131-138 8 p.

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