Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

Eleonora Porcu, Sina Rueger, Kaido Lepik, Mawusse Agbessi, Habibul Ahsan, Isabel Alves, Anand Andiappan, Wibowo Arindrarto, Philip Awadalla, Alexis Battle, Frank Beutner, Marc Jan Bonder, Dorret Boomsma, Mark Christiansen, Annique Claringbould, Patrick Deelen, Tonu Esko, Marie-Julie Fave, Lude Franke, Timothy FraylingSina A. Gharib, Gregory Gibson, Bastiaan T. Heijmans, Gibran Hemani, Rick Jansen, Mika Kahonen, Anette Kalnapenkis, Silva Kasela, Johannes Kettunen, Yungil Kim, Holger Kirsten, Peter Kovacs, Knut Krohn, Jaanika Kronberg-Guzman, Viktorija Kukushkina, Bernett Lee, Terho Lehtimaki, Markus Loeffler, Urko M. Marigorta, Hailang Mei, Lili Milani, Grant W. Montgomery, Martina Mueler-Nurasyid, Matthias Nauck, Coen D. A. Stehouwer, Aaron Isaacs, Casper G. Schalkwijk, Coen D. A. Stehouwer, Carla J. H. van der Kallen, Marleen M. J. van Greevenbroek, eQTLGen Consortium, BIOS Consortium

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number3300
Number of pages12
JournalNature Communications
Volume10
DOIs
Publication statusPublished - 24 Jul 2019

Keywords

  • INSTRUMENTAL VARIABLES
  • VARIANTS
  • DISEASE
  • ASSOCIATION
  • MUTATION
  • STATISTICS
  • EXPRESSION
  • PLEIOTROPY
  • OBESITY
  • FAMILY

Cite this

Porcu, E., Rueger, S., Lepik, K., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Arindrarto, W., Awadalla, P., Battle, A., Beutner, F., Bonder, M. J., Boomsma, D., Christiansen, M., Claringbould, A., Deelen, P., Esko, T., Fave, M-J., Franke, L., ... BIOS Consortium (2019). Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits. Nature Communications, 10, [3300]. https://doi.org/10.1038/s41467-019-10936-0