PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

Jessica van Setten; Jennifer A. Brody; Yalda Jamshidi; Brenton R. Swenson; Anne M. Butler; Harry Campbell; Fabiola M. Del Greco; Daniel S. Evans; Quince Gibson; Daniel F. Gudbjartsson; Kathleen F. Kerr; Bouwe P. Krijthe; Leo-Pekka Lyytikainen; Christian Muller; Martina Muller-Nurasyid; Ilja M. Nolte; Sandosh Padmanabhan; Marylyn D. Ritchie; Antonietta Robino; Albert V. Smith; Maristella Steri; Toshiko Tanaka; Alexander Teumer; Stella Trompet; Sheila Ulivi; Niek Verweij; Xiaoyan Yin; David O. Arnar; Folkert W. Asselbergs; Joel S. Bader; John Barnard; Josh Bis; Stefan Blankenberg; Eric Boerwinkle; Yuki Bradford; Brendan M. Buckley; Mina K. Chung; Dana Crawford; Marcel den Hoed; Josh C. Denny; Anna F. Dominiczak; Georg B. Ehret; Mark Eijgelsheim; Patrick T. Ellinor; Stephan B. Felix; Oscar H. Franco; Lude Franke; Tamara B. Harris; Hilma Holm; Gandin Ilaria; Annamaria Iorio; Mika Kahonen; Ivana Kolcic; Jan A. Kors; Edward G. Lakatta; Lenore J. Launer; Honghuang Lin; Henry J. Lin; Ruth J. F. Loos; Steven A. Lubitz; Peter W. Macfarlane; Jared W. Magnani; Irene Mateo Leach; Thomas Meitinger; Braxton D. Mitchell; Thomas Munzel; George J. Papanicolaou; Annette Peters; Arne Pfeufer; Peter P. Pramstaller; Olli T. Raitakari; Jerome I. Rotter; Igor Rudan; Nilesh J. Samani; David Schlessinger; Claudia T. Silva Aldana; Moritz F. Sinner; Jonathan D. Smith; Harold Snieder; Elsayed Z. Soliman; Timothy D. Spector; David J. Stott; Konstantin Strauch; Kirill V. Tarasov; Unnur Thorsteinsdottir; Andre G. Uitterlinden; David R. Van Wagoner; Uwe Volker; Henry Volzke; Melanie Waldenberger; Harm Jan Westra; Philipp S. Wild; Tanja Zeller; Alvaro Alonso; Christy L. Avery; Stefania Bandinelli; Emelia J. Benjamin; Francesco Cucca; Marcus Dorr; Luigi Ferrucci; Paolo Gasparini; Vilmundur Gudnason; Caroline Hayward; Susan R. Heckbert; Andrew A. Hicks; J. Wouter Jukema; Stefan Kaab; Terho Lehtimaki; Yongmei Liu; Patricia B. Munroe; Afshin Parsa; Ozren Polasek; Bruce M. Psaty; Dan M. Roden; Renate B. Schnabel; Gianfranco Sinagra; Kari Stefansson; Bruno H. Stricker; Pim van der Harst; Cornelia M. van Duijn; James F. Wilson; Sina A. Gharib; Paul I. W. de Bakker; Aaron Isaacs; Dan E. Arking; Nona Sotoodehnia

doi:10.1038/s41467-018-04766-9

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

Jessica van Setten^*, Jennifer A. Brody, Yalda Jamshidi, Brenton R. Swenson, Anne M. Butler, Harry Campbell, Fabiola M. Del Greco, Daniel S. Evans, Quince Gibson, Daniel F. Gudbjartsson, Kathleen F. Kerr, Bouwe P. Krijthe, Leo-Pekka Lyytikainen, Christian Muller, Martina Muller-Nurasyid, Ilja M. Nolte, Sandosh Padmanabhan, Marylyn D. Ritchie, Antonietta Robino, Albert V. SmithMaristella Steri, Toshiko Tanaka, Alexander Teumer, Stella Trompet, Sheila Ulivi, Niek Verweij, Xiaoyan Yin, David O. Arnar, Folkert W. Asselbergs, Joel S. Bader, John Barnard, Josh Bis, Stefan Blankenberg, Eric Boerwinkle, Yuki Bradford, Brendan M. Buckley, Mina K. Chung, Dana Crawford, Marcel den Hoed, Josh C. Denny, Anna F. Dominiczak, Georg B. Ehret, Mark Eijgelsheim, Patrick T. Ellinor, Stephan B. Felix, Oscar H. Franco, Lude Franke, Tamara B. Harris, Hilma Holm, Gandin Ilaria, Annamaria Iorio, Mika Kahonen, Ivana Kolcic, Jan A. Kors, Edward G. Lakatta, Lenore J. Launer, Honghuang Lin, Henry J. Lin, Ruth J. F. Loos, Steven A. Lubitz, Peter W. Macfarlane, Jared W. Magnani, Irene Mateo Leach, Thomas Meitinger, Braxton D. Mitchell, Thomas Munzel, George J. Papanicolaou, Annette Peters, Arne Pfeufer, Peter P. Pramstaller, Olli T. Raitakari, Jerome I. Rotter, Igor Rudan, Nilesh J. Samani, David Schlessinger, Claudia T. Silva Aldana, Moritz F. Sinner, Jonathan D. Smith, Harold Snieder, Elsayed Z. Soliman, Timothy D. Spector, David J. Stott, Konstantin Strauch, Kirill V. Tarasov, Unnur Thorsteinsdottir, Andre G. Uitterlinden, David R. Van Wagoner, Uwe Volker, Henry Volzke, Melanie Waldenberger, Harm Jan Westra, Philipp S. Wild, Tanja Zeller, Alvaro Alonso, Christy L. Avery, Stefania Bandinelli, Emelia J. Benjamin, Francesco Cucca, Marcus Dorr, Luigi Ferrucci, Paolo Gasparini, Vilmundur Gudnason, Caroline Hayward, Susan R. Heckbert, Andrew A. Hicks, J. Wouter Jukema, Stefan Kaab, Terho Lehtimaki, Yongmei Liu, Patricia B. Munroe, Afshin Parsa, Ozren Polasek, Bruce M. Psaty, Dan M. Roden, Renate B. Schnabel, Gianfranco Sinagra, Kari Stefansson, Bruno H. Stricker, Pim van der Harst, Cornelia M. van Duijn, James F. Wilson, Sina A. Gharib, Paul I. W. de Bakker, Aaron Isaacs, Dan E. Arking, Nona Sotoodehnia

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

35 Citations (Web of Science)

Original language	English
Article number	2904
Number of pages	11
Journal	Nature Communications
Volume	9
DOIs	https://doi.org/10.1038/s41467-018-04766-9
Publication status	Published - 25 Jul 2018

Keywords

COMMON VARIANTS
HEART-RATE
QRS DURATION
CARDIAC CONDUCTION
FIBRILLATION
EPIDEMIOLOGY
COHORTS
RISK
RARE
SNPS

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10.1038/s41467-018-04766-9

https://www.nature.com/articles/s41467-018-04766-9.pdf

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van Setten, J., Brody, J. A., Jamshidi, Y., Swenson, B. R., Butler, A. M., Campbell, H., Del Greco, F. M., Evans, D. S., Gibson, Q., Gudbjartsson, D. F., Kerr, K. F., Krijthe, B. P., Lyytikainen, L-P., Muller, C., Muller-Nurasyid, M., Nolte, I. M., Padmanabhan, S., Ritchie, M. D., Robino, A., ... Sotoodehnia, N. (2018). PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. Nature Communications, 9, [2904]. https://doi.org/10.1038/s41467-018-04766-9

van Setten, Jessica ; Brody, Jennifer A. ; Jamshidi, Yalda ; Swenson, Brenton R. ; Butler, Anne M. ; Campbell, Harry ; Del Greco, Fabiola M. ; Evans, Daniel S. ; Gibson, Quince ; Gudbjartsson, Daniel F. ; Kerr, Kathleen F. ; Krijthe, Bouwe P. ; Lyytikainen, Leo-Pekka ; Muller, Christian ; Muller-Nurasyid, Martina ; Nolte, Ilja M. ; Padmanabhan, Sandosh ; Ritchie, Marylyn D. ; Robino, Antonietta ; Smith, Albert V. ; Steri, Maristella ; Tanaka, Toshiko ; Teumer, Alexander ; Trompet, Stella ; Ulivi, Sheila ; Verweij, Niek ; Yin, Xiaoyan ; Arnar, David O. ; Asselbergs, Folkert W. ; Bader, Joel S. ; Barnard, John ; Bis, Josh ; Blankenberg, Stefan ; Boerwinkle, Eric ; Bradford, Yuki ; Buckley, Brendan M. ; Chung, Mina K. ; Crawford, Dana ; den Hoed, Marcel ; Denny, Josh C. ; Dominiczak, Anna F. ; Ehret, Georg B. ; Eijgelsheim, Mark ; Ellinor, Patrick T. ; Felix, Stephan B. ; Franco, Oscar H. ; Franke, Lude ; Harris, Tamara B. ; Holm, Hilma ; Ilaria, Gandin ; Iorio, Annamaria ; Kahonen, Mika ; Kolcic, Ivana ; Kors, Jan A. ; Lakatta, Edward G. ; Launer, Lenore J. ; Lin, Honghuang ; Lin, Henry J. ; Loos, Ruth J. F. ; Lubitz, Steven A. ; Macfarlane, Peter W. ; Magnani, Jared W. ; Leach, Irene Mateo ; Meitinger, Thomas ; Mitchell, Braxton D. ; Munzel, Thomas ; Papanicolaou, George J. ; Peters, Annette ; Pfeufer, Arne ; Pramstaller, Peter P. ; Raitakari, Olli T. ; Rotter, Jerome I. ; Rudan, Igor ; Samani, Nilesh J. ; Schlessinger, David ; Aldana, Claudia T. Silva ; Sinner, Moritz F. ; Smith, Jonathan D. ; Snieder, Harold ; Soliman, Elsayed Z. ; Spector, Timothy D. ; Stott, David J. ; Strauch, Konstantin ; Tarasov, Kirill V. ; Thorsteinsdottir, Unnur ; Uitterlinden, Andre G. ; Van Wagoner, David R. ; Volker, Uwe ; Volzke, Henry ; Waldenberger, Melanie ; Westra, Harm Jan ; Wild, Philipp S. ; Zeller, Tanja ; Alonso, Alvaro ; Avery, Christy L. ; Bandinelli, Stefania ; Benjamin, Emelia J. ; Cucca, Francesco ; Dorr, Marcus ; Ferrucci, Luigi ; Gasparini, Paolo ; Gudnason, Vilmundur ; Hayward, Caroline ; Heckbert, Susan R. ; Hicks, Andrew A. ; Jukema, J. Wouter ; Kaab, Stefan ; Lehtimaki, Terho ; Liu, Yongmei ; Munroe, Patricia B. ; Parsa, Afshin ; Polasek, Ozren ; Psaty, Bruce M. ; Roden, Dan M. ; Schnabel, Renate B. ; Sinagra, Gianfranco ; Stefansson, Kari ; Stricker, Bruno H. ; van der Harst, Pim ; van Duijn, Cornelia M. ; Wilson, James F. ; Gharib, Sina A. ; de Bakker, Paul I. W. ; Isaacs, Aaron ; Arking, Dan E. ; Sotoodehnia, Nona. / PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. In: Nature Communications. 2018 ; Vol. 9.

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title = "PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity",

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year = "2018",

month = jul,

day = "25",

doi = "10.1038/s41467-018-04766-9",

language = "English",

volume = "9",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

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van Setten, J, Brody, JA, Jamshidi, Y, Swenson, BR, Butler, AM, Campbell, H, Del Greco, FM, Evans, DS, Gibson, Q, Gudbjartsson, DF, Kerr, KF, Krijthe, BP, Lyytikainen, L-P, Muller, C, Muller-Nurasyid, M, Nolte, IM, Padmanabhan, S, Ritchie, MD, Robino, A, Smith, AV, Steri, M, Tanaka, T, Teumer, A, Trompet, S, Ulivi, S, Verweij, N, Yin, X, Arnar, DO, Asselbergs, FW, Bader, JS, Barnard, J, Bis, J, Blankenberg, S, Boerwinkle, E, Bradford, Y, Buckley, BM, Chung, MK, Crawford, D, den Hoed, M, Denny, JC, Dominiczak, AF, Ehret, GB, Eijgelsheim, M, Ellinor, PT, Felix, SB, Franco, OH, Franke, L, Harris, TB, Holm, H, Ilaria, G, Iorio, A, Kahonen, M, Kolcic, I, Kors, JA, Lakatta, EG, Launer, LJ, Lin, H, Lin, HJ, Loos, RJF, Lubitz, SA, Macfarlane, PW, Magnani, JW, Leach, IM, Meitinger, T, Mitchell, BD, Munzel, T, Papanicolaou, GJ, Peters, A, Pfeufer, A, Pramstaller, PP, Raitakari, OT, Rotter, JI, Rudan, I, Samani, NJ, Schlessinger, D, Aldana, CTS, Sinner, MF, Smith, JD, Snieder, H, Soliman, EZ, Spector, TD, Stott, DJ, Strauch, K, Tarasov, KV, Thorsteinsdottir, U, Uitterlinden, AG, Van Wagoner, DR, Volker, U, Volzke, H, Waldenberger, M, Westra, HJ, Wild, PS, Zeller, T, Alonso, A, Avery, CL, Bandinelli, S, Benjamin, EJ, Cucca, F, Dorr, M, Ferrucci, L, Gasparini, P, Gudnason, V, Hayward, C, Heckbert, SR, Hicks, AA, Jukema, JW, Kaab, S, Lehtimaki, T, Liu, Y, Munroe, PB, Parsa, A, Polasek, O, Psaty, BM, Roden, DM, Schnabel, RB, Sinagra, G, Stefansson, K, Stricker, BH, van der Harst, P, van Duijn, CM, Wilson, JF, Gharib, SA, de Bakker, PIW, Isaacs, A, Arking, DE & Sotoodehnia, N 2018, 'PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity', Nature Communications, vol. 9, 2904. https://doi.org/10.1038/s41467-018-04766-9

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. / van Setten, Jessica; Brody, Jennifer A.; Jamshidi, Yalda; Swenson, Brenton R.; Butler, Anne M.; Campbell, Harry; Del Greco, Fabiola M.; Evans, Daniel S.; Gibson, Quince; Gudbjartsson, Daniel F.; Kerr, Kathleen F.; Krijthe, Bouwe P.; Lyytikainen, Leo-Pekka; Muller, Christian; Muller-Nurasyid, Martina; Nolte, Ilja M.; Padmanabhan, Sandosh; Ritchie, Marylyn D.; Robino, Antonietta; Smith, Albert V.; Steri, Maristella; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; Ulivi, Sheila; Verweij, Niek; Yin, Xiaoyan; Arnar, David O.; Asselbergs, Folkert W.; Bader, Joel S.; Barnard, John; Bis, Josh; Blankenberg, Stefan; Boerwinkle, Eric; Bradford, Yuki; Buckley, Brendan M.; Chung, Mina K.; Crawford, Dana; den Hoed, Marcel; Denny, Josh C.; Dominiczak, Anna F.; Ehret, Georg B.; Eijgelsheim, Mark; Ellinor, Patrick T.; Felix, Stephan B.; Franco, Oscar H.; Franke, Lude; Harris, Tamara B.; Holm, Hilma; Ilaria, Gandin; Iorio, Annamaria; Kahonen, Mika; Kolcic, Ivana; Kors, Jan A.; Lakatta, Edward G.; Launer, Lenore J.; Lin, Honghuang; Lin, Henry J.; Loos, Ruth J. F.; Lubitz, Steven A.; Macfarlane, Peter W.; Magnani, Jared W.; Leach, Irene Mateo; Meitinger, Thomas; Mitchell, Braxton D.; Munzel, Thomas; Papanicolaou, George J.; Peters, Annette; Pfeufer, Arne; Pramstaller, Peter P.; Raitakari, Olli T.; Rotter, Jerome I.; Rudan, Igor; Samani, Nilesh J.; Schlessinger, David; Aldana, Claudia T. Silva; Sinner, Moritz F.; Smith, Jonathan D.; Snieder, Harold; Soliman, Elsayed Z.; Spector, Timothy D.; Stott, David J.; Strauch, Konstantin; Tarasov, Kirill V.; Thorsteinsdottir, Unnur; Uitterlinden, Andre G.; Van Wagoner, David R.; Volker, Uwe; Volzke, Henry; Waldenberger, Melanie; Westra, Harm Jan; Wild, Philipp S.; Zeller, Tanja; Alonso, Alvaro; Avery, Christy L.; Bandinelli, Stefania; Benjamin, Emelia J.; Cucca, Francesco; Dorr, Marcus; Ferrucci, Luigi; Gasparini, Paolo; Gudnason, Vilmundur; Hayward, Caroline; Heckbert, Susan R.; Hicks, Andrew A.; Jukema, J. Wouter; Kaab, Stefan; Lehtimaki, Terho; Liu, Yongmei; Munroe, Patricia B.; Parsa, Afshin; Polasek, Ozren; Psaty, Bruce M.; Roden, Dan M.; Schnabel, Renate B.; Sinagra, Gianfranco; Stefansson, Kari; Stricker, Bruno H.; van der Harst, Pim; van Duijn, Cornelia M.; Wilson, James F.; Gharib, Sina A.; de Bakker, Paul I. W.; Isaacs, Aaron; Arking, Dan E.; Sotoodehnia, Nona.

In: Nature Communications, Vol. 9, 2904, 25.07.2018.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

AU - van Setten, Jessica

AU - Brody, Jennifer A.

AU - Jamshidi, Yalda

AU - Swenson, Brenton R.

AU - Butler, Anne M.

AU - Campbell, Harry

AU - Del Greco, Fabiola M.

AU - Evans, Daniel S.

AU - Gibson, Quince

AU - Gudbjartsson, Daniel F.

AU - Kerr, Kathleen F.

AU - Krijthe, Bouwe P.

AU - Lyytikainen, Leo-Pekka

AU - Muller, Christian

AU - Muller-Nurasyid, Martina

AU - Nolte, Ilja M.

AU - Padmanabhan, Sandosh

AU - Ritchie, Marylyn D.

AU - Robino, Antonietta

AU - Smith, Albert V.

AU - Steri, Maristella

AU - Tanaka, Toshiko

AU - Teumer, Alexander

AU - Trompet, Stella

AU - Ulivi, Sheila

AU - Verweij, Niek

AU - Yin, Xiaoyan

AU - Arnar, David O.

AU - Asselbergs, Folkert W.

AU - Bader, Joel S.

AU - Barnard, John

AU - Bis, Josh

AU - Blankenberg, Stefan

AU - Boerwinkle, Eric

AU - Bradford, Yuki

AU - Buckley, Brendan M.

AU - Chung, Mina K.

AU - Crawford, Dana

AU - den Hoed, Marcel

AU - Denny, Josh C.

AU - Dominiczak, Anna F.

AU - Ehret, Georg B.

AU - Eijgelsheim, Mark

AU - Ellinor, Patrick T.

AU - Felix, Stephan B.

AU - Franco, Oscar H.

AU - Franke, Lude

AU - Harris, Tamara B.

AU - Holm, Hilma

AU - Ilaria, Gandin

AU - Iorio, Annamaria

AU - Kahonen, Mika

AU - Kolcic, Ivana

AU - Kors, Jan A.

AU - Lakatta, Edward G.

AU - Launer, Lenore J.

AU - Lin, Honghuang

AU - Lin, Henry J.

AU - Loos, Ruth J. F.

AU - Lubitz, Steven A.

AU - Macfarlane, Peter W.

AU - Magnani, Jared W.

AU - Leach, Irene Mateo

AU - Meitinger, Thomas

AU - Mitchell, Braxton D.

AU - Munzel, Thomas

AU - Papanicolaou, George J.

AU - Peters, Annette

AU - Pfeufer, Arne

AU - Pramstaller, Peter P.

AU - Raitakari, Olli T.

AU - Rotter, Jerome I.

AU - Rudan, Igor

AU - Samani, Nilesh J.

AU - Schlessinger, David

AU - Aldana, Claudia T. Silva

AU - Sinner, Moritz F.

AU - Smith, Jonathan D.

AU - Snieder, Harold

AU - Soliman, Elsayed Z.

AU - Spector, Timothy D.

AU - Stott, David J.

AU - Strauch, Konstantin

AU - Tarasov, Kirill V.

AU - Thorsteinsdottir, Unnur

AU - Uitterlinden, Andre G.

AU - Van Wagoner, David R.

AU - Volker, Uwe

AU - Volzke, Henry

AU - Waldenberger, Melanie

AU - Westra, Harm Jan

AU - Wild, Philipp S.

AU - Zeller, Tanja

AU - Alonso, Alvaro

AU - Avery, Christy L.

AU - Bandinelli, Stefania

AU - Benjamin, Emelia J.

AU - Cucca, Francesco

AU - Dorr, Marcus

AU - Ferrucci, Luigi

AU - Gasparini, Paolo

AU - Gudnason, Vilmundur

AU - Hayward, Caroline

AU - Heckbert, Susan R.

AU - Hicks, Andrew A.

AU - Jukema, J. Wouter

AU - Kaab, Stefan

AU - Lehtimaki, Terho

AU - Liu, Yongmei

AU - Munroe, Patricia B.

AU - Parsa, Afshin

AU - Polasek, Ozren

AU - Psaty, Bruce M.

AU - Roden, Dan M.

AU - Schnabel, Renate B.

AU - Sinagra, Gianfranco

AU - Stefansson, Kari

AU - Stricker, Bruno H.

AU - van der Harst, Pim

AU - van Duijn, Cornelia M.

AU - Wilson, James F.

AU - Gharib, Sina A.

AU - de Bakker, Paul I. W.

AU - Isaacs, Aaron

AU - Arking, Dan E.

AU - Sotoodehnia, Nona

PY - 2018/7/25

Y1 - 2018/7/25

KW - COMMON VARIANTS

KW - HEART-RATE

KW - QRS DURATION

KW - CARDIAC CONDUCTION

KW - FIBRILLATION

KW - EPIDEMIOLOGY

KW - COHORTS

KW - RISK

KW - RARE

KW - SNPS

U2 - 10.1038/s41467-018-04766-9

DO - 10.1038/s41467-018-04766-9

M3 - Article

C2 - 30046033

VL - 9

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 2904

ER -