Considerations for the Assessment of Substrates, Genetics and Risk Factors in Patients with Atrial Fibrillation

D. Linz, S. Verheule, A. Isaacs, U. Schotten*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Successful translation of research focussing on atrial arrhythmogenic mechanisms has potential to provide a mechanism-tailored classification and to support personalised treatment approaches in patients with AF. The clinical uptake and clinical implementation of new diagnostic techniques and treatment strategies require translational research approaches on various levels. Diagnostic translation involves the development of clinical diagnostic tools. Additionally, multidisciplinary teams are required for collaborative translation to describe genetic mechanisms, molecular pathways, electrophysiological characteristics and concomitant risk factors. In this article, current approaches for AF substrate characterisation, analysis of genes potentially involved in AF and strategies for AF risk factor assessment are summarised. The authors discuss challenges and obstacles to clinical translation and implementation into clinical practice.
Original languageEnglish
Pages (from-to)132-139
Number of pages8
JournalArrhythmia & Electrophysiology Review
Volume10
Issue number3
DOIs
Publication statusPublished - 1 Sep 2021

Keywords

  • Atrial fibrillation
  • mechanisms
  • risk factors
  • substrate
  • genes
  • OF-FUNCTION MUTATION
  • SLEEP-APNEA SEVERITY
  • MAGNETIC-RESONANCE
  • HEART-FAILURE
  • FOLLOW-UP
  • PERSISTENT
  • VARIANTS
  • FIBROSIS
  • ABLATION
  • LOCI

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