Considerations for the Assessment of Substrates, Genetics and Risk Factors in Patients with Atrial Fibrillation

D. Linz; S. Verheule; A. Isaacs; U. Schotten

doi:10.15420/aer.2020.51

Considerations for the Assessment of Substrates, Genetics and Risk Factors in Patients with Atrial Fibrillation

D. Linz, S. Verheule, A. Isaacs, U. Schotten^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Successful translation of research focussing on atrial arrhythmogenic mechanisms has potential to provide a mechanism-tailored classification and to support personalised treatment approaches in patients with AF. The clinical uptake and clinical implementation of new diagnostic techniques and treatment strategies require translational research approaches on various levels. Diagnostic translation involves the development of clinical diagnostic tools. Additionally, multidisciplinary teams are required for collaborative translation to describe genetic mechanisms, molecular pathways, electrophysiological characteristics and concomitant risk factors. In this article, current approaches for AF substrate characterisation, analysis of genes potentially involved in AF and strategies for AF risk factor assessment are summarised. The authors discuss challenges and obstacles to clinical translation and implementation into clinical practice.

Original language	English
Pages (from-to)	132-139
Number of pages	8
Journal	Arrhythmia & Electrophysiology Review
Volume	10
Issue number	3
DOIs	https://doi.org/10.15420/aer.2020.51
Publication status	Published - 1 Sept 2021

Keywords

Atrial fibrillation
mechanisms
risk factors
substrate
genes
OF-FUNCTION MUTATION
SLEEP-APNEA SEVERITY
MAGNETIC-RESONANCE
HEART-FAILURE
FOLLOW-UP
PERSISTENT
VARIANTS
FIBROSIS
ABLATION
LOCI

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10.15420/aer.2020.51Licence: CC BY-NC

Cite this

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abstract = "Successful translation of research focussing on atrial arrhythmogenic mechanisms has potential to provide a mechanism-tailored classification and to support personalised treatment approaches in patients with AF. The clinical uptake and clinical implementation of new diagnostic techniques and treatment strategies require translational research approaches on various levels. Diagnostic translation involves the development of clinical diagnostic tools. Additionally, multidisciplinary teams are required for collaborative translation to describe genetic mechanisms, molecular pathways, electrophysiological characteristics and concomitant risk factors. In this article, current approaches for AF substrate characterisation, analysis of genes potentially involved in AF and strategies for AF risk factor assessment are summarised. The authors discuss challenges and obstacles to clinical translation and implementation into clinical practice.",

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KW - PERSISTENT

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