Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

Ashley van der Spek, Linda Broer, Harmen H. M. Draisma, Rene Pool, Eva Albrecht, Marian Beekman, Massimo Mangino, Mait Raag, Dale R. Nyholt, Harish K. Dharuri, Veryan Codd, Najaf Amin, Eco J. C. de Geus, Joris Deelen, Ayse Demirkan, Idil Yet, Krista Fischer, Toomas Haller, Anjali K. Henders, Aaron IsaacsSarah E. Medland, Grant W. Montgomery, Simon P. Mooijaart, Konstantin Strauch, H. Eka D. Suchiman, Anika A. M. Vaarhorst, Diana van Heemst, Rui Wang-Sattler, John B. Whitfield, Gonneke Willemsen, Margaret J. Wright, Nicholas G. Martin, Nilesh J. Samani, Andres Metspalu, P. Eline Slagboom, Tim D. Spector, Dorret Boomsma, Cornelia M. van Duijn*, Christian Gieger

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number11623
Number of pages12
JournalScientific Reports
Volume9
DOIs
Publication statusPublished - 12 Aug 2019

Keywords

  • PLASMA TOTAL HOMOCYSTEINE
  • LOW-DENSITY-LIPOPROTEIN
  • WHITE BLOOD-CELLS
  • CARDIOVASCULAR-DISEASE
  • LIFE-SPAN
  • METHIONINE RESTRICTION
  • FAMILIAL LONGEVITY
  • ENDOTHELIAL-CELLS
  • HEART-DISEASE
  • MORTALITY

Cite this

van der Spek, A., Broer, L., Draisma, H. H. M., Pool, R., Albrecht, E., Beekman, M., ... Gieger, C. (2019). Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium. Scientific Reports, 9, [11623]. https://doi.org/10.1038/s41598-019-47282-6
van der Spek, Ashley ; Broer, Linda ; Draisma, Harmen H. M. ; Pool, Rene ; Albrecht, Eva ; Beekman, Marian ; Mangino, Massimo ; Raag, Mait ; Nyholt, Dale R. ; Dharuri, Harish K. ; Codd, Veryan ; Amin, Najaf ; de Geus, Eco J. C. ; Deelen, Joris ; Demirkan, Ayse ; Yet, Idil ; Fischer, Krista ; Haller, Toomas ; Henders, Anjali K. ; Isaacs, Aaron ; Medland, Sarah E. ; Montgomery, Grant W. ; Mooijaart, Simon P. ; Strauch, Konstantin ; Suchiman, H. Eka D. ; Vaarhorst, Anika A. M. ; van Heemst, Diana ; Wang-Sattler, Rui ; Whitfield, John B. ; Willemsen, Gonneke ; Wright, Margaret J. ; Martin, Nicholas G. ; Samani, Nilesh J. ; Metspalu, Andres ; Slagboom, P. Eline ; Spector, Tim D. ; Boomsma, Dorret ; van Duijn, Cornelia M. ; Gieger, Christian. / Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length : the ENGAGE consortium. In: Scientific Reports. 2019 ; Vol. 9.
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title = "Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium",
keywords = "PLASMA TOTAL HOMOCYSTEINE, LOW-DENSITY-LIPOPROTEIN, WHITE BLOOD-CELLS, CARDIOVASCULAR-DISEASE, LIFE-SPAN, METHIONINE RESTRICTION, FAMILIAL LONGEVITY, ENDOTHELIAL-CELLS, HEART-DISEASE, MORTALITY",
author = "{van der Spek}, Ashley and Linda Broer and Draisma, {Harmen H. M.} and Rene Pool and Eva Albrecht and Marian Beekman and Massimo Mangino and Mait Raag and Nyholt, {Dale R.} and Dharuri, {Harish K.} and Veryan Codd and Najaf Amin and {de Geus}, {Eco J. C.} and Joris Deelen and Ayse Demirkan and Idil Yet and Krista Fischer and Toomas Haller and Henders, {Anjali K.} and Aaron Isaacs and Medland, {Sarah E.} and Montgomery, {Grant W.} and Mooijaart, {Simon P.} and Konstantin Strauch and Suchiman, {H. Eka D.} and Vaarhorst, {Anika A. M.} and {van Heemst}, Diana and Rui Wang-Sattler and Whitfield, {John B.} and Gonneke Willemsen and Wright, {Margaret J.} and Martin, {Nicholas G.} and Samani, {Nilesh J.} and Andres Metspalu and Slagboom, {P. Eline} and Spector, {Tim D.} and Dorret Boomsma and {van Duijn}, {Cornelia M.} and Christian Gieger",
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month = "8",
day = "12",
doi = "10.1038/s41598-019-47282-6",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
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van der Spek, A, Broer, L, Draisma, HHM, Pool, R, Albrecht, E, Beekman, M, Mangino, M, Raag, M, Nyholt, DR, Dharuri, HK, Codd, V, Amin, N, de Geus, EJC, Deelen, J, Demirkan, A, Yet, I, Fischer, K, Haller, T, Henders, AK, Isaacs, A, Medland, SE, Montgomery, GW, Mooijaart, SP, Strauch, K, Suchiman, HED, Vaarhorst, AAM, van Heemst, D, Wang-Sattler, R, Whitfield, JB, Willemsen, G, Wright, MJ, Martin, NG, Samani, NJ, Metspalu, A, Slagboom, PE, Spector, TD, Boomsma, D, van Duijn, CM & Gieger, C 2019, 'Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium', Scientific Reports, vol. 9, 11623. https://doi.org/10.1038/s41598-019-47282-6

Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length : the ENGAGE consortium. / van der Spek, Ashley; Broer, Linda; Draisma, Harmen H. M.; Pool, Rene; Albrecht, Eva; Beekman, Marian; Mangino, Massimo; Raag, Mait; Nyholt, Dale R.; Dharuri, Harish K.; Codd, Veryan; Amin, Najaf; de Geus, Eco J. C.; Deelen, Joris; Demirkan, Ayse; Yet, Idil; Fischer, Krista; Haller, Toomas; Henders, Anjali K.; Isaacs, Aaron; Medland, Sarah E.; Montgomery, Grant W.; Mooijaart, Simon P.; Strauch, Konstantin; Suchiman, H. Eka D.; Vaarhorst, Anika A. M.; van Heemst, Diana; Wang-Sattler, Rui; Whitfield, John B.; Willemsen, Gonneke; Wright, Margaret J.; Martin, Nicholas G.; Samani, Nilesh J.; Metspalu, Andres; Slagboom, P. Eline; Spector, Tim D.; Boomsma, Dorret; van Duijn, Cornelia M.; Gieger, Christian.

In: Scientific Reports, Vol. 9, 11623, 12.08.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length

T2 - the ENGAGE consortium

AU - van der Spek, Ashley

AU - Broer, Linda

AU - Draisma, Harmen H. M.

AU - Pool, Rene

AU - Albrecht, Eva

AU - Beekman, Marian

AU - Mangino, Massimo

AU - Raag, Mait

AU - Nyholt, Dale R.

AU - Dharuri, Harish K.

AU - Codd, Veryan

AU - Amin, Najaf

AU - de Geus, Eco J. C.

AU - Deelen, Joris

AU - Demirkan, Ayse

AU - Yet, Idil

AU - Fischer, Krista

AU - Haller, Toomas

AU - Henders, Anjali K.

AU - Isaacs, Aaron

AU - Medland, Sarah E.

AU - Montgomery, Grant W.

AU - Mooijaart, Simon P.

AU - Strauch, Konstantin

AU - Suchiman, H. Eka D.

AU - Vaarhorst, Anika A. M.

AU - van Heemst, Diana

AU - Wang-Sattler, Rui

AU - Whitfield, John B.

AU - Willemsen, Gonneke

AU - Wright, Margaret J.

AU - Martin, Nicholas G.

AU - Samani, Nilesh J.

AU - Metspalu, Andres

AU - Slagboom, P. Eline

AU - Spector, Tim D.

AU - Boomsma, Dorret

AU - van Duijn, Cornelia M.

AU - Gieger, Christian

PY - 2019/8/12

Y1 - 2019/8/12

KW - PLASMA TOTAL HOMOCYSTEINE

KW - LOW-DENSITY-LIPOPROTEIN

KW - WHITE BLOOD-CELLS

KW - CARDIOVASCULAR-DISEASE

KW - LIFE-SPAN

KW - METHIONINE RESTRICTION

KW - FAMILIAL LONGEVITY

KW - ENDOTHELIAL-CELLS

KW - HEART-DISEASE

KW - MORTALITY

U2 - 10.1038/s41598-019-47282-6

DO - 10.1038/s41598-019-47282-6

M3 - Article

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 11623

ER -