Search results

  • (Systematic) Review article

    Non-alcoholic fatty liver disease and cardiovascular disease: assessing the evidence for causality

    Brouwers, M. C. G. J., Simons, N., Stehouwer, C. D. A. & Isaacs, A., Feb 2020, In: Diabetologia. 63, 2, p. 253-260 8 p.

    Research output: Contribution to journal(Systematic) Review article peer-review

    Open Access
  • Article

    52 Genetic Loci Influencing Myocardial Mass

    van der Harst, P., van Setten, J., Verweij, N., Vogler, G., Franke, L., Maurano, M. T., Wang, X. C., Leach, I. M., Eijgelsheim, M., Sotoodehnia, N., Hayward, C., Sorice, R., Meirelles, O., Lyytikainen, L. P., Polasek, O., Tanaka, T., Arking, D. E., Ulivi, S., Trompet, S., Muller-Nurasyid, M., & 31 othersSmith, A. V., Dorr, M., Kerr, K. F., Magnani, J. W., Del Greco, F., Zhang, W. H., Nolte, I. M., Silva, C. T., Padmanabhan, S., Tragante, V., Esko, T., Abecasis, G. R., Adriaens, M. E., Andersen, K., Barnett, P., Bis, J. C., Bodmer, R., Buckley, B. M., Campbell, H., Cannon, M. V., Chakravarti, A., Chen, L. Y., Delitala, A., Devereux, R. B., Doevendans, P. A., Dominiczak, A. F., Ferrucci, L., Ford, I., Gieger, C., Harris, T. B. & Isaacs, A., 27 Sept 2016, In: Journal of the American College of Cardiology. 68, 13, p. 1435-1448 14 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • A characterization of cis- and trans-heritability of RNA-Seq-based gene expression

    Ouwens, K. G., Jansen, R., Nivard, M. G., van Dongen, J., Frieser, M. J., Hottenga, J-J., Arindrarto, W., Claringbould, A., van Iterson, M., Mei, H., Franke, L., Heijmans, B. T., 't Hoen, P. A. C., van Meurs, J., Brooks, A., Penninx, B. W. J. H., Boomsma, D., Isaacs, A., Pool, R., Hottenga, J. J., & 31 othersvan Greevenbroek, M. M. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Wijmenga, C., Zhernakova, S., Tigchelaar, E. F., Slagboom, P. E., Beekman, M., Deelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., van Galen, M., Bot, J., Zhernakova, D., van't Hof, P., Deelen, P., Nooren, I., Moed, M. & BIOS Consortium, Feb 2020, In: European Journal of Human Genetics. 28, 2, p. 253-263 11 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
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  • A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy

    Silva, C. T., Zorkoltseva, I. V., Niemeijer, M. N., van den Berg, M. E., Amin, N., Demirkan, A., van Leeuwen, E., Iglesias, A. I., Pineros-Hernandez, L. B., Restrepo, C. M., Kors, J. A., Kirichenko, A. V., Willemsen, R., Oostra, B. A., Stricker, B. H., Uitterlinden, A. G., Axenovich, T. I., van Duijn, C. M. & Isaacs, A., 5 Mar 2018, In: BMC Medical Genomics. 11, 10 p., 22.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • A Combined Linkage and Exome Sequencing Analysis for Electrocardiogram Parameters in the Erasmus Rucphen Family Study

    Silva, C. T., Zorkoltseva, I. V., Amin, N., Demirkan, A., van Leeuwen, E. M., Kors, J. A., van den Berg, M., Stricker, B. H., Uitterlinden, A. G., Kirichenko, A. V., Witteman, J. C. M., Willemsen, R., Oostra, B. A., Axenovich, T. I., van Duijn, C. M. & Isaacs, A., 8 Nov 2016, In: Frontiers in Genetics. 7, 10 p., 190.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14

    Solouki, A. M., Verhoeven, V. J. M., van Duijn, C. M., Verkerk, A. J. M. H., Ikram, M. K., Hysi, P. G., Despriet, D. D. G., van Koolwijk, L. M., Ho, L., Ramdas, W. D., Czudowska, M., Kuijpers, R. W. A. M., Amin, N., Struchalin, M., Aulchenko, Y. S., van Rij, G., Riemslag, F. C. C., Young, T. L., Mackey, D. A., Spector, T. D., & 15 othersGorgels, T. G. M. F., Willemse-Assink, J. J. M., Isaacs, A., Kramer, R., Swagemakers, S. M. A., Bergen, A. A. B., van Oosterhout, A. A. L. J., Oostra, B. A., Rivadeneira, F., Uitterlinden, A. G., Hofman, A., de Jong, P. T. V. M., Hammond, C. J., Vingerling, J. R. & Klaver, C. C. W., Oct 2010, In: Nature Genetics. 42, 10, p. 897-901 5 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  • A genome-wide linkage study of individuals with high scores on NEO personality traits

    Amin, N., Schuur, M., Gusareva, E. S., Isaacs, A., Aulchenko, Y. S., Kirichenko, A. V., Zorkoltseva, I. V., Axenovich, T. I., Oostra, B. A., Janssens, A. C. J. W. & van Duijn, C. M., Oct 2012, In: Molecular Psychiatry. 17, 10, p. 1031-41 11 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol

    Surakka, I., Isaacs, A., Karssen, L. C., Laurila, P-P. P., Middelberg, R. P. S., Tikkanen, E., Ried, J. S., Lamina, C., Mangino, M., Igl, W., Hottenga, J-J., Lagou, V., van der Harst, P., Mateo Leach, I., Esko, T., Kutalik, Z., Wainwright, N. W., Struchalin, M. V., Sarin, A-P., Kangas, A. J., & 31 othersViikari, J. S., Perola, M., Rantanen, T., Petersen, A-K., Soininen, P., Johansson, A., Soranzo, N., Heath, A. C., Papamarkou, T., Prokopenko, I., Tönjes, A., Kronenberg, F., Döring, A., Rivadeneira, F., Montgomery, G. W., Whitfield, J. B., Kähönen, M., Lehtimäki, T., Freimer, N. B., Willemsen, G., de Geus, E. J. C., Palotie, A., Sandhu, M. S., Waterworth, D. M., Metspalu, A., Stumvoll, M., Uitterlinden, A. G., Jula, A., Navis, G., Wolffenbuttel, B. H. R. & ENGAGE Consortium, Oct 2011, In: Plos Genetics. 7, 10, p. e1002333

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • A metabolomic profile is associated with the risk of incident coronary heart disease

    Vaarhorst, A. A. M., Verhoeven, A., Weller, C. M., Böhringer, S., Göraler, S., Meissner, A., Deelder, A. M., Henneman, P., Gorgels, A. P. M., van den Brandt, P. A., Schouten, L. J., van Greevenbroek, M. M., Merry, A. H. H., Verschuren, W. M. M., van den Maagdenberg, A. M. J. M., van Dijk, K. W., Isaacs, A., Boomsma, D., Oostra, B. A., van Duijn, C. M., & 5 othersJukema, J. W., Boer, J. M. A., Feskens, E., Heijmans, B. T. & Slagboom, P. E., 1 Jan 2014, In: American Heart Journal. 168, 1, p. 45-52.e7

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

    Liu, J., Carnero-Montoro, E., van Dongen, J., Lent, S., Nedeljkovic, I., Ligthart, S., Tsai, P-C., Martin, T. C., Mandaviya, P. R., Jansen, R., Peters, M. J., Duijts, L., Jaddoe, V. W. V., Tiemeier, H., Felix, J. F., Willemsen, G., de Geus, E. J. C., Chu, A. Y., Levy, D., Hwang, S-J., & 37 othersBressler, J., Gondalia, R., Salfati, E. L., Herder, C., Hidalgo, B. A., Tanaka, T., Moore, A. Z., Lemaitre, R. N., Jhun, M. A., Smith, J. A., Sotoodehnia, N., Bandinelli, S., Ferrucci, L., Arnett, D. K., Grallert, H., Assimes, T. L., Hou, L., Baccarelli, A., Whitsel, E. A., van Dijk, K. W., Amin, N., Uitterlinden, A. G., Sijbrands, E. J. G., Franco, O. H., Dehghan, A., Spector, T. D., Dupuis, J., Hivert, M-F., Rotter, J., Meigs, J. B., Pankow, J. S., van Meurs, J. B. J., Isaacs, A., Boomsma, D., Bell, J. T., Demirkan, A. & van Duijn, C. M., 13 Jun 2019, In: Nature Communications. 10, 11 p., 2581.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • A pharmacogenetic analysis of determinants of hypertension and blood pressure response to angiotensin-converting enzyme inhibitor therapy in patients with vascular disease and healthy individuals

    Brugts, J. J., Isaacs, A., de Maat, M. P., Boersma, E., van Duijn, C. M., Akkerhuis, K. M., Uitterlinden, A. G., Witteman, J. C., Cambien, F., Ceconi, C., Remme, W., Bertrand, M., Ninomiya, T., Harrap, S., Chalmers, J., Macmahon, S., Fox, K., Ferrari, R., Simoons, M. L. & Danser, A. J., Mar 2011, In: Journal of Hypertension. 29, 3, p. 509-19 11 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  • A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

    Ried, J. S., Jeff, J. M., Chu, A. Y., Bragg-Gresham, J. L., van Dongen, J., Huffman, J. E., Ahluwalia, T. S., Cadby, G., Eklund, N., Eriksson, J., Esko, T., Feitosa, M. F., Goel, A., Gorski, M., Hayward, C., Heard-Costa, N. L., Jackson, A. U., Jokinen, E., Kanoni, S., Kristiansson, K., & 32 othersKutalik, Z., Lahti, J., Luan, J., Maegi, R., Mahajan, A., Mangino, M., Medina-Gomez, C., Monda, K. L., Nolte, I. M., Perusse, L., Prokopenko, I., Qi, L., Rose, L. M., Salvi, E., Smith, M. T., Snieder, H., Stancakova, A., Sung, Y. J., Tachmazidou, I., Teumer, A., Thorleifsson, G., van der Harst, P., Walker, R. W., Wang, S. R., Wild, S. H., Willems, S. M., Wong, A., Zhang, W., Albrecht, E., Isaacs, A., Author collaboration & Roos, R. J. F., 23 Nov 2016, In: Nature Communications. 7, 11 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • A SNP panel for identification of DNA and RNA specimens

    Yousefi, S., Abbassi-Daloii, T., Kraaijenbrink, T., Vermaat, M., Mei, H., van't Hof, P., van Iterson, M., Zhernakova, D. V., Claringbould, A., Franke, L., 't Hart, L. M., Slieker, R. C., van der Heijden, A., de Knijff, P., 't Hoen, P. A. C., BIOS Consortium, Jansen, R., van Meurs, J., Heijmans, B. T., Boomsma, D. I., & 45 othersvan Dongen, J., Hottenga, J-J., Slagboom, P. E., Suchiman, H. E. D., van Iterson, M., van Zwet, E. W., 't Hoen, P., Pool, R., van Greevenbroek, M., Stehouwer, C., van der Kallen, C., Schalkwijk, C., Wijmenga, C., Zhernakova, A., Tigchelaar, E. F., Beekman, M., Deelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., Bot, J., Zhernakova, D. V., Van't Hof, P., Deelen, P., Nooren, I., Moed, M., Vermaat, M., Bonder, M. J., van Dijk, F., van Galen, M., Arindrarto, W., Kielbasa, S. M., Swertz, M. A., Isaacs, A. & Franke, L., 25 Jan 2018, In: BMC Genomics. 19, 90, 12 p., 90.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks

    Peloso, G. M., Auer, P. L., Bis, J. C., Voorman, A., Morrison, A. C., Stitziel, N. O., Brody, J. A., Khetarpal, S. A., Crosby, J. R., Fornage, M., Isaacs, A., Jakobsdottir, J., Feitosa, M. F., Davies, G., Huffman, J. E., Manichaikul, A., Davis, B., Lohman, K., Joon, A. Y., Smith, A. V., & 32 othersGrove, M. L., Zanoni, P., Redon, V., Demissie, S., Lawson, K., Peters, U., Carlson, C., Jackson, R. D., Ryckman, K. K., Mackey, R. H., Robinson, J. G., Siscovick, D. S., Schreiner, P. J., Mychaleckyj, J. C., Pankow, J. S., Hofman, A., Uitterlinden, A. G., Harris, T. B., Taylor, K. D., Stafford, J. M., Reynolds, L. M., Marioni, R. E., Dehghan, A., Franco, O. H., Patel, A. P., Lu, Y., Hindy, G., Gottesman, O., Bottinger, E. P., Melander, O., NHLBI GO Exome Sequencing Project & Cupples, L. A., 6 Feb 2014, In: American Journal of Human Genetics. 94, 2, p. 223-32 10 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • Association of the IGF1 gene with fasting insulin levels

    Willems, S. M., Cornes, B. K., Brody, J. A., Morrison, A. C., Lipovich, L., Dauriz, M., Chen, Y., Liu, C-T., Rybin, D. V., Gibbs, R. A., Muzny, D., Pankow, J. S., Psaty, B. M., Boerwinkle, E., Rotter, J. I., Siscovick, D. S., Vasan, R. S., Kaplan, R. C., Isaacs, A., Dupuis, J., & 2 othersvan Duijn, C. M. & Meigs, J. B., Sept 2016, In: European Journal of Human Genetics. 24, 9, p. 1337-1343

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • Open Access
  • Cathepsin D gene and the risk of Alzheimer's disease: a population-based study and meta-analysis

    Schuur, M., Ikram, M. A., van Swieten, J. C., Isaacs, A., Vergeer-Drop, J. M., Hofman, A., Oostra, B. A., Breteler, M. M. B. & van Duijn, C. M., Sept 2011, In: Neurobiology of Aging. 32, 9, p. 1607-14 8 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  • CLEC4M and STXBP5 gene variations contribute to von Willebrand factor level variation in von Willebrand disease

    WiN Study Group, Jun 2015, In: Journal of Thrombosis and Haemostasis. 13, 6, p. 956-66 11 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
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  • Clinical and electrophysiological predictors of device-detected new-onset atrial fibrillation during 3 years after cardiac surgery

    Bidar, E., Zeemering, S., Gilbers, M., Isaacs, A., Verheule, S., Zink, M. D., Maesen, B., Bramer, S., Kawczynski, M., Van Gelder, I. C., Crijns, H. J. G. M., Maessen, J. G. & Schotten, U., 1 Dec 2021, In: EP Europace. 23, 12, p. 1922-1930 9 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval

    Lin, H., van Setten, J., Smith, A. V., Bihlmeyer, N. A., Warren, H. R., Brody, J. A., Radmanesh, F., Hall, L., Grarup, N., Muller-Nurasyid, M., Boutin, T., Verweij, N., Lin, H. J., Li-Gao, R., van den Berg, M. E., Marten, J., Weiss, S., Prins, B. P., Haessler, J., Lyytikainen, L-P., & 78 othersMei, H., Harris, T. B., Launer, L. J., Li, M., Alonso, A., Soliman, E. Z., Connell, J. M., Huang, P. L., Weng, L-C., Jameson, H. S., Hucker, W., Hanley, A., Tucker, N. R., Chen, Y-D. I., Bis, J. C., Rice, K. M., Sitlani, C. M., Kors, J. A., Xie, Z., Wen, C., Magnani, J. W., Nelson, C. P., Kanters, J. K., Sinner, M. F., Strauch, K., Peters, A., Waldenberger, M., Meitinger, T., Bork-Jensen, J., Pedersen, O., Linneberg, A., Rudan, I., de Boer, R. A., van der Meer, P., Yao, J., Guo, X., Taylor, K. D., Sotoodehnia, N., Rotter, J. I., Mook-Kanamori, D. O., Trompet, S., Rivadeneira, F., Uitterlinden, A., Eijgelsheim, M., Padmanabhan, S., Smith, B. H., Volzke, H., Mangino, M., Spector, T. D., Bots, M. L., Perez, M., Kahonen, M., Raitakari, O. T., Gudnason, V., Arking, D. E., Munroe, P. B., Psaty, B. M., van Duijn, C. M., Benjamin, E. J., Rosand, J., Samani, N. J., Hansen, T., Kaab, S., Polasek, O., van der Harst, P., Heckbert, S. R., Jukema, J. W., Stricker, B. H., Hayward, C., Dorr, M., Jamshidi, Y., Asselbergs, F. W., Kooperberg, C., Lehtimaki, T., Wilson, J. G., Ellinor, P. T., Lubitz, S. A. & Isaacs, A., 1 May 2018, In: Circulation: Genomic and Precision Medicine. 11, 5, 11 p., e002037   .

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium

    Mitchell, G. F., Verwoert, G. C., Tarasov, K. V., Isaacs, A., Smith, A. V., Yasmin, Rietzschel, E. R., Tanaka, T., Liu, Y., Parsa, A., Najjar, S. S., O'Shaughnessy, K. M., Sigurdsson, S., De Buyzere, M. L., Larson, M. G., Sie, M. P. S., Andrews, J. S., Post, W. S., Mattace-Raso, F. U. S., McEniery, C. M., & 55 othersEiriksdottir, G., Segers, P., Vasan, R. S., van Rijn, M. J. E., Howard, T. D., McArdle, P. F., Dehghan, A., Jewell, E. S., Newhouse, S. J., Bekaert, S., Hamburg, N. M., Newman, A. B., Hofman, A., Scuteri, A., De Bacquer, D., Ikram, M. A., Psaty, B. M., Fuchsberger, C., Olden, M., Wain, L. V., Elliott, P., Smith, N. L., Felix, J. F., Erdmann, J., Vita, J. A., Sutton-Tyrrell, K., Sijbrands, E. J. G., Sanna, S., Launer, L. J., De Meyer, T., Johnson, A. D., Schut, A. F. C., Herrington, D. M., Rivadeneira, F., Uda, M., Wilkinson, I. B., Aspelund, T., Gillebert, T. C., Van Bortel, L., Benjamin, E. J., Oostra, B. A., Ding, J., Gibson, Q., Uitterlinden, A. G., Abecasis, G. R., Cockcroft, J. R., Gudnason, V., De Backer, G. G., Ferrucci, L., Harris, T. B., Shuldiner, A. R., van Duijn, C. M., Levy, D., Lakatta, E. G. & Witteman, J. C. M., 1 Feb 2012, In: Circulation : Cardiovascular Genetics. 5, 1, p. 81-90 10 p.

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    Open Access
  • Common variants associated with plasma triglycerides and risk for coronary artery disease

    Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Gao, C., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H-Y., Demirkan, A., Den Hertog, H. M., Donnelly, L. A., Ehret, G. B., Esko, T., & 29 othersFeitosa, M. F., Ferreira, T., Fischer, K., Fontanillas, P., Fraser, R. M., Freitag, D. F., Gurdasani, D., Heikkila, K., Hyppoenen, E., Isaacs, A., Jackson, A. U., Johansson, A., Johnson, T., Kaakinen, M., Kettunen, J., Kleber, M. E., Li, X., Luan, J., Lyytikainen, L-P., Magnusson, P. K. E., Mangino, M., Mihailov, E., Montasser, M. E., Mueller-Nurasyid, M., Nolte, I. M., O'Connell, J. R., Palmer, C. D., Perola, M. & Author collaboration, Nov 2013, In: Nature Genetics. 45, 11, p. 1345-1352 9 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  • Common variants in Mendelian kidney disease genes and their association with renal function

    Parsa, A., Fuchsberger, C., Köttgen, A., O'Seaghdha, C. M., Pattaro, C., de Andrade, M., Chasman, D. I., Teumer, A., Endlich, K., Olden, M., Chen, M-H., Tin, A., Kim, Y. J., Taliun, D., Li, M., Feitosa, M., Gorski, M., Yang, Q., Hundertmark, C., Foster, M. C., & 139 othersGlazer, N., Isaacs, A., Rao, M., Smith, A. V., O'Connell, J. R., Struchalin, M., Tanaka, T., Li, G., Hwang, S-J., Atkinson, E. J., Lohman, K., Cornelis, M. C., Johansson, A., Tönjes, A., Dehghan, A., Couraki, V., Holliday, E. G., Sorice, R., Kutalik, Z., Lehtimäki, T., Esko, T., Deshmukh, H., Ulivi, S., Chu, A. Y., Murgia, F., Trompet, S., Imboden, M., Kollerits, B., Pistis, G., Harris, T. B., Launer, L. J., Aspelund, T., Eiriksdottir, G., Mitchell, B. D., Boerwinkle, E., Schmidt, H., Hofer, E., Hu, F., Demirkan, A., Oostra, B. A., Turner, S. T., Ding, J., Andrews, J. S., Freedman, B. I., Giulianini, F., Koenig, W., Illig, T., Döring, A., Wichmann, H-E., Zgaga, L., Zemunik, T., Boban, M., Minelli, C., Wheeler, H. E., Igl, W., Zaboli, G., Wild, S. H., Wright, A. F., Campbell, H., Ellinghaus, D., Nöthlings, U., Jacobs, G., Biffar, R., Ernst, F., Homuth, G., Kroemer, H. K., Nauck, M., Stracke, S., Völker, U., Völzke, H., Kovacs, P., Stumvoll, M., Mägi, R., Hofman, A., Uitterlinden, A. G., Rivadeneira, F., Aulchenko, Y. S., Polasek, O., Hastie, N., Vitart, V., Helmer, C., Wang, J. J., Stengel, B., Ruggiero, D., Bergmann, S., Kähönen, M., Viikari, J., Nikopensius, T., Province, M., Colhoun, H., Doney, A., Robino, A., Krämer, B. K., Portas, L., Ford, I., Buckley, B. M., Adam, M., Thun, G-A., Paulweber, B., Haun, M., Sala, C., Mitchell, P., Ciullo, M., Vollenweider, P., Raitakari, O., Metspalu, A., Palmer, C., Gasparini, P., Pirastu, M., Jukema, J. W., Probst-Hensch, N. M., Kronenberg, F., Toniolo, D., Gudnason, V., Shuldiner, A. R., Coresh, J., Schmidt, R., Ferrucci, L., van Duijn, C. M., Borecki, I., Kardia, S. L. R., Liu, Y., Curhan, G. C., Rudan, I., Gyllensten, U., Wilson, J. F., Franke, A., Pramstaller, P. P., Rettig, R., Prokopenko, I., Witteman, J., Hayward, C., Ridker, P. M., Bochud, M., Heid, I. M., Siscovick, D. S., Fox, C. S., Kao, W. L. & Böger, C. A., Dec 2013, In: Journal of the American Society of Nephrology. 24, 12, p. 2105-17 13 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • Considerations for the Assessment of Substrates, Genetics and Risk Factors in Patients with Atrial Fibrillation

    Linz, D., Verheule, S., Isaacs, A. & Schotten, U., 1 Sept 2021, In: Arrhythmia & Electrophysiology Review. 10, 3, p. 132-139 8 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
  • Defining the role of common variation in the genomic and biological architecture of adult human height

    Wood, A. R., Esko, T., Yang, J., Vedantam, S., Pers, T. H., Gustafsson, S., Chu, A. Y., Estrada, K., Luan, J., Kutalik, Z., Amin, N., Buchkovich, M. L., Croteau-Chonka, D. C., Day, F. R., Duan, Y., Fall, T., Fehrmann, R., Ferreira, T., Jackson, A. U., Karjalainen, J., & 34 othersLo, K. S., Locke, A. E., Mägi, R., Mihailov, E., Porcu, E., Randall, J. C., Scherag, A., Vinkhuyzen, A. A. E., Westra, H-J., Winkler, T. W., Workalemahu, T., Zhao, J. H., Absher, D., Albrecht, E., Anderson, D., Baron, J., Beekman, M., Demirkan, A., Ehret, G. B., Feenstra, B., Feitosa, M. F., Fischer, K., Fraser, R. M., Goel, A., Gong, J., Justice, A. E., Kanoni, S., Isaacs, A., Wong, A., Jacobs, K. B., Electronic Medical Records and Genomics (eMERGE) Consortium, Visscher, P. M., Hirschhorn, J. N. & Frayling, T. M., Nov 2014, In: Nature Genetics. 46, 11, p. 1173-86 14 p.

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  • Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

    ENGAGE Consortium, Jul 2015, In: Plos Genetics. 11, 7, e1005230.

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  • Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

    Iotchkova, V., Huang, J., Morris, J. A., Jain, D., Barbieri, C., Walter, K., Min, J. L., Chen, L., Astle, W., Cocca, M., Deelen, P., Elding, H., Farmaki, A-E., Franklin, C. S., Franberg, M., Gaunt, T. R., Hofman, A., Jiang, T., Kleber, M. E., Lachance, G., & 47 othersLuan, J., Malerba, G., Matchan, A., Mead, D., Memari, Y., Ntalla, I., Panoutsopoulou, K., Pazoki, R., Perry, J. R. B., Rivadeneira, F., Sabater-Lleal, M., Sennblad, B., Shin, S-Y., Southam, L., Traglia, M., van Dijk, F., van Leeuwen, E. M., Zaza, G., Zhang, W., Amin, N., Butterworth, A., Chambers, J. C., Dedoussis, G., Dehghan, A., Franco, O. H., Franke, L., Frontini, M., Gambaro, G., Gasparini, P., Hamsten, A., Issacs, A., Kooner, J. S., Kooperberg, C., Langenberg, C., Marz, W., Scott, R. A., Swertz, M. A., Toniolo, D., Uitterlinden, A. G., van Duijn, C. M., Watkins, H., Zeggini, E., Maurano, M. T., Timpson, N. J., Reiner, A. P., Auer, P. L. & Soranzo, N., Nov 2016, In: Nature Genetics. 48, 11, p. 1303-1312

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  • Discovery and refinement of loci associated with lipid levels

    Willer, C. J., Schmidt, E. M., Sengupta, S., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H-Y., Demirkan, A., Den Hertog, H. M., Do, R., Donnelly, L. A., Ehret, G. B., Esko, T., Feitosa, M. F., & 31 othersFerreira, T., Fischer, K., Fontanillas, P., Fraser, R. M., Freitag, D. F., Gurdasani, D., Heikkilä, K., Hyppönen, E., Isaacs, A., Jackson, A. U., Johansson, Å., Johnson, T., Kaakinen, M., Kettunen, J., Kleber, M. E., Li, X., Luan, J., Lyytikäinen, L-P., Magnusson, P. K. E., Mangino, M., Mihailov, E., Montasser, M. E., Müller-Nurasyid, M., Nolte, I. M., O'Connell, J. R., Palmer, C. D., Perola, M., Petersen, A-K., Wong, A., Wolffenbuttel, B. H. R. & Global Lipids Genetics Consortium, Nov 2013, In: Nature Genetics. 45, 11, p. 1274-1283 10 p.

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  • Discovery of novel heart rate-associated loci using the Exome Chip

    van den Berg, M. E., Warren, H. R., Cabrera, C. P., Verweij, N., Mifsud, B., Haessler, J., Bihlmeyer, N. A., Fu, Y-P., Weiss, S., Lin, H. J., Grarup, N., Li-Gao, R., Pistis, G., Shah, N., Brody, J. A., Mueller-Nurasyid, M., Lin, H., Mei, H., Smith, A. V., Lyytikainen, L-P., & 101 othersHall, L. M., van Setten, J., Trompet, S., Prins, B. P., Isaacs, A., Radmanesh, F., Marten, J., Entwistle, A., Kors, J. A., Silva, C. T., Alonso, A., Bis, J. C., de Boer, R., de Haan, H. G., de Mutsert, R., Dedoussis, G., Dominiczak, A. F., Doney, A. S. F., Ellinor, P. T., Eppinga, R. N., Felix, S. B., Guo, X., Hagemeijer, Y., Hansen, T., Harris, T. B., Heckbert, S. R., Huang, P. L., Hwang, S-J., Kahonen, M., Kanters, J. K., Kolcic, I., Launer, L. J., Li, M., Yao, J., Linneberg, A., Liu, S., Macfarlane, P. W., Mangino, M., Morris, A. D., Mulas, A., Murray, A. D., Nelson, C. P., Orru, M., Padmanabhan, S., Peters, A., Porteous, D. J., Poulter, N., Psaty, B. M., Qi, L., Raitakari, O. T., Rivadeneira, F., Roselli, C., Rudan, I., Sattar, N., Sever, P., Sinner, M. F., Soliman, E. Z., Spector, T. D., Stanton, A. V., Stirrups, K. E., Taylor, K. D., Tobin, M. D., Uitterlinden, A., Vaartjes, I., Hoes, A. W., van der Meer, P., Voelker, U., Waldenberger, M., Xie, Z., Zoledziewska, M., Tinker, A., Polasek, O., Rosand, J., Jamshidi, Y., van Duijn, C. M., Zeggini, E., Jukema, J. W., Asselbergs, F. W., Samani, N. J., Lehtimaki, T., Gudnason, V., Wilson, J., Lubitz, S. A., Kaeaeb, S., Sotoodehnia, N., Caulfield, M. J., Palmer, C. N. A., Sanna, S., Mook-Kanamori, D. O., Deloukas, P., Pedersen, O., Rotter, J. I., Doerr, M., O'Donnell, C. J., Hayward, C., Arking, D. E., Kooperberg, C., van der Harst, P., Eijgelsheim, M., Stricker, B. H. & Munroe, P. B., 15 Jun 2017, In: Human Molecular Genetics. 26, 12, p. 2346-2363 18 p.

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  • Discriminative Ability of Plasma Branched-Chain Amino Acid Levels for Glucose Intolerance in Families At Risk for Type 2 Diabetes

    Jainandunsing, S., Wattimena, J. L. D., Verhoeven, A. J. M., Langendonk, J. G., Rietveld, T., Isaacs, A. J., Sijbrands, E. J. G. & de Rooij, F. W. M., 1 Apr 2016, In: Metabolic syndrome and related disorders. 14, 3, p. 175-181

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  • Disease variants alter transcription factor levels and methylation of their binding sites

    Bonder, M. J., Luijk, R., Zhernakova, D. V., Moed, M., Deelen, P., Vermaat, M., van Iterson, M., van Dijk, F., van Galen, M., Bot, J., Slieker, R. C., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Arindrarto, W., Kielbasa, S. M., & 33 othersJonkers, I., van 't Hof, P., Nooren, I., Beekman, M., Deelen, J., van Heemst, D., Zhernakova, A., Tigchelaar, E. F., Swertz, M. A., Hofman, A., Uitterlinden, A. G., Pool, R., van Dongen, J., Hottenga, J. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., van den Berg, L. H., van Zwet, E. W., Mei, H., Li, Y., Lemire, M., Hudson, T. J., Slagboom, P. E., Wijmenga, C., Veldink, J. H., van Greevenbroek, M. M. J., van Duijn, C. M., Boomsma, D. I., Isaacs, A., BIOS Consortium, Heijmans, B. T. & Franke, L., Jan 2017, In: Nature Genetics. 49, 1, p. 131-138 8 p.

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  • Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval

    Avery, C. L., Sitlani, C. M., Arking, D. E., Arnett, D. K., Bis, J. C., Boerwinkle, E., Buckley, B. M., Ida Chen, Y-D., de Craen, A. J. M., Eijgelsheim, M., Enquobahrie, D., Evans, D. S., Ford, I., Garcia, M. E., Gudnason, V., Harris, T. B., Heckbert, S. R., Hochner, H., Hofman, A., Hsueh, W-C., & 34 othersIsaacs, A., Jukema, J. W., Knekt, P., Kors, J. A., Krijthe, B. P., Kristiansson, K., Laaksonen, M., Liu, Y., Li, X., Macfarlane, P. W., Newton-Cheh, C., Nieminen, M. S., Oostra, B. A., Peloso, G. M., Porthan, K., Rice, K., Rivadeneira, F. F., Rotter, J. I., Salomaa, V., Sattar, N., Siscovick, D. S., Slagboom, P. E., Smith, A. V., Sotoodehnia, N., Stott, D. J., Stricker, B. H., Stürmer, T., Trompet, S., Uitterlinden, A. G., van Duijn, C., Westendorp, R. G. J., Witteman, J. C., Whitsel, E. A. & Psaty, B. M., Feb 2014, In: Pharmacogenomics Journal. 14, 1, p. 6-13 8 p.

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  • Dynamic risk assessment to improve quality of care in patients with atrial fibrillation: the 7th AFNET/EHRA Consensus Conference

    Fabritz, L., Crijns, H. J. G. M., Guasch, E., Goette, A., Häusler, K. G., Kotecha, D., Lewalter, T., Meyer, C., Potpara, T. S., Rienstra, M., Schnabel, R. B., Willems, S., Breithardt, G., Camm, A. J., Chan, A., Chua, W., de Melis, M., Dimopoulou, C., Dobrev, D., Easter, C., & 38 othersEckardt, L., Haase, D., Hatem, S., Healey, J. S., Heijman, J., Hohnloser, S. H., Huebner, T., Ilyas, B. S., Isaacs, A., Kutschka, I., Leclercq, C., Lip, G. Y. H., Marinelli, E. A., Merino, J. L., Mont, L., Nabauer, M., Oldgren, J., Pürerfellner, H., Ravens, U., Savelieva, I., Sinner, M. F., Sitch, A., Smolnik, R., Steffel, J., Stein, K., Stoll, M., Svennberg, E., Thomas, D., Van Gelder, I. C., Vardar, B., Wakili, R., Wieloch, M., Zeemering, S., Ziegler, P. D., Heidbuchel, H., Hindricks, G., Schotten, U. & Kirchhof, P., Mar 2021, In: EP Europace. 23, 3, p. 329-344 16 p.

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  • Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults

    van Dongen, J., Zilhao, N. R., Sugden, K., Hannon, E. J., Mill, J., Caspi, A., Agnew-Blais, J., Arseneault, L., Corcoran, D. L., Moffitt, T. E., Poulton, R., Franke, B., Boomsma, D., Heijmans, B. T., t'Hoen, P. A. G., van Meurs, J., Isaacs, A., Jansen, R., Franke, L., Pool, R., & 31 othersHottenga, J. J., van Greevenbroek, M. M. J., Stehouwer, C. D. A., van der Kallen, C. J. H., Schalkwijk, C. G., Wijmenga, C., Zhernakova, S., Tigchelaar, E. F., Slagboom, P. E., Beekman, M., Deelen, J., van Heemst, D., Veldink, J. H., van den Berg, L. H., van Duijn, C. M., Hofman, B. A., Uitterlinden, A. G., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Mei, H., van Iterson, M., van Galen, M., Bot, J., Zhernakova, D., van t'Hof, P. & BIOS Consortium, 15 Oct 2019, In: Biological Psychiatry. 86, 8, p. 599-607 9 p.

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  • Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

    Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity, Chambers, J. C., Grallert, H. & Kooner, J. S., 5 Jan 2017, In: Nature. 541, 7635, p. 81-86 6 p.

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  • Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

    Prins, B. P., Mead, T. J., Brody, J. A., Sveinbjornsson, G., Ntalla, I., Bihlmeyer, N. A., van den Berg, M., Bork-Jensen, J., Cappellani, S., Van Duijvenboden, S., Klena, N. T., Gabriel, G. C., Liu, X., Gulec, C., Grarup, N., Haessler, J., Hall, L. M., Iorio, A., Isaacs, A., Li-Gao, R., & 93 othersLin, H., Liu, C-T., Lyytikainen, L-P., Marten, J., Mei, H., Muller-Nurasyid, M., Orini, M., Padmanabhan, S., Radmanesh, F., Ramirez, J., Robino, A., Schwartz, M., van Setten, J., Smith, A. V., Verweij, N., Warren, H. R., Weiss, S., Alonso, A., Arnar, D. O., Bots, M. L., de Boer, R. A., Dominiczak, A. F., Eijgelsheim, M., Ellinor, P. T., Guo, X., Felix, S. B., Harris, T. B., Hayward, C., Heckbert, S. R., Huang, P. L., Jukema, J. W., Kahonen, M., Kors, J. A., Lambiase, P. D., Launer, L. J., Li, M., Linneberg, A., Nelson, C. P., Pedersen, O., Perez, M., Peters, A., Polasek, O., Psaty, B. M., Raitakari, O. T., Rice, K. M., Rotter, J. I., Sinner, M. F., Soliman, E. Z., Spector, T. D., Strauch, K., Thorsteinsdottir, U., Tinker, A., Trompet, S., Uitterlinden, A., Vaartjes, I., van der Meer, P., Volker, U., Volzke, H., Waldenberger, M., Wilson, J. G., Xie, Z., Asselbergs, F. W., Dorr, M., van Duijn, C. M., Gasparini, P., Gudbjartsson, D. F., Gudnason, V., Hansen, T., Kaab, S., Kanters, J. K., Kooperberg, C., Lehtimaki, T., Lin, H. J., Lubitz, S. A., Mook-Kanamori, D. O., Conti, F. J., Newton-Cheh, C. H., Rosand, J., Rudan, I., Samani, N. J., Sinagra, G., Smith, B. H., Holm, H., Stricker, B. H., Ulivi, S., Sotoodehnia, N., Apte, S. S., van der Harst, P., Stefansson, K., Munroe, P. B., Arking, D. E., Lo, C. W. & Jamshidi, Y., 17 Jul 2018, In: Genome Biology. 19, 17 p., 87.

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  • ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals

    Bihlmeyer, N. A., Brody, J. A., Smith, A. V., Warren, H. R., Lin, H., Isaacs, A., Liu, C-T., Marten, J., Radmanesh, F., Hall, L. M., Grarup, N., Mei, H., Muller-Nurasyid, M., Huffman, J. E., Verweij, N., Guo, X., Yao, J., Li-Gao, R., van den Berg, M., Weiss, S., & 80 othersPrins, B. P., van Setten, J., Haessler, J., Lyytikainen, L-P., Li, M., Alonso, A., Soliman, E. Z., Bis, J. C., Austin, T., Chen, Y-D. I., Psaty, B. M., Harrris, T. B., Launer, L. J., Padmanabhan, S., Dominiczak, A., Huang, P. L., Xie, Z., Ellinor, P. T., Kors, J. A., Campbell, A., Murray, A. D., Nelson, C. P., Tobin, M. D., Bork-Jensen, J., Hansen, T., Pedersen, O., Linneberg, A., Sinner, M. F., Peters, A., Waldenberger, M., Meitinger, T., Perz, S., Kolcic, I., Rudan, I., de Boer, R. A., van der Meer, P., Lin, H. J., Taylor, K. D., de Mutsert, R., Trompet, S., Jukema, J. W., Maan, A. C., Stricker, B. H. C., Rivadeneira, F., Uitterlinden, A., Volker, U., Homuth, G., Volzke, H., Felix, S. B., Mangino, M., Spector, T. D., Bots, M. L., Perez, M., Raitakari, O. T., Kahonen, M., Mononen, N., Gudnason, V., Munroe, P. B., Lubitz, S. A., van Duijn, C. M., Newton-Cheh, C. H., Hayward, C., Rosand, J., Samani, N. J., Kanters, J. K., Wilson, J. G., Kaab, S., Polasek, O., van der Harst, P., Heckbert, S. R., Rotter, J. I., Mook-Kanamori, D. O., Eij-Gelsheim, M., Dorr, M., Jamshidi, Y., Asselbergs, F. W., Kooperberg, C., Lehtimaki, T., Arking, D. E. & Sotoodehnia, N., 1 Jan 2018, In: Circulation : Cardiovascular Genetics. 11, 1, 63 p., e001758.

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  • Failing beta-cell adaptation in South Asian families with a high risk of type 2 diabetes

    Jainandunsing, S., Özcan, B., Rietveld, T., van Miert, J. N. I., Isaacs, A. J., Langendonk, J. G., de Rooij, F. W. M. & Sijbrands, E. J. G., Feb 2015, In: Acta Diabetologica. 52, 1, p. 11-9 9 p.

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  • Fifteen Genetic Loci Associated With the Electrocardiographic P Wave

    Christophersen, I. E., Magnani, J. W., Yin, X., Barnard, J., Weng, L-C., Arking, D. E., Niemeijer, M. N., Lubitz, S. A., Avery, C. L., Duan, Q., Felix, S. B., Bis, J. C., Kerr, K. F., Isaacs, A., Mueller-Nurasyid, M., Mueller, C., North, K. E., Reiner, A. P., Tinker, L. F., Kors, J. A., & 32 othersTeumer, A., Petersmann, A., Sinner, M. F., Buzkova, P., Smith, J. D., Van Wagoner, D. R., Voelker, U., Waldenberger, M., Peters, A., Meitinger, T., Limacher, M. C., Wilhelmsen, K. C., Psaty, B. M., Hofman, A., Uitterlinden, A., Krijthe, B. P., Zhang, Z-M., Schnabel, R. B., Kaeaeb, S., van Duijn, C., Rotter, J. I., Sotoodehnia, N., Doerr, M., Li, Y., Chung, M. K., Soliman, E. Z., Alonso, A., Whitsel, E. A., Stricker, B. H., Benjamin, E. J., Heckbert, S. R. & Ellinor, P. T., Aug 2017, In: Circulation : Cardiovascular Genetics. 10, 4, 57 p., 001667.

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  • Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans

    Evans, D. S., Avery, C. L., Nalls, M. A., Li, G., Barnard, J., Smith, E. N., Tanaka, T., Butler, A. M., Buxbaum, S. G., Alonso, A., Arking, D. E., Berenson, G. S., Bis, J. C., Buyske, S., Carty, C. L., Chen, W., Chung, M. K., Cummings, S. R., Deo, R., Eaton, C. B., & 41 othersFox, E. R., Heckbert, S. R., Heiss, G., Hindorff, L. A., Hsueh, W-C., Isaacs, A., Jamshidi, Y., Kerr, K. F., Liu, F., Liu, Y., Lohman, K. K., Magnani, J. W., Maher, J. F., Mehra, R., Meng, Y. A., Musani, S. K., Newton-Cheh, C., North, K. E., Psaty, B. M., Redline, S., Rotter, J. I., Schnabel, R. B., Schork, N. J., Shohet, R. V., Singleton, A. B., Smith, J. D., Soliman, E. Z., Srinivasan, S. R., Taylor, H. A. . J., Van Wagoner, D. R., Wilson, J. G., Young, T., Zhang, Z-M., Zonderman, A. B., Evans, M. K., Ferrucci, L., Murray, S. S., Tranah, G. J., Whitsel, E. A., Reiner, A. P. & Sotoodehnia, N., 1 Oct 2016, In: Human Molecular Genetics. 25, 19, p. 4350-4368

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  • Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C

    van Leeuwen, E. M., Huffman, J. E., Bis, J. C., Isaacs, A., Mulder, M., Sabo, A., Smith, A. V., Demissie, S., Manichaikul, A., Brody, J. A., Feitosa, M. F., Duan, Q., Schraut, K. E., Navarro, P., van Vliet-Ostaptchouk, J. V., Zhu, G., Mbarek, H., Trompet, S., Verweij, N., Lyytikäinen, L-P., & 32 othersDeelen, J., Nolte, I. M., van der Laan, S. W., Davies, G., Vermeij-Verdoold, A. J., van Oosterhout, A. A., Vergeer-Drop, J. M., Arking, D. E., Trochet, H., Medina-Gomez, C., Rivadeneira, F., Uitterlinden, A. G., Dehghan, A., Franco, O. H., Sijbrands, E. J., Hofman, A., White, C. C., Mychaleckyj, J. C., Peloso, G. M., Swertz, M. A., Willemsen, G., de Geus, E. J., Milaneschi, Y., Penninx, B. W., Ford, I., Buckley, B. M., de Craen, A. J., Starr, J. M., Deary, I. J., Pasterkamp, G., Generation Scotland & van Duijn, C., 2015, In: NPJ aging and mechanisms of disease. 1, p. 15011

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  • FTO genotype is associated with phenotypic variability of body mass index

    Yang, J., Loos, R. J. F., Powell, J. E., Medland, S. E., Speliotes, E. K., Chasman, D. I., Rose, L. M., Thorleifsson, G., Steinthorsdottir, V., Maegi, R., Waite, L. L., Smith, A. V., Yerges-Armstrong, L. M., Monda, K. L., Hadley, D., Mahajan, A., Li, G., Kapur, K., Vitart, V., Huffman, J. E., & 151 othersWang, S. R., Palmer, C., Esko, T., Fischer, K., Zhao, J. H., Demirkan, A., Isaacs, A., Feitosa, M. F., Luan, J., Heard-Costa, N. L., White, C. C., Jackson, A. U., Preuss, M., Ziegler, A., Eriksson, J., Kutalik, Z., Frau, F., Nolte, I. M., van Vliet-Ostaptchouk, J. V., Hottenga, J-J., Jacobs, K. B., Verweij, N., Goel, A., Medina-Gomez, C., Estrada, K., Bragg-Gresham, J. L., Sanna, S., Sidore, C., Tyrer, J. P., Teumer, A., Prokopenko, I., Mangino, M., Lindgren, C. M., Assimes, T. L., Shuldiner, A. R., Hui, J., Beilby, J. P., McArdle, W. L., Hall, P., Haritunians, T., Zgaga, L., Kolcic, I., Polasek, O., Zemunik, T., Oostra, B. A., Junttila, M. J., Groenberg, H., Schreiber, S., Peters, A., Hicks, A. A., Stephens, J. C., Foad, N. S., Laitinen, J., Pouta, A., Kaakinen, M., Willemsen, G., Vink, J. M., Wild, S. H., Navis, G., Asselbergs, F. W., Homuth, G., John, U., Iribarren, C., Harris, T. B., Launer, L. J., Gudnason, V., O'Connell, J. R., Boerwinkle, E., Cadby, G., Palmer, L. J., James, A. L., Musk, A. W., Ingelsson, E., Psaty, B. M., Beckmann, J. S., Waeber, G., Vollenweider, P., Hayward, C., Wright, A. F., Rudan, I., Groop, L. C., Metspalu, A., Khaw, K-T., Duijn, C. M. V., Borecki, I. B., Province, M. A., Wareham, N. J., Tardif, J-C., Huikuri, H. V., Cupples, L. A., Atwood, L. D., Fox, C. S., Boehnke, M., Collins, F. S., Mohlke, K. L., Erdmann, J., Schunkert, H., Hengstenberg, C., Stark, K., Lorentzon, M., Ohlsson, C., Cusi, D., Staessen, J. A., Van der Klauw, M. M., Pramstaller, P. P., Kathiresan, S., Jolley, J. D., Ripatti, S., Jarvelin, M-R., de Geus, E. J. C., Boomsma, D. I., Penninx, B. W. J. H., Wilson, J. F., Campbell, H., Chanock, S. J., van der Harst, P., Hamsten, A., Watkins, H., Hofman, A., Witteman, J. C. M., Zillikens, M. C., Uitterlinden, A. G., Rivadeneira, F., Kiemeney, L. A., Vermeulen, S. H., Abecasis, G. R., Schlessinger, D., Schipf, S., Stumvoll, M., Toenjes, A., Spector, T. D., North, K. E., Lettre, G., McCarthy, M. I., Berndt, S. I., Heath, A. C., Madden, P. A. F., Nyholt, D. R., Montgomery, G. W., Martin, N. G., McKnight, B., Strachan, D. P., Hill, W. G., Snieder, H., Ridker, P. M., Thorsteinsdottir, U., Stefansson, K., Frayling, T. M., Hirschhorn, J. N., Goddard, M. E. & Visscher, P. M., 11 Oct 2012, In: Nature. 490, 7419, p. 267–272

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  • Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci

    Tragante, V., Barnes, M. R., Ganesh, S. K., Lanktree, M. B., Guo, W., Franceschini, N., Smith, E. N., Johnson, T., Holmes, M. V., Padmanabhan, S., Karczewski, K. J., Almoguera, B., Barnard, J., Baumert, J., Chang, Y-P. C., Elbers, C. C., Farrall, M., Fischer, M. E., Gaunt, T. R., Gho, J. M. I. H., & 116 othersGieger, C., Goel, A., Gong, Y., Isaacs, A., Kleber, M. E., Mateo Leach, I., McDonough, C. W., Meijs, M. F. L., Melander, O., Nelson, C. P., Nolte, I. M., Pankratz, N., Price, T. S., Shaffer, J., Shah, S., Tomaszewski, M., van der Most, P. J., Van Iperen, E. P. A., Vonk, J. M., Witkowska, K., Wong, C. O. L., Zhang, L., Beitelshees, A. L., Berenson, G. S., Bhatt, D. L., Brown, M., Burt, A., Cooper-DeHoff, R. M., Connell, J. M., Cruickshanks, K. J., Curtis, S. P., Davey-Smith, G., Delles, C., Gansevoort, R. T., Guo, X., Haiqing, S., Hastie, C. E., Hofker, M. H., Hovingh, G. K., Kim, D. S., Kirkland, S. A., Klein, B. E., Klein, R., Li, Y. R., Maiwald, S., Newton-Cheh, C., O'Brien, E. T., Onland-Moret, N. C., Palmas, W., Parsa, A., Penninx, B. W., Pettinger, M., Vasan, R. S., Ranchalis, J. E., M Ridker, P., Rose, L. M., Sever, P., Shimbo, D., Steele, L., Stolk, R. P., Thorand, B., Trip, M. D., van Duijn, C. M., Verschuren, W. M., Wijmenga, C., Wyatt, S., Young, J. H., Zwinderman, A. H., Bezzina, C. R., Boerwinkle, E., Casas, J. P., Caulfield, M. J., Chakravarti, A., Chasman, D. I., Davidson, K. W., Doevendans, P. A., Dominiczak, A. F., FitzGerald, G. A., Gums, J. G., Fornage, M., Hakonarson, H., Halder, I., Hillege, H. L., Illig, T., Jarvik, G. P., Johnson, J. A., Kastelein, J. J. P., Koenig, W., Kumari, M., März, W., Murray, S. S., O'Connell, J. R., Oldehinkel, A. J., Pankow, J. S., Rader, D. J., Redline, S., Reilly, M. P., Schadt, E. E., Kottke-Marchant, K., Snieder, H., Snyder, M., Stanton, A. V., Tobin, M. D., Uitterlinden, A. G., van der Harst, P., van der Schouw, Y. T., Samani, N. J., Watkins, H., Johnson, A. D., Reiner, A. P., Zhu, X., de Bakker, P. I. W., Levy, D., Asselbergs, F. W., Munroe, P. B. & Keating, B. J., 6 Mar 2014, In: American Journal of Human Genetics. 94, 3, p. 349-60 12 p.

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    Open Access
  • General maternal medication use, folic acid, the MDR1 C3435T polymorphism, and the risk of a child with a congenital heart defect

    Obermann-Borst, S. A., Isaacs, A., Younes, Z., van Schaik, R. H. N., van der Heiden, I. P., van Duyn, C. M., Steegers, E. A. P. & Steegers-Theunissen, R. P. M., Mar 2011, In: American Journal of Obstetrics and Gynecology. 204, 3, p. 236.e1-8

    Research output: Contribution to journalArticleAcademicpeer-review

  • Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

    Young, W. J., Lahrouchi, N., Isaacs, A., Duong, T., Foco, L., Ahmed, F., Brody, J. A., Salman, R., Noordam, R., Benjamins, J-W., Haessler, J., Lyytikäinen, L-P., Repetto, L., Concas, M. P., van den Berg, M. E., Weiss, S., Baldassari, A. R., Bartz, T. M., Cook, J. P., Evans, D. S., & 146 othersFreudling, R., Hines, O., Isaksen, J. L., Lin, H., Mei, H., Moscati, A., Müller-Nurasyid, M., Nursyifa, C., Qian, Y., Richmond, A., Roselli, C., Ryan, K. A., Tarazona-Santos, E., Thériault, S., van Duijvenboden, S., Warren, H. R., Yao, J., Raza, D., Aeschbacher, S., Ahlberg, G., Alonso, A., Andreasen, L., Bis, J. C., Boerwinkle, E., Campbell, A., Catamo, E., Cocca, M., Cutler, M. J., Darbar, D., De Grandi, A., De Luca, A., Ding, J., Ellervik, C., Ellinor, P. T., Felix, S. B., Froguel, P., Fuchsberger, C., Gögele, M., Graff, C., Graff, M., Guo, X., Hansen, T., Heckbert, S. R., Huang, P. L., Huikuri, H. V., Hutri-Kähönen, N., Ikram, M. A., Jackson, R. D., Junttila, J., Kavousi, M., Kors, J. A., Leal, T. P., Lemaitre, R. N., Lin, H. J., Lind, L., Linneberg, A., Liu, S., MacFarlane, P. W., Mangino, M., Meitinger, T., Mezzavilla, M., Mishra, P. P., Mitchell, R. N., Mononen, N., Montasser, M. E., Morrison, A. C., Nauck, M., Nauffal, V., Navarro, P., Nikus, K., Pare, G., Patton, K. K., Pelliccione, G., Pittman, A., Porteous, D. J., Pramstaller, P. P., Preuss, M. H., Raitakari, O. T., Reiner, A. P., Ribeiro, A. L. P., Rice, K. M., Risch, L., Schlessinger, D., Schotten, U., Schurmann, C., Shen, X., Shoemaker, M. B., Sinagra, G., Sinner, M. F., Soliman, E. Z., Stoll, M., Strauch, K., Tarasov, K., Taylor, K. D., Tinker, A., Trompet, S., Uitterlinden, A., Völker, U., Völzke, H., Waldenberger, M., Weng, L-C., Whitsel, E. A., Wilson, J. G., Avery, C. L., Conen, D., Correa, A., Cucca, F., Dörr, M., Gharib, S. A., Girotto, G., Grarup, N., Hayward, C., Jamshidi, Y., Järvelin, M-R., Jukema, J. W., Kääb, S., Kähönen, M., Kanters, J. K., Kooperberg, C., Lehtimäki, T., Lima-Costa, M. F., Liu, Y., Loos, R. J. F., Lubitz, S. A., Mook-Kanamori, D. O., Morris, A. P., O'Connell, J. R., Olesen, M. S., Orini, M., Padmanabhan, S., Pattaro, C., Peters, A., Psaty, B. M., Rotter, J. I., Stricker, B., van der Harst, P., van Duijn, C. M., Verweij, N., Wilson, J. F., Arking, D. E., Ramirez, J., Lambiase, P. D., Sotoodehnia, N., Mifsud, B., Newton-Cheh, C. & Munroe, P. B., 1 Sept 2022, In: Nature Communications. 13, 1, 18 p., 5144.

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  • Genetic architecture of circulating lipid levels

    Demirkan, A., Amin, N., Isaacs, A., Jarvelin, M-R., Whitfield, J. B., Wichmann, H-E., Kyvik, K. O. H. M., Rudan, I., Gieger, C., Hicks, A. A., Johansson, Å., Hottenga, J-J., Smith, J. J., Wild, S. H., Pedersen, N. L., Willemsen, G., Mangino, M., Hayward, C., Uitterlinden, A. G., Hofman, A., & 27 othersWitteman, J., Montgomery, G. W., Pietiläinen, K. H., Rantanen, T., Kaprio, J., Döring, A., Pramstaller, P. P., Gyllensten, U., de Geus, E. J. C., Penninx, B. W., Wilson, J. F., Rivadeneria, F., Magnusson, P. K. E., Boomsma, D. I., Spector, T., Campbell, H., Hoehne, B., Martin, N. G., Oostra, B. A., McCarthy, M., Peltonen-Palotie, L., Aulchenko, Y., Visscher, P. M., Ripatti, S., Janssens, A. C. J. W., van Duijn, C. M. & ENGAGE Consortium, Jul 2011, In: European Journal of Human Genetics. 19, 7, p. 813-9 7 p.

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  • Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

    Young, W. J., Haessler, J., Benjamins, J. W., Repetto, L., Yao, J., Isaacs, A., Harper, A. R., Ramirez, J., Garnier, S., van Duijvenboden, S., Baldassari, A. R., Concas, M. P., Duong, T. V., Foco, L., Isaksen, J. L., Mei, H., Noordam, R., Nursyifa, C., Richmond, A., Santolalla, M. L., & 33 othersSitlani, C. M., Soroush, N., Thériault, S., Trompet, S., Aeschbacher, S., Ahmadizar, F., Alonso, A., Brody, J. A., Campbell, A., Correa, A., Darbar, D., De Luca, A., Deleuze, J. F., Ellervik, C., Fuchsberger, C., Goel, A., Grace, C., Guo, X., Hansen, T., Heckbert, S. R., Jackson, R. D., Kors, J. A., Lima-Costa, M. F., Linneberg, A., Macfarlane, P. W., Morrison, A. C., Navarro, P., Porteous, D. J., Schotten, U., Stoll, M., Tereshchenko, L. G., Munroe, P. B. & Et al., 1 Dec 2023, In: Nature Communications. 14, 1, 16 p., 1411.

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  • Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

    Pattaro, C., Teumer, A., Gorski, M., Chu, A. Y., Li, M., Mijatovic, V., Garnaas, M., Tin, A., Sorice, R., Li, Y., Taliun, D., Olden, M., Foster, M., Yang, Q., Chen, M-H., Pers, T. H., Johnson, A. D., Ko, Y-A., Fuchsberger, C., Tayo, B., & 31 othersNalls, M., Feitosa, M. F., Isaacs, A., Dehghan, A., d'Adamo, P., Adeyemo, A., Dieffenbach, A. K., Zonderman, A. B., Nolte, I. M., van der Most, P. J., Wright, A. F., Shuldiner, A. R., Morrison, A. C., Hofman, A., Smith, A. V., Dreisbach, A. W., Franke, A., Uitterlinden, A. G., Metspalu, A., Tonjes, A., Lupo, A., Robino, A., Johansson, A., Demirkan, A., Kollerits, B., Freedman, B. I., Ponte, B., Oostra, B. A., Paulweber, B., Kraemer, B. K. & Author collaboration, Jan 2016, In: Nature Communications. 7, 19 p.

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  • Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

    Arking, D. E., Pulit, S. L., Crotti, L., van der Harst, P., Munroe, P. B., Koopmann, T. T., Sotoodehnia, N., Rossin, E. J., Morley, M., Wang, X., Johnson, A. D., Lundby, A., Gudbjartsson, D. F., Noseworthy, P. A., Eijgelsheim, M., Bradford, Y., Tarasov, K. V., Dörr, M., Müller-Nurasyid, M., Lahtinen, A. M., & 32 othersNolte, I. M., Smith, A. V., Bis, J. C., Isaacs, A., Newhouse, S. J., Evans, D. S., Post, W. S., Waggott, D., Lyytikäinen, L-P., Hicks, A. A., Eisele, L., Ellinghaus, D., Hayward, C., Navarro, P., Ulivi, S., Tanaka, T., Tester, D. J., Chatel, S., Gustafsson, S., Kumari, M., Morris, R. W., Naluai, Å. T., Padmanabhan, S., Kluttig, A., Strohmer, B., Panayiotou, A. G., Torres, M., Knoflach, M., Hubacek, J. A., den Hoed, M., CARe Consortium & Newton-Cheh, C. H., Aug 2014, In: Nature Genetics. 46, 8, p. 826-36 11 p.

    Research output: Contribution to journalArticleAcademicpeer-review

  • Genetic Determinants of Electrocardiographic P-Wave Duration and Relation to Atrial Fibrillation

    Weng, L-C., Hall, A. W., Choi, S. H., Jurgens, S. J., Haessler, J., Bihlmeyer, N. A., Grarup, N., Lin, H., Teumer, A., Li-Gao, R., Yao, J., Guo, X., Brody, J. A., Mueller-Nurasyid, M., Schramm, K., Verweij, N., van den Berg, M. E., van Setten, J., Isaacs, A., Ramirez, J., & 40 othersWarren, H. R., Padmanabhan, S., Kors, J. A., de Boer, R. A., van der Meer, P., Sinner, M. F., Waldenberger, M., Psaty, B. M., Taylor, K. D., Voelker, U., Kanters, J. K., Li, M., Alonso, A., Perez, M. V., Vaartjes, I., Bots, M. L., Huang, P. L., Heckbert, S. R., Lin, H. J., Kornej, J., Munroe, P. B., van Duijn, C. M., Asselbergs, F. W., Stricker, B. H., van der Harst, P., Kaeaeb, S., Peters, A., Sotoodehnia, N., Rotter, J. I., Mook-Kanamori, D. O., Doerr, M., Felix, S. B., Linneberg, A., Hansen, T., Arking, D. E., Kooperberg, C., Benjamin, E. J., Lunetta, K. L., Ellinor, P. T. & Lubitz, S. A., Oct 2020, In: Circulation: Genomic and Precision Medicine. 13, 5, p. 387-395 9 p., 002874.

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