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Aaron Isaacs

 https://orcid.org/0000-0001-5037-4834
20102024

Research activity per year

  • 122 Article
  • 5 Comment/Letter to the editor
  • 3 Erratum / corrigendum / retractions
  • 1 (Systematic) Review article

Search results

  • 2010

    A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14

    Solouki, A. M., Verhoeven, V. J. M., van Duijn, C. M., Verkerk, A. J. M. H., Ikram, M. K., Hysi, P. G., Despriet, D. D. G., van Koolwijk, L. M., Ho, L., Ramdas, W. D., Czudowska, M., Kuijpers, R. W. A. M., Amin, N., Struchalin, M., Aulchenko, Y. S., van Rij, G., Riemslag, F. C. C., Young, T. L., Mackey, D. A., Spector, T. D., & 15 othersGorgels, T. G. M. F., Willemse-Assink, J. J. M., Isaacs, A., Kramer, R., Swagemakers, S. M. A., Bergen, A. A. B., van Oosterhout, A. A. L. J., Oostra, B. A., Rivadeneira, F., Uitterlinden, A. G., Hofman, A., de Jong, P. T. V. M., Hammond, C. J., Vingerling, J. R. & Klaver, C. C. W., Oct 2010, In: Nature Genetics. 42, 10, p. 897-901 5 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • 2011

    A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol

    Surakka, I., Isaacs, A., Karssen, L. C., Laurila, P-P. P., Middelberg, R. P. S., Tikkanen, E., Ried, J. S., Lamina, C., Mangino, M., Igl, W., Hottenga, J-J., Lagou, V., van der Harst, P., Mateo Leach, I., Esko, T., Kutalik, Z., Wainwright, N. W., Struchalin, M. V., Sarin, A-P., Kangas, A. J., & 31 othersViikari, J. S., Perola, M., Rantanen, T., Petersen, A-K., Soininen, P., Johansson, A., Soranzo, N., Heath, A. C., Papamarkou, T., Prokopenko, I., Tönjes, A., Kronenberg, F., Döring, A., Rivadeneira, F., Montgomery, G. W., Whitfield, J. B., Kähönen, M., Lehtimäki, T., Freimer, N. B., Willemsen, G., de Geus, E. J. C., Palotie, A., Sandhu, M. S., Waterworth, D. M., Metspalu, A., Stumvoll, M., Uitterlinden, A. G., Jula, A., Navis, G., Wolffenbuttel, B. H. R. & ENGAGE Consortium, Oct 2011, In: Plos Genetics. 7, 10, p. e1002333

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • A pharmacogenetic analysis of determinants of hypertension and blood pressure response to angiotensin-converting enzyme inhibitor therapy in patients with vascular disease and healthy individuals

    Brugts, J. J., Isaacs, A., de Maat, M. P., Boersma, E., van Duijn, C. M., Akkerhuis, K. M., Uitterlinden, A. G., Witteman, J. C., Cambien, F., Ceconi, C., Remme, W., Bertrand, M., Ninomiya, T., Harrap, S., Chalmers, J., Macmahon, S., Fox, K., Ferrari, R., Simoons, M. L. & Danser, A. J., Mar 2011, In: Journal of Hypertension. 29, 3, p. 509-19 11 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Cathepsin D gene and the risk of Alzheimer's disease: a population-based study and meta-analysis

    Schuur, M., Ikram, M. A., van Swieten, J. C., Isaacs, A., Vergeer-Drop, J. M., Hofman, A., Oostra, B. A., Breteler, M. M. B. & van Duijn, C. M., Sept 2011, In: Neurobiology of Aging. 32, 9, p. 1607-14 8 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • General maternal medication use, folic acid, the MDR1 C3435T polymorphism, and the risk of a child with a congenital heart defect

    Obermann-Borst, S. A., Isaacs, A., Younes, Z., van Schaik, R. H. N., van der Heiden, I. P., van Duyn, C. M., Steegers, E. A. P. & Steegers-Theunissen, R. P. M., Mar 2011, In: American Journal of Obstetrics and Gynecology. 204, 3, p. 236.e1-8

    Research output: Contribution to journal › Article › Academic › peer-review

  • Genetic architecture of circulating lipid levels

    Demirkan, A., Amin, N., Isaacs, A., Jarvelin, M-R., Whitfield, J. B., Wichmann, H-E., Kyvik, K. O. H. M., Rudan, I., Gieger, C., Hicks, A. A., Johansson, Å., Hottenga, J-J., Smith, J. J., Wild, S. H., Pedersen, N. L., Willemsen, G., Mangino, M., Hayward, C., Uitterlinden, A. G., Hofman, A., & 27 othersWitteman, J., Montgomery, G. W., Pietiläinen, K. H., Rantanen, T., Kaprio, J., Döring, A., Pramstaller, P. P., Gyllensten, U., de Geus, E. J. C., Penninx, B. W., Wilson, J. F., Rivadeneria, F., Magnusson, P. K. E., Boomsma, D. I., Spector, T., Campbell, H., Hoehne, B., Martin, N. G., Oostra, B. A., McCarthy, M., Peltonen-Palotie, L., Aulchenko, Y., Visscher, P. M., Ripatti, S., Janssens, A. C. J. W., van Duijn, C. M. & ENGAGE Consortium, Jul 2011, In: European Journal of Human Genetics. 19, 7, p. 813-9 7 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Genetic risk factors for cerebral small-vessel disease in hypertensive patients from a genetically isolated population

    Schuur, M., van Swieten, J. C., Schol-Gelok, S., Ikram, M. A., Vernooij, M. W., Liu, F., Isaacs, A., de Boer, R., de Koning, I., Niessen, W. J., Vrooman, H., Oostra, B. A., van der Lugt, A., Breteler, M. M. B. & van Duijn, C. M., Jan 2011, In: Journal of Neurology Neurosurgery and Psychiatry. 82, 1, p. 41-4 4 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

    International Consortium for Blood Pressure Genome-Wide Association Studies, 6 Oct 2011, In: Nature. 478, 7367, p. 103-109 7 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque

    Bis, J. C., Kavousi, M., Franceschini, N., Isaacs, A., Abecasis, G. R., Schminke, U., Post, W. S., Smith, A. V., Cupples, L. A., Markus, H. S., Schmidt, R., Huffman, J. E., Lehtimäki, T., Baumert, J., Münzel, T., Heckbert, S. R., Dehghan, A., North, K., Oostra, B., Bevan, S., & 31 othersStoegerer, E-M., Hayward, C., Raitakari, O., Meisinger, C., Schillert, A., Sanna, S., Völzke, H., Cheng, Y-C., Thorsson, B., Fox, C. S., Rice, K., Rivadeneira, F., Nambi, V., Halperin, E., Petrovic, K. E., Peltonen, L., Wichmann, H. E., Schnabel, R. B., Dörr, M., Parsa, A., Aspelund, T., Demissie, S., Kathiresan, S., Reilly, M. P., Taylor, K., Uitterlinden, A., Couper, D. J., Sitzer, M., Kähönen, M., Illig, T. & CARDIoGRAM Consortium, 11 Sept 2011, In: Nature Genetics. 43, 10, p. 940-7 8 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Variants in STAT5B associate with serum TC and LDL-C levels

    Kornfeld, J-W., Isaacs, A., Vitart, V., Pospisilik, J. A., Meitinger, T., Gyllensten, U., Wilson, J. F., Rudan, I., Campbell, H., Penninger, J. M., Sexl, V., Moriggl, R., van Duijn, C., Pramstaller, P. P. & Hicks, A. A., Sept 2011, In: Journal of Clinical Endocrinology & Metabolism. 96, 9, p. E1496-501

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Variation in the von Willebrand factor gene is associated with von Willebrand factor levels and with the risk for cardiovascular disease

    van Schie, M. C., de Maat, M. P. M., Isaacs, A., van Duijn, C. M., Deckers, J. W., Dippel, D. W. J. & Leebeek, F. W. G., 27 Jan 2011, In: Blood. 117, 4, p. 1393-9 7 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • 2012

    A genome-wide linkage study of individuals with high scores on NEO personality traits

    Amin, N., Schuur, M., Gusareva, E. S., Isaacs, A., Aulchenko, Y. S., Kirichenko, A. V., Zorkoltseva, I. V., Axenovich, T. I., Oostra, B. A., Janssens, A. C. J. W. & van Duijn, C. M., Oct 2012, In: Molecular Psychiatry. 17, 10, p. 1031-41 11 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium

    Mitchell, G. F., Verwoert, G. C., Tarasov, K. V., Isaacs, A., Smith, A. V., Yasmin, Rietzschel, E. R., Tanaka, T., Liu, Y., Parsa, A., Najjar, S. S., O'Shaughnessy, K. M., Sigurdsson, S., De Buyzere, M. L., Larson, M. G., Sie, M. P. S., Andrews, J. S., Post, W. S., Mattace-Raso, F. U. S., McEniery, C. M., & 55 othersEiriksdottir, G., Segers, P., Vasan, R. S., van Rijn, M. J. E., Howard, T. D., McArdle, P. F., Dehghan, A., Jewell, E. S., Newhouse, S. J., Bekaert, S., Hamburg, N. M., Newman, A. B., Hofman, A., Scuteri, A., De Bacquer, D., Ikram, M. A., Psaty, B. M., Fuchsberger, C., Olden, M., Wain, L. V., Elliott, P., Smith, N. L., Felix, J. F., Erdmann, J., Vita, J. A., Sutton-Tyrrell, K., Sijbrands, E. J. G., Sanna, S., Launer, L. J., De Meyer, T., Johnson, A. D., Schut, A. F. C., Herrington, D. M., Rivadeneira, F., Uda, M., Wilkinson, I. B., Aspelund, T., Gillebert, T. C., Van Bortel, L., Benjamin, E. J., Oostra, B. A., Ding, J., Gibson, Q., Uitterlinden, A. G., Abecasis, G. R., Cockcroft, J. R., Gudnason, V., De Backer, G. G., Ferrucci, L., Harris, T. B., Shuldiner, A. R., van Duijn, C. M., Levy, D., Lakatta, E. G. & Witteman, J. C. M., 1 Feb 2012, In: Circulation : Cardiovascular Genetics. 5, 1, p. 81-90 10 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • FTO genotype is associated with phenotypic variability of body mass index

    Yang, J., Loos, R. J. F., Powell, J. E., Medland, S. E., Speliotes, E. K., Chasman, D. I., Rose, L. M., Thorleifsson, G., Steinthorsdottir, V., Maegi, R., Waite, L. L., Smith, A. V., Yerges-Armstrong, L. M., Monda, K. L., Hadley, D., Mahajan, A., Li, G., Kapur, K., Vitart, V., Huffman, J. E., & 151 othersWang, S. R., Palmer, C., Esko, T., Fischer, K., Zhao, J. H., Demirkan, A., Isaacs, A., Feitosa, M. F., Luan, J., Heard-Costa, N. L., White, C. C., Jackson, A. U., Preuss, M., Ziegler, A., Eriksson, J., Kutalik, Z., Frau, F., Nolte, I. M., van Vliet-Ostaptchouk, J. V., Hottenga, J-J., Jacobs, K. B., Verweij, N., Goel, A., Medina-Gomez, C., Estrada, K., Bragg-Gresham, J. L., Sanna, S., Sidore, C., Tyrer, J. P., Teumer, A., Prokopenko, I., Mangino, M., Lindgren, C. M., Assimes, T. L., Shuldiner, A. R., Hui, J., Beilby, J. P., McArdle, W. L., Hall, P., Haritunians, T., Zgaga, L., Kolcic, I., Polasek, O., Zemunik, T., Oostra, B. A., Junttila, M. J., Groenberg, H., Schreiber, S., Peters, A., Hicks, A. A., Stephens, J. C., Foad, N. S., Laitinen, J., Pouta, A., Kaakinen, M., Willemsen, G., Vink, J. M., Wild, S. H., Navis, G., Asselbergs, F. W., Homuth, G., John, U., Iribarren, C., Harris, T. B., Launer, L. J., Gudnason, V., O'Connell, J. R., Boerwinkle, E., Cadby, G., Palmer, L. J., James, A. L., Musk, A. W., Ingelsson, E., Psaty, B. M., Beckmann, J. S., Waeber, G., Vollenweider, P., Hayward, C., Wright, A. F., Rudan, I., Groop, L. C., Metspalu, A., Khaw, K-T., Duijn, C. M. V., Borecki, I. B., Province, M. A., Wareham, N. J., Tardif, J-C., Huikuri, H. V., Cupples, L. A., Atwood, L. D., Fox, C. S., Boehnke, M., Collins, F. S., Mohlke, K. L., Erdmann, J., Schunkert, H., Hengstenberg, C., Stark, K., Lorentzon, M., Ohlsson, C., Cusi, D., Staessen, J. A., Van der Klauw, M. M., Pramstaller, P. P., Kathiresan, S., Jolley, J. D., Ripatti, S., Jarvelin, M-R., de Geus, E. J. C., Boomsma, D. I., Penninx, B. W. J. H., Wilson, J. F., Campbell, H., Chanock, S. J., van der Harst, P., Hamsten, A., Watkins, H., Hofman, A., Witteman, J. C. M., Zillikens, M. C., Uitterlinden, A. G., Rivadeneira, F., Kiemeney, L. A., Vermeulen, S. H., Abecasis, G. R., Schlessinger, D., Schipf, S., Stumvoll, M., Toenjes, A., Spector, T. D., North, K. E., Lettre, G., McCarthy, M. I., Berndt, S. I., Heath, A. C., Madden, P. A. F., Nyholt, D. R., Montgomery, G. W., Martin, N. G., McKnight, B., Strachan, D. P., Hill, W. G., Snieder, H., Ridker, P. M., Thorsteinsdottir, U., Stefansson, K., Frayling, T. M., Hirschhorn, J. N., Goddard, M. E. & Visscher, P. M., 11 Oct 2012, In: Nature. 490, 7419, p. 267–272

    Research output: Contribution to journal › Article › Academic › peer-review

  • Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM

    Amin, N., Byrne, E., Johnson, J., Chenevix-Trench, G., Walter, S., Nolte, I. M., Vink, J. M., Rawal, R., Mangino, M., Teumer, A., Keers, J. C., Verwoert, G., Baumeister, S., Biffar, R., Petersmann, A., Dahmen, N., Doering, A., Isaacs, A., Broer, L., Wray, N. R., & 32 othersMontgomery, G. W., Levy, D., Psaty, B. M., Gudnason, V., Chakravarti, A., Sulem, P., Gudbjartsson, D. F., Kiemeney, L. A., Thorsteinsdottir, U., Stefansson, K., van Rooij, F. J. A., Aulchenko, Y. S., Hottenga, J. J., Rivadeneira, F. R., Hofman, A., Uitterlinden, A. G., Hammond, C. J., Shin, S-Y., Ikram, A., Witteman, J. C. M., Janssens, A. C. J. W., Snieder, H., Tiemeier, H., Wolfenbuttel, B. H. R., Oostra, B. A., Heath, A. C., Wichmann, E., Spector, T. D., Grabe, H. J., Boomsma, D. I., KConFab Investigators & van Duijn, C. M., Nov 2012, In: Molecular Psychiatry. 17, 11, p. 1116-29 14 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Genome-wide association and functional follow-up reveals new loci for kidney function

    Pattaro, C., Köttgen, A., Teumer, A., Garnaas, M., Böger, C. A., Fuchsberger, C., Olden, M., Chen, M-H., Tin, A., Taliun, D., Li, M., Gao, X., Gorski, M., Yang, Q., Hundertmark, C., Foster, M. C., O'Seaghdha, C. M., Glazer, N., Isaacs, A., Liu, C-T., & 31 othersSmith, A. V., O'Connell, J. R., Struchalin, M., Tanaka, T., Li, G., Johnson, A. D., Gierman, H. J., Feitosa, M., Hwang, S-J., Atkinson, E. J., Lohman, K., Cornelis, M. C., Johansson, Å., Tönjes, A., Dehghan, A., Chouraki, V., Holliday, E. G., Sorice, R., Kutalik, Z., Lehtimäki, T., Esko, T., Deshmukh, H., Ulivi, S., Chu, A. Y., Murgia, F., Trompet, S., Imboden, M., Kollerits, B., Pistis, G., Wang, J. J. & CARDIoGRAM Consortium, 2012, In: Plos Genetics. 8, 3, p. e1002584

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations

    Demirkan, A., van Duijn, C. M., Ugocsai, P., Isaacs, A., Pramstaller, P. P., Liebisch, G., Wilson, J. F., Johansson, Å., Rudan, I., Aulchenko, Y. S., Kirichenko, A. V., Janssens, A. C. J. W., Jansen, R. C., Gnewuch, C., Domingues, F. S., Pattaro, C., Wild, S. H., Jonasson, I., Polasek, O., Zorkoltseva, I. V., & 31 othersHofman, A., Karssen, L. C., Struchalin, M., Floyd, J., Igl, W., Biloglav, Z., Broer, L., Pfeufer, A., Pichler, I., Campbell, S., Zaboli, G., Kolcic, I., Rivadeneira, F., Huffman, J., Hastie, N. D., Uitterlinden, A., Franke, L., Franklin, C. S., Vitart, V., Nelson, C. P., Preuss, M., Bis, J. C., O'Donnell, C. J., Franceschini, N., Witteman, J. C. M., Axenovich, T., Oostra, B. A., Meitinger, T., Hicks, A. A., Hayward, C. & DIAGRAM Consortium, 2012, In: Plos Genetics. 8, 2, p. e1002490

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function

    Chasman, D. I., Fuchsberger, C., Pattaro, C., Teumer, A., Böger, C. A., Endlich, K., Olden, M., Chen, M-H., Tin, A., Taliun, D., Li, M., Gao, X., Gorski, M., Yang, Q., Hundertmark, C., Foster, M. C., O'Seaghdha, C. M., Glazer, N., Isaacs, A., Liu, C-T., & 31 othersSmith, A. V., O'Connell, J. R., Struchalin, M., Tanaka, T., Li, G., Johnson, A. D., Gierman, H. J., Feitosa, M. F., Hwang, S-J., Atkinson, E. J., Lohman, K., Cornelis, M. C., Johansson, A., Tönjes, A., Dehghan, A., Lambert, J-C., Holliday, E. G., Sorice, R., Kutalik, Z., Lehtimäki, T., Esko, T., Deshmukh, H., Ulivi, S., Chu, A. Y., Murgia, F., Trompet, S., Imboden, M., Coassin, S., Pistis, G., Wang, J. J. & CARDIoGRAM Consortium, 15 Dec 2012, In: Human Molecular Genetics. 21, 24, p. 5329-43 15 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

    Scott, R. A., Lagou, V., Welch, R. P., Wheeler, E., Montasser, M. E., Luan, J., Mägi, R., Strawbridge, R. J., Rehnberg, E., Gustafsson, S., Kanoni, S., Rasmussen-Torvik, L. J., Yengo, L., Lecoeur, C., Shungin, D., Sanna, S., Sidore, C., Johnson, P. C. D., Jukema, J. W., Johnson, T., & 36 othersMahajan, A., Verweij, N., Thorleifsson, G., Hottenga, J-J., Shah, S., Smith, A. V., Sennblad, B., Gieger, C., Salo, P., Perola, M., Timpson, N. J., Evans, D. M., Pourcain, B. S., Wu, Y., Andrews, J. S., Hui, J., Bielak, L. F., Zhao, W., Horikoshi, M., Navarro, P., Isaacs, A., O'Connell, J. R., Stirrups, K., Vitart, V., Hayward, C., Esko, T., Mihailov, E., Fraser, R. M., Fall, T., Voight, B. F., DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Florez, J. C., Langenberg, C., Ingelsson, E., Prokopenko, I. & Barroso, I., Sept 2012, In: Nature Genetics. 44, 9, p. 991-1005 15 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Linkage analysis for plasma amyloid beta levels in persons with hypertension implicates Aβ-40 levels to presenilin 2

    Ibrahim-Verbaas, C. A., Zorkoltseva, I. V., Amin, N., Schuur, M., Coppus, A. M. W., Isaacs, A., Aulchenko, Y. S., Breteler, M. M. B., Ikram, M. A., Axenovich, T. I., Verbeek, M. M., van Swieten, J. C., Oostra, B. A. & van Duijn, C. M., Dec 2012, In: Human Genetics. 131, 12, p. 1869-76 8 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

    Dastani, Z., Hivert, M-F., Timpson, N., Perry, J. R. B., Yuan, X., Scott, R. A., Henneman, P., Heid, I. M., Kizer, J. R., Lyytikäinen, L-P., Fuchsberger, C., Tanaka, T., Morris, A. P., Small, K., Isaacs, A., Beekman, M., Coassin, S., Lohman, K., Qi, L., Kanoni, S., & 31 othersPankow, J. S., Uh, H-W., Wu, Y., Bidulescu, A., Rasmussen-Torvik, L. J., Greenwood, C. M. T., Ladouceur, M., Grimsby, J., Manning, A. K., Liu, C-T., Kooner, J., Mooser, V. E., Vollenweider, P., Kapur, K. A., Chambers, J., Wareham, N. J., Langenberg, C., Frants, R., Willems-Vandijk, K., Oostra, B. A., Willems, S. M., Lamina, C., Winkler, T. W., Psaty, B. M., Tracy, R. P., Brody, J., Chen, I., Viikari, J., Kähönen, M., Vogelzangs, N. & DIAGRAM+ Consortium, 2012, In: Plos Genetics. 8, 3, p. e1002607

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Nucleotide excision DNA repair is associated with age-related vascular dysfunction

    Durik, M., Kavousi, M., van der Pluijm, I., Isaacs, A., Cheng, C., Verdonk, K., Loot, A. E., Oeseburg, H., Bhaggoe, U. M., Leijten, F., van Veghel, R., de Vries, R., Rudez, G., Brandt, R., Ridwan, Y. R., van Deel, E. D., de Boer, M., Tempel, D., Fleming, I., Mitchell, G. F., & 12 othersVerwoert, G. C., Tarasov, K. V., Uitterlinden, A. G., Hofman, A., Duckers, H. J., van Duijn, C. M., Oostra, B. A., Witteman, J. C. M., Duncker, D. J., Danser, A. H. J., Hoeijmakers, J. H. & Roks, A. J. M., 24 Jul 2012, In: Circulation. 126, 4, p. 468-78 11 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
  • 2013

    Common variants associated with plasma triglycerides and risk for coronary artery disease

    Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Gao, C., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H-Y., Demirkan, A., Den Hertog, H. M., Donnelly, L. A., Ehret, G. B., Esko, T., & 29 othersFeitosa, M. F., Ferreira, T., Fischer, K., Fontanillas, P., Fraser, R. M., Freitag, D. F., Gurdasani, D., Heikkila, K., Hyppoenen, E., Isaacs, A., Jackson, A. U., Johansson, A., Johnson, T., Kaakinen, M., Kettunen, J., Kleber, M. E., Li, X., Luan, J., Lyytikainen, L-P., Magnusson, P. K. E., Mangino, M., Mihailov, E., Montasser, M. E., Mueller-Nurasyid, M., Nolte, I. M., O'Connell, J. R., Palmer, C. D., Perola, M. & Author collaboration, Nov 2013, In: Nature Genetics. 45, 11, p. 1345-1352 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Common variants in Mendelian kidney disease genes and their association with renal function

    Parsa, A., Fuchsberger, C., Köttgen, A., O'Seaghdha, C. M., Pattaro, C., de Andrade, M., Chasman, D. I., Teumer, A., Endlich, K., Olden, M., Chen, M-H., Tin, A., Kim, Y. J., Taliun, D., Li, M., Feitosa, M., Gorski, M., Yang, Q., Hundertmark, C., Foster, M. C., & 139 othersGlazer, N., Isaacs, A., Rao, M., Smith, A. V., O'Connell, J. R., Struchalin, M., Tanaka, T., Li, G., Hwang, S-J., Atkinson, E. J., Lohman, K., Cornelis, M. C., Johansson, A., Tönjes, A., Dehghan, A., Couraki, V., Holliday, E. G., Sorice, R., Kutalik, Z., Lehtimäki, T., Esko, T., Deshmukh, H., Ulivi, S., Chu, A. Y., Murgia, F., Trompet, S., Imboden, M., Kollerits, B., Pistis, G., Harris, T. B., Launer, L. J., Aspelund, T., Eiriksdottir, G., Mitchell, B. D., Boerwinkle, E., Schmidt, H., Hofer, E., Hu, F., Demirkan, A., Oostra, B. A., Turner, S. T., Ding, J., Andrews, J. S., Freedman, B. I., Giulianini, F., Koenig, W., Illig, T., Döring, A., Wichmann, H-E., Zgaga, L., Zemunik, T., Boban, M., Minelli, C., Wheeler, H. E., Igl, W., Zaboli, G., Wild, S. H., Wright, A. F., Campbell, H., Ellinghaus, D., Nöthlings, U., Jacobs, G., Biffar, R., Ernst, F., Homuth, G., Kroemer, H. K., Nauck, M., Stracke, S., Völker, U., Völzke, H., Kovacs, P., Stumvoll, M., Mägi, R., Hofman, A., Uitterlinden, A. G., Rivadeneira, F., Aulchenko, Y. S., Polasek, O., Hastie, N., Vitart, V., Helmer, C., Wang, J. J., Stengel, B., Ruggiero, D., Bergmann, S., Kähönen, M., Viikari, J., Nikopensius, T., Province, M., Colhoun, H., Doney, A., Robino, A., Krämer, B. K., Portas, L., Ford, I., Buckley, B. M., Adam, M., Thun, G-A., Paulweber, B., Haun, M., Sala, C., Mitchell, P., Ciullo, M., Vollenweider, P., Raitakari, O., Metspalu, A., Palmer, C., Gasparini, P., Pirastu, M., Jukema, J. W., Probst-Hensch, N. M., Kronenberg, F., Toniolo, D., Gudnason, V., Shuldiner, A. R., Coresh, J., Schmidt, R., Ferrucci, L., van Duijn, C. M., Borecki, I., Kardia, S. L. R., Liu, Y., Curhan, G. C., Rudan, I., Gyllensten, U., Wilson, J. F., Franke, A., Pramstaller, P. P., Rettig, R., Prokopenko, I., Witteman, J., Hayward, C., Ridker, P. M., Bochud, M., Heid, I. M., Siscovick, D. S., Fox, C. S., Kao, W. L. & Böger, C. A., Dec 2013, In: Journal of the American Society of Nephrology. 24, 12, p. 2105-17 13 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Discovery and refinement of loci associated with lipid levels

    Willer, C. J., Schmidt, E. M., Sengupta, S., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H-Y., Demirkan, A., Den Hertog, H. M., Do, R., Donnelly, L. A., Ehret, G. B., Esko, T., Feitosa, M. F., & 31 othersFerreira, T., Fischer, K., Fontanillas, P., Fraser, R. M., Freitag, D. F., Gurdasani, D., Heikkilä, K., Hyppönen, E., Isaacs, A., Jackson, A. U., Johansson, Å., Johnson, T., Kaakinen, M., Kettunen, J., Kleber, M. E., Li, X., Luan, J., Lyytikäinen, L-P., Magnusson, P. K. E., Mangino, M., Mihailov, E., Montasser, M. E., Müller-Nurasyid, M., Nolte, I. M., O'Connell, J. R., Palmer, C. D., Perola, M., Petersen, A-K., Wong, A., Wolffenbuttel, B. H. R. & Global Lipids Genetics Consortium, Nov 2013, In: Nature Genetics. 45, 11, p. 1274-1283 10 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Genetic loci for coronary calcification and serum lipids relate to aortic and carotid calcification

    Bos, D., Ikram, M. A., Isaacs, A., Verhaaren, B. F. J., Hofman, A., van Duijn, C. M., Witteman, J. C. M., van der Lugt, A. & Vernooij, M. W., Feb 2013, In: Circulation : Cardiovascular Genetics. 6, 1, p. 47-53 7 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

    Köttgen, A., Albrecht, E., Teumer, A., Vitart, V., Krumsiek, J., Hundertmark, C., Pistis, G., Ruggiero, D., O'Seaghdha, C. M., Haller, T., Yang, Q., Tanaka, T., Johnson, A. D., Kutalik, Z., Smith, A. V., Shi, J., Struchalin, M., Middelberg, R. P. S., Brown, M. J., Gaffo, A. L., & 31 othersPirastu, N., Li, G., Hayward, C., Zemunik, T., Huffman, J., Yengo, L., Zhao, J. H., Demirkan, A., Feitosa, M. F., Liu, X., Malerba, G., Lopez, L. M., van der Harst, P., Li, X., Kleber, M. E., Hicks, A. A., Nolte, I. M., Johansson, A., Murgia, F., Wild, S. H., Bakker, S. J. L., Peden, J. F., Dehghan, A., Steri, M., Tenesa, A., Lagou, V., Salo, P., Mangino, M., Isaacs, A., Wolffenbuttel, B. H. R. & LifeLines Cohort Study, Feb 2013, In: Nature Genetics. 45, 2, p. 145-54 10 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

    den Hoed, M., Eijgelsheim, M., Esko, T., Brundel, B. J. J. M., Peal, D. S., Evans, D. M., Nolte, I. M., Segrè, A. V., Holm, H., Handsaker, R. E., Westra, H-J., Johnson, T., Isaacs, A., Yang, J., Lundby, A., Zhao, J. H., Kim, Y. J., Go, M. J., Almgren, P., Bochud, M., & 32 othersBoucher, G., Cornelis, M. C., Gudbjartsson, D., Hadley, D., van der Harst, P., Hayward, C., den Heijer, M., Igl, W., Jackson, A. U., Kutalik, Z., Luan, J., Kemp, J. P., Kristiansson, K., Ladenvall, C., Lorentzon, M., Montasser, M. E., Njajou, O. T., O'Reilly, P. F., Padmanabhan, S., St Pourcain, B., Rankinen, T., Salo, P., Tanaka, T., Timpson, N. J., Vitart, V., Waite, L., Wheeler, W., Zhang, W., Draisma, H. H. M., Wong, A., Global BPgen Consortium & Loos, R. J. F., Jun 2013, In: Nature Genetics. 45, 6, p. 621-31 11 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Loci influencing blood pressure identified using a cardiovascular gene-centric array

    CARDIOGRAM, METASTROKE, Keating, B. J. & Asselbergs, F. W., 15 Apr 2013, In: Human Molecular Genetics. 22, 8, p. 1663-78 16 p.

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    Open Access

  • Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

    Broer, L., Codd, V., Nyholt, D. R., Deelen, J., Mangino, M., Willemsen, G., Albrecht, E., Amin, N., Beekman, M., de Geus, E. J. C., Henders, A., Nelson, C. P., Steves, C. J., Wright, M. J., de Craen, A. J. M., Isaacs, A., Matthews, M., Moayyeri, A., Montgomery, G. W., Oostra, B. A., & 7 othersVink, J. M., Spector, T. D., Slagboom, P. E., Martin, N. G., Samani, N. J., van Duijn, C. M. & Boomsma, D. I., Oct 2013, In: European Journal of Human Genetics. 21, 10, p. 1163-8 6 p.

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    Open Access

  • New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

    Horikoshi, M., Yaghootkar, H., Mook-Kanamori, D. O., Sovio, U., Taal, H. R., Hennig, B. J., Bradfield, J. P., St Pourcain, B., Evans, D. M., Charoen, P., Kaakinen, M., Cousminer, D. L., Lehtimäki, T., Kreiner-Møller, E., Warrington, N. M., Bustamante, M., Feenstra, B., Berry, D. J., Thiering, E., Pfab, T., & 37 othersBarton, S. J., Shields, B. M., Kerkhof, M., van Leeuwen, E. M., Fulford, A. J., Kutalik, Z., Zhao, J. H., den Hoed, M., Mahajan, A., Lindi, V., Goh, L-K., Hottenga, J-J., Wu, Y., Raitakari, O. T., Harder, M. N., Meirhaeghe, A., Ntalla, I., Salem, R. M., Jameson, K. A., Zhou, K., Monies, D. M., Lagou, V., Kirin, M., Heikkinen, J., Adair, L. S., Alkuraya, F. S., Al-Odaib, A., Amouyel, P., Andersson, E. A., Isaacs, A., Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), McCarthy, M. I., Jaddoe, V. W., Jarvelin, M-R., Timpson, N. J., Prokopenko, I. & Freathy, R., Jan 2013, In: Nature Genetics. 45, 1, p. 76-82 7 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Plasma phosphatidylcholine and sphingomyelin concentrations are associated with depression and anxiety symptoms in a Dutch family-based lipidomics study

    Demirkan, A., Isaacs, A., Ugocsai, P., Liebisch, G., Struchalin, M., Rudan, I., Wilson, J. F., Pramstaller, P. P., Gyllensten, U., Campbell, H., Schmitz, G., Oostra, B. A. & van Duijn, C. M., Mar 2013, In: Journal of Psychiatric Research. 47, 3, p. 357-62 6 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Plasma proprotein convertase subtilisin kexin type 9 levels are related to markers of cholesterol synthesis in familial combined hyperlipidemia

    Brouwers, M. C. G. J., Konrad, R. J., van Himbergen, T. M., Isaacs, A., Otokozawa, S., Troutt, J. S., Schaefer, E. J., van Greevenbroek, M. M. J., Stalenhoef, A. F. H. & de Graaf, J., Nov 2013, In: Nutrition Metabolism and Cardiovascular Diseases. 23, 11, p. 1115-1121

    Research output: Contribution to journal › Article › Academic › peer-review

  • Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions

    Amin, N., Hottenga, J-J., Hansell, N. K., Janssens, A. C. J. W., de Moor, M. H. M., Madden, P. A. F., Zorkoltseva, I. V., Penninx, B. W., Terracciano, A., Uda, M., Tanaka, T., Esko, T., Realo, A., Ferrucci, L., Luciano, M., Davies, G., Metspalu, A., Abecasis, G. R., Deary, I. J., Raikkonen, K., & 19 othersBierut, L. J., Costa, P. T., Saviouk, V., Zhu, G., Kirichenko, A. V., Isaacs, A., Aulchenko, Y. S., Willemsen, G., Heath, A. C., Pergadia, M. L., Medland, S. E., Axenovich, T. I., de Geus, E., Montgomery, G. W., Wright, M. J., Oostra, B. A., Martin, N. G., Boomsma, D. I. & van Duijn, C. M., Aug 2013, In: European Journal of Human Genetics. 21, 8, p. 876-82 7 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease

    Isaacs, A., Willems, S. M., Bos, D., Dehghan, A., Hofman, A., Ikram, M. A., Uitterlinden, A. G., Oostra, B. A., Franco, O. H., Witteman, J. C. & van Duijn, C. M., Sept 2013, In: Arteriosclerosis Thrombosis and Vascular Biology. 33, 9, p. 2233-9 7 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • The molecular genetic architecture of self-employment

    van der Loos, M. J. H. M., Rietveld, C. A., Eklund, N., Koellinger, P. D., Rivadeneira, F., Abecasis, G. R., Ankra-Badu, G. A., Baumeister, S. E., Benjamin, D. J., Biffar, R., Blankenberg, S., Boomsma, D. I., Cesarini, D., Cucca, F., de Geus, E. J. C., Dedoussis, G., Deloukas, P., Dimitriou, M., Eiriksdottir, G., Eriksson, J., & 48 othersGieger, C., Gudnason, V., Höhne, B., Holle, R., Hottenga, J-J., Isaacs, A., Järvelin, M-R., Johannesson, M., Kaakinen, M., Kähönen, M., Kanoni, S., Laaksonen, M. A., Lahti, J., Launer, L. J., Lehtimäki, T., Loitfelder, M., Magnusson, P. K. E., Naitza, S., Oostra, B. A., Perola, M., Petrovic, K., Quaye, L., Raitakari, O., Ripatti, S., Scheet, P., Schlessinger, D., Schmidt, C. O., Schmidt, H., Schmidt, R., Senft, A., Smith, A. V., Spector, T. D., Surakka, I., Svento, R., Terracciano, A., Tikkanen, E., van Duijn, C. M., Viikari, J., Völzke, H., Wichmann, H-E., Wild, P. S., Willems, S. M., Willemsen, G., van Rooij, F. J. A., Groenen, P. J. F., Uitterlinden, A. G., Hofman, A. & Thurik, A. R., 2013, In: PLOS ONE. 8, 4, p. e60542

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    Open Access

  • The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

    Fall, T., Hägg, S., Mägi, R., Ploner, A., Fischer, K., Horikoshi, M., Sarin, A-P., Thorleifsson, G., Ladenvall, C., Kals, M., Kuningas, M., Draisma, H. H. M., Ried, J. S., van Zuydam, N. R., Huikari, V., Mangino, M., Sonestedt, E., Benyamin, B., Nelson, C. P., Rivera, N. V., & 31 othersKristiansson, K., Shen, H-Y., Havulinna, A. S., Dehghan, A., Donnelly, L. A., Kaakinen, M., Nuotio, M-L., Robertson, N., de Bruijn, R. F. A. G., Ikram, M. A., Amin, N., Balmforth, A. J., Braund, P. S., Doney, A. S. F., Döring, A., Elliott, P., Esko, T., Franco, O. H., Gretarsdottir, S., Hartikainen, A-L., Heikkilä, K., Herzig, K-H., Holm, H., Hottenga, J. J., Hyppönen, E., Illig, T., Isaacs, A., Isomaa, B., Karssen, L. C., Kettunen, J. & European Network for Genetic and Genomic Epidemiology (ENGAGE) consortium, 2013, In: PLOS Medicine . 10, 6, p. e1001474

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    Open Access
  • 2014

    A metabolomic profile is associated with the risk of incident coronary heart disease

    Vaarhorst, A. A. M., Verhoeven, A., Weller, C. M., Böhringer, S., Göraler, S., Meissner, A., Deelder, A. M., Henneman, P., Gorgels, A. P. M., van den Brandt, P. A., Schouten, L. J., van Greevenbroek, M. M., Merry, A. H. H., Verschuren, W. M. M., van den Maagdenberg, A. M. J. M., van Dijk, K. W., Isaacs, A., Boomsma, D., Oostra, B. A., van Duijn, C. M., & 5 othersJukema, J. W., Boer, J. M. A., Feskens, E., Heijmans, B. T. & Slagboom, P. E., 1 Jan 2014, In: American Heart Journal. 168, 1, p. 45-52.e7

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    Open Access

  • Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks

    Peloso, G. M., Auer, P. L., Bis, J. C., Voorman, A., Morrison, A. C., Stitziel, N. O., Brody, J. A., Khetarpal, S. A., Crosby, J. R., Fornage, M., Isaacs, A., Jakobsdottir, J., Feitosa, M. F., Davies, G., Huffman, J. E., Manichaikul, A., Davis, B., Lohman, K., Joon, A. Y., Smith, A. V., & 32 othersGrove, M. L., Zanoni, P., Redon, V., Demissie, S., Lawson, K., Peters, U., Carlson, C., Jackson, R. D., Ryckman, K. K., Mackey, R. H., Robinson, J. G., Siscovick, D. S., Schreiner, P. J., Mychaleckyj, J. C., Pankow, J. S., Hofman, A., Uitterlinden, A. G., Harris, T. B., Taylor, K. D., Stafford, J. M., Reynolds, L. M., Marioni, R. E., Dehghan, A., Franco, O. H., Patel, A. P., Lu, Y., Hindy, G., Gottesman, O., Bottinger, E. P., Melander, O., NHLBI GO Exome Sequencing Project & Cupples, L. A., 6 Feb 2014, In: American Journal of Human Genetics. 94, 2, p. 223-32 10 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Defining the role of common variation in the genomic and biological architecture of adult human height

    Wood, A. R., Esko, T., Yang, J., Vedantam, S., Pers, T. H., Gustafsson, S., Chu, A. Y., Estrada, K., Luan, J., Kutalik, Z., Amin, N., Buchkovich, M. L., Croteau-Chonka, D. C., Day, F. R., Duan, Y., Fall, T., Fehrmann, R., Ferreira, T., Jackson, A. U., Karjalainen, J., & 34 othersLo, K. S., Locke, A. E., Mägi, R., Mihailov, E., Porcu, E., Randall, J. C., Scherag, A., Vinkhuyzen, A. A. E., Westra, H-J., Winkler, T. W., Workalemahu, T., Zhao, J. H., Absher, D., Albrecht, E., Anderson, D., Baron, J., Beekman, M., Demirkan, A., Ehret, G. B., Feenstra, B., Feitosa, M. F., Fischer, K., Fraser, R. M., Goel, A., Gong, J., Justice, A. E., Kanoni, S., Isaacs, A., Wong, A., Jacobs, K. B., Electronic Medical Records and Genomics (eMERGE) Consortium, Visscher, P. M., Hirschhorn, J. N. & Frayling, T. M., Nov 2014, In: Nature Genetics. 46, 11, p. 1173-86 14 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval

    Avery, C. L., Sitlani, C. M., Arking, D. E., Arnett, D. K., Bis, J. C., Boerwinkle, E., Buckley, B. M., Ida Chen, Y-D., de Craen, A. J. M., Eijgelsheim, M., Enquobahrie, D., Evans, D. S., Ford, I., Garcia, M. E., Gudnason, V., Harris, T. B., Heckbert, S. R., Hochner, H., Hofman, A., Hsueh, W-C., & 34 othersIsaacs, A., Jukema, J. W., Knekt, P., Kors, J. A., Krijthe, B. P., Kristiansson, K., Laaksonen, M., Liu, Y., Li, X., Macfarlane, P. W., Newton-Cheh, C., Nieminen, M. S., Oostra, B. A., Peloso, G. M., Porthan, K., Rice, K., Rivadeneira, F. F., Rotter, J. I., Salomaa, V., Sattar, N., Siscovick, D. S., Slagboom, P. E., Smith, A. V., Sotoodehnia, N., Stott, D. J., Stricker, B. H., Stürmer, T., Trompet, S., Uitterlinden, A. G., van Duijn, C., Westendorp, R. G. J., Witteman, J. C., Whitsel, E. A. & Psaty, B. M., Feb 2014, In: Pharmacogenomics Journal. 14, 1, p. 6-13 8 p.

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    Open Access

  • Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci

    Tragante, V., Barnes, M. R., Ganesh, S. K., Lanktree, M. B., Guo, W., Franceschini, N., Smith, E. N., Johnson, T., Holmes, M. V., Padmanabhan, S., Karczewski, K. J., Almoguera, B., Barnard, J., Baumert, J., Chang, Y-P. C., Elbers, C. C., Farrall, M., Fischer, M. E., Gaunt, T. R., Gho, J. M. I. H., & 116 othersGieger, C., Goel, A., Gong, Y., Isaacs, A., Kleber, M. E., Mateo Leach, I., McDonough, C. W., Meijs, M. F. L., Melander, O., Nelson, C. P., Nolte, I. M., Pankratz, N., Price, T. S., Shaffer, J., Shah, S., Tomaszewski, M., van der Most, P. J., Van Iperen, E. P. A., Vonk, J. M., Witkowska, K., Wong, C. O. L., Zhang, L., Beitelshees, A. L., Berenson, G. S., Bhatt, D. L., Brown, M., Burt, A., Cooper-DeHoff, R. M., Connell, J. M., Cruickshanks, K. J., Curtis, S. P., Davey-Smith, G., Delles, C., Gansevoort, R. T., Guo, X., Haiqing, S., Hastie, C. E., Hofker, M. H., Hovingh, G. K., Kim, D. S., Kirkland, S. A., Klein, B. E., Klein, R., Li, Y. R., Maiwald, S., Newton-Cheh, C., O'Brien, E. T., Onland-Moret, N. C., Palmas, W., Parsa, A., Penninx, B. W., Pettinger, M., Vasan, R. S., Ranchalis, J. E., M Ridker, P., Rose, L. M., Sever, P., Shimbo, D., Steele, L., Stolk, R. P., Thorand, B., Trip, M. D., van Duijn, C. M., Verschuren, W. M., Wijmenga, C., Wyatt, S., Young, J. H., Zwinderman, A. H., Bezzina, C. R., Boerwinkle, E., Casas, J. P., Caulfield, M. J., Chakravarti, A., Chasman, D. I., Davidson, K. W., Doevendans, P. A., Dominiczak, A. F., FitzGerald, G. A., Gums, J. G., Fornage, M., Hakonarson, H., Halder, I., Hillege, H. L., Illig, T., Jarvik, G. P., Johnson, J. A., Kastelein, J. J. P., Koenig, W., Kumari, M., März, W., Murray, S. S., O'Connell, J. R., Oldehinkel, A. J., Pankow, J. S., Rader, D. J., Redline, S., Reilly, M. P., Schadt, E. E., Kottke-Marchant, K., Snieder, H., Snyder, M., Stanton, A. V., Tobin, M. D., Uitterlinden, A. G., van der Harst, P., van der Schouw, Y. T., Samani, N. J., Watkins, H., Johnson, A. D., Reiner, A. P., Zhu, X., de Bakker, P. I. W., Levy, D., Asselbergs, F. W., Munroe, P. B. & Keating, B. J., 6 Mar 2014, In: American Journal of Human Genetics. 94, 3, p. 349-60 12 p.

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    Open Access

  • Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

    Arking, D. E., Pulit, S. L., Crotti, L., van der Harst, P., Munroe, P. B., Koopmann, T. T., Sotoodehnia, N., Rossin, E. J., Morley, M., Wang, X., Johnson, A. D., Lundby, A., Gudbjartsson, D. F., Noseworthy, P. A., Eijgelsheim, M., Bradford, Y., Tarasov, K. V., Dörr, M., Müller-Nurasyid, M., Lahtinen, A. M., & 32 othersNolte, I. M., Smith, A. V., Bis, J. C., Isaacs, A., Newhouse, S. J., Evans, D. S., Post, W. S., Waggott, D., Lyytikäinen, L-P., Hicks, A. A., Eisele, L., Ellinghaus, D., Hayward, C., Navarro, P., Ulivi, S., Tanaka, T., Tester, D. J., Chatel, S., Gustafsson, S., Kumari, M., Morris, R. W., Naluai, Å. T., Padmanabhan, S., Kluttig, A., Strohmer, B., Panayiotou, A. G., Torres, M., Knoflach, M., Hubacek, J. A., den Hoed, M., CARe Consortium & Newton-Cheh, C. H., Aug 2014, In: Nature Genetics. 46, 8, p. 826-36 11 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

    Benyamin, B., Esko, T., Ried, J. S., Radhakrishnan, A., Vermeulen, S. H., Traglia, M., Gögele, M., Anderson, D., Broer, L., Podmore, C., Luan, J., Kutalik, Z., Sanna, S., van der Meer, P., Tanaka, T., Wang, F., Westra, H-J., Franke, L., Mihailov, E., Milani, L., & 32 othersHälldin, J., Häldin, J., Winkelmann, J., Meitinger, T., Thiery, J., Peters, A., Waldenberger, M., Rendon, A., Jolley, J., Sambrook, J., Kiemeney, L. A., Sweep, F. C., Sala, C. F., Schwienbacher, C., Pichler, I., Hui, J., Demirkan, A., Isaacs, A., Amin, N., Steri, M., Waeber, G., Verweij, N., Powell, J. E., Nyholt, D. R., Heath, A. C., Madden, P. A. F., Visscher, P. M., Wright, M. J., Montgomery, G. W., Martin, N. G., InterAct Consortium & Whitfield, J. B., 29 Oct 2014, In: Nature Communications. 5, p. 4926

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant

    Pop, A. S., Levenga, J., de Esch, C. E. F., Buijsen, R. A. M., Nieuwenhuizen, I. M., Li, T., Isaacs, A., Gasparini, F., Oostra, B. A. & Willemsen, R., Mar 2014, In: Psychopharmacology. 231, 6, p. 1227-35 9 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels

    van Leeuwen, E. M., Smouter, F. A. S., Kam-Thong, T., Karbalai, N., Smith, A. V., Harris, T. B., Launer, L. J., Sitlani, C. M., Li, G., Brody, J. A., Bis, J. C., White, C. C., Jaiswal, A., Oostra, B. A., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Boerwinkle, E., Ballantyne, C. M., Gudnason, V., & 8 othersPsaty, B. M., Cupples, L. A., Järvelin, M-R., Ripatti, S., Isaacs, A., Müller-Myhsok, B., Karssen, L. C. & van Duijn, C. M., 2014, In: PLOS ONE. 9, 10, p. e109290

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access

  • Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol

    Lange, L. A., Hu, Y., Zhang, H., Xue, C., Schmidt, E. M., Tang, Z-Z., Bizon, C., Lange, E. M., Smith, J. D., Turner, E. H., Jun, G., Kang, H. M., Peloso, G., Auer, P., Li, K-P., Flannick, J., Zhang, J., Fuchsberger, C., Gaulton, K., Lindgren, C., & 31 othersLocke, A., Manning, A., Sim, X., Rivas, M. A., Holmen, O. L., Gottesman, O., Lu, Y., Ruderfer, D., Stahl, E. A., Duan, Q., Li, Y., Durda, P., Jiao, S., Isaacs, A., Hofman, A., Bis, J. C., Correa, A., Griswold, M. E., Jakobsdottir, J., Smith, A. V., Schreiner, P. J., Feitosa, M. F., Zhang, Q., Huffman, J. E., Crosby, J., Wassel, C. L., Do, R., Franceschini, N., Martin, L. W., Robinson, J. G. & NHLBI Grand Opportunity Exome Sequencing Project, 6 Feb 2014, In: American Journal of Human Genetics. 94, 2, p. 233-45 13 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
  • 2015

    CLEC4M and STXBP5 gene variations contribute to von Willebrand factor level variation in von Willebrand disease

    WiN Study Group, Jun 2015, In: Journal of Thrombosis and Haemostasis. 13, 6, p. 956-66 11 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access
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  • Correction: Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

    Benyamin, B., Esko, T., Ried, J. S., Radhakrishnan, A., Vermeulen, S. H., Traglia, M., Gögele, M., Anderson, D., Broer, L., Podmore, C., Luan, J., Kutalik, Z., Sanna, S., van der Meer, P., Tanaka, T., Wang, F., Westra, H-J., Franke, L., Mihailov, E., Milani, L., & 49 othersHälldin, J., Winkelmann, J., Meitinger, T., Thiery, J., Peters, A., Waldenberger, M., Rendon, A., Jolley, J., Sambrook, J., Kiemeney, L. A., Sweep, F. C., Sala, C. F., Schwienbacher, C., Pichler, I., Hui, J., Demirkan, A., Isaacs, A., Amin, N., Steri, M., Waeber, G., Verweij, N., Powell, J. E., Nyholt, D. R., Heath, A. C., Madden, P. A. F., Visscher, P. M., Wright, M. J., Montgomery, G. W., Martin, N. G., Hernandez, D., Bandinelli, S., van der Harst, P., Uda, M., Vollenweider, P., Scott, R. A., Langenberg, C., Wareham, N. J., van Duijn, C., Beilby, J., Pramstaller, P. P., Hicks, A. A., Ouwehand, W. H., Oexle, K., Gieger, C., Metspalu, A., Camaschella, C., Toniolo, D., Swinkels, D. W. & Whitfield, J. B., 30 Mar 2015, In: Nature Communications. 6, p. 6542

    Research output: Contribution to journal › Erratum / corrigendum / retractions › Academic

    Open Access

  • Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

    ENGAGE Consortium, Jul 2015, In: Plos Genetics. 11, 7, e1005230.

    Research output: Contribution to journal › Article › Academic › peer-review

    Open Access