No photo of Hendric Hemker
  • Universiteitssingel50, UNS50

    6229 ER Maastricht

    Netherlands

19972019
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Research Output 1997 2019

2019
38 Downloads (Pure)

Begrijpen v ingrijpen

Hemker, C., 17 May 2019, Maastricht: Maastricht University.

Research output: Book/ReportBookPopular

Open Access
File

Heparins: A Shift of Paradigm

Hemker, H. C., Al Dieri, R. & Beguin, S., 15 Nov 2019, In : Frontiers in medicine. 6, p. 1-8 8 p., 254.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Exploring the limits of modelling thrombus formation Comment on Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones by AV Belyaev et al.

Hemker, H. C., Bloemen, S. & Hemker, P. W., Nov 2018, In : Physics of Life Reviews. 26-27, p. 100-105 6 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Increased blood levels of cellular fibronectin in asthma: Relation to the asthma severity, inflammation, and prothrombotic blood alterations

Bazan-Socha, S., Kuczia, P., Potaczek, D. P., Mastalerz, L., Cybulska, A., Zareba, L., Kremers, R., Hemker, C. & Undas, A., 1 Aug 2018, In : Respiratory Medicine. 141, p. 64-71 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin

Kremers, R. M. W., Zuily, S., Kelchtermans, H., Peters, T. C., Bloemen, S., Regnault, V., Hemker, H. C., de Groot, P. G., Wahl, D. & de Laat, B., 12 Jun 2018, In : Blood advances. 2, 11, p. 1315-1324 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Thrombin generation in low plasma volumes

Bloemen, S., Kelchtermans, H. & Hemker, H. C., 15 May 2018, In : Thrombosis Journal. 16, 4 p., 10.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Open Access
2017

Computational modelling of clot development in patient-specific cerebral aneurysm cases: rebuttal

Kremers, R. M. W., de Laat, B., Wagenvoord, R. J. & Hemker, H. C., Feb 2017, In : Journal of Thrombosis and Haemostasis. 15, 2, p. 399-399 1 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Computational modelling of clot development in patient-specific cerebral aneurysm cases: comment

Kremers, R. M. W., de Laat, B., Wagenvoord, R. J. & Hemker, H. C., Feb 2017, In : Journal of Thrombosis and Haemostasis. 15, 2, p. 395-396 2 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis

Kremers, R. M. W., Kleinegris, M-C., Ninivaggi, M., de Laat, B., ten Cate, H., Koek, G. H., Wagenvoord, R. J. & Hemker, H. C., 4 May 2017, In : PLOS ONE. 12, 5, 17 p., 0177020.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Proposal for standardized preanalytical and analytical conditions for measuring thrombin generation in hemophilia: communication from the SSC of the ISTH

Dargaud, Y., Wolberg, A. S., Gray, E., Negrier, C. & Hemker, H. C., Aug 2017, In : Journal of Thrombosis and Haemostasis. 15, 8, p. 1704-1707 4 p.

Research output: Contribution to journalEditorialAcademicpeer-review

Sex hormone-binding globulin and thrombin generation in women using hormonal contraception

Hugon-Rodin, J., Alhenc-Gelas, M., Hemker, H. C., Brailly-Tabard, S., Guiochon-Mantel, A., Plu-Bureau, G. & Scarabin, P-Y., 2017, In : Biomarkers. 22, 1, p. 81-85 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016
1 Citation (Scopus)

A century of heparin: past, present and future

Hemker, H., Dec 2016, In : Journal of Thrombosis and Haemostasis. 14, 12, p. 2329-2338 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

A reduction of prothrombin conversion by cardiac surgery with cardiopulmonary bypass shifts the haemostatic balance towards bleeding

Kremers, R. M. W., Bosch, Y. P. J., Bloemen, S., de Laat, B., Weerwind, P. W., Mochtar, B., Maessen, J. G., Wagenvoord, R. J., Al Dieri, R. & Hemker, H. C., Sep 2016, In : Thrombosis and Haemostasis. 116, 3, p. 442-451

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Asthma is associated with enhanced thrombin formation and impaired fibrinolysis

Bazan-Socha, S., Mastalerz, L., Cybulska, A., Zareba, L., Kremers, R., Zabczyk, M., Pulka, G., Iwaniec, T., Hemker, C. & Undas, A., Jul 2016, In : Clinical and Experimental Allergy. 46, 7, p. 932-944 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Can Global Assays Make Anticoagulation Safer and More Effective?

Hemker, H. C., Jan 2016, In : Clinical advances in hematology & oncology : H&O. 14, 1, p. 35-37

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Comment on the use of computational models to study the effect of apixaban and rivaroxaban on thrombin generation

Kremers, R. M. W., Wagenvoord, R. J. & Hemker, H. C., Apr 2016, In : Thrombosis and Haemostasis. 115, 4, p. 869-870

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Effect of five therapeutic strategies on the coagulation defect induced by the thrombomodulin c.1611C > A mutation

Dargaud, Y., Jourdy, Y., Le Quellec, S., Hemker, H., Lindhout, T., Castoldi, E. & Negrier, C., Sep 2016, In : British Journal of Haematology. 174, 6, p. 993-996

Research output: Contribution to journalEditorialAcademicpeer-review

Het meten van trombinevorming: Nieuwe technieken: 5 jaar later

Hemker, H., 2016, In : Nederlands Tijdschrift voor Geneeskunde. 160, D318.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Low paediatric thrombin generation is caused by an attenuation of prothrombin conversion

Kremers, R. M. W., Wagenvoord, R. J., de Laat, B., Monagle, P., Hemker, H. C. & Ignjatovic, V., Jun 2016, In : Thrombosis and Haemostasis. 115, 6, p. 1090-1100

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Simultaneous measurement of thrombin generation and fibrin formation in whole blood under flow conditions

Kelchtermans, H., Pelkmans, L., Bouwhuis, A., Schurgers, E., Lindhout, T., Huskens, D., Miszta, A., Hemker, H. C., Lance, M. D. & de Laat, B., Jul 2016, In : Thrombosis and Haemostasis. 116, 1, p. 134-145

Research output: Contribution to journalArticleAcademicpeer-review

Thrombin Generation and Atherothrombosis: What Does the Evidence Indicate?

ten Cate, H. & Hemker, H., Aug 2016, In : Journal of the American Heart Association. 5, 8, e003553.

Research output: Contribution to journalArticleAcademicpeer-review

Thrombin Generation in Zebrafish Blood

Schurgers, E., Moorlag, M., Hemker, H., Lindhout, T., Kelchtermans, H. & de Laat, B., 12 Feb 2016, In : PLOS ONE. 11, 2, e0149135.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015
2 Citations (Scopus)

Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation

Dargaud, Y., Scoazec, J. Y., Wielders, S. J. H., Trzeciak, C., Hackeng, T. M., Negrier, C., Hemker, H. C., Lindhout, T. & Castoldi, E., 26 Feb 2015, In : Blood. 125, 9, p. 1497-1501

Research output: Contribution to journalArticleAcademicpeer-review

The application of thrombin generation in real life clinical situations

Hemker, H. C., Jul 2015, In : Thrombosis Research. 136, 1, p. 3-4

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

The balance of pro- and anticoagulant processes underlying thrombin generation

Kremers, R. M. W., Peters, T. C., Wagenvoord, R. J. & Hemker, H. C., Mar 2015, In : Journal of Thrombosis and Haemostasis. 13, 3, p. 437-447

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Thrombin Generating Capacity and Phenotypic Association in ABO Blood Groups

Kremers, R. M. W., Mohamed, A. B. O., Pelkmans, L., Hindawi, S., Hemker, H. C., de Laat, H. B., Huskens, D. & Al Dieri, R., 28 Oct 2015, In : PLOS ONE. 10, 10, e0141491.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Thrombin generation: biochemical possibilities and clinical reality

Hemker, H. C., 16 Jul 2015, In : Blood. 126, 3, p. 288-289

Research output: Contribution to journalArticleAcademicpeer-review

2014
5 Citations (Scopus)

Measurement of thrombin generation intra-operatively and its association with bleeding tendency after cardiac surgery

Bosch, Y. P. J., al Dieri, R., ten Cate, H., Nelemans, P. J., Bloemen, S., de Laat, B., Hemker, C., Weerwind, P. W., Maessen, J. G. & Mochtar, B., Mar 2014, In : Thrombosis Research. 133, 3, p. 488-494 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

50 Citations (Scopus)

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis

Wildhagen, K. C. A. A., Garcia de Frutos, P., Reutelingsperger, C. P., Schrijver, R., Areste, C., Ortega-Gomez, A., Deckers, N. M., Hemker, H. C., Soehnlein, O. & Nicolaes, G. A. F., 13 Feb 2014, In : Blood. 123, 7, p. 1098-1101

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

The effect of fibrin(ogen) on thrombin generation and decay

Kremers, R. M. W., Wagenvoord, R. J. & Hemker, H. C., Sep 2014, In : Thrombosis and Haemostasis. 112, 3, p. 486-494

Research output: Contribution to journalArticleAcademicpeer-review

2013

A new regulatory function of activated factor V: inhibition of the activation by tissue factor/factor VII(a) of factor X

Al Dieri, R., Bloemen, S., Kelchtermans, H., Wagenvoord, R. & Hemker, H. C., Mar 2013, In : Journal of Thrombosis and Haemostasis. 11, 3, p. 503-511

Research output: Contribution to journalArticleAcademicpeer-review

Data management in Thrombin Generation

Hemker, H. C. & Kremers, R., Jan 2013, In : Thrombosis Research. 131, 1, p. 3-11

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Large inter-individual variation of the pharmacodynamic effect of anticoagulant drugs on thrombin generation

Bloemen, S., Hemker, H. C. & Al Dieri, R., Apr 2013, In : Haematologica-the Hematology Journal. 98, 4, p. 549-554

Research output: Contribution to journalArticleAcademicpeer-review

2012
26 Citations (Scopus)

Is there value in kinetic modeling of thrombin generation? No (unless...)

Hemker, H. C., Kerdelo, S. & Kremers, R. M. W., Aug 2012, In : Journal of Thrombosis and Haemostasis. 10, 8, p. 1470-1477

Research output: Contribution to journalArticleAcademicpeer-review

Thrombin generation: What have we learned?

Al Dieri, R., de Laat, B. & Hemker, H. C., Sep 2012, In : Blood Reviews. 26, 5, p. 197-203

Research output: Contribution to journalArticleAcademicpeer-review

Whole-Blood Thrombin Generation Monitored with a Calibrated Automated Thrombogram-Based Assay

Ninivaggi, M., Apitz-Castro, R., Dargaud, Y., de Laat, B., Hemker, H. C. & Lindhout, T., Aug 2012, In : Clinical Chemistry. 58, 8, p. 1252-1259

Research output: Contribution to journalArticleAcademicpeer-review

2011

Increased thrombin generation among postmenopausal women using hormone therapy: importance of the route of estrogen administration and progestogens

Scarabin, P-Y., Hemker, H. C., Clement, C., Soisson, V. & Alhenc-Gelas, M., Aug 2011, In : Menopause-The Journal of the North American Menopause Society. 18, 8, p. 873-879

Research output: Contribution to journalArticleAcademicpeer-review

Thrombin generation assay using factor IXa as a trigger to quantify accurately factor VIII levels in haemophilia A

Ninivaggi, M., Dargaud, Y., Van Oerle, R., De Laat, B., Hemker, H. C. & Lindhout, T., Aug 2011, In : Journal of Thrombosis and Haemostasis. 9, 8, p. 1549-1555

Research output: Contribution to journalArticleAcademicpeer-review

2010

Evaluation of the procoagulant activity in the plasma of cancer patients using a thrombin generation assay

Debaugnies, F., Azerad, M-A., Noubouossie, D., Rozen, L., Hemker, H. C., Corazza, F., Efira, A. & Demulder, A., Dec 2010, In : Thrombosis Research. 126, 6, p. 531-535

Research output: Contribution to journalArticleAcademicpeer-review

High Subretinal Fluid Procoagulant Activity in Rhegmatogenous Retinal Detachment

Ricker, L. J. A. G., Al Dieri, R., Beckers, G. J. M., Pels, E., Liem, A. T. A., Hendrikse, F., Kijlstra, A., Hemker, H. C. & La Heij, E. C., Oct 2010, In : Investigative Ophthalmology & Visual Science. 51, 10, p. 5234-5239

Research output: Contribution to journalArticleAcademicpeer-review

Monitoring platelet dependent thrombin generation in mice

Dargaud, Y., Spronk, H. M. H., Leenders, P., Hemker, H. C. & Ten Cate, H., Nov 2010, In : Thrombosis Research. 126, 5, p. 436-441

Research output: Contribution to journalArticleAcademicpeer-review

The paradoxical stimulation by a reversible thrombin inhibitor of thrombin generation in plasma measured with thrombinography is caused by alpha(2)-macroglobulin-thrombin

Wagenvoord, R. J., Deinum, J., Elg, M. & Hemker, H. C., Jun 2010, In : Journal of Thrombosis and Haemostasis. 8, 6, p. 1281-1289

Research output: Contribution to journalArticleAcademicpeer-review

2007
22 Citations (Scopus)
160 Downloads (Pure)

Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk

Lecompte, T., Wahl, D., Perret - Guillaume, C., Hemker, H. C., Lacolley, P. & Regnault, V., 1 Jan 2007, In : Haematologica-the Hematology Journal. 92(5), p. 714-5

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
29 Citations (Scopus)
131 Downloads (Pure)

Randomized, placebo-controlled trial of low molecular weight heparin in active ulcerative colitis

de Bievre, M. A., Vrij, A. A., Schoon, E. J., Dijkstra, G., de Jong, A. E., Oberndorff-Klein Woolthuis, A. H., Hemker, H. C. & Stockbrugger, R. W., 1 Jan 2007, In : Inflammatory Bowel Diseases. 13, 6, p. 753-758

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
7 Citations (Scopus)
90 Downloads (Pure)

The initiation phase--a review of old (clotting-) times

Hemker, H. C., 1 Jan 2007, In : Thrombosis and Haemostasis. 98(1), p. 20-3

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
5 Citations (Scopus)
125 Downloads (Pure)

Thrombin generation in mesalazine refractory ulcerative colitis and the influence of low molecular weight heparin

Vrij, A. A., Oberndorff-Klein Woolthuis, A. H., Dijkstra, G., de Jong, A. E., Wagenvoord, R., Hemker, H. C. & Stockbrugger, R. W., 1 Jan 2007, In : Journal of Thrombosis and Thrombolysis. 24, 2, p. 175-182

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
2005
14 Citations (Scopus)
114 Downloads (Pure)

During coagulation, thrombin generation shifts from chemical to diffusional control

Hemker, H. C., de Smed, E. & Hemker, P. W., 1 Jan 2005, In : Journal of Thrombosis and Haemostasis. 3, p. 2399-2400

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
186 Citations (Scopus)
1055 Downloads (Pure)

Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B.

Dargaud, Y., Beguin, S., Lienhart, A., al Dieri, R., Trzeciak, C., Bordet, J. C., Hemker, H. C. & Negrier, C., 1 Jan 2005, In : Thrombosis and Haemostasis. 93, p. 475-480

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
3 Citations (Scopus)
111 Downloads (Pure)

Good mathematical practice: simulation of the hemostatic-thrombotic mechanism, a powerful tool but one that must be used with circumspection

Hemker, H. C. & Ataullakhanov, F. I., 1 Jan 2005, In : Pathophysiology of Haemostasis and Thrombosis. 34, p. 55-57

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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2003
10 Citations (Scopus)
141 Downloads (Pure)

von Willebrand factor stimulates thrombin-induced exposure of procoagulant phospholipids on the surface of fibrin-adherent platelets

Briedé, J. J., Wielders, S. J. H., Heemskerk, J. W. M., Baruch, D., Hemker, H. C. & Lindhout, T., 1 Jan 2003, In : Thrombosis and Haemostasis. 1, 3, p. 559-565 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
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