Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation

Yesim Dargaud*, Jean Yves Scoazec, Simone J. H. Wielders, Christine Trzeciak, Tilman M. Hackeng, Claude Negrier, H. Coenraad Hemker, Theo Lindhout, Elisabetta Castoldi

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


We describe a family with an autosomal dominant disorder characterized by severe trauma- and surgery-related bleeding. The proband, who experienced life-threatening bleeding during a routine operation, had normal clotting times, but markedly reduced prothrombin consumption. Plasma levels of all coagulation factors and of the main coagulation inhibitors were normal. Thrombin generation at low triggers was severely impaired and mixing experiments suggested the presence of a coagulation inhibitor. Using whole exome sequencing, the underlying genetic defect was identified as the THBD c.1611C>A mutation (p.Cys537Stop), which predicts a truncated form of thrombomodulin that is shed from the vascular endothelium. The patient had decreased expression of endothelium-bound thrombomodulin, but extremely elevated levels of soluble thrombomodulin in plasma, impairing the propagation phase of coagulation via rapid activation of protein C and consequent inactivation of factors Va and VIIIa. The same thrombomodulin mutation has been recently described in an unrelated British family with strikingly similar features.
Original languageEnglish
Pages (from-to)1497-1501
Issue number9
Publication statusPublished - 26 Feb 2015


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