Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk

T. Lecompte, D. Wahl, C. Perret - Guillaume, H.C. Hemker, P. Lacolley, V. Regnault

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Abstract

Interference of antiphospholipid antibodies (aPL) with coagulation was investigated in 40 aPL-patients (24 with thrombosis) using thrombography. Impairment of the activated protein C anticoagulant pathway was partially offset by the genuine anticoagulant effect. The net result, a procoagulant phenotype, was associated with a 7-fold increased risk of thrombosis in aPL-patients.
Original languageEnglish
Pages (from-to)714-5
JournalHaematologica-the Hematology Journal
Volume92(5)
DOIs
Publication statusPublished - 1 Jan 2007

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