Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk

T. Lecompte; D. Wahl; C. Perret - Guillaume; H.C. Hemker; P. Lacolley; V. Regnault

doi:10.3324/haematol.10577

Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk

T. Lecompte, D. Wahl^*, C. Perret - Guillaume, H.C. Hemker, P. Lacolley, V. Regnault

^*Corresponding author for this work

CARIM School for Cardiovascular Diseases

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Abstract

Interference of antiphospholipid antibodies (aPL) with coagulation was investigated in 40 aPL-patients (24 with thrombosis) using thrombography. Impairment of the activated protein C anticoagulant pathway was partially offset by the genuine anticoagulant effect. The net result, a procoagulant phenotype, was associated with a 7-fold increased risk of thrombosis in aPL-patients.

Original language	English
Pages (from-to)	714-5
Journal	Haematologica-the Hematology Journal
Volume	92(5)
DOIs	https://doi.org/10.3324/haematol.10577
Publication status	Published - 1 Jan 2007

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title = "Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk",

abstract = "Interference of antiphospholipid antibodies (aPL) with coagulation was investigated in 40 aPL-patients (24 with thrombosis) using thrombography. Impairment of the activated protein C anticoagulant pathway was partially offset by the genuine anticoagulant effect. The net result, a procoagulant phenotype, was associated with a 7-fold increased risk of thrombosis in aPL-patients.",

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AU - Lecompte, T.

AU - Wahl, D.

AU - Perret - Guillaume, C.

AU - Hemker, H.C.

AU - Lacolley, P.

AU - Regnault, V.

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AB - Interference of antiphospholipid antibodies (aPL) with coagulation was investigated in 40 aPL-patients (24 with thrombosis) using thrombography. Impairment of the activated protein C anticoagulant pathway was partially offset by the genuine anticoagulant effect. The net result, a procoagulant phenotype, was associated with a 7-fold increased risk of thrombosis in aPL-patients.

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DO - 10.3324/haematol.10577

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