No photo of Hendric Hemker
  • Universiteitssingel50, UNS50

    6229 ER Maastricht

    Netherlands

1960 …2020

Research output per year

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Research Output

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Article
2019

Heparins: A Shift of Paradigm

Hemker, H. C., Al Dieri, R. & Beguin, S., 15 Nov 2019, In : Frontiers in medicine. 6, p. 1-8 8 p., 254.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Increased blood levels of cellular fibronectin in asthma: Relation to the asthma severity, inflammation, and prothrombotic blood alterations

Bazan-Socha, S., Kuczia, P., Potaczek, D. P., Mastalerz, L., Cybulska, A., Zareba, L., Kremers, R., Hemker, C. & Undas, A., 1 Aug 2018, In : Respiratory Medicine. 141, p. 64-71 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin

Kremers, R. M. W., Zuily, S., Kelchtermans, H., Peters, T. C., Bloemen, S., Regnault, V., Hemker, H. C., de Groot, P. G., Wahl, D. & de Laat, B., 12 Jun 2018, In : Blood advances. 2, 11, p. 1315-1324 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis

Kremers, R. M. W., Kleinegris, M-C., Ninivaggi, M., de Laat, B., ten Cate, H., Koek, G. H., Wagenvoord, R. J. & Hemker, H. C., 4 May 2017, In : PLOS ONE. 12, 5, 17 p., 0177020.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Sex hormone-binding globulin and thrombin generation in women using hormonal contraception

Hugon-Rodin, J., Alhenc-Gelas, M., Hemker, H. C., Brailly-Tabard, S., Guiochon-Mantel, A., Plu-Bureau, G. & Scarabin, P-Y., 2017, In : Biomarkers. 22, 1, p. 81-85 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

2016

A century of heparin: past, present and future

Hemker, H., Dec 2016, In : Journal of Thrombosis and Haemostasis. 14, 12, p. 2329-2338 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

A reduction of prothrombin conversion by cardiac surgery with cardiopulmonary bypass shifts the haemostatic balance towards bleeding

Kremers, R. M. W., Bosch, Y. P. J., Bloemen, S., de Laat, B., Weerwind, P. W., Mochtar, B., Maessen, J. G., Wagenvoord, R. J., Al Dieri, R. & Hemker, H. C., Sep 2016, In : Thrombosis and Haemostasis. 116, 3, p. 442-451

Research output: Contribution to journalArticleAcademicpeer-review

Asthma is associated with enhanced thrombin formation and impaired fibrinolysis

Bazan-Socha, S., Mastalerz, L., Cybulska, A., Zareba, L., Kremers, R., Zabczyk, M., Pulka, G., Iwaniec, T., Hemker, C. & Undas, A., Jul 2016, In : Clinical and Experimental Allergy. 46, 7, p. 932-944 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Can Global Assays Make Anticoagulation Safer and More Effective?

Hemker, H. C., Jan 2016, In : Clinical advances in hematology & oncology : H&O. 14, 1, p. 35-37

Research output: Contribution to journalArticleAcademicpeer-review

Het meten van trombinevorming: Nieuwe technieken: 5 jaar later

Hemker, H., 2016, In : Nederlands Tijdschrift voor Geneeskunde. 160, D318.

Research output: Contribution to journalArticleAcademicpeer-review

Low paediatric thrombin generation is caused by an attenuation of prothrombin conversion

Kremers, R. M. W., Wagenvoord, R. J., de Laat, B., Monagle, P., Hemker, H. C. & Ignjatovic, V., Jun 2016, In : Thrombosis and Haemostasis. 115, 6, p. 1090-1100

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Simultaneous measurement of thrombin generation and fibrin formation in whole blood under flow conditions

Kelchtermans, H., Pelkmans, L., Bouwhuis, A., Schurgers, E., Lindhout, T., Huskens, D., Miszta, A., Hemker, H. C., Lance, M. D. & de Laat, B., Jul 2016, In : Thrombosis and Haemostasis. 116, 1, p. 134-145

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Thrombin Generation and Atherothrombosis: What Does the Evidence Indicate?

ten Cate, H. & Hemker, H., Aug 2016, In : Journal of the American Heart Association. 5, 8, e003553.

Research output: Contribution to journalArticleAcademicpeer-review

Thrombin Generation in Zebrafish Blood

Schurgers, E., Moorlag, M., Hemker, H., Lindhout, T., Kelchtermans, H. & de Laat, B., 12 Feb 2016, In : PLOS ONE. 11, 2, e0149135.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2015

Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation

Dargaud, Y., Scoazec, J. Y., Wielders, S. J. H., Trzeciak, C., Hackeng, T. M., Negrier, C., Hemker, H. C., Lindhout, T. & Castoldi, E., 26 Feb 2015, In : Blood. 125, 9, p. 1497-1501

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

The application of thrombin generation in real life clinical situations

Hemker, H. C., Jul 2015, In : Thrombosis Research. 136, 1, p. 3-4

Research output: Contribution to journalArticleAcademicpeer-review

The balance of pro- and anticoagulant processes underlying thrombin generation

Kremers, R. M. W., Peters, T. C., Wagenvoord, R. J. & Hemker, H. C., Mar 2015, In : Journal of Thrombosis and Haemostasis. 13, 3, p. 437-447

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Thrombin Generating Capacity and Phenotypic Association in ABO Blood Groups

Kremers, R. M. W., Mohamed, A. B. O., Pelkmans, L., Hindawi, S., Hemker, H. C., de Laat, H. B., Huskens, D. & Al Dieri, R., 28 Oct 2015, In : PLOS ONE. 10, 10, e0141491.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Thrombin generation: biochemical possibilities and clinical reality

Hemker, H. C., 16 Jul 2015, In : Blood. 126, 3, p. 288-289

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
2014

Measurement of thrombin generation intra-operatively and its association with bleeding tendency after cardiac surgery

Bosch, Y. P. J., al Dieri, R., ten Cate, H., Nelemans, P. J., Bloemen, S., de Laat, B., Hemker, C., Weerwind, P. W., Maessen, J. G. & Mochtar, B., Mar 2014, In : Thrombosis Research. 133, 3, p. 488-494 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis

Wildhagen, K. C. A. A., Garcia de Frutos, P., Reutelingsperger, C. P., Schrijver, R., Areste, C., Ortega-Gomez, A., Deckers, N. M., Hemker, H. C., Soehnlein, O. & Nicolaes, G. A. F., 13 Feb 2014, In : Blood. 123, 7, p. 1098-1101

Research output: Contribution to journalArticleAcademicpeer-review

50 Citations (Scopus)

The effect of fibrin(ogen) on thrombin generation and decay

Kremers, R. M. W., Wagenvoord, R. J. & Hemker, H. C., Sep 2014, In : Thrombosis and Haemostasis. 112, 3, p. 486-494

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)
2013

A new regulatory function of activated factor V: inhibition of the activation by tissue factor/factor VII(a) of factor X

Al Dieri, R., Bloemen, S., Kelchtermans, H., Wagenvoord, R. & Hemker, H. C., Mar 2013, In : Journal of Thrombosis and Haemostasis. 11, 3, p. 503-511

Research output: Contribution to journalArticleAcademicpeer-review

Data management in Thrombin Generation

Hemker, H. C. & Kremers, R., Jan 2013, In : Thrombosis Research. 131, 1, p. 3-11

Research output: Contribution to journalArticleAcademicpeer-review

Large inter-individual variation of the pharmacodynamic effect of anticoagulant drugs on thrombin generation

Bloemen, S., Hemker, H. C. & Al Dieri, R., Apr 2013, In : Haematologica-the Hematology Journal. 98, 4, p. 549-554

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)
2012

Is there value in kinetic modeling of thrombin generation? No (unless...)

Hemker, H. C., Kerdelo, S. & Kremers, R. M. W., Aug 2012, In : Journal of Thrombosis and Haemostasis. 10, 8, p. 1470-1477

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Thrombin generation: What have we learned?

Al Dieri, R., de Laat, B. & Hemker, H. C., Sep 2012, In : Blood Reviews. 26, 5, p. 197-203

Research output: Contribution to journalArticleAcademicpeer-review

Whole-Blood Thrombin Generation Monitored with a Calibrated Automated Thrombogram-Based Assay

Ninivaggi, M., Apitz-Castro, R., Dargaud, Y., de Laat, B., Hemker, H. C. & Lindhout, T., Aug 2012, In : Clinical Chemistry. 58, 8, p. 1252-1259

Research output: Contribution to journalArticleAcademicpeer-review

2011

Increased thrombin generation among postmenopausal women using hormone therapy: importance of the route of estrogen administration and progestogens

Scarabin, P-Y., Hemker, H. C., Clement, C., Soisson, V. & Alhenc-Gelas, M., Aug 2011, In : Menopause-The Journal of the North American Menopause Society. 18, 8, p. 873-879

Research output: Contribution to journalArticleAcademicpeer-review

Thrombin generation assay using factor IXa as a trigger to quantify accurately factor VIII levels in haemophilia A

Ninivaggi, M., Dargaud, Y., Van Oerle, R., De Laat, B., Hemker, H. C. & Lindhout, T., Aug 2011, In : Journal of Thrombosis and Haemostasis. 9, 8, p. 1549-1555

Research output: Contribution to journalArticleAcademicpeer-review

2010

Evaluation of the procoagulant activity in the plasma of cancer patients using a thrombin generation assay

Debaugnies, F., Azerad, M-A., Noubouossie, D., Rozen, L., Hemker, H. C., Corazza, F., Efira, A. & Demulder, A., Dec 2010, In : Thrombosis Research. 126, 6, p. 531-535

Research output: Contribution to journalArticleAcademicpeer-review

High Subretinal Fluid Procoagulant Activity in Rhegmatogenous Retinal Detachment

Ricker, L. J. A. G., Al Dieri, R., Beckers, G. J. M., Pels, E., Liem, A. T. A., Hendrikse, F., Kijlstra, A., Hemker, H. C. & La Heij, E. C., Oct 2010, In : Investigative Ophthalmology & Visual Science. 51, 10, p. 5234-5239

Research output: Contribution to journalArticleAcademicpeer-review

Monitoring platelet dependent thrombin generation in mice

Dargaud, Y., Spronk, H. M. H., Leenders, P., Hemker, H. C. & Ten Cate, H., Nov 2010, In : Thrombosis Research. 126, 5, p. 436-441

Research output: Contribution to journalArticleAcademicpeer-review

The paradoxical stimulation by a reversible thrombin inhibitor of thrombin generation in plasma measured with thrombinography is caused by alpha(2)-macroglobulin-thrombin

Wagenvoord, R. J., Deinum, J., Elg, M. & Hemker, H. C., Jun 2010, In : Journal of Thrombosis and Haemostasis. 8, 6, p. 1281-1289

Research output: Contribution to journalArticleAcademicpeer-review

2007

Caution in the interpretation of continuous thrombin generation assays: A rebuttal

Hemker, H. C. & De Smedt, E. ., 12 Mar 2007, In : Journal of Thrombosis and Haemostasis. 5, 5, p. 1085-1087 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Differential impact of conventional and low-dose oral hormone therapy (HT), tibolone and raloxifene on functionality of the activated protein C system

Eilertsen, A. L., Liestol, S., Mowinckel, M-C., Hemker, H. C. & Sandset, P-M., 2007, In : Thrombosis and Haemostasis. 97, 6, p. 938-943 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk

Lecompte, T., Wahl, D., Perret - Guillaume, C., Hemker, H. C., Lacolley, P. & Regnault, V., 1 Jan 2007, In : Haematologica-the Hematology Journal. 92(5), p. 714-5

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
22 Citations (Scopus)
206 Downloads (Pure)

Randomized, placebo-controlled trial of low molecular weight heparin in active ulcerative colitis

de Bievre, M. A., Vrij, A. A., Schoon, E. J., Dijkstra, G., de Jong, A. E., Oberndorff-Klein Woolthuis, A. H., Hemker, H. C. & Stockbrugger, R. W., 1 Jan 2007, In : Inflammatory Bowel Diseases. 13, 6, p. 753-758

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
29 Citations (Scopus)
198 Downloads (Pure)

The initiation phase--a review of old (clotting-) times

Hemker, H. C., 1 Jan 2007, In : Thrombosis and Haemostasis. 98(1), p. 20-3

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
7 Citations (Scopus)
139 Downloads (Pure)

Thrombin generation in mesalazine refractory ulcerative colitis and the influence of low molecular weight heparin

Vrij, A. A., Oberndorff-Klein Woolthuis, A. H., Dijkstra, G., de Jong, A. E., Wagenvoord, R., Hemker, H. C. & Stockbrugger, R. W., 1 Jan 2007, In : Journal of Thrombosis and Thrombolysis. 24, 2, p. 175-182

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
5 Citations (Scopus)
171 Downloads (Pure)
2006

Fixed dosage of low-molecular-weight heparins causes large individual variation in coagulability, only partly correlated to body weight

Al Dieri, R., Alban, S. ., Beguin, S. . & Hemker, H. C., 2006, In : Journal of Thrombosis and Haemostasis. 4, 1, p. 83-89 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Mathematical and biological models of blood coagulation: A rebuttal

Hemker, H. C., De Smedt, E. & Hemker, P. W., 1 Jan 2006, In : Journal of Thrombosis and Haemostasis. 4, 3, p. 710-711 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

New approaches for measuring coagulation

Barrowcliffe, T. W., Cattaneo, M., Podda, G. M., Bucciarelli, P., Lussana, F., Lecchi, A., Toh, C. H., Hemker, H. C., Béguin, S., Ingerslev, J. & Sorensen, B., Jul 2006, In : Haemophilia. 12, Suppl. 3, p. 76-81 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The limits of simulation of the clotting system

Wagenvoord, R., Hemker, P. W. & Hemker, H. C., 1 Jan 2006, In : Journal of Thrombosis and Haemostasis. 4, 6, p. 1331-1338 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
5 Downloads (Pure)

Thrombin generation: A function test of the haemostatic-thrombotic system

Hemker, H. C., Al Dieri, R., De Smedt, E. & Beguin, S., 1 Jan 2006, In : Thrombosis and Haemostasis. 96, 5, p. 553-561 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
28 Downloads (Pure)
2005

During coagulation, thrombin generation shifts from chemical to diffusional control

Hemker, H. C., de Smed, E. & Hemker, P. W., 1 Jan 2005, In : Journal of Thrombosis and Haemostasis. 3, p. 2399-2400

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
14 Citations (Scopus)
161 Downloads (Pure)

Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B.

Dargaud, Y., Beguin, S., Lienhart, A., al Dieri, R., Trzeciak, C., Bordet, J. C., Hemker, H. C. & Negrier, C., 1 Jan 2005, In : Thrombosis and Haemostasis. 93, p. 475-480

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
186 Citations (Scopus)
1114 Downloads (Pure)

Good mathematical practice: simulation of the hemostatic-thrombotic mechanism, a powerful tool but one that must be used with circumspection

Hemker, H. C. & Ataullakhanov, F. I., 1 Jan 2005, In : Pathophysiology of Haemostasis and Thrombosis. 34, p. 55-57

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
File
3 Citations (Scopus)
162 Downloads (Pure)

Laboratory monitoring of low-molecular-weight heparin therapy: Part II

Hemker, H. C., Al Dieri, R. & Beguin, S., 2005, In : Journal of Thrombosis and Haemostasis. 3, 3, p. 571-573 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2004

Factor XI-dependent reciprocal thrombin generation consolidates blood coagulation when tissue factor is not available

Wielders, S. J. H., Beguin, S., Hemker, H. C. & Lindhout, T., 2004, In : Arteriosclerosis Thrombosis and Vascular Biology. 24, 6, p. 1138-1142 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access