20052020

Research output per year

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Research Output

2020

Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage

Bustelo, M., Barkhuizen, M., van den Hove, D. L. A., Steinbusch, H. W. M., Bruno, M. A., Fabian Loidl, C. & Danilo Gavilanes, A. W., 9 Jun 2020, In : Frontiers in Neurology. 11, 15 p., 483.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

DNA methylation in the 5-HTT regulatory region is associated with CO2-induced fear in panic disorder patients

Leibold, N. K., Weidner, M. T., Ziegler, C., Ortega, G., Domschke, K., Lesch, K. P., Van den Hove, D. L. & Schruers, K. R., Jul 2020, In : European Neuropsychopharmacology. 36, p. 154-159 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Psychosis-associated DNA methylomic variation in Alzheimer's disease cortex

Pishva, E., Creese, B., Smith, A. R., Viechtbauer, W., Proitsi, P., van den Hove, D. L. A., Ballard, C., Mill, J. & Lunnon, K., May 2020, In : Neurobiology of Aging. 89, p. 83-88 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Statistical differences resulting from selection of stable reference genes after hypoxia and hypothermia in the neonatal rat brain

Bustelo, M., Bruno, M. A., Loidl, C. F., Rey-Funes, M., Steinbusch, H. W. M., Gavilanes, A. W. D. & van den Hove, D. L. A., 21 May 2020, In : PLOS ONE. 15, 5, 12 p., 0233387.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

5-HTT independent effects of fluoxetine on neuroplasticity

Levy, M. J. F., Boulle, F., Emerit, M. B., Poilbout, C., Steinbusch, H. W. M., Van den Hove, D. L. A., Kenis, G. & Lanfumey, L., 19 Apr 2019, In : Scientific Reports. 9, 11 p., 6311.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Active Amyloid-beta Vaccination Results in Epigenetic Changes in the Hippocampus of an Alzheimer's Disease-Like Mouse Model

Lardenoije, R., van den Hove, D. L. A., Jung, S. E., Havermans, M., Blackburn, P., Liu, B., Rutten, B. P. F. & Lemere, C. A., 2019, In : Current Alzheimer Research. 16, 9, p. 861-870 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Alzheimer's disease-associated (hydroxy)methylomic changes in the brain and blood

Lardenoije, R., Roubroeks, J. A. Y., Pishva, E., Leber, M., Wagner, H., Iatrou, A., Smith, A. R., Smith, R. G., Eijssen, L. M. T., Kleineidam, L., Kawalia, A., Hoffmann, P., Luck, T., Riedel-Heller, S., Jessen, F., Maier, W., Wagner, M., Hurlemann, R., Kenis, G., Ali, M. & 9 others, del Sol, A., Mastroeni, D., Delvaux, E., Coleman, P. D., Mill, J., Rutten, B. P. F., Lunnon, K., Ramirez, A. & van den Hove, D. L. A., 27 Nov 2019, In : Clinical epigenetics. 11, 1, 15 p., 164.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Circulating Serum MicroRNAs as Potential Diagnostic Biomarkers of Posttraumatic Stress Disorder: A Pilot Study

Snijders, C., Krauskopf, J., Pishva, E., Eijssen, L., Machiels, B., Kleinjans, J., Kenis, G., van den Hove, D., Kim, M. O., Boks, M. P. M., Vinkers, C. H., Vermetten, E., Geuze, E., Rutten, B. P. F. & de Nijs, L., 22 Nov 2019, In : Frontiers in Genetics. 10, 10 p., 1042.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Early-life stress impairs developmental programming in Cadherin 13 (CDH13)-deficient mice

Kiser, D. P., Popp, S., Schmitt-Boehrer, A. G., Strekalova, T., van den Hove, D. L., Lesch, K-P. & Rivero, O., 8 Mar 2019, In : Progress in Neuro-Psychopharmacology & Biological Psychiatry. 89, p. 158-168 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Effects of DNA methyltransferase inhibition on pattern separation performance in mice

Argyrousi, E. K., de Nijs, L., Lagatta, D. C., Schlütter, A., Weidner, M. T., Zoeller, J., van Goethem, N. P., Joca, S. R. L., van den Hove, D. L. A. & Prickaerts, J., Mar 2019, In : Neurobiology of Learning and Memory. 159, p. 6-15 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

From OPC to Oligodendrocyte: An Epigenetic Journey

Tiane, A., Schepers, M., Rombaut, B., Hupperts, R., Prickaerts, J., Hellings, N., van den Hove, D. & Vanmierlo, T., Oct 2019, In : Cells. 8, 10, 19 p., 1236.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Identification of Cholecystokinin by Genome-Wide Profiling as Potential Mediator of Serotonin-Dependent Behavioral Effects of Maternal Separation in the Amygdala

Weidner, M. T., Lardenoije, R., Eijssen, L., Mogavero, F., De Groodt, L. P. M. T., Popp, S., Palme, R., Foerstner, K. U., Strekalova, T., Steinbusch, H. W. M., Schmitt-Boehrer, A. G., Glennon, J. C., Waider, J., van den Hove, D. L. A. & Lesch, K-P., 10 May 2019, In : Frontiers in Neuroscience. 13, 17 p., 460.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer's disease-related dysregulation

Haertle, L., Mueller, T., Lardenoije, R., Maierhofer, A., Dittrich, M., Riemens, R. J. M., Stora, S., Roche, M., Leber, M., Riedel-Heller, S., Wagner, M., Scherer, M., Ravel, A., Mircher, C., Cieuta-Walti, C., Durand, S., van de Hove, D. L. A., Hoffmann, P., Ramirez, A., Haaf, T. & 2 others, El Hajj, N. & Megarbane, A., 16 Dec 2019, In : Clinical epigenetics. 11, 1, 11 p., 195.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease

Smith, A. R., Smith, R. G., Pishva, E., Hannon, E., Roubroeks, J. A. Y., Burrage, J., Troakes, C., Al-Sarraj, S., Sloan, C., Mill, J., van den Hove, D. L. & Lunnon, K., 21 Mar 2019, In : Clinical epigenetics. 11, 13 p., 52.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Systemic multipotent adult progenitor cells improve long-term neurodevelopmental outcomes after preterm hypoxic-ischemic encephalopathy

Barkhuizen, M., van Mechelen, R., Vermeer, M., Chedraui, P., Paes, D., van den Hove, D. L. A., Vaes, B., Mays, R. W., Steinbusch, H. W. M., Robertson, N. J., Kramer, B. W. & Gavilanes, A. W. D., 19 Apr 2019, In : Behavioural Brain Research. 362, p. 77-81 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2018

Age-Related Disturbances In Dna (Hydroxy) Methylation In App/Ps1 Mice

Chouliaras, L., Lardenoije, R., Kenis, G., Mastroeni, D., Hof, P. R., van Os, J., Steinbusch, H. W. M., van Leeuwen, F. W., Rutten, B. P. F. & van den Hove, D. L. A., 1 Jan 2018, In : Translational Neuroscience. 9, 1, p. 190-202 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease

Lardenoije, R., van den Hove, D. L. A., Havermans, M., Van Casteren, A., Le, K. X., Palmour, R., Lemere, C. A. & Rutten, B. P. F., 1 Jan 2018, In : Molecular and Cellular Neuroscience. 86, p. 1-15 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Behavioral testing and litter effects in the rabbit

Gumus, H. G., Agyemang, A. A., Romantsik, O., Sandgren, R., Karlsson, H., Gram, M., Vallius, S., Ley, D., van den Hove, D. L. A. & Bruschettini, M., 1 Nov 2018, In : Behavioural Brain Research. 353, p. 236-241 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Differential anxiety-related behaviours and brain activation in Tph2-deficient female mice exposed to adverse early environment

Auth, C. S., Weidner, M. T., Popp, S., Strekalova, T., Schmitt-Boehrer, A. G., van den Hove, D. L. A., Lesch, K-P. & Waider, J., Nov 2018, In : European Neuropsychopharmacology. 28, 11, p. 1270-1283 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

Directing neuronal cell fate in vitro: Achievements and challenges

Riemens, R. J. M., van den Hove, D. L. A., Esteller, M. & Delgado-Morales, R., 1 Sep 2018, In : Progress in Neurobiology. 168, p. 42-68 27 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Gestational stress in mouse dams negatively affects gestation and postpartum hippocampal BDNF and P11 protein levels

Vanmierlo, T., De Vry, J., Nelissen, E., Sierksma, A., Roumans, N., Steinbusch, H. W. M., Wennogle, L. P., van den Hove, D. & Prickaerts, J., 1 Apr 2018, In : Molecular and Cellular Neuroscience. 88, p. 292-299 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Neuroepigenetics of Aging and Age-Related Neurodegenerative Disorders

Lardenoije, R., Pishva, E., Lunnon, K. & van den Hove, D. L., 31 Jul 2018, Progress in Molecular Biology and Translational Science: Neuroepigenetics and mental illness . Rutten, B. P. F. (ed.). 1 ed. San Diego, CA: Elsevier Inc., Vol. 158. p. 49-82 34 p. (Progress in Molecular Biology and Translational Science).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

Levy, M. J. F., Boulle, F., Steinbusch, H. W., van den Hove, D. L. A., Kenis, G. & Lanfumey, L., 1 Aug 2018, In : Psychopharmacology. 235, 8, p. 2195-2220 26 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Paradoxical effects of mutant ubiquitin on Aβ plaque formation in an Alzheimer mouse model

Verheijen, B. M., Stevens, J. A. A., Gentier, R. J. G., van't Hekke, C. D., van den Hove, D. L. A., Hermes, D. J. H. P., Steinbusch, H. W. M., Ruijter, J. M., Grimm, M. O. W., Haupenthal, V. J., Annaert, W., Hartmann, T. & van Leeuwen, F. W., 1 Dec 2018, In : Neurobiology of Aging. 72, p. 62-71 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Perinatal selective serotonin reuptake inhibitor medication (SSRI) effects on social behaviors, neurodevelopment and the epigenome

Gemmel, M., Bogi, E., Ragan, C., Hazlett, M., Dubovicky, M., van den Hove, D. L., Oberlander, T. F., Charlier, T. D. & Pawluski, J. L., 1 Feb 2018, In : Neuroscience and Biobehavioral Reviews. 85, p. 102-116 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

2017

25 years of research on global asphyxia in the immature rat brain

Barkhuizen, M., van den Hove, D. L. A., Vles, J. S. H., Steinbusch, H. W. M., Kramer, B. W. & Gavilanes, A. W. D., Apr 2017, In : Neuroscience and Biobehavioral Reviews. 75, p. 166-182 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

101 Downloads (Pure)

Epigenetic dysregulation of brainstem nuclei in the pathogenesis of Alzheimer's disease: looking in the correct place at the right time?

Iatrou, A., Kenis, G., Rutten, B. P. F., Lunnon, K. & van den Hove, D. L. A., Feb 2017, In : Cellular and Molecular Life Sciences. 74, 3, p. 509-523 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access

Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases

Roubroeks, J. A. Y., Smith, R. G., van den Hove, D. L. A. & Lunnon, K., Oct 2017, In : Journal of Neurochemistry. 143, 2, p. 158-170 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Impact of varying social experiences during life history on behaviour, gene expression, and vasopressin receptor gene methylation in mice

Bodden, C., van den Hove, D., Lesch, K-P. & Sachser, N., 18 Aug 2017, In : Scientific Reports. 7, 10 p., 8719.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Newborn genome-wide DNA methylation in association with pregnancy anxiety reveals a potential role for GABBR1

Vangeel, E. B., Pishva, E., Hompes, T., van den Hove, D., Lambrechts, D., Allegaert, K., Freson, K., Izzi, B. & Claes, S., 3 Oct 2017, In : Clinical epigenetics. 9, 12 p., 107.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2016

Behavioral and neurochemical characterization of Tr kappa B-dependent mechanisms of agomelatine in glucocorticoid receptor-impaired mice

Boulle, F., Velthuis, H., Koedam, K., Steinbusch, H. W., van den Hove, D. L. A., Kenis, G., Gabriel, C., Mocaer, E., Franc, B., Rognan, D., Mongeau, R. & Lanfumey, L., Jan 2016, In : European Neuropsychopharmacology. 26, 1, p. 65-77

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

CO2 exposure as translational cross-species experimental model for panic

Leibold, N. K., van den Hove, D. L. A., Viechtbauer, W., Buchanan, G. F., Goossens, L., Lange, I., Knuts, I., Lesch, K. P., Steinbusch, H. W. M. & Schruers, K. R. J., 6 Sep 2016, In : Translational Psychiatry. 6, e885.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Developmental fluoxetine exposure increases behavioral despair and alters epigenetic regulation of the hippocampal BDNF gene in adult female offspring

Boulle, F., Pawluski, J. L., Homberg, J. R., Machiels, B., Kroeze, Y., Kumar, N., Steinbusch, H. W. M., Kenis, G. & van den Hove, D. L. A., Apr 2016, In : Hormones and Behavior. 80, p. 47-57

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Effects of prenatal Poly I:C exposure on global histone deacetylase (HDAC) and DNA methyltransferase (DNMT) activity in the mouse brain

Lopez, Y. P., Kenis, G., Stettinger, W., Neumeier, K., de Jonge, S., Steinbusch, H. W. M., Zill, P., van den Hove, D. L. A. & Myint, A. M., Jul 2016, In : Molecular Biology Reports. 43, 7, p. 711-717

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Fluoxetine Treatment Induces Seizure Behavior and Premature Death in APPswe/PS1dE9 Mice

Sierksma, A. S. R., de Nijs, L., Hoogland, G., Vanmierlo, T., van Leeuwen, F. W., Rutten, B. P. F., Steinbusch, H. W. M., Prickaerts, J. & van den Hove, D. L. A., 2016, In : Journal of Alzheimer's Disease. 51, 3, p. 677-682

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment

Bey, K., Wolfsgruber, S., Karaca, I., Wagner, H., Lardenoije, R., Becker, J., Milz, E., Kornhuber, J., Peters, O., Froelich, L., Huell, M., Ruether, E., Wiltfang, J., Riedel-Heller, S., Scherer, M., Jessen, F., Maier, W., van den Hove, D. L., Rutten, B. P. F., Wagner, M. & 1 others, Ramirez, A., May 2016, In : Epigenomics. 8, 5, p. 593-598

Research output: Contribution to journalArticleAcademicpeer-review

Prenatal stress and early-life exposure to fluoxetine have enduring effects on anxiety and hippocampal BDNF gene expression in adult male offspring

Boulle, F., Pawluski, J. L., Homberg, J. R., Machiels, B., Kroeze, Y., Kumar, N., Steinbusch, H. W. M., Kenis, G. & Van den Hove, D. L. A., May 2016, In : Developmental Psychobiology. 58, 4, p. 427-438

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Quinolinic acid-immunoreactivity in the naive mouse brain

Lopez, Y. P., Kenis, G., Rutten, B. P. F., Myint, A. M., Steinbusch, H. W. M. & van den Hove, D. L. A., Jan 2016, In : Journal of Chemical Neuroanatomy. 71, p. 6-12

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency

van den Hurk, M., Kenis, G., Bardy, C., van den Hove, D. L., Gage, F. H., Steinbusch, H. W. & Rutten, B. P., Aug 2016, In : Epigenomics. 8, 8, p. 1131-1149

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
2015

Cadherin-13, a risk gene for ADHD and comorbid disorders, impacts GABAergic function in hippocampus and cognition

Rivero, O., Selten, M. M., Sich, S., Popp, S., Bacmeister, L., Amendola, E., Negwer, M., Schubert, D., Proft, F., Kiser, D., Schmitt, A. G., Gross, C., Kolk, S. M., Strekalova, T., van den Hove, D., Resink, T. J., Nadif Kasri, N. & Lesch, K. P., 13 Oct 2015, In : Translational Psychiatry. 5, e655.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Defeat stress in rodents: From behavior to molecules

Hammels, C., Pishva, E., De Vry, J., van den Hove, D. L. A., Prickaerts, J., van Winkel, R., Selten, J-P., Lesch, K-P., Daskalakis, N. P., Steinbusch, H. W. M., van Os, J., Kenis, G. & Rutten, B. P. F., Dec 2015, In : Neuroscience and Biobehavioral Reviews. 59, p. 111-40 30 p.

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)
5 Citations (Scopus)

DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts

Chouliaras, L., Kenis, G., Visser, P. J., Scheltens, P., Tsolaki, M., Jones, R. W., Kehoe, P. G., Graff, C., Girtler, N. G., Wallin, A. K., Rikkert, M. O., Spiru, L., Elias-Sonnenschein, L. S., Ramakers, I. H. G. B., Pishva, E., van Os, J., Steinbusch, H. W. M., Verhey, F. R. J., van den Hove, D. L. A. & Rutten, B. P. F., 2015, In : Epigenomics. 7, 4, p. 533-537

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

EFFECTS OF STRESS EARLY IN GESTATION ON HIPPOCAMPAL NEUROGENESIS AND GLUCOCORTICOID RECEPTOR DENSITY IN PREGNANT RATS

Pawluski, J. L., Csaszar, E., Savage, E., Martinez-Claros, M., Steinbusch, H. W. M. & van den Hove, D., 2 Apr 2015, In : Neuroscience. 290, p. 379-388

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Effects of Subcutaneous LPS Injection on Gestational Length and Intrauterine and Neonatal Mortality in Mice

Lopez, Y. P., Steinbusch, H. W. M., Rutten, B., Kenis, G., van den Hove, D. L. & Myint, A. M., 2015, In : Neuroimmunomodulation. 22, 4, p. 274-278

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Epigenetic modifications in mouse cerebellar Purkinje cells: effects of aging, caloric restriction, and overexpression of superoxide dismutase 1 on 5-methylcytosine and 5-hydroxymethylcytosine

Lardenoije, R., van den Hove, D. L. A., Vaessen, T. S. J., Iatrou, A., Meuwissen, K. P. V., van Hagen, B. T. J., Kenis, G., Steinbusch, H. W. M., Schmitz, C. & Rutten, B. P. F., Nov 2015, In : Neurobiology of Aging. 36, 11, p. 3079-3089

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Interaction of brain 5-HT synthesis deficiency, chronic stress and sex differentially impact emotional behavior in Tph2 knockout mice

Gutknecht, L., Popp, S., Waider, J., Sommerlandt, F. M. J., Goeppner, C., Post, A., Reif, A., van den Hove, D., Strekalova, T., Schmitt, A., Colaco, M. B. N., Sommer, C., Palme, R. & Lesch, K-P., Jul 2015, In : Psychopharmacology. 232, 14, p. 2429-2441

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)