An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene

Janou A. Y. Roubroeks; Adam R. Smith; Rebecca G. Smith; Ehsan Pishva; Zina Ibrahim; Martina Sattlecker; Eilis J. Hannon; Iwona Kloszewska; Patrizia Mecocci; Hilkka Soininen; Magda Tsolaki; Bruno Vellas; Lars-Olof Wahlund; Dag Aarsland; Petroula Proitsi; Angela Hodges; Simon Lovestone; Stephen J. Newhouse; Richard J. B. Dobson; Jonathan Mill; Daniel L. A. van den Hove; Katie Lunnon

doi:10.1016/j.neurobiolaging.2020.06.023

An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene

Janou A. Y. Roubroeks, Adam R. Smith, Rebecca G. Smith, Ehsan Pishva, Zina Ibrahim, Martina Sattlecker, Eilis J. Hannon, Iwona Kloszewska, Patrizia Mecocci, Hilkka Soininen, Magda Tsolaki, Bruno Vellas, Lars-Olof Wahlund, Dag Aarsland, Petroula Proitsi, Angela Hodges, Simon Lovestone, Stephen J. Newhouse, Richard J. B. Dobson, Jonathan MillDaniel L. A. van den Hove, Katie Lunnon^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	26-45
Number of pages	20
Journal	Neurobiology of Aging
Volume	95
DOIs	https://doi.org/10.1016/j.neurobiolaging.2020.06.023
Publication status	Published - Nov 2020

Keywords

Alzheimer's disease (AD)
Biomarker
Blood
DNA methylation
HOXB6
Mild cognitive impairment (MCI)
MILD COGNITIVE IMPAIRMENT
MESSENGER-RNA EXPRESSION
METHYLATION
BIOMARKERS
OXYTOCIN
DISCOVERY
ALGORITHM
DEMENTIA
PATTERN
PACKAGE

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10.1016/j.neurobiolaging.2020.06.023Licence: CC BY

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Roubroeks, J. A. Y., Smith, A. R., Smith, R. G., Pishva, E., Ibrahim, Z., Sattlecker, M., Hannon, E. J., Kloszewska, I., Mecocci, P., Soininen, H., Tsolaki, M., Vellas, B., Wahlund, L-O., Aarsland, D., Proitsi, P., Hodges, A., Lovestone, S., Newhouse, S. J., Dobson, R. J. B., ... Lunnon, K. (2020). An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene. Neurobiology of Aging, 95, 26-45. https://doi.org/10.1016/j.neurobiolaging.2020.06.023

Roubroeks, Janou A. Y. ; Smith, Adam R. ; Smith, Rebecca G. ; Pishva, Ehsan ; Ibrahim, Zina ; Sattlecker, Martina ; Hannon, Eilis J. ; Kloszewska, Iwona ; Mecocci, Patrizia ; Soininen, Hilkka ; Tsolaki, Magda ; Vellas, Bruno ; Wahlund, Lars-Olof ; Aarsland, Dag ; Proitsi, Petroula ; Hodges, Angela ; Lovestone, Simon ; Newhouse, Stephen J. ; Dobson, Richard J. B. ; Mill, Jonathan ; van den Hove, Daniel L. A. ; Lunnon, Katie. / An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene. In: Neurobiology of Aging. 2020 ; Vol. 95. pp. 26-45.

@article{1ac0f82ae5ec4d75a961188d4779c247,

title = "An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene",

keywords = "Alzheimer's disease (AD), Biomarker, Blood, DNA methylation, HOXB6, Mild cognitive impairment (MCI), MILD COGNITIVE IMPAIRMENT, MESSENGER-RNA EXPRESSION, METHYLATION, BIOMARKERS, OXYTOCIN, DISCOVERY, ALGORITHM, DEMENTIA, PATTERN, PACKAGE",

author = "Roubroeks, {Janou A. Y.} and Smith, {Adam R.} and Smith, {Rebecca G.} and Ehsan Pishva and Zina Ibrahim and Martina Sattlecker and Hannon, {Eilis J.} and Iwona Kloszewska and Patrizia Mecocci and Hilkka Soininen and Magda Tsolaki and Bruno Vellas and Lars-Olof Wahlund and Dag Aarsland and Petroula Proitsi and Angela Hodges and Simon Lovestone and Newhouse, {Stephen J.} and Dobson, {Richard J. B.} and Jonathan Mill and {van den Hove}, {Daniel L. A.} and Katie Lunnon",

year = "2020",

month = nov,

doi = "10.1016/j.neurobiolaging.2020.06.023",

language = "English",

volume = "95",

pages = "26--45",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Science",

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Roubroeks, JAY, Smith, AR, Smith, RG, Pishva, E, Ibrahim, Z, Sattlecker, M, Hannon, EJ, Kloszewska, I, Mecocci, P, Soininen, H, Tsolaki, M, Vellas, B, Wahlund, L-O, Aarsland, D, Proitsi, P, Hodges, A, Lovestone, S, Newhouse, SJ, Dobson, RJB, Mill, J, van den Hove, DLA & Lunnon, K 2020, 'An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene', Neurobiology of Aging, vol. 95, pp. 26-45. https://doi.org/10.1016/j.neurobiolaging.2020.06.023

An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene. / Roubroeks, Janou A. Y.; Smith, Adam R.; Smith, Rebecca G.; Pishva, Ehsan; Ibrahim, Zina; Sattlecker, Martina; Hannon, Eilis J.; Kloszewska, Iwona; Mecocci, Patrizia; Soininen, Hilkka; Tsolaki, Magda; Vellas, Bruno; Wahlund, Lars-Olof; Aarsland, Dag; Proitsi, Petroula; Hodges, Angela; Lovestone, Simon; Newhouse, Stephen J.; Dobson, Richard J. B.; Mill, Jonathan; van den Hove, Daniel L. A.; Lunnon, Katie.

In: Neurobiology of Aging, Vol. 95, 11.2020, p. 26-45.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene

AU - Roubroeks, Janou A. Y.

AU - Smith, Adam R.

AU - Smith, Rebecca G.

AU - Pishva, Ehsan

AU - Ibrahim, Zina

AU - Sattlecker, Martina

AU - Hannon, Eilis J.

AU - Kloszewska, Iwona

AU - Mecocci, Patrizia

AU - Soininen, Hilkka

AU - Tsolaki, Magda

AU - Vellas, Bruno

AU - Wahlund, Lars-Olof

AU - Aarsland, Dag

AU - Proitsi, Petroula

AU - Hodges, Angela

AU - Lovestone, Simon

AU - Newhouse, Stephen J.

AU - Dobson, Richard J. B.

AU - Mill, Jonathan

AU - van den Hove, Daniel L. A.

AU - Lunnon, Katie

PY - 2020/11

Y1 - 2020/11

KW - Alzheimer's disease (AD)

KW - Biomarker

KW - Blood

KW - DNA methylation

KW - HOXB6

KW - Mild cognitive impairment (MCI)

KW - MILD COGNITIVE IMPAIRMENT

KW - MESSENGER-RNA EXPRESSION

KW - METHYLATION

KW - BIOMARKERS

KW - OXYTOCIN

KW - DISCOVERY

KW - ALGORITHM

KW - DEMENTIA

KW - PATTERN

KW - PACKAGE

U2 - 10.1016/j.neurobiolaging.2020.06.023

DO - 10.1016/j.neurobiolaging.2020.06.023

M3 - Article

C2 - 32745807

VL - 95

SP - 26

EP - 45

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -