Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer's disease-related dysregulation

Larissa Haertle, Tobias Mueller, Roy Lardenoije, Anna Maierhofer, Marcus Dittrich, Renzo J. M. Riemens, Samantha Stora, Mathilde Roche, Markus Leber, Steffi Riedel-Heller, Michael Wagner, Martin Scherer, Aime Ravel, Clotilde Mircher, Cecile Cieuta-Walti, Sophie Durand, Daniel L. A. van de Hove, Per Hoffmann, Alfredo Ramirez, Thomas HaafNady El Hajj, Andre Megarbane*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number195
Number of pages11
JournalClinical epigenetics
Volume11
Issue number1
DOIs
Publication statusPublished - 16 Dec 2019

Keywords

  • Trisomy 21
  • DNA methylation
  • Intellectual disability
  • Down syndrome
  • Cognitive function
  • Alzheimer's disease
  • Infinium Methylation EPIC arrays
  • GENOME-WIDE ASSOCIATION
  • DOWN-SYNDROME
  • DNA METHYLATION
  • EPIGENETIC DYSREGULATION
  • INTELLECTUAL DISABILITY
  • METAANALYSIS
  • CHILDREN
  • DEMENTIA
  • IMMUNITY
  • RECEPTOR

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