Epigenome-Wide Association Studies in Psychiatry: Achievements and Problems

Katherine Bassil; Nadya Ali; Ehsan Pishva; Daniel L.A. van den Hove

doi:10.1007/978-3-030-94475-9_18

Epigenome-Wide Association Studies in Psychiatry: Achievements and Problems

Katherine Bassil, Nadya Ali, Ehsan Pishva, Daniel L.A. van den Hove^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

Abstract

Genetic variation can only explain a small portion of risk to psychiatric disorders, including major depressive disorder, schizophrenia, and post-traumatic stress disorder. Epidemiological studies are increasingly showing a link between environmental factors and the development of various psychiatric disorders, mainly mediated by underlying epigenetic mechanisms. DNA methylation is one of the most studied epigenetic mechanisms in psychiatric disorders. Epigenome-wide association studies (EWAS) typically used to study changes in DNA methylation still face methodological challenges and limitations at both the fundamental, technical, and data analysis levels. In this chapter, we offer a brief overview of some EWAS studies in different psychiatric disorders and discuss the current challenges, pitfalls, and future considerations for this field.

Original language	English
Title of host publication	Epigenetic Epidemiology: Second Edition
Publisher	Springer International Publishing
Pages	427-444
Number of pages	18
ISBN (Electronic)	9783030944759
ISBN (Print)	9783030944742
DOIs	https://doi.org/10.1007/978-3-030-94475-9_18
Publication status	Published - 1 Jan 2022

Keywords

DNA methylation
Environment
Epigenetics
Psychiatric disorders
Psychiatry

Access to Document

10.1007/978-3-030-94475-9_18

Cite this

@inbook{7f40f427d93046fc80010506f83272be,

title = "Epigenome-Wide Association Studies in Psychiatry: Achievements and Problems",

abstract = "Genetic variation can only explain a small portion of risk to psychiatric disorders, including major depressive disorder, schizophrenia, and post-traumatic stress disorder. Epidemiological studies are increasingly showing a link between environmental factors and the development of various psychiatric disorders, mainly mediated by underlying epigenetic mechanisms. DNA methylation is one of the most studied epigenetic mechanisms in psychiatric disorders. Epigenome-wide association studies (EWAS) typically used to study changes in DNA methylation still face methodological challenges and limitations at both the fundamental, technical, and data analysis levels. In this chapter, we offer a brief overview of some EWAS studies in different psychiatric disorders and discuss the current challenges, pitfalls, and future considerations for this field.",

keywords = "DNA methylation, Environment, Epigenetics, Psychiatric disorders, Psychiatry",

author = "Katherine Bassil and Nadya Ali and Ehsan Pishva and {van den Hove}, {Daniel L.A.}",

note = "Publisher Copyright: {\textcopyright} The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.",

year = "2022",

month = jan,

day = "1",

doi = "10.1007/978-3-030-94475-9_18",

language = "English",

isbn = "9783030944742",

pages = "427--444",

booktitle = "Epigenetic Epidemiology: Second Edition",

publisher = "Springer International Publishing",

address = "Switzerland",

}

TY - CHAP

T1 - Epigenome-Wide Association Studies in Psychiatry

T2 - Achievements and Problems

AU - Bassil, Katherine

AU - Ali, Nadya

AU - Pishva, Ehsan

AU - van den Hove, Daniel L.A.

N1 - Publisher Copyright: © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Genetic variation can only explain a small portion of risk to psychiatric disorders, including major depressive disorder, schizophrenia, and post-traumatic stress disorder. Epidemiological studies are increasingly showing a link between environmental factors and the development of various psychiatric disorders, mainly mediated by underlying epigenetic mechanisms. DNA methylation is one of the most studied epigenetic mechanisms in psychiatric disorders. Epigenome-wide association studies (EWAS) typically used to study changes in DNA methylation still face methodological challenges and limitations at both the fundamental, technical, and data analysis levels. In this chapter, we offer a brief overview of some EWAS studies in different psychiatric disorders and discuss the current challenges, pitfalls, and future considerations for this field.

AB - Genetic variation can only explain a small portion of risk to psychiatric disorders, including major depressive disorder, schizophrenia, and post-traumatic stress disorder. Epidemiological studies are increasingly showing a link between environmental factors and the development of various psychiatric disorders, mainly mediated by underlying epigenetic mechanisms. DNA methylation is one of the most studied epigenetic mechanisms in psychiatric disorders. Epigenome-wide association studies (EWAS) typically used to study changes in DNA methylation still face methodological challenges and limitations at both the fundamental, technical, and data analysis levels. In this chapter, we offer a brief overview of some EWAS studies in different psychiatric disorders and discuss the current challenges, pitfalls, and future considerations for this field.

KW - DNA methylation

KW - Environment

KW - Epigenetics

KW - Psychiatric disorders

KW - Psychiatry

U2 - 10.1007/978-3-030-94475-9_18

DO - 10.1007/978-3-030-94475-9_18

M3 - Chapter

SN - 9783030944742

SP - 427

EP - 444

BT - Epigenetic Epidemiology: Second Edition

PB - Springer International Publishing

ER -

Epigenome-Wide Association Studies in Psychiatry: Achievements and Problems

Abstract

Keywords

Access to Document

Fingerprint

Cite this